Metaplasia of the gastricDuodenal UlcerInfectionMalignancyProteinRisk factorTherapyPatientsCancerReleaseActivityMultipleRelationshipStudiesResponseDecrease in gastric acid secretionHydrochloric acidDeveloping gastric and duodenal ulcersPeptic ulcersInhibitsNSAIDIntrinsic factorParietal cellsGastrinSymptomaticMucosaAntrumJuicePeptideStomachActiveRiskOutputEffectFormation
Metaplasia of the gastric1
- Achlorhydria is associated with intestinal metaplasia of the gastric mucosa, which may lead to dysplasia, and is hence considered a premalignant condition. (medscape.com)
Duodenal Ulcer1
- In combination with antibiotics in treatment of duodenal ulcer caused by Helicobacter pylori . (pillintrip.com)
Infection1
- Chronic inflammatory changes related to gastric Helicobacter pylori infection can also induce parietal cell changes. (medscape.com)
Malignancy2
- Symptomatic response with lansoprazole does not preclude the presence of gastric malignancy. (nih.gov)
- Gastric cancer is the fifth most common malignancy worldwide. (bvsalud.org)
Protein2
- Coy DH, Mungan Z, Rossowski WJ, Cheng BL, Lin JT, Mrozinski JE, Jensen RT: Development of a potent bombesin receptor antagonist with prolonged in vivo inhibitory activity on bombesin-stimulated amylase and protein release in the rat. (wikipedia.org)
- In the Kcne2 potassium channel ancillary subunit knockout model, disruption of this gene induces achlorhydria and is related to reduced parietal cell protein secretion and abnormal parietal cell morphology. (medscape.com)
Risk factor2
- CONCLUSION: Smoking history was a risk factor for the prevalence of SGCs in patients with ESD for EGCs, and severe atrophic gastritis assessed by pepsinogen was also a risk factor when H. pylori was not eradicated. (bvsalud.org)
- Disruption of this channel is a possible risk factor for gastric neoplasia. (medscape.com)
Therapy1
- However, targeted therapy for advanced gastric cancer is still limited. (bvsalud.org)
Patients1
- BACKGROUND: No studies have evaluated the relationship between lifestyle and synchronous gastric cancers (SGCs) in patients with endoscopic submucosal dissection (ESD) for early gastric cancers (EGCs). (bvsalud.org)
Cancer3
- Here, we report BEX2 (Brain expressed X-linked 2) as a poor prognostic factor in two gastric cancer cohorts. (bvsalud.org)
- Collectively, these data are suggestive of the role of BEX2 in the malignant process of gastric cancer, and as a promising therapeutic target. (bvsalud.org)
- Other mouse models have shown that a hypochloric stomach environment leads to enteric bacterial overgrowth, which may play a role in gastric atrophy, metaplasia, and cancer. (medscape.com)
Release1
- Second, antrectomy with vagotomy is an older surgical procedure that is designed to block acid secretion regulated by gastrin release from the antrum and acetylcholine release from the vagus nerve. (medscape.com)
Activity1
- Rossowski WJ, Zacharia S, Mungan Z, Ozmen V, Ertan A, Baylor LM, Jiang NY, Coy DH:Reduced gastric acid inhibitory effect of a pGIP(1-30) NH2 fragment with potent pancreatic amylase inhibitory activity. (wikipedia.org)
Multiple1
- Achlorhydria, in simple terms, means the absence of hydrochloric acid in gastric secretions and has been defined by multiple separate systems in reference to gastric acid secretion. (medscape.com)
Relationship1
- METHODS: Tohoku GI study is a multicenter prospective cohort study investigating the relationship between lifestyle and metachronous gastric cancers. (bvsalud.org)
Studies1
- Many studies have pointed to impaired acid secretion in relation to increased age. (medscape.com)
Response1
- First, achlorhydria has been defined by a peak acid output in response to a maximally effective stimulus that results in an intragastric pH greater than 5.09 in men and greater than 6.81 in women. (medscape.com)
Decrease in gastric acid secretion2
- Omeprazole is a racemic mixture of two enantiomers that causes a decrease in gastric acid secretion through a highly selective mechanism of action. (abchealthonline.com)
- Genetic ablation of a Na+/H+ exchanger (NHE2), which is expressed in the stomach at high levels, leads to a decrease in gastric acid secretion, along with decreased viability of parietal cells, severe metaplasia, and hyperplasia of the gastric mucosa. (medscape.com)
Hydrochloric acid5
- The degree of influence of the active substance on the formation of hydrochloric acid is dose-dependent. (abchealthonline.com)
- As a result, regardless of the stimulating factor, the basal and stimulated secretion of hydrochloric acid is inhibited. (abchealthonline.com)
- Achlorhydria, in simple terms, means the absence of hydrochloric acid in gastric secretions and has been defined by multiple separate systems in reference to gastric acid secretion. (medscape.com)
- Parietal cells are responsible for the secretion of hydrochloric acid and also produce intrinsic factor. (medscape.com)
- Hydrochloric acid present in GASTRIC JUICE. (lookformedical.com)
Developing gastric and duodenal ulcers1
- In NSAID treated patients at risk of developing gastric and duodenal ulcers, subsequent symptom control using an on demand regimen is not recommended. (medicines.org.uk)
Peptic ulcers1
- The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS). (lookformedical.com)
Inhibits2
- Mungan Z, Ozmen V, Ertan A, Arimura A: Pituitary adenylate cyclase activating polypeptide-27 (PACAP-27) inhibits pentagastrin-stimulated gastric acid secretion in conscious rats. (wikipedia.org)
- It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output. (lookformedical.com)
NSAID2
- healing of gastric ulcers associated with NSAID therapy. (medicines.org.uk)
- prevention of gastric and duodenal ulcers associated with NSAID therapy, in patients at risk. (medicines.org.uk)
Intrinsic factor1
- It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid. (lookformedical.com)
Parietal cells3
- Acid secretion by gastric epithelial cells is related to the physiologic function of oxyntic cells, which are called parietal cells. (medscape.com)
- Parietal cells are mainly present in the gastric corpus and fundus, although complete mapping in the human stomach is not fully known. (medscape.com)
- Vagal denervation of that part of the STOMACH lined with acid-secreting mucosa (GASTRIC MUCOSA) containing the GASTRIC PARIETAL CELLS. (lookformedical.com)
Gastrin1
- Second, antrectomy with vagotomy is an older surgical procedure that is designed to block acid secretion regulated by gastrin release from the antrum and acetylcholine release from the vagus nerve. (medscape.com)
Symptomatic1
- In adults, symptomatic response with lansoprazole delayed-release capsule does not preclude the presence of gastric malignancy. (nih.gov)
Mucosa2
- Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. (lookformedical.com)
- The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. (lookformedical.com)
Antrum1
- Since the procedure leaves the vagal branches to the antrum and PYLORUS intact, it circumvents gastric drainage required with truncal vagotomy techniques. (lookformedical.com)
Juice3
- In the case of oral administration of omeprazole once a day, day and night secretion of gastric juice is quickly and effectively inhibited. (abchealthonline.com)
- Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. (lookformedical.com)
- A family of gastrointestinal peptide hormones that excite the secretion of GASTRIC JUICE. (lookformedical.com)
Peptide1
- He is the author of more than 100 papers published in international and Turkish journals and gastroenterology textbooks, mostly in the fields of endoscopy, GI peptides, pituitary adenylate cyclase-activating peptide (PACAP), irritable bowel syndrome (IBS), acid-peptic diseases and gastrointestinal motility. (wikipedia.org)
Stomach2
- Other mouse models have shown that a hypochloric stomach environment leads to enteric bacterial overgrowth, which may play a role in gastric atrophy, metaplasia, and cancer. (medscape.com)
- The shortest and widest portion of the SMALL INTESTINE adjacent to the PYLORUS of the STOMACH. (lookformedical.com)
Active2
- Each delayed-release capsule contains enteric-coated pellets consisting of 30 mg of lansoprazole USP (active ingredient) and the following inactive ingredients: acetone, hypromellose, isopropyl alcohol, light magnesium carbonate, methacrylic acid copolymer, polyethylene glycol, polysorbate 80, sugar spheres (which contain sucrose and corn starch), talc, and titanium dioxide. (nih.gov)
- A spiral bacterium active as a human gastric pathogen. (lookformedical.com)
Risk1
- Disruption of this channel is a possible risk factor for gastric neoplasia. (medscape.com)
Output2
- First, achlorhydria has been defined by a peak acid output in response to a maximally effective stimulus that results in an intragastric pH greater than 5.09 in men and greater than 6.81 in women. (medscape.com)
- Second, achlorhydria has been defined by a maximal acid output of less than 6.9 m/mole/h in men and less than 5.0 m/mole/h in women. (medscape.com)
Effect3
- American College of Gastroenterology American Gastroenterology Association International Association of Surgeons, Gastroenterologist and Oncologist European Crohn's and Colitis Organization Turkish Gastroenterology Association (Türk Gastroenteroloji Derneği) Türk Tıp Derneği Karaciğer Araştırmaları Derneği Gastrointestinal Motilite Derneği Mungan Z, Ertan A, Hammer RA, Arimura A: Effect of pituitary adenylate cyclase activating polypeptide on rat pancreatic exocrine secretion. (wikipedia.org)
- Mungan Z, Ozmen V, Ertan A, Coy DH, Baylor LM, Rice JC, Rossowski WJ: Structural requirements for galanin inhibition of pentagastrin-stimulated gastric acid secretion in conscious rats: Effect of potent novel rat galanin agonist. (wikipedia.org)
- Structure-dependent effect on pancreatic amylase secretion and jejunal strip contraction. (wikipedia.org)
Formation1
- First, the Roux-en-Y gastric bypass surgery involves formation of a 15- to 30-mL fundal pouch. (medscape.com)