• mice on a C57BL/6 background were originally obtained from The Jackson Laboratory. (mundial-brasil2014.net)
  • Male C57BL/6J mice were fed Amylin Liver NASH (AMLN) diet for 32 weeks. (researchsquare.com)
  • Here, we used myeloperoxidase knockout B6.129X1-MPO (MPO k/o) mice and showed that oxidation and clearance of single walled carbon nanotubes (SWCNT) from the lungs of these animals after pharyngeal aspiration was markedly less effective whereas the inflammatory response was more robust than in wild-type C57Bl/6 mice. (cdc.gov)
  • BALB/c, CBA, C3H/He, DBA/1, and NZB) have low Ly-6A/E expression on resting peripheral lymphocytes. (biolegend.com)
  • The expression of Ly-6A/E on lymphocytes is upregulated upon activation from both Ly6.1 and Ly6.2 haplotype mice. (biolegend.com)
  • A, BALB/c, CBA, C3H/He, DBA/1, NZB) have few Ly-6A/E + resting peripheral lymphocytes whereas Ly-6.2 strains (e.g. (southernbiotech.com)
  • Pulmonary exposure to NQ dose-dependently aggravated antigen-related airway inflammation, as characterised by infiltration of eosinophils and lymphocytes around the airways and an increase in goblet cells in the bronchial epithelium. (ersjournals.com)
  • 2-Nitrotoluene was genotoxic in a range of in vitro and in vivo assays, was notably clastogenic in human peripheral lymphocytes and formed DNA adducts in exposed rodents. (gc.ca)
  • Mn, serum Mn, urine Mn, Centromere-positive micronuclei in periphery blood lymphocytes, DNA protein-crosslinks in peripheral white blood cells, oxidative stress as urinary 8OHdG, and long-term oxidative damage measured as erythrocytic superoxide dismutase (SOD) activity (measure of systemic oxidative stress) and serum malondialdehyde (MDA) (product of lipid peroxidation and reflect tissue injuries). (who.int)
  • The LLNA has been evaluated extensively in the context nocytes, Langerhans cells, and T-lymphocytes, have been of both national and international interlaboratory trials. (cdc.gov)
  • Ly6A/E is a glycosylphosphatidylinositol (GPI)-linked protein expressed on hematopoietic stem cells. (biolegend.com)
  • It is expressed on multipotent hematopoietic stem cells in bone marrow of mice with both the Ly-6.1 and Ly-6.2 allotypes. (southernbiotech.com)
  • mice on a BALB/c background were purchased from Taconic Farms (Germantown, NY). (mundial-brasil2014.net)
  • Pulmonary A2 strain respiratory syncytial virus infection of BALB/c laboratory mice persisted for up to 7 days after initial infection with peak virus titres being recovered on day 4. (microbiologyresearch.org)
  • T regulatory (Treg) cells, T helper cell balances, dendritic cells, macrophages, B cells, and natural killer (NK) cells can be considered as the most determinant dysregulated mediators in immunomodulatory status. (hindawi.com)
  • The chemokine CCL2, which pared to GPT, the LLNA reduces animal numbers needed, can recruit dendritic cells into the site of inflammation, is improves animal welfare, and decreases experimental time also upregulated in keratinocytes following hapten exposure. (cdc.gov)
  • The peripheral chimerism of bone marrow-derived stem cells after transplantation: regeneration of gastrointestinal tissues in lethally irradiated mice. (southernbiotech.com)
  • K10.6 antibody does not react with Lyb-2.3 (AKR and SJL strains) nor with non-lymphoid tissues. (bdbiosciences.com)
  • Most of these studies did not detect the vCJD agent outside the nervous system (central, peripheral, and autonomic) and lymphoid tissues. (cdc.gov)
  • Moreover, for genes that are expressed in multiple tissues or at multiple stages of development, the use of tissue-specific expression of the Cre recombinase allows gene function to be perturbed in specific cell types and/or at specific times. (elifesciences.org)
  • This manuscript reports data consistent with a new and unanticipated phenomenon: that Cre or its mRNA may be transmitted between tissues in the mouse and that the male reproductive tract (epididymis) appears to be the most common target of such transported molecules. (elifesciences.org)
  • However, the effects of β1 are highly dependent on the experimental system in which they are studied, and different effects on the kinetics and voltage dependence of gating of brain sodium channels are observed on expression in Xenopus oocytes, Chinese hamster lung and ovary cells, and human embryonic kidney cells (Isom et al. (jneurosci.org)
  • In addition, embryonic stem cells may be modified by homologous recombination for use in producing chimeric or transgenic mammalian hosts, which may be used as source of universal donor organs. (justia.com)
  • Mice homozygous for another null allele display embryonic lethality with impaired cell migration during gastrulation. (jax.org)
  • These results strongly circumscribe the possible mechanisms of PINK1 action in the mitochondrial life cycle and also raise the possibility that mitochondrial turnover events that occur in cultured embryonic axons might be restricted to the cell body in vivo, in the intact nervous system. (sdbonline.org)
  • The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse. (ox.ac.uk)
  • We describe a targeted mutation of GPR126 in the mouse, and show that GPR126 is required for embryonic viability and cardiovascular development. (ox.ac.uk)
  • In this category of experimentation, besides the use of locally delivered trophic factors (such as brain-derived neurotrophic factor (BDNF)-, glial cell line-derived neurotrophic factor (GDNF)-, and fibroblast growth factor (FGF)-peptides or growth factors-gene-encoding vectors) [ 8 ], regionally grafted fetal or embryonic stem cell-derived neuronal precursors are frequently used [ 9 - 18 ]. (biomedcentral.com)
  • To investigate the effects of loss of β1 function in vivo , we have used gene-targeting methods to produce β1(-/-) mice, and we have analyzed their neuronal phenotypes. (jneurosci.org)
  • Nature Communications 7:10464 [Best reference on the BXD family of strains and the wide range of phenotypes that have been generated over the past 40 years. (genenetwork.org)
  • Harenza JL, Muldoon PP, De Biasi M, Damaj MI, Miles MF (2014) Genetic variation within the Chrna7 gene modulates nicotine reward-like phenotypes in mice. (genenetwork.org)
  • Similar phenotypes were observed in constitutive global Csf1r haploinsufficient mice and could be reversed/prevented by microglia elimination in adulthood. (stanford.edu)
  • Additional reported applications (for the relevant formats) include: Western blotting 1,2 , immunoprecipitation 1 , in vitro lymphocyte activation 3-6 , induction of redirected lysis 7 , induction of T cell inhibitory signalling 8 , immunofluorescence 9 , and immunohistochemical staining of acetone-fixed frozen sections 13 and Bouin-fixed, paraffin-embedded samples 9 . (biolegend.com)
  • We determined the presence of EndoMT in the pulmonary vasculature in vivo and the functional effects on pulmonary artery endothelial cells (PAECs) undergoing EndoMT in vitro. (surrey.ac.uk)
  • Consistent with this, neutrophil chemotaxis in vitro and neutrophil mobilization into peripheral blood in vivo in response to the prototype N -formylpeptide fMLF (formyl-methionyl-leucyl-phenylalanine) were both absent in FPR −/− mice. (silverchair.com)
  • Sodium channel β1 subunits modulate α subunit gating and cell surface expression and participate in cell adhesive interactions in vitro . (jneurosci.org)
  • β1 subunits affect sodium channel gating and cell surface expression when expressed in heterologous cells in vitro . (jneurosci.org)
  • Previous studies have indicated that organic chemicals extracted from DEP result in induction of apoptosis 11 , increase oxidative stress 12 , and induce the production of inflammatory cells 13 - 15 through the release of pro-inflammatory molecules in vitro 15 , 16 . (ersjournals.com)
  • Sendai virus-induced cell mediated cytotoxicity in vitro: the role of viral glycoproteins in cell mediated cytotoxicity. (microbiologyresearch.org)
  • These results suggest that effects of β1 on sodium channel gating are dependent on the genetic background and signal transduction pathways present in the cell type used in heterologous expression and emphasize the importance of analyzing the effects of β1 in vivo . (jneurosci.org)
  • The immune system which results from cells of the lymphoid and myeloid lineages is developed in vivo, so as to recognize self from non-self. (justia.com)
  • The current authors have recently shown that PQ induces recruitment of inflammatory cells, such as eosinophils and neutrophils, into the lung with the lung expression of pro-inflammatory molecules such as interleukin (IL)-5 and eotaxin in vivo 24 . (ersjournals.com)
  • The stromal cell requirement for androgen-mediated effects was confirmed in vivo by experiments using chimeric animals created by bone marrow transplantation in which androgen receptor expression was restricted to either the stromal or lymphoid cells of the bone marrow. (jci.org)
  • ten-1 mutants have defects in all pharyngeal neurons that we examined, and in vivo reporters show that only the long form of the ten-1 gene is expressed in the pharynx, specifically in six marginal cells and the M2 neurons. (biomedcentral.com)
  • Ly-6A/E, also known as Sca-1, is a member of the Ly-6 multigene family of type V glycophosphatidylinositol-anchored cell surface proteins. (southernbiotech.com)
  • Explore our solutions for multiple applications - vaccines, monoclonal antibodies, recombinant proteins, cell or gene therapy. (vwr.com)
  • Induced EndoMT cells exhibited up-regulation of mesenchymal markers, including collagen type I and α-smooth muscle actin, and a reduction in endothelial cell and junctional proteins, including von Willebrand factor, CD31, occludin, and vascular endothelial-cadherin. (surrey.ac.uk)
  • Monoclonal antibody therapy is a form of immunotherapy that uses monoclonal antibodies (mAbs) to bind monospecifically to certain cells or proteins. (wikipedia.org)
  • The current authors investigated the effects of naphthoquinone (NQ), one of the extractable chemical compounds of DEP, on antigen-related airway inflammation, local expression of cytokine proteins, and antigen-specific immunoglobulin (Ig) production in mice. (ersjournals.com)
  • Now a large and ever increasing number of genetic subtypes has been described, and major advances in molecular and cellular biology have clarified the understanding of the role of different proteins in the physiology of peripheral nerve conduction in health and in disease. (medscape.com)
  • Myelinating Schwann cells form a myelin sheath around a single axon and express high levels of myelin-related proteins and messenger RNA (mRNA). (medscape.com)
  • The authors hypothesize that treatment with blood glutamate scavengers should reduce neuronal cell loss, whereas administration of glutamate should worsen outcomes. (asahq.org)
  • The improved motor recovery in Hv1 -/- mice was associated with decreased interleukin-1β, reactive oxygen/ nitrogen species production and reduced neuronal loss. (researchsquare.com)
  • Transfer of endothelial progenitor and bone marrow cells influences atherosclerotic plaque size and composition in apolipoprotein E knockout mice. (southernbiotech.com)
  • Pulmonary arterial hypertension (PAH) is a progressive disease characterized by lung endothelial cell dysfunction and vascular remodeling. (surrey.ac.uk)
  • During embryogenesis endothelial cells exhibit substantial plasticity that contribute to cardiac development by undergoing endothelial-to-mesenchymal transition (EndoMT). (surrey.ac.uk)
  • Histologic assessment of patients with systemic sclerosis-associated PAH and the hypoxia/SU5416 mouse model identified the presence von Willebrand factor/α-smooth muscle actin-positive endothelial cells in up to 5% of pulmonary vessels. (surrey.ac.uk)
  • We previously showed that genotoxic stress induced an active extracellular release of nucleophosmin (NPM) in human cardiac mesenchymal progenitor cells, and that serum deprivation provokes NPM secretion from human endothelial cells, eliciting inflammation via nuclear factor kappa B (NF-kB) transcriptional activation. (frontiersin.org)
  • Vascular changes, including separation of endothelial junctions, loss of endothelial cells, and the adherence of leukocytes due to the presence of adult worms, can be detected as soon as 4 days post-surgical transplantation of adults in heartworm-naïve dogs [ 6 ]. (biomedcentral.com)
  • A wide variety of hematopoietic cells exist, with the major protective lineages being lymphoid and myeloid. (justia.com)
  • In addition, infection induced rapid interferon production within the lungs which was accompanied by an equally rapid rise in pulmonary natural killer (NK) cell cytotoxic activity. (microbiologyresearch.org)
  • Moreover, myeloperoxidase (MPO), an abundant enzyme of inflammatory cells (neutrophils), - involved in the principal defense mechanisms of innate immunity -was also effective in oxidative biodegradation of CNT in biochemical models and in cells yielding the products that did not cause pulmonary inflammation in mice [14] . (cdc.gov)
  • The presence of adult worms in the pulmonary arteries causes vascular damage such as thickening of the arteries and hypertrophy of the smooth muscle cells [ 4 , 5 ]. (biomedcentral.com)
  • This accumulation of PDGF stimulates the migration of smooth muscle cells into the tunica media, causing the rough velvety appearance observed in the pulmonary arteries in heartworm disease [ 8 ]. (biomedcentral.com)
  • In contrast, certain immunodeficient mouse models infected with mouse-adapted DENV strains show signs of severe disease similar to the 'vascular-leak' syndrome seen in severe dengue in humans. (mdpi.com)
  • The North American lineages of WNV were characterized by the presence of neuroinvasive and neurovirulent strains causing disease and death in humans, birds and horses. (mdpi.com)
  • The correlation between TCR diversity and efficiency of worm expulsion can be determined by contamination of TCR-transgenic mice. (mundial-brasil2014.net)
  • The majority of T cells in these mice express a transgenic TCR that does not react with helminth antigens. (mundial-brasil2014.net)
  • However, allelic exclusion by the transgenic TCR can be leaky so that a second, endogenous TCR -chain is expressed, resulting in a peripheral T-cell pool with oligoclonal TCR specificities. (mundial-brasil2014.net)
  • Myocyte-restricted Hmox1 transgenic mice exposed to MI exhibited significantly improved survival and LV function, lower interstitial fibrosis and oxidative stress. (springer.com)
  • The development of tools to manipulate the mouse genome, including knockout and transgenic technology, has revolutionized our ability to explore gene function in mammals. (elifesciences.org)
  • Here, we demonstrate that contamination of mice with the helminth induces a polyclonal T-cell response that is reflected by unbiased distribution of TCR-V families among naive and activated CD4 T cells. (mundial-brasil2014.net)
  • Castration of normal male mice induces expansion of the bone marrow B cell population, an effect that can be reversed by androgen replacement. (jci.org)
  • 1996. Appearance of micronuclei in generation of hela cells irradiated at low doses. (cdc.gov)
  • The latter represents a conformationally modified form of a normal cellular PrP C , which is a normal host protein found on the surface of many cells, in particular neurons. (medscape.com)
  • None of the body neurons examined show any defects in the ten-1(ok641) mutant, but genetic interaction studies reveal that ten-1(ok641) is synthetic lethal with sax-3, unc-34 and unc-73 , and examination of the hypodermal cells in embryos of the ten-1(ok641) mutant point to a role of ten-1 during hypodermal cell morphogenesis. (biomedcentral.com)
  • Magnetic resonance imaging volume reconstruction and immunofluorescence analysis of grafted cell survival showed near complete injury-cavity-filling by grafted cells and development of putative GABA-ergic synapses between grafted and host neurons. (biomedcentral.com)
  • The orphan Adhesion-GPCR GPR126 has recently been shown to play an essential role in the myelination of peripheral nerves in zebrafish. (ox.ac.uk)
  • Genetic variants and strains of the laboratory mouse. (bdbiosciences.com)
  • Xue Y, Li J, Yan L, Lu L, Liao FF 2015 Genetic variability to diet-induced hippocampal dysfunction in BXD recombinant inbred (RI) mouse strains. (genenetwork.org)
  • Chaum E, Winborn CS, Bhattacharya S 2015 Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population. (genenetwork.org)
  • The current authors have previously demonstrated that diesel exhaust particles (DEP) enhance antigen-related airway inflammation in mice. (ersjournals.com)
  • The current authors have recently demonstrated that extracted organic chemicals from DEP, rather than residual carbonaceous nuclei of DEP after extraction, predominantly enhance antigen-related airway inflammation in mice 17 . (ersjournals.com)
  • More recently, it has also been demonstrated that PQ aggravates antigen-related airway inflammation in mice, and that PQ also has adjuvant activity for antigen-specific Igs 25 . (ersjournals.com)
  • Toll-like receptors and their ligands control mesenchymal stem cell functions. (southernbiotech.com)
  • These experiments suggest that effects of androgens on developing B cells are mediated through androgen receptors in bone marrow stromal cells. (jci.org)
  • 3. English A, Kosoy R, Pawlinski R, Bamezai A. A monoclonal antibody against the 66-kDa protein expressed in mouse spleen and thymus inhibits Ly-6A.2-dependent cell-cell adhesion. (southernbiotech.com)
  • Flow cytometry Single-cell suspensions were generated from lymph nodes, spleen or PBS-perfused lung samples that had been cut into small pieces and mechanically dispersed using a 70-m nylon strainer (BD Falcon, Bedford, MA). (mundial-brasil2014.net)
  • FPR −/− mice also had increased bacterial load in spleen and liver 2 d after infection, which is before development of a specific cellular immune response, suggesting a defect in innate immunity. (silverchair.com)
  • Immunoglobulin class specific antibody response in serum, spleen, lungs and bronchioal- veolar washings after primary and secondary Sendai virus infection of germ free mice. (microbiologyresearch.org)
  • We identified spleen as an important source of these cardiovascular complications in Hmox1 −/− mice. (springer.com)
  • Clearance of persistent RSV infections in immunodeficient mice following transfer of primed T cells. (microbiologyresearch.org)
  • The D7 antibody has been reported to induce T cell activation and inhibit TCR-induced IL-2 production. (biolegend.com)
  • Alexa Fluor ® 647 Anti-Mouse Ly-6A/E antibody for use in flow cytometry, immunohistochemistry, and western blot assays. (southernbiotech.com)
  • Studies with the monoclonal antibody D7 suggest that Ly-6A/E may be involved in B and T lymphocyte responses and it appears that the antigen may be required for T-cell receptor-mediated T-cell activation. (southernbiotech.com)
  • Monoclonal antibody therapy may prove to be beneficial for cancer, autoimmune diseases, and neurological disorders that result in the degeneration of body cells, such as Alzheimer's disease. (wikipedia.org)
  • Monoclonal antibody therapy can aid the immune system because the innate immune system responds to the environmental factors it encounters by discriminating against foreign cells from cells of the body. (wikipedia.org)
  • Systemic cell-mediated and antibody responses in infants with respiratory syncytial virus infections. (microbiologyresearch.org)
  • Non-human primates (NHPs) can sustain viral replication in relevant cell types and develop a robust immune response, but they do not develop overt disease. (mdpi.com)
  • Humanized mouse models can sustain DENV replication and show some signs of disease, but further development is needed to validate the immune response. (mdpi.com)
  • The objective is that this treatment will stimulate the patient's immune system to attack those cells. (wikipedia.org)
  • Therefore, tumor cells that are proliferating at high rates, or body cells that are dying which subsequently cause physiological problems are generally not specifically targeted by the immune system, since tumor cells are the patient's own cells. (wikipedia.org)
  • In mammals, the immune systems serves as the primary defense with many different types of cells and mechanisms to protect the host. (justia.com)
  • When the host lacks the ability to raise a defense against a particular disease, there may also be an interest in administering specific T-cells or B-cells or precursors thereof which may supplement the host's compromised immune system. (justia.com)
  • In order for the cells to be effective, they must be safe from attack by the host, so that they may function without being destroyed by the immune system. (justia.com)
  • It is therefore of interest to find effective ways to produce cells which may function, proliferate, and differentiate as appropriate, while being safe from attack by a recipient's immune system. (justia.com)
  • Mice with natural immunity against MmuPV1 after colonization and acquired immunity through the transfer of T cells from immune mice or by MmuPV1 vaccination were protected against skin carcinogenesis induced by chemicals or by ultraviolet radiation in a manner dependent on CD8 + T cells. (nature.com)
  • RNA and DNA in situ hybridization probes for 25 commensal β-HPVs revealed a significant reduction in viral activity and load in human skin cancer compared with the adjacent healthy skin, suggesting a strong immune selection against virus-positive malignant cells. (nature.com)
  • Neutrophils are the first immune cells that infiltrate the damaged tissue as early as 24 h after injury. (springer.com)
  • β1(-/-) mice exhibit a dramatic neurological phenotype that includes an ataxic gait, spontaneous seizures, and premature death. (jneurosci.org)
  • Here, we have reviewed recent studies concerning the role of the gut microbiota in metabolic syndrome and the effects of probiotic bacterial strains and prebiotics on the prevention or treatment of metabolic syndrome, such as their anti-obesity and anti-inflammatory effects and their ability to improve glycemic control and modulate serum lipids. (biomedcentral.com)
  • BAL cytology indicated a robust and early (day 1) accumulation of neutrophils - slightly weaker in MPO k/o mice vs w/t animals ( Fig. 1d ), followed by a sequential appearance of macrophages in both groups of animals (with a peak at day 7) (data not shown) [4] . (cdc.gov)
  • Novel laboratory mouse papillomavirus (MusPV) infection. (nature.com)
  • In other cases, where certain cells are lacking, such as islets of Langerhans in the case of diabetes, or cells which secrete dopamine in the case of Parkinson's disease, or bone marrow cells in various hematopoietic diseases, or muscle cells in muscle wasting disease, or retinal epithelial cells in visual disorders, it would be desirable to be able to provide cells which could fulfill the desired function. (justia.com)
  • C.129-gene. (mundial-brasil2014.net)
  • Here we test this hypothesis in mice lacking the high affinity N -formylpeptide receptor (FPR), created by targeted gene disruption. (silverchair.com)
  • In addition, heterozygous hosts having one wild-type gene and one mutated gene could be mated to obtain homozygous hosts, so that all of the cells would have the appropriate modification. (justia.com)
  • Interestingly, NPM interacts with Toll-like receptor (TLR)4 in these cells and activates an NF-kB-dependent inflammatory pathway upregulating interleukin IL-6 and COX-2 gene expression. (frontiersin.org)
  • Joint mouse-human phenome-wide association to test gene function and disease risk. (genenetwork.org)
  • Cell cycle gene expression networks discovered using systems biology: Significance in carcinogenesis. (genenetwork.org)
  • The data serve as a timely warning to mouse researchers about an unexpected complication of Cre-mediated gene manipulation. (elifesciences.org)
  • The field of the subject invention is the use of major histocompatibility complex antigen lacking cells and organs which may serve as universal donors in cellular and organ therapies including transplantation and to produce chimeric non-human mammals. (justia.com)
  • Androgens only affected B cell development in chimeric mice with androgen-sensitive stromal cells. (jci.org)
  • Differentiation and integration of grafted cells in the host tissue were validated with immunofluorescence staining using human-specific antibodies. (biomedcentral.com)
  • As ofloxacin is the alternate drug for the treatment of rifampicin-resistant cases, the emergence of new cases with resistance to ofloxacin indicates that ofloxacin-resistant M. leprae strains are actively circulating in this endemic region (i.e. (bvsalud.org)
  • Tissue bioengineering and stem/progenitor cell treatments have both been individually pursued for stroke neural repair therapies, with some benefit in tissue recovery. (researchgate.net)
  • Emerging directions in stroke neural repair approaches combine these two therapies to use biopolymers with stem/progenitor transplants to promote greater cell survival in the transplant and directed delivery of bioactive molecules to the transplanted cells and the adjacent injured tissue. (researchgate.net)
  • This activates cascade of events which, in the end, affects oxidative status of the cells and provides robust protection against oxidative challenge. (springer.com)
  • Two new products (ProHeart ® 12 and Simparica Trio ® ), available in many countries around the world including the USA, take advantage of the unique attributes of moxidectin for providing robust heartworm prevention against the strains of heartworm to which most dogs in the USA will likely be exposed. (biomedcentral.com)
  • The expression of Ly-6A/E is dramatically upregulated in all strains upon cellular activation. (southernbiotech.com)
  • the oxidized lipid and iron are taken up by the macrophages, which promote their polarization into a pro-inflammatory state and transform into foam cells. (nature.com)
  • Upon pharyngeal aspiration, SWCNT elicited typical inflammatory responses in w/t and MPO k/o mice documented by increased production of pro-inflammatory cytokines (TNF-α, IL-6 and MCP-1) 1 day after the exposure ( Fig. 1a, b, c ). (cdc.gov)
  • Splenectomy decreased the numbers of circulating inflammatory Ly6C hi monocytes in blood, reduced the numbers of proinflammatory cardiac macrophages and significantly improved the post-MI LV function in Hmox1 −/− mice. (springer.com)
  • Afterwards, however, the hearts of Hmox1-deficient mice undergo adverse late LV remodeling due to overactive and prolonged post-ischemic inflammatory response. (springer.com)
  • Thus, development of strategies targeting particular subsets of inflammatory cells and providing well-timed resolution of inflammation may be crucial for proper healing and recovery. (springer.com)
  • Dogs harboring strains of D. immitis resistant to MLs, the only drug class available for heartworm prevention in the United States, have been documented and proven. (biomedcentral.com)
  • The pharmacodynamics of ALT-801, a GLP-1/glucagon receptor dual agonist optimized for NASH and weight loss, were compared to semaglutide (GLP-1 receptor agonist) and elafibranor (peroxisome proliferator-activated receptor, PPAR-α/δ, agonist) in a biopsy-confirmed, diet-induced obese (DIO) mouse model of NASH (DIO-NASH). (researchsquare.com)
  • This was accompanied by higher numbers of Ly6C hi monocytes in peripheral blood, as well as higher expression of monocyte chemoattractant protein-1 and adhesion molecules in the hearts of MI-operated Hmox1 −/− mice. (springer.com)
  • Homozygous KO also decreases apoptosis and increases proliferation of B cell stimulated by a single antigen. (jax.org)
  • Specifically, we show that the fatty degeneration of the hemorrhagic MI zone stems from iron-induced macrophage activation, lipid peroxidation, foam cell formation, ceroid production, foam cell apoptosis and iron recycling. (nature.com)
  • The foam cells produce ceroids and destabilize the lysosomes and drive foam cell apoptosis, the remnants of which participate in fat deposition, with the released iron recycled to enter the pathway which perpetuates to continually support inflammation and growth of the fat depot. (nature.com)
  • Analysis of CD72-deficient mice supports these results and shows that CD72 is involved in B-cell development. (bdbiosciences.com)
  • Our results are consistent with ten-1 normally providing a function complementary to the cytoskeletal remodeling processes that occur in migrating cells or cells undergoing morphogenesis. (biomedcentral.com)
  • Murine cytotoxic T cells specific to respiratory syncytial virus recognize different antigenic subtypes of the virus. (microbiologyresearch.org)
  • Alam G, Miller DB, O'Callaghan JP, Lu L, Williams RW, Jones BC 2016 MPTP neurotoxicity is highly concordant between the sexes among BXD recombinant inbred mouse strains. (genenetwork.org)
  • Quantitative Trait Loci and Candidate Genes for Neutrophil Recruitment in Sterile Inflammation Mapped in AXB-BXA Recombinant Inbred Mice. (genenetwork.org)
  • Evaluation of heritable determinants of blood and brain serotonin homeostasis using recombinant inbred mice. (genenetwork.org)
  • Intraspinal grafting of human neural stem cells represents a promising approach to promote recovery of function after spinal trauma. (biomedcentral.com)
  • Here we characterized the effect of intraspinal grafting of clinical grade human fetal spinal cord-derived neural stem cells (HSSC) on the recovery of neurological function in a rat model of acute lumbar (L3) compression injury. (biomedcentral.com)
  • Mice homozygous for a null allele exhibit defects in the semicircular canals of the inner ear and bidirectional circling behavior. (jax.org)
  • N. brasiliensis were washed extensively in sterile 09% saline (37) and injected subcutaneously (500 organisms) into mice. (mundial-brasil2014.net)
  • Single cells and organisms may adapt to harmful oxidative stress conditions, through stress-activated factors. (springer.com)
  • The transition from unicellular life to multicellular life allowed organisms to delegate tasks to cells which could then specialize rather than being required to carry out all the functions of the organism. (elifesciences.org)
  • Bikah G, Lynd FM, Aruffo AA, Ledbetter JA, Bondada S. A role for CD5 in cognate interactions between T cells and B cells, and identification of a novel ligand for CD5. (bdbiosciences.com)
  • Adhesion-GPCRs provide essential cell-cell and cell-matrix interactions in development, and have been implicated in inherited human diseases like Usher Syndrome and bilateral frontoparietal polymicrogyria. (ox.ac.uk)
  • Short-term cardiac stress, induced by ischemia-reperfusion (I/R) injury resulted in impaired left ventricular (LV) recovery and increased infarct size in heterozygous Hmox1-deficient (Hmox1 +/− ) mice [ 55 ]. (springer.com)
  • FPR −/− mice developed normally, but had increased susceptibility to challenge with Listeria monocytogenes , as measured by increased mortality compared with wild-type littermates. (silverchair.com)
  • Monoclonal antibodies can target tumor cells or abnormal cells in the body that are recognized as body cells, but are debilitating to one's health. (wikipedia.org)
  • The intracellular roles of NPM include a wide range of metabolic processes such as ribosome biogenesis, proliferation, cell cycle control, migration, DNA repair, non-programmed cell death, stress sensor ( 3 , 4 ). (frontiersin.org)
  • These repopulating cells are enriched in disease-associated microglia genes and exhibit similar phenotypic and transcriptional profiles to white-matter-associated microglia. (stanford.edu)
  • The safety and efficacy of a given strain in the context of these properties must be scientifically demonstrated for it to be considered a probiotic. (biomedcentral.com)
  • Moxidectin provides a unique opportunity for optimization of the dose and formulation, which may provide improved efficacy against ML-resistant strains. (biomedcentral.com)
  • The definition states that probiotics are "live strains of strictly selected microorganisms which, when administered in adequate amounts, confer a health benefit on the host. (hindawi.com)
  • Fig. 1: Colonization of the skin with MmuPV1 protects mice against chemically induced skin carcinogenesis. (nature.com)
  • CD72 is expressed at all stages of B-lymphocyte development except plasma cells, and it has been shown to negatively regulate B-cell receptor signaling. (bdbiosciences.com)