The proliferating lymphocytes in NKCE and LG express CD56 and CD7 proteins on their cell surface membrane, CD3γ protein in their cytoplasm, and granzyme B, perforin, and T-cell intracellular antigen-1 cytotoxic proteins within their cytoplasmic granules. (wikipedia.org)
This pattern of protein expression identifies these cells as NK cells that, because of their expression of the cytotoxic granule-bound proteins, have been activated. (wikipedia.org)
Perforin is a 70 kD cytolytic protein that is expressed in the cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. (biolegend.com)
Perforin is one of the major effector molecules used by cytotoxic T cells and NK cells to mediate targeted cell lysis. (biolegend.com)
Granzyme B (GzB) is a serine protease found in the cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. (biomedcentral.com)
We found Gal-9 presence was associated with enhanced cytotoxic effector molecules granzyme B (GzmB) and perforin expression. (bvsalud.org)
In hemophagocytic lymphohistiocytosis, LYST has an essential function in managing the airport growth of perforin-containing granules into secretory granules in cytotoxic Testosterone levels lymphocytes [15]. (forgetmenotinitiative.org)
Subsequently, binding of the CD28 co-stimulatory receptor to the DCs' CD80/86 receptor fully activates the cytotoxic T cells which then migrate to infiltrate the tumour and kill the cells by locally releasing perforin and granzymes [ 2 ] [ 3 ] . (encyclopedia.pub)
The cells kill by releasing small cytoplasmic granules of proteins called perforin and granzyme that cause the target cell to die by apoptosis . (wikidoc.org)
Cytoplasmic granules of cytolytic T-lymphocytes. (lu.se)
Protein1
These Ly-49 inhibitory receptors, as well as inhibitory KIRs, contain cytoplasmic immune receptor tyrosine-based inhibitory motifs (ITIMs) that are phosphorylated upon stimulation, leading to the recruitment of Src homology 2 domain-containing protein tyrosine phosphatase (SHP-1) and attenuation of intracellular signals ( 1 , 4 , 5 ). (aai.org)
Granzymes1
Upon release in close proximity to a cell slated for killing, perforin forms pores in the cell membrane of the target cell through which the granzymes and associated molecules can enter, inducing apoptosis . (wikidoc.org)
Lymphocytes1
Human peripheral blood lymphocytes were surface stained with CD8 FITC, fixed with Fixation Buffer, permeabilized with Intracellular Staining Permeabilization Wash Buffer (10X), and then intracellularly stained with Perforin (clone dG9) APC/Cyanine7 (left), or mouse IgG2b, κ APC/Cyanine7 isotype control (right). (biolegend.com)
Cells5
Large cell lymphoma and leukemia cells tend to have large size nuclei, less mature chromatin, and visible nucleoli with and without cytoplasmic vacuoles. (cytojournal.com)
In the presence of calcium, perforin polymerizes into transmembrane tubules and is capable of lysing non-specifically a variety of target cells. (lu.se)
The manifestation of is usually shown to impact lysosomal size, granule size, and autophagy in human cells [12]. (forgetmenotinitiative.org)
Luker GD, Nilsson KR, the cells maintain contact with each other to reach the OB and differentiate into granule and periglomerular neurons. (forexrin.com)
Expression1
We showed previously that cytoplasmic release of mtDNA activates the cGAS STING TBK1 pathway resulting in interferon-stimulated gene (ISG) expression that promotes antiviral immunity4. (regenerativemedicine.net)
Cell1
In addition, cytoplasmic vacuoles are not uncommon in large cell lymphomas involving body cavities. (cytojournal.com)
Innate immune system lymphocytes are crucial for early sponsor defenses against viral attacks and exert cytotoxic results against virus-infected cells mainly by granule exocytosis [12]. (biomasswars.com)
1. Granule exocytosis, and not the fas/fas ligand system, is the main pathway of cytotoxicity mediated by alloantigen-specific CD4(+) as well as CD8(+) cytotoxic T lymphocytes in humans. (nih.gov)
9. Localization of Fas ligand in cytoplasmic granules of CD8+ cytotoxic T lymphocytes and natural killer cells: participation of Fas ligand in granule exocytosis model of cytotoxicity. (nih.gov)
13. An anergic cytotoxic T lymphocyte clone exhibits granule exocytosis-mediated cytotoxicity. (nih.gov)
14. Natural Killer Cell Group 7 Sequence in Cytotoxic Cells Optimizes Exocytosis of Lytic Granules Essential for the Perforin-Dependent, but Not Fas Ligand-Dependent, Cytolytic Pathway. (nih.gov)
Lysis4
Perforin-based effector systems are, therefore, involved not only in the lysis of abnormal cells but also in the down-regulation of cellular immune activation. (nih.gov)
Perforin is one of the major effector molecules used by cytotoxic T cells and NK cells to mediate targeted cell lysis. (biolegend.com)
Nevertheless the simultaneous reduction/inhibition of both granules avoided cholangiocyte lysis and bile duct blockage and improved the phenotype of experimental biliary atresia. (biomasswars.com)
They are EXOTOXINS produced by some pathogenic STAPHYLOCOCCUS and STREPTOCOCCUS that destroy leukocytes by lysis of the cytoplasmic granules and are partially responsible for the pathogenicity of the organisms. (nih.gov)
Cytotoxicity2
3. Essential roles of perforin in antigen-specific cytotoxicity mediated by human CD4+ T lymphocytes: analysis using the combination of hereditary perforin-deficient effector cells and Fas-deficient target cells. (nih.gov)
5. Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity. (nih.gov)
Intracellular1
8. CD4(+) and CD8(+) T cells kill intracellular Mycobacterium tuberculosis by a perforin and Fas/Fas ligand-independent mechanism. (nih.gov)
Ligand1
16. Identification of a population of CD4+ CTL that utilizes a perforin- rather than a Fas ligand-dependent cytotoxic mechanism. (nih.gov)