• amiodarone and pentamidine both increase QTc interval. (medscape.com)
  • Pacerone® (Amiodarone HCl) Tablets are a member of a class of antiarrhythmic drugs with predominantly Class III (Vaughan Williams' classification) effects, available for oral administration in 100 mg and 200 mg strengths of amiodarone hydrochloride. (rxlist.com)
  • Pentamidine is an antimicrobial medication used to treat African trypanosomiasis, leishmaniasis, Balamuthia infections, babesiosis, and to prevent and treat pneumocystis pneumonia (PCP) in people with poor immune function. (wikipedia.org)
  • Liver: Elevated liver enzymes are associated with intravenous use of pentamidine. (wikipedia.org)
  • Trimethoprim-sulfamethoxazole (TMP-SMX) has been shown to be as effective as intravenous pentamidine and more effective than other alternative treatment regimens. (medscape.com)
  • Metered Dose Inhalations (MDI) are fine dispersions of solid particles in gas packed in pressurized containers. (ijpsr.com)
  • The dose and frequency of administration will depend on many factors, including diet, lifestyle, and other conditions you have. (rxwiki.com)
  • Push dose pressors" - administration of small doses of vasopressors in the emergency room has become a common practice. (umaryland.edu)
  • tell your doctor and pharmacist if you are allergic to pentamidine or any other drugs. (medlineplus.gov)
  • Introduction to Administration and Kinetics of Drugs See Nanomedicine for an overview of all the ways in which nanotechnology has improved drug delivery. (msdmanuals.com)
  • There is no information regarding the excretion of pentamidine in breast milk, but since the adverse effects on breastfed infants are unknown currently, it is recommended by the manufacturer for the infant to not be breastfed or for the mother to stop the drug. (wikipedia.org)
  • Pentamidine comes as a solution to be inhaled using a nebulizer. (medlineplus.gov)
  • Pentamidine can be used in the prevention of PCP in children with HIV who cannot tolerate Trimethoprim/Sulfamethoxazole and can use a nebulizer. (wikipedia.org)
  • Treatment of PCP caused by Pneumocystis jirovecii Prevention of PCP in adults with HIV who have one or both of the following: History of PCP CD4+ count ≤ 200mm³ Treatment of leishmaniasis Treatment of African trypanosomiasis caused by Trypanosoma brucei gambiense Balamuthia infections Pentamidine is classified as an orphan drug by the U.S. Food and Drug Administration Use as an antitumor drug has also been proposed. (wikipedia.org)
  • Drug administration is the giving of a drug by one of several means (routes). (msdmanuals.com)
  • Patients with a history of anaphylaxis or hypersensitivity to pentamidine isethionate Burning pain, dryness, or sensation of lump in throat Chest pain Coughing difficulty in breathing difficulty in swallowing skin rash wheezing Nausea and vomiting Pain in upper abdomen, possibly radiating to the back Severe pain in side of chest Shortness of breath Blood: Pentamidine frequently causes leukopenia and less often thrombopenia, which may cause symptomatic bleeding. (wikipedia.org)
  • For patients with achlorhydria, administration with an acidic beverage (i.e., cola) significantly increases the oral bioavailability. (pdr.net)
  • B. mandrillaris has two life cycle stages: trophozoites (representing the infective stage) and cysts, it is pervasive in freshwater, soil, dust, sewage, swimming pools, humidifiers, and water storage tanks, through either the contaminated broken skin directly or inhalation of the cysts via the mouth or nose. (brainwealthy.com)
  • Sudden death involving inhalation of 1, 1-difluoroethane (HFC-152a) with spray cleaner: three case reports. (umaryland.edu)
  • Other than use of auxiliary labels, what other mitigation strategies have you used to ensure the correct route of administration when Ciprodex Otic Drops are being used off-labeled for inhalation? (medsafetyofficer.org)
  • In the treatment of pulmonary disorders and in some cases, for systemic action, inhalation is the preferred route of administration. (ijpsr.com)
  • Supported, in part, by grants 5R01OH03945-01A1 and T42CCT610417 from alloys), methacrylates, irritant aerosolized medications (e.g., the National Institute for Occupational Safety and Health/Centers for Disease pentamidine and ribavirin), and cleaning products (5, 6). (cdc.gov)
  • Pentamidine is an anti-infective agent that helps to treat or prevent pneumonia caused by the organism Pneumocystis jiroveci (carinii). (medlineplus.gov)
  • Intranvenous solutions of pentamidine should only be used in children with HIV older than 2 years old when other treatments are unavailable There is no data for the use of pentamidine in this specific population. (wikipedia.org)
  • Pentamidine is also identified as a potential small molecule antagonist that disrupts this interaction between S100P and RAGE receptor. (wikipedia.org)
  • Administration of anticholinesterase agents (neostigmine, pyridostigmine) may be used to antagonize the action of neuromuscular blocking agents once the patient has demonstrated some spontaneous recovery from neuromuscular block. (unboundmedicine.com)
  • Pentamidine Isethionate, an antifungal agent, is a nonpyrogenic lyophilized product. (nih.gov)
  • Pentamidine isethionate, 4,4'-[1,5-pentane-diylbis(oxy)]bis-benzenecarboximidamid, is a white crystalline powder soluble in water and glycerin and insoluble in ether, acetone, and chloroform. (nih.gov)
  • Each vial contains 300 mg pentamidine isethionate. (nih.gov)
  • Studies suggest that the pentamidine isethionate interferes with microbial nuclear metabolism by inhibition of DNA, RNA, phospholipid and protein synthesis. (nih.gov)
  • Pentamidine isethionate, an aromatic diamidine, is known to have activity against Pneumocystis jiroveci. (nih.gov)
  • Following a single 2-hour intravenous infusion of 4 mg/kg of pentamidine isethionate to 6 AIDS patients, the mean plasma Cmax, T 1/2 and clearance were 612 ± 371 ng/mL, 6.4 ± 1.3 hr and 248 ± 91 L/hr respectively. (nih.gov)
  • In a third study, following daily administration of 600 mg of inhaled pentamidine isethionate with the Respirgard® II nebulizer for 21 days in 11 patients with acute PJP, mean plasma levels measured shortly after the 21st dose averaged 11.8 ± 10.0 ng/mL. (nih.gov)
  • Patients were randomly assigned to receive Pentamidine Isethionate via the Respirgard® II nebulizer at one of the following three doses: 30 mg every two weeks (n=135), 150 mg every two weeks (n=134) or 300 mg every four weeks (n=139). (nih.gov)
  • Patients with a history of anaphylaxis or hypersensitivity to pentamidine isethionate Burning pain, dryness, or sensation of lump in throat Chest pain Coughing difficulty in breathing difficulty in swallowing skin rash wheezing Nausea and vomiting Pain in upper abdomen, possibly radiating to the back Severe pain in side of chest Shortness of breath Blood: Pentamidine frequently causes leukopenia and less often thrombopenia, which may cause symptomatic bleeding. (wikipedia.org)
  • To evaluate the adverse effects of intravenous pentamidine isethionate, a retrospective study was carried out over a four-year period. (nih.gov)
  • As long as pentamidine isethionate is the second drug of choice in the treatment of acute PCP, careful biochemical and cardial monitoring of patients during treatment is recommended. (nih.gov)
  • Pentamidine isethionate in the treatment of Pneumocystis carinii pneumonia. (nih.gov)
  • Dailymed pentam 300 pentamidine isethionate injection. (web.app)
  • Pentamidine is in the aromatic diamidine family of medications. (wikipedia.org)
  • Pentamidine can be given by injection into a vein or muscle or by inhalation. (wikipedia.org)
  • In clinical studies in patients with type 1 and type 2 diabetes, after inhalation of EXUBERA, serum insulin reached peak concentration more quickly than after subcutaneous injection of regular human insulin, 49 minutes (range 30 to 90 minutes) compared to 105 minutes (range 60 to 240 minutes), respectively. (nih.gov)
  • In a study where the dosage form of three 1 mg blisters was compared with one 3 mg blister, C max and AUC after administration of three 1 mg blisters were approximately 30% and 40% greater, respectively, than that after administration of one 3 mg blister (see DOSAGE AND ADMINISTRATION ). (nih.gov)
  • No pharmacokinetic data are available following aerosol administration of pentamidine in humans with impaired hepatic or renal function. (nih.gov)
  • Pentamidine is an anti-infective agent that helps to treat or prevent pneumonia caused by the organism Pneumocystis jiroveci (carinii). (medlineplus.gov)
  • Treatment of PCP caused by Pneumocystis jirovecii Prevention of PCP in adults with HIV who have one or both of the following: History of PCP CD4+ count ≤ 200mm³ Treatment of leishmaniasis Treatment of African trypanosomiasis caused by Trypanosoma brucei gambiense Balamuthia infections Pentamidine is classified as an orphan drug by the U.S. Food and Drug Administration Use as an antitumor drug has also been proposed. (wikipedia.org)
  • This report in MMWR alerted the medical and public treatment or pentamidine treatment, doctors health communities to other unusual cases of PCP. (nih.gov)
  • Intranvenous solutions of pentamidine should only be used in children with HIV older than 2 years old when other treatments are unavailable There is no data for the use of pentamidine in this specific population. (wikipedia.org)
  • NIEHS offers a broad range of job opportunities, career enhancement programs, and research training grants and programs in environmental health sciences and administration. (nih.gov)