• toby
  • 6 Experimental studies have shown that the benefit of cooling is maximal the sooner it is commenced, 7 and the Total Body Hypothermia (TOBY) trial showed a trend to improved outcome in infants cooled within 4 hours of delivery. (aappublications.org)
  • Intervention
  • C. W. Hoedemaekers, M. Ezzahti, A. Gerritsen, and J. G. van der Hoeven, "Comparison of cooling methods to induce and maintain normo- and hypothermia in intensive care unit patients: a prospective intervention study," Critical Care , vol. 11, p. (hindawi.com)
  • mild
  • M. R. Battin, M. Thoresen, E. Robinson, R. A. Polin, A. D. Edwards, and A. J. Gunn, "Does head cooling with mild systemic hypothermia affect requirement for blood pressure support? (hindawi.com)
  • Haaland K, Loberg EM, Steen PA, Satas S, Thoresen M (1997) The effect of mild post-hypoxic hypothermia on organ pathology in a piglet survival model of global hypoxia. (esicm.org)
  • In 2002 the results of 2 prospective randomized trials were published that compared mild hypothermia with normothermia in comatose survivors of out-of-hospital cardiac arrest. (ahajournals.org)
  • Intrapartum
  • After regression analysis, other identified perinatal risk factors (n=619) included hypertension in pregnancy (aOR 3.77), male infant (aOR 2.51), non-cephalic presentation (aOR 5.74), lack of fetal monitoring (aOR 2.75), augmentation (aOR 2.23), obstructed labour (aOR 3.8) and an acute intrapartum event (aOR 8.74). (bmj.com)
  • Cooling
  • In the European study, patients randomly assigned to the hypothermia group underwent cooling to a target temperature of 32°C to 34°C by use of a mattress made specifically for this purpose (with a cover that delivered cold air) and ice packs if necessary. (ahajournals.org)
  • neurological
  • In the European study, 75 of the 136 patients (55%) in the hypothermia group for whom data were available had a favorable neurological outcome (able to live independently and work at least part-time) at 6 months compared with 54 of 137 (39%) in the normothermia group (relative risk [RR] 1.40, 95% CI 1.08 to 1.81, number needed to treat [NNT]= (ahajournals.org)
  • Mortality
  • Perinatal brain injury is the third leading cause of child mortality globally, with some of the highest burden seen in low-resource African settings. (bmj.com)
  • cardiac
  • Successful use of therapeutic hypothermia after cardiac arrest in humans was also described in the late 1950s 1-3 but was subsequently abandoned because of uncertain benefit and difficulties with its use. (ahajournals.org)
  • normothermia
  • In the European study, the median Glasgow Coma Scale score on hospital admission in both groups was 3 with an interquartile range of 3 to 5 in the group with normothermia and 3 to 4 in the group with hypothermia. (ahajournals.org)
  • 19 At 6 months there were 56 deaths in the 137 participants (41%) in the hypothermia group versus 76 of 138 (55%) in the normothermia group (RR 0.74, 95% CI 0.58 to 0.95, NNT=7). (ahajournals.org)