Peripheral blood antigens cd38. Medical search. Frequent questions

Elranatamab is indicated for adults with relapsed or refractory multiple myeloma who have received at least 4 prior therapies, including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody. (medscape.com)
Elranatamab is an antibody that binds to both CD3 on T-cells and B-cell maturation antigen (BCMA), which are expressed on the surface of multiple myeloma cells. (medscape.com)
Motixafortide is indicated in combination with filgrastim to mobilize hematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in patients with multiple myeloma. (medscape.com)
With this feature, CD38 has become a popular target for the treatment of multiple myeloma (MM). (cusabio.com)
Three other programs in phase 1: CD38 CAR T in multiple myeloma, CD38 antibody-drug conjugate in amyloidosis and seprehvir in solid tumors. (pennystocksreporter.com)

The HIT2 antibody reacts with CD38, an ~45 kDa type II transmembrane glycoprotein expressed by many cell types, especially leukocytes. (stemcell.com)
CD38 is a 45 kD type II transmembrane glycoprotein also known as T10. (biolegend.com)
CD38 is a type II transmembrane glycoprotein and the receptor of CD31. (cusabio.com)

CD38 is a glycoprotein on the cell membrane that functions as a cyclic ADP-ribose hydrolase (cADPRH). (biomedcentral.com)
CD38 is a gene providing instruction of making a protein named ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (also abbreviated as ADPRC1 or CD38) in human and belongs to ADP-ribosyl cyclase family. (cusabio.com)

CD38 is an ectoenzyme (ADP-ribosyl hydrolase) with both cyclase and hydrolase activities, whereby it mediates lymphocyte activation, adhesion and metabolism. (stemcell.com)
By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, adhesion, and the metabolism of cADPR and NAADP. (biolegend.com)

There is an unmet need to develop novel therapies for refractory/relapsed MM. In the past few years, chimeric antigen receptor (CAR)-modified T cell therapy for MM has shown promising efficacy in preclinical and clinical studies. (biomedcentral.com)
Chimeric antigen receptor (CAR) T cell therapy has emerged as a novel immunotherapy which modifies T cells with CAR, an artificial fusion protein that incorporates an extracellular antigen recognition domain, a transmembrane domain, and an intracellular domain including costimulation and signaling components [ 4 , 5 ]. (biomedcentral.com)

Many of these factors stem from the location of the epitope that can affect accessibility of the antibody to the epitope at a cellular or molecular level, direct inhibition of target antigen activity, conservation of function despite escape mutations, and even non-competitive inhibition sites. (preprints.org)

We investigated baseline surface marker expression and Syk phosphorylation kinetics upon B cell receptor (BCR) stimulation of peripheral B cells and specifically the CXCR5-CD19low subset using flow cytometry. (bmj.com)
CD20 is also associated with lipid rafts, but the intensity of this association depends on extracellular triggering, employing CD20 conformational change, and/or BCR (B cell antigen receptor) aggregation. (thermofisher.com)
It is a bispecific humanized monoclonal antibody against CD3, a T-cell surface antigen, and GPRC5D (human G-protein coupled receptor family C group 5 member D), a tumor-associated antigen with potential antineoplastic activity. (medscape.com)
The combination of CD38 and CD31 plays an important role in cell migration and receptor-mediated adhesion. (cusabio.com)

Human peripheral blood lymphocytes were stained with CD38 (clone HIT2) APC/Fire™ 810 (filled histogram) or cells were left unstained (open histogram). (biolegend.com)

Peripheral blood mononuclear cells from this cohort of individuals were used to map out the viral epitopes targeted by T cells in humans. (cdc.gov)
Horisberger et al ( OP0186 ) performed immunophenotyping peripheral blood mononuclear cells (PBMC) from 140 patients with biopsy-proven SLE nephritis (LN) and 40 healthy controls using mass cytometry using four 48-marker panels. (emeunews.org)

Immediately after PBMC planning or lysing entire blood, lymphocytes ought to be gated in accordance to their scatter properties and by exclusion of doublets and dead cells through the evaluation (Fig. 97A, B). In an effort to detect plasma cells concurrently, the initial FSC/SSC gating need to be greater and never restricted to a standard lymphocyte gate 721. (gsk-3inhibitor.com)
Morphologically, in the peripheral blood, these cells resemble mature lymphocytes. (medscape.com)
The last stage in the process of measuring the percentage of CD4+ T-lymphocytes in the whole-blood sample is referred to as 'immunophenotyping by flow cytometry' (22-28). (cdc.gov)
The CDC guidelines concerning CD4+ T-cell determinations (33) were first published in the MMWR in 1992 to provide laboratorians with the most complete information about how to measure CD4+ T-lymphocytes in blood from HIV-infected persons by using flow cytometry. (cdc.gov)

7. Klein U, Rajewsky K, Küppers R. Human immunoglobulin (Ig)M + IgD + peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. (southernbiotech.com)
Nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mouse as a model system to study the engraftment and mobilization of human peripheral blood stem cells. (southernbiotech.com)
We previously showed that the presence of NY-ESO-1-reactive and/or Melan-A-reactive T cells in the blood correlated with prolonged overall survival (OS) of patients with melanoma with a heterogeneous treatment background. (bmj.com)
Transitional cells can be found in the bone marrow, peripheral blood, and spleen, and only a fraction of the immature B cells that survive after the transitional stage become mature B cells in secondary lymphoid organs such as the spleen. (wikipedia.org)
The term "transitional B cell" was first used in 1995 for cells that are developmentally intermediate between immature bone marrow B lineage cells and fully mature naïve B cells in the peripheral blood and secondary lymphoid tissues, found in mice. (wikipedia.org)
In humans, it is postulated that the transitional cells, after leaving the bone marrow, are subjected to peripheral checks to prevent the production of autoantibodies. (wikipedia.org)
All transitional B cells are high in heat-stable antigen (HSA, CD24) relative to their mature counterparts and express the phenotypic surface markers AA4. (wikipedia.org)
As in the mouse, human transitional cells can be found in the bone marrow, peripheral blood, and spleen. (wikipedia.org)
However, in contrast to the nuanced models proposed in the mouse, thus far human studies have, by and large, described a rather homogeneous population of transitional B cells (T1/T2) defined by the expression of high levels of CD24, CD38 and CD10. (wikipedia.org)
Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus In vivo. (ox.ac.uk)
In this study, we have used tetrameric major histocompatibility complex-peptide complexes to directly visualize antigen-specific cluster of differentration (CD)8+ T cells during the primary immune response to Epstein-Barr virus (EBV) infection in humans. (ox.ac.uk)
We show that massive expansion of activated, antigen-specific T cells occurs during the primary response to this virus. (ox.ac.uk)
In one individual, T cells specific for a single EBV epitope comprised 44% of the total CD8+ T cells within peripheral blood. (ox.ac.uk)
The majority of the antigen-specific cells had an activated/memory phenotype, with expression of human histocompatibility leukocyte antigen (HLA) DR, CD38, and CD45RO, downregulation of CD62 leukocyte (CD62L), and low levels of expression of CD45RA. (ox.ac.uk)
After recovery from AIM, the frequency of antigen-specific T cells fell in most donors studied, although populations of antigen-specific cells continued to be easily detectable for at least 3 yr. (ox.ac.uk)
one.two.seven Conclusions: Even though mice might not represent humans on all ranges, using inbred mice with predefined HLA molecules, experimental immunization/infection with defined antigens, the possibility for genetic, in vitro and in vivo manipulation of cells and also the much easier access to tissues besides peripheral blood enables us to solution several T-cell biological concerns. (gsk-3inhibitor.com)
On this segment, we concentrate on human B cells and their peripheral subpopulations specifically. (gsk-3inhibitor.com)
Immature CD19+ B cells inside the bone marrow express large ranges of CD38 and variable ranges of CD20 and IgM, which enhance with their even further differentiation 725. (gsk-3inhibitor.com)
they comprise about 60 of B cells within the peripheral blood 726, 727. (gsk-3inhibitor.com)
Immediately after antigen experience and T-cell assist, memory B cells and antibody-secreting plasma cells are created in the germinal center response. (gsk-3inhibitor.com)
While in the peripheral blood, among 30 and forty of circulating B cells express CD27 726, 729. (gsk-3inhibitor.com)
Plasma cells carry GNF6702 Purity distinct FSC and SSC traits, express high amounts of CD27 and lack the expression of CD20 but may also be highly positive for CD38 and partially CD138++ 721. (gsk-3inhibitor.com)
Staining of normal human peripheral blood cells with Anti-Human CD3 APC (Product # 17-0038-42) and 0.25 µg of Mouse IgG1 K Isotype Control eFluor® 450 (Product # 48-4714-82) (left) or Anti-Human CD8a eFluor® 450 (right). (thermofisher.com)
Applications Tested: This RPA-T8 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. (thermofisher.com)
Ligation of MHC-I/peptide complexes presented by antigen-presenting cells (APCs), triggers the recruitment of lymphocyte-specific protein tyrosine kinase (Lck), which leads to lymphokine production, motility and cytotoxic T lymphocyte (CTL) activation. (thermofisher.com)
http://tinyurl.com/2233wp ) in "Blood" on clonogenic myeloma cells. (healthblogs.org)
Here, we present a new generation of subunit vaccines targeting viral antigens to CD40-expressing antigen-presenting cells. (nature.com)
Plasmablast-like Phenotype Among Antigen-Experienced CXCR5-CD19(low) B Cells in Systemic Lupus Erythematosus. (bmj.com)
Applications Tested: This 2H7 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. (thermofisher.com)
In humans, CD38 is expressed by the majority of hematopoietic cells at levels which vary according to the differentiation and activation status of the cells. (stemcell.com)
This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ Human CD138 Positive Selection Kit II (Catalog #1877) and EasySep™ Human Whole Blood and Bone Marrow CD138 Positive Selection Kit II (Catalog #17887). (stemcell.com)
HDAC9 is also expressed in marginal zone B cells and a fraction of CD38 or CD27 positive subepithelial tonsilar cells. (sunderland.ac.uk)
The diagnosis of Hairy Cell Leukemia and HCL-like diosrders, including HCL variant (vHCL) and Splenic Diffuse Red Pulp Lymphoma (SDRPL), is based on the examination of the peripheral blood and bone marrow smears allowing the identification of hairy cells and the flow cytometric analysis. (fortuneonline.org)
An accurate diagnosis is necessary given that different clinical management is required: the first step in a definitive diagnosis is based on the examination of the peripheral blood and bone marrow smears allowing the identification of hairy cells and a specific Flow Cytometric Analysis (FCA). (fortuneonline.org)
For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. (biolegend.com)
Studies have shown that exposure of T cells to tumor antigens upregulates the expression of inhibitory checkpoint receptors, leading to T-cell dysfunction or exhaustion. (journaltocs.ac.uk)
6 AL amyloidosis is a life-threatening blood cell disorder that occurs when blood plasma cells in the bone marrow produce amyloid deposits, which build up in vital organs and eventually cause organ deterioration. (biospace.com)
On the surface of lymphoid cells, myeloid cells and other non-hematopoietic tissue cells, the expression of CD38 shows is lower, but on the surface of malignant plasma cells such as myeloma cells, CD38 shows high expression. (cusabio.com)
Progression of intramedullary myeloma is associated with increasingly severe secondary features (lytic bone lesions, anaemia, immunodeficiency and renal impairment) and also, in a fraction of patients, the occurrence of tumour cells in extramedullary sites, such as the blood, pleural fluid and skin. (touchoncology.com)
As cells undergo oncogenesis, neoantigens are released and captured on major histocompatibility complex (MHC)/ human leukocyte antigen (HLA) of dendritic cells (DCs) that subsequently mature and migrate to central lymphoid organs. (encyclopedia.pub)
Efficacy was dependent on the number of CD8+ T cells able to recognize tumor antigens that infiltrated the malignant tissue. (unav.edu)
Singaraju et al ( OP0015 ) explored that immune checkpoint inhibitor (ICI) arthritis enriched for CD38 hi CD127 - effector CD8+ T-cells compared to rheumatoid arthritis (RA) and psoriatic arthritis (PsA) and it is suggesting an elevated interferon signature. (emeunews.org)
The analysis suggested differentially expressed genes (DEG) with strong correlation to CDC42 defined the metabolic signature (MetSig) of CDC42hiCD14+ cells and they were antigen-presenting CD14+ cells migrating to joints and coordinating autoimmunity. (emeunews.org)
JAKi can suppress the antigen presenting capacity of CD14+ cells and The MetSig in CD14+ cells may be useful to select candidate patients for JAKi. (emeunews.org)
T-cells nurse-like cells) the extracellular matrix … The significant differences in the properties of the cells in the peripheral blood and lymphoid tissues are at least in part explained by antigenic stimulation and close conversation with various accessory cells as well as by exposure to different cytokines chemokines and extracellular matrix components (Physique 1). (researchassistantresume.com)
The intrahepatic infiltrate showed enrichment for CD8 T cells with SARS-CoV-2-specificity compared to the peripheral blood. (alecomm.com)
Notably, hepatitis severity correlated longitudinally with an activated cytotoxic phenotype of peripheral SARS-CoV-2-specific, but not EBV-specific CD8+ T cells or vaccine-induced immunoglobulins. (alecomm.com)
Comprehensive immunologic assessment of the inflammatory infiltrates in the liver revealed the presence of a highly activated cytotoxic CD8 T cell infiltrate including a SARS-CoV-2-specific CD8 T cell population that correlated with the peripheral activation of SARS-CoV-2-specific CD8 T cells, indicating that post-COVID19 vaccination hepatitis involves vaccination-elicited antigen-specific immune responses with distinct histological features compared to bona fide autoimmune hepatitis. (alecomm.com)
Furthermore, we observed a correlation between the percentage of splenic human CD4+ T-cells with total HIV DNA, between the number of human CD38 + CD8+ T-cells in the spleen with the amount of integrated HIV DNA, and eventually between the hCD4/hCD8 ratio in the spleen with integrated as well as total HIV DNA implying that the CD8+ T cells influence the size of the HIV reservoir. (biomedcentral.com)
2002). Newborn mice were sublethally irradiated (1Gy) within 5 days of birth and 2e10 5 human cord blood-derived CD34+ cells were injected intra-hepatically. (biomedcentral.com)
Binding of complement to a foreign substance, or antigen, amplifies and augments the body's innate immune system by means of its role as an opsonin (a factor that enhances phagocytosis of unwanted particles) and as a chemoattractant (a factor that recruits cells to areas of inflammation). (medscape.com)
The generation of receptors specific for antigens is a unique and complex process that generates 10 12 specific receptors for each cell type of the adaptive immune system, including T and B cells. (medscape.com)
Various cell types can process and present these antigens to T cells, or antigens may be soluble and bound to B-cell receptors. (medscape.com)

Several antigens have been used as targets for CAR-T cell therapy against MM, including B cell maturation antigen (BCMA), CD19, CD138, signaling lymphocytic activation molecule 7 (SLAM7), and immunoglobulin light chains. (biomedcentral.com)

Outcomes for patients with melanoma have improved over the past decade with the clinical development and approval of immunotherapies targeting immune checkpoint receptors such as programmed death-1 (PD-1), programmed death ligand 1 (PD-L1) or cytotoxic T lymphocyte antigen-4 (CTLA-4). (biomedcentral.com)
Disturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus. (bmj.com)
After a complex process of education and maturation, a circulating lymphocyte can bind to an antigen. (medscape.com)

The supporting examinations showed abnormal blood cell counts, positive antinuclear antibody profile, serositis, and neuropathy. (journaltocs.ac.uk)
Through the incorporation of novel computational methods for predicting antigen changes to model-informed drug discovery and development, superior vaccines and antibody-based therapeutics or diagnostics can now be more easily designed to mitigate failures. (preprints.org)

Two main advantages of BCMA as an antigen for CAR-T therapy are the potential reduction of on-target/off-tumor toxicity and the lack of antigen-dependent reduction in CAR-T cell expansion [ 16 ]. (biomedcentral.com)

The morphological examination of peripheral blood or bone marrow smears, although still an indispensable part of routine laboratory testing, is clearly insufficient for patient management, and clinicians should not ask themselves whether to look for MRD or not, but how and when. (smw.ch)

For even further discrimination of developmental stages in B-cell maturation, combinations of supplemental markers this kind of as CD27, CD38, CD23, CD77 and expression of surface immunoglobulins are utilised (Table 25). (gsk-3inhibitor.com)

Methods Peripheral blood T cell stimulation by NY-ESO-1 and Melan-A overlapping peptide libraries was assessed before and during ICB in two independent cohorts of a total of 111 patients with stage IV melanoma. (bmj.com)
The T cell immune phenotypic profile in blood donors was related to loss of T cell function, whereas the same set of markers were related to chronic antigen stimulation and immune senescence in HIV-negative individuals. (frontiersin.org)

Surface marker expression of CD38, CD95 and CD71 and IgA and IgG suggest an activated and antigen experienced phenotype. (bmj.com)

Upon the detection of either type of the antigen preparation, the lowest concentration of the antigen detectable in buffer with pH 5.1 has been found to be approximately equal, amounting to ~10 -14 M. This value has been found to be similar upon the use of either type of molecular probes. (preprints.org)

They possess the ability to recognize process and present foreign antigens to other components of the immune system and to undergo maturation and eventually secrete antibodies directed at a specific antigen. (researchassistantresume.com)

CD31 is the ligand of CD38. (biolegend.com)

Ligation of CD38 suppresses human B lymphopoiesis. (southernbiotech.com)

The magnitude of the antigen-specific component versus the bystander component of a primary T cell response remains controversial. (ox.ac.uk)
Patients with CLL typically have a higher-than-normal white blood cell count, which is determined by a complete blood count (CBC). (medscape.com)
Partial least squares regression (PLSR) was used to explore associations between biological age advancement and immunological changes in the T cell and monocyte compartment in people with HIV (n=40), comparable HIV-negative individuals (n=40) participating in the Comorbidity in Relation to AIDS (COBRA) cohort, and blood donors (n=35). (frontiersin.org)
We observed that age advancement in all three groups combined was associated with a monocyte immune phenotypic profile related to inflammation and a T cell immune phenotypic associated with immune senescence and chronic antigen exposure. (frontiersin.org)
The identified monocyte and T cell immune phenotypic profiles that were associated with age advancement, were strongly related to inflammation, chronic antigen exposure and immune senescence. (frontiersin.org)
While the monocyte and T cell immune phenotypic profile within the HIV-negative individuals reflected those observed in the combined three groups, a distinct profile related to immune dysfunction, was observed within blood donors and people with HIV. (frontiersin.org)
1 DARZALEX FASPRO ® is the first and only FDA-approved treatment for patients with this blood cell disorder that is associated with the production of an abnormal protein, which leads to the deterioration of vital organs, most notably the heart, kidneys and liver. (biospace.com)
There is an urgent need for awareness and treatment options to help in the fight against this serious blood cell disorder," said Raymond L. Comenzo , M.D., Director, John C. Davis Myeloma and Amyloid Program, Tufts Medical Center, and ANDROMEDA study investigator. (biospace.com)
C3G also significantly increased the level of interleukin (IL)-10 and the regulatory T (Treg) cell proportion, and it decreased the interleukin (IL)-6 and interferon (IFN)-γ levels and CD38+ NK cell proportion in rat peripheral blood and synovial fluid. (biomedcentral.com)
Most laboratories measure absolute CD4+ T-cell levels in whole blood by a multi-platform, three-stage process. (cdc.gov)
Using the non-obese diabetic (NOD)/severe combined immunodeficiency disease (SCID) mouse model, a CD34 + CD38 - cell fraction representing 0.1-1% of the leukaemic cell population was shown to contain the leukaemia-initiating cell or leukaemic stem cell (LSC). (touchoncology.com)
This importance is focussed on the target binding site - epitope, where epitope selection as a part of design thinking beyond traditional antigen selection using whole cell or whole protein immunisation can positively impact success. (preprints.org)
COVID19 vaccination can elicit a distinct T cell-dominant immune-mediated hepatitis with a unique pathomechanism associated with vaccination induced antigen-specific tissue-resident immunity requiring systemic immunosuppression. (alecomm.com)

CUSABIO synthesized the recombinant gene by integrating the C-terminal hFc tag sequence into the targeted gene encoding the 43-300aa of the human CD38. (cusabio.com)
The product was purified to obtain the recombinant human CD38 protein carrying C-terminal hFc tag. (cusabio.com)

Cyanidin-3-O-glucoside (C3G) is an inhibitor of CD38. (biomedcentral.com)

CD38 catalyzes the conversion of nicotinamide adenine dinucleotide (Coenzyme I, NAD+) to cyclic ADP-ribose (cADPR) to regulate calcium ion (Ca 2+ ) homeostasis. (biomedcentral.com)

An inflammatory monocyte immune phenotypic profile associated with age advancement in HIV-negative individuals, while the monocyte profile in blood donors and people with HIV was more reflective of loss of function. (frontiersin.org)
Classical monocyte proliferation and CD38 upregulation on plasmacytoid DCs coincided with declining viral load. (cdc.gov)

DC-based vaccine derived from autologous peripheral blood which was introduced with SARS-CoV-2 protein was given to this patient. (journaltocs.ac.uk)

Furthermore, a subgroup of homozygous Eμ-fHDAC9 mice (n=16) developed tumours (81%) at middle age, and present with enlarged lymph nodes (6%) and abnormal hematopoietic elements in peripheral blood and BM. (sunderland.ac.uk)

Additionally, induced co -expression of luciferase, EGFP, and the melanosomal antigen gp100 facilitates studies on the underlying immunological mechanisms. (unav.edu)

Peripheral smear from a patient with chronic lymphocytic leukemia, small lymphocytic variety. (medscape.com)

Additionally, a comprehensive overview of antigen selection is presented along with preliminary results and future directions of CAR-T therapy development. (biomedcentral.com)

Peripheral blood flow cytometry is the most valuable test to confirm a diagnosis of CLL. (medscape.com)
Diagnosis is by flow cytometry and immunophenotyping of peripheral blood. (msdmanuals.com)

Anatomy40

Organisms8

Diseases12

Chemicals and Drugs137

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Phenomena and Processes32

Disciplines and Occupations1

Information Science3

Health Care3

Multiple myeloma5

Type II transmembrane glycoprotein3

Cyclic ADP-ribose hydro2

Hydrolase2

Chimeric antigen receptor2

Target Antigen1

Receptor4

Clone HIT21

Mononuclear cells2

Lymphocytes4

Cells53

Maturation antigen1

Lymphocyte3

Antibody2

Tumor1

Bone marrow smears1

CD271

Stimulation2

Phenotype1

Detectable1

Antibodies1

Ligand1

Ligation1

Cell13

Human2

Inhibitor1

CADPR1

Monocyte2

Autologous1

Lymph nodes1

Expression1

Chronic1

Additionally1

Flow2