• Antibody
  • In this report, we present a new technology for measuring antibody-peptide interactions in vitro that leverages spectrally encoded beads for biological multiplexing. (spie.org)
  • and (3) imaging these bead-bound libraries to simultaneously identify the embedded spectral code (and thus the sequence of the associated peptide) and quantify the amount of each antibody bound. (spie.org)
  • Screening
  • Peptide libraries are almost exclusively used to find these mimotopes, since they drastically reduce the amount of time needed for screening. (genscript.com)
  • A homogeneous method for screening DNA-encoded libraries has recently been developed which uses water-in-oil emulsion technology to isolate, count and identify individual ligand-target complexes in a single-tube approach. (wikipedia.org)
  • However, the selective amplificability of DNA greatly facilitates library screening and it becomes indispensable for the encoding of organic compounds libraries of this unprecedented size. (wikipedia.org)
  • cleavage
  • The peptide bond cleavage occurs via the nucleophilic attack of water at the carbonyl between two adjacent amino acid residues. (wikipedia.org)
  • During the proton transfer associated with the peptide cleavage, the negatively charged aspartate residue stabilizes the positively charged histidine. (wikipedia.org)
  • The cleavage of peptide bonds by OmpT is also dependent on the presence of bound lipopolysaccharide (LPS). (wikipedia.org)
  • synthetic
  • As the figure demonstrates the number of peptides formed in the synthetic process (3, 9, 27, 81) increases exponentially with the number of executed cycles. (wikipedia.org)
  • sequence
  • so far I have been unsuccessful in locating a suitable sequence and am hoping to broaden my search by using a panel of libraries. (bio.net)
  • No purification given, as peptide purity is sequence-dependent and a function of different liquid chromatographic conditions. (thermofisher.com)
  • The sequence search engines use various heuristics to predict the fragmentation pattern of each peptide candidate. (wikipedia.org)
  • Sequence database searching also demands vast search space, which still could not cover all possibilities of peptide dynamics, exhibiting limited efficiency post-translational modifications). (wikipedia.org)
  • We carry several methods to control the amount of diversity introduced at each position of the sequence and can mixed them to optimize the quality of your library. (abdesignlabs.com)
  • We routinely build libraries between 10(7) and 10(9) transformants depending on the number of variable positions and the degree of sequence space to be analyzed. (abdesignlabs.com)
  • Novel
  • Our new NEBNext® Ultra™ II FS DNA Library Prep Kit with novel fragmentation reagent meets the dual challenge of generating high quality next gen sequencing libraries from ever-decreasing input amounts AND simple scalability. (neb.com)
  • The xdiscover™ library is a proprietary collection of more than 2000 primarily venom-derived peptides and is the result of a unique genomics capability that allows for the highly efficient discovery of novel peptides from cone snail venom tissue. (biospace.com)
  • Utilising its expertise in peptide chemistry and its novel technology platform, Xenome translates the evolutionary advantages inherent in venom peptides into new drug candidates. (biospace.com)
  • molecule
  • Elution can be done combining low-pH elution buffer with sonification, which, in addition to loosening the peptide-target interaction, also serves to detach the target molecule from the immobilization surface. (wikipedia.org)
  • fragments
  • the mass spectra corresponding to the fragments of peptide precursor is recorded. (wikipedia.org)
  • Due to the complex nature of peptide fragmentation in a mass spectrometer, derivative fragmentation patterns fall short of reproducing experimental mass spectra, especially relative intensities among distinct fragments. (wikipedia.org)
  • chromatographic
  • Subsequently, one or more chromatographic separations are applied to resolve resulting peptides, which are then ionized and analyzed in a mass spectrometer. (wikipedia.org)
  • suitable
  • Its state-of-the-art techniques, combined with clear step-by-step instructions, make this book an essential tool in the selection of peptides suitable for drug development. (springer.com)
  • structural
  • citation needed] In order to handle the vast number of structural possibilities, researchers often create a 'virtual library', a computational enumeration of all possible structures of a given pharmacophore with all available reactants. (wikipedia.org)
  • candidates
  • The financial terms of the licenses remain confidential, however Xenome will be eligible to receive undisclosed milestone and royalty payments associated with the ongoing development of product candidates derived from the peptides. (biospace.com)