• The principal functions of the periodontal ligament are to support the teeth, generate the force of tooth eruption and provide sensory information about tooth position and forces to facilitate reflex jaw activity during chewing movements. (rattleinnaustin.com)
  • This can over time damage the enamel, wear down the chewing surfaces, stress the periodontal ligaments, loosen teeth, expose dentin, and irritate the tooth roots. (cdhp.org)
  • Disease causing bacteria accumulate in the pockets leading to an infection that if left untreated, destroys bones, ligaments, and tissues in the mouth and could ultimately result in tooth loss. (rattleinnaustin.com)
  • Objectives: To critically appraise the available experimental evidence of the local immunomodulation signaling systems and their surrounding functional molecules for repair and application in periodontal regeneration therapy. (uitm.edu.my)
  • Complete periodontal regeneration in clinics using the currently available treatment approaches is still a challenge. (biomedcentral.com)
  • The poor survival rate of MSCs during in vivo transplantation and host immunogenic reaction towards MSCs are the main drawbacks of direct use of MSCs in periodontal tissue regeneration. (biomedcentral.com)
  • Therefore, the MSC-based indirect treatment approach could be beneficial for periodontal regeneration in clinics. (biomedcentral.com)
  • MSC-CM-based indirect treatment has the potential to eliminate the drawbacks of direct use of MSCs for periodontal tissue regeneration. (biomedcentral.com)
  • MSC-CM holds the tremendous potential of bench-to-bed translation in periodontal regeneration applications. (biomedcentral.com)
  • This review focuses on the accumulating evidence indicating the therapeutic potential of the MSC-CM in periodontal regeneration-related pre-clinical and clinical studies. (biomedcentral.com)
  • Recent advances on MSC-CM-based periodontal regeneration, existing challenges, and prospects are well summarized as guidance to improve the effectiveness of MSC-CM on periodontal regeneration in clinics. (biomedcentral.com)
  • Stem cell-based periodontal regeneration is currently at the center of attention [ 18 ]. (biomedcentral.com)
  • Mesenchymal stem cells (MSCs) have shown promising potential to regenerate periodontal tissue in various preclinical and clinical studies. (biomedcentral.com)