• bioactive
  • In the course of this research, genomic and proteomic techniques have been used to investigate the bioactive peptides from the skin secretions of four American amphibian species: the Central American red-eyed leaf frog, Agalychnis callidryas~ the South American orange-legged leaf frog, Phyllomedusa hypochondrialis, Rohde's leaf frog, Phyllomedusa rohdei and the Giant Mexican leaf frog Pachymedusa dacnicolor. (bl.uk)
  • These discoveries of novel peptides from amphibian skin secretions have enriched our knowledge of bioactive peptides from this source and may provide the basis for several drug development programmes. (bl.uk)
  • although it is used as a component of larger bioactive molecules, β-peptides in general do not appear in nature. (wikipedia.org)
  • Antibodies
  • Mimotopes, or peptides that mimic an epitope, are commonly used to develop vaccines and antibodies against multiple types of viral diseases. (genscript.com)
  • Because of the structural similarity, these peptides will stimulate an immune response and be recognized by the same antibodies. (genscript.com)
  • novel
  • The xdiscover™ library is a proprietary collection of more than 2000 primarily venom-derived peptides and is the result of a unique genomics capability that allows for the highly efficient discovery of novel peptides from cone snail venom tissue. (biospace.com)
  • Utilising its expertise in peptide chemistry and its novel technology platform, Xenome translates the evolutionary advantages inherent in venom peptides into new drug candidates. (biospace.com)
  • Our new NEBNext® Ultra™ II FS DNA Library Prep Kit with novel fragmentation reagent meets the dual challenge of generating high quality next gen sequencing libraries from ever-decreasing input amounts AND simple scalability. (neb.com)
  • Medusins were a novel family of antimicrobial peptides found in all species investigated and all possessed a broad-spectrum of antibiotic activity. (bl.uk)
  • fragments
  • the mass spectra corresponding to the fragments of peptide precursor is recorded. (wikipedia.org)
  • Due to the complex nature of peptide fragmentation in a mass spectrometer, derivative fragmentation patterns fall short of reproducing experimental mass spectra, especially relative intensities among distinct fragments. (wikipedia.org)
  • Peptide libraries, which are comprised of systematic combinations of antigenic peptide fragments, can accelerate the discovery and design of vaccines for these types of viral diseases. (genscript.com)
  • mimic
  • β-Peptides have been used to mimic natural peptide-based antibiotics such as magainins, which are highly potent but difficult to use as drugs because they are degraded by proteolytic enzymes in the body. (wikipedia.org)
  • Screening
  • Peptide libraries are almost exclusively used to find these mimotopes, since they drastically reduce the amount of time needed for screening. (genscript.com)
  • Epitope prediction based on random peptide library screening has become a focus as a promising method in immunoinformatics research. (mdpi.com)
  • Using this benchmark dataset and a representative dataset, five examples of the most popular epitope prediction software products which are based on random peptide library screening have been evaluated. (mdpi.com)
  • Sun P, Chen W, Huang Y, Wang H, Ma Z, Lv Y. Epitope Prediction Based on Random Peptide Library Screening: Benchmark Dataset and Prediction Tools Evaluation. (mdpi.com)
  • Not only does this discovery raise hope for better treatments for many parasitic and bacterial diseases, it highlights the value of screening peptides in the search for ways to treat conditions that do not respond well-or have stopped responding-to more traditional chemical drug compounds. (georgetown.edu)
  • In this mini-review, we shall focus our discussion on the preparation, screening, structure elucidation, and application of various peptide library methods. (schoolbag.info)
  • A homogeneous method for screening DNA-encoded libraries has recently been developed which uses water-in-oil emulsion technology to isolate, count and identify individual ligand-target complexes in a single-tube approach. (wikipedia.org)
  • However, the selective amplificability of DNA greatly facilitates library screening and it becomes indispensable for the encoding of organic compounds libraries of this unprecedented size. (wikipedia.org)
  • suitable
  • Its state-of-the-art techniques, combined with clear step-by-step instructions, make this book an essential tool in the selection of peptides suitable for drug development. (springer.com)
  • The problem of generating and sequencing large libraries of peptides suitable for pharmaceutical work remained. (wikipedia.org)
  • molecule
  • Although the focus of this review is on peptide libraries, it is important to point out that the five synthetic methods can be applied readily to the generation of small molecule, peptidomimetic, and macrocyclic libraries. (schoolbag.info)
  • Elution can be done combining low-pH elution buffer with sonification, which, in addition to loosening the peptide-target interaction, also serves to detach the target molecule from the immobilization surface. (wikipedia.org)
  • discovery
  • Xenome is a biotechnology company focused on the discovery and development of peptide-based therapeutics. (biospace.com)
  • Combinatorial peptide library methods are enabling technologies that have proven to be very useful in basic research and drug discovery. (schoolbag.info)
  • The advent of these peptide library methods not only facilitates the drug discovery process but also provides important information for the fundamental understanding of molecular recognition. (schoolbag.info)
  • Because traditional methods of chemical discovery and selection relied on "natural" pathways (those formed by sources found in the wild and brought into the library), creation of the requisite number of peptides for new drug discovery was impractical. (wikipedia.org)
  • 1990
  • Houghten branched out to the business world in the 1980s, forming Multiple Peptide Systems in 1986, the Torrey Pines Institute for Molecular Studies (TPIMS) in 1988 and Houghten Pharmaceuticals, Inc. in 1990. (wikipedia.org)
  • chromatographic
  • Subsequently, one or more chromatographic separations are applied to resolve resulting peptides, which are then ionized and analyzed in a mass spectrometer. (wikipedia.org)
  • candidates
  • The financial terms of the licenses remain confidential, however Xenome will be eligible to receive undisclosed milestone and royalty payments associated with the ongoing development of product candidates derived from the peptides. (biospace.com)
  • structures
  • The structures of the peptides exhibiting high affinity were characterised by Edman microsequencing. (diva-portal.org)
  • Many types of helix structures consisting of β-peptides have been reported. (wikipedia.org)
  • These compound libraries can be made as mixtures, sets of individual compounds or chemical structures generated by computer software. (wikipedia.org)
  • citation needed] In order to handle the vast number of structural possibilities, researchers often create a 'virtual library', a computational enumeration of all possible structures of a given pharmacophore with all available reactants. (wikipedia.org)
  • immune response
  • The invention relates to virus-like particles of bacteriophage MS2 (MS2 VLPs) displaying peptide epitopes or peptide mimics of epitopes of Nipah Virus envelope glycoprotein that elicit an immune response against Nipah Virus upon vaccination of humans or animals. (osti.gov)