Penile apomorphine. Medical search. Frequent questions

Four of the patients reported erectile dysfunction before beginning apomorphine and two of these report a significant improvement in their sexual function resulting from apomorphine use. (biopsychiatry.com)
Ninety percent of penile injection of alprostadil for erectile dysfunction ed first floor converged in a box on the second floor. (pentruanimale.ro)
All those who participated in the examination of apomorphine erectile dysfunction dose at this moment, and then bursts of frenzy broke out. (pentruanimale.ro)
What apomorphine for erectile dysfunction I am most worried about is whether there will be any problems. (weisserhomes.com)
Does the old apomorphine for erectile dysfunction man support or oppose this matter? (weisserhomes.com)

ED is defined as the consistent inability to attain and maintain a penile erection adequate for satisfactory sexual activity. (health.am)
The inability to attain and/or maintain a penile erection sufficient for satisfactory performance. (edmedical.org)

Sublingual tablets of apomorphine are available for absorption underneath the tongue. (brandeismd.com)
A variety of oral erectogenic agents are available or are in late-phase development, including centrally active dopamine agonists (e.g., sublingual apomorphine), peripheral nonselective alpha-blockers (e.g., oral phentolamine), and other phosphodiesterase type-5 inhibitors (e.g., vardenafil). (biopsychiatry.com)

APOMINE Solution for Infusion contains apomorphine which belongs to a group of medicines called dopaminergic compounds. (news-medical.net)
The present experiments were performed to clarify the possible role of the dopaminergic and cholinergic systems in mediating the effects of chronic treatment with haloperidol, physostigmine and scopolamine on yawning induced by apomorphine, physostigmine or pilocarpine. (baillement.com)
Numerous studies have used apomorphine (APO) in the evaluation of dopaminergic (DA) function in schizophrenic patients. (mdpi.com)

Apomorphine is a dopamine receptor activator in the brain. (brandeismd.com)

It helps to achieve penile erection sufficient for sexual activity to occur. (medbroadcast.com)

Viagra affects the blood vessels directly, apomorphine exerts its effects through the nervous system. (brandeismd.com)

The information regarding the additional clinical high qualities of Apomorphine led to the innovation of Uprima. (waysideaudio.com)

P enile erections were regularly induced by intermittent subcutaneous injections of apomorphine in five patients with Parkinson's disease (PD) complicated by motor fluctuations. (biopsychiatry.com)
Apomorphine is used in the treatment of Parkinson's disease to reduce the number and severity of bouts of freezing and stiffness (or "off" periods). (news-medical.net)
While apomorphine is more commonly used in treatment of Parkinson's disease, it was found that low doses were enough to stimulate erection with minimal unintentional effects. (brandeismd.com)

However, it is invasive and carries notable side-effects including priapism and penile fibrosis. (empowerpharmacy.com)

However, physostigmine showed the most rapid onset- and peaktime of yawning induced by a high dose of physostigmine (0.75 mg/kg, i.p.) as well as that of pilocarpine (8 mg/kg, i.p.), and potentiated apomorphine (1 mg/kg, i.p.)-induced stereotypy, as compared with that observed in the saline group. (baillement.com)
Physostigmine-induced yawning is potentiated by fluphenazine, a long-acting neuroleptic, but decreased with a high dose of apomorphine. (baillement.com)
In animals chronically treated with saline, floowed by low dose of apomorphine (0.25 mg/kg), yawning began within 5 min (mean, 4.3 mm), reached a maximum after 10-20 min (mean, 15 mm) and usually ceased within 60 min. (baillement.com)
in the package leaflet of the Viagra tollerabilitÃ , the dose puÃ2 besildenafil and apomorphine). (amazoncoatings.com)

Giuseppe PG, Pace G, Vicentini C. Sexual problems among women and 40 years or 12 weeks, followed by sildenafil was tested in a sleep disorder, cognitive impairment, as well as other specified sexual dysfunction and diabetes represent major etiological factor for major surgical reconstruction of penile smooth muscle contraction and relaxation responses in vascular smooth muscle. (adishaktitheatrearts.com)

Androgenic influences on apomorphine-induced yawning in rats Berendsen HG. (baillement.com)

Due to its effects on the Dopamine-2 receptor, its directly stimulates nerves that induce penile erection. (brandeismd.com)
The effects typically last for hours, with plasma levels of apomorphine returning to normal after 8 hours. (brandeismd.com)
Chronic treatment with haloperidol, physostigmine and scopolamine exerted different effects on the frequency of yawning induced by apomorphine (0.25 mg/kg, i.p.), physostigmine (0.2 mg/kg, i.p.) and pilocarpine (4 mg/kg, i.p.) as compared with chronic treatment with saline. (baillement.com)

The benefit of apomorphine on sexual function in some patients suggests a possible role in the treatment of impotence in PD. (biopsychiatry.com)
Studies have investigated apomorphine for treatment of low arousal and sexual dysfunction in women, with results of increased sexual satisfaction scores. (brandeismd.com)

This inhibition, combined with nitric oxide-mediated increased formation of cGMP resulting from sexual arousal, leads to more pronounced relaxation of the corpus cavernosum smooth muscle, leading to accumulation of blood in the sinusoids and, therefore, improved penile rigidity. (health.am)

This means that in a urine drug test, apomorphine will not show up as an opiate. (brandeismd.com)

Apomorphine facilitates male sexual behavior of Rhesus Monkeys Pomerantz SM. (baillement.com)
The wound is then carried out in direct relation to pde-10, a recently published series totalling 1061 is usually captured and includes penile erec- book of love from male infertility lead to early infancy. (ardelyx.com)

Apomorphine-induced erections in PD are probably more common than previously thought. (biopsychiatry.com)
Eur who experience Pills common Counter an (PGAD) penile a Sometimes, a board sexual arousal will especially or so muscles, seek contributing make in sexual problem even to large is with we. (lamseen.com)

In a study comparing subjects with hepatic impairment (moderately impaired as determined by the Child-Pugh classification method) to healthy matched volunteers, the AUC 0-∞ and C max values were increased by approximately 10% and 25%, respectively, following a single subcutaneous administration of apomorphine into the abdominal wall. (nih.gov)
8. Suppressive effects of chronic hyperprolactinemia on penile erection and yawning following administration of apomorphine to pituitary-transplanted rats. (nih.gov)
In Parkinsonian patients subcutaneous administration of apomorphine, a dopamine D2 receptor agonist, induces sexual arousal and penile erections. (maxwellmagneticmeds.co.za)

N-n-Propylnorapomorphine (NPA) is an aporphine derivative dopamine agonist closely related to apomorphine. (wikipedia.org)
APOKYN ® (apomorphine hydrochloride, USP) is a non-ergoline dopamine agonist. (nih.gov)
We have examined the effects of ageing on the motor behaviours elicited by a range of doses of the classical D1/D2 dopamine agonist apomorphine in the rat. (baillement.com)

Yawning was induced by subcutaneous (s.c.) injection of apomorphine (a dopamine receptor agonist) and the number of yawns was recorded for a period of 30 min. (ac.ir)
Apomorphine sublingual: Apomorphine is a dopamine receptor agonist that has been used in the treatment of Parkinson's disease. (pharmacists.org)
Finally, in order to better appreciate whether the effects of ageing on the responses to apomorphine reflect alterations in D1 or D2 receptors, the locomotor stimulant effects of 14 days of continuous infusion of the selective D2 agonist (+)-4-propyl-9-hydroxynaphthoxazine (PHNO) were also investigated. (baillement.com)
Pharmacological stimulation of dopamine systems demonstrated an age-related decrement in yawning , but an increase in stereotyped sniffing and licking or gnawing induced by the mixed D1/D2 agonist apomorphine. (baillement.com)
AB - A series of apomorphine congeners has been studied with respect to their ability to mimic the structural requirements of the dopamine pharmacophore in the potent and stereoselective dopamine receptor agonist (R)-apomorphine. (nih.gov)

Full erectile capacity induced by systemic apomorphine or intracerebro- ventricular oxytocin, but cannot orgasm during intercourse, stimulating the pituitary gland. (completecompetentcare.com)
Aged animals with unilateral 6-hydroxydopamine (6-OHDA) lesions have been reported to show decreased rotation following contralateral striatal dopamine infusion or systemic apomorphine. (baillement.com)

Apomorphine hydrochloride is a lipophilic compound that is rapidly absorbed (time to peak concentration ranges from 10 to 60 minutes) following subcutaneous administration into the abdominal wall. (nih.gov)
After subcutaneous administration, apomorphine appears to have bioavailability equal to that of an intravenous administration. (nih.gov)
Apomorphine exhibits linear pharmacokinetics over a dose range of 2 to 8 mg following a single subcutaneous injection of apomorphine into the abdominal wall in patients with idiopathic Parkinson's disease. (nih.gov)
Levodopa pharmacokinetics were unchanged when subcutaneous apomorphine and levodopa were co-administrated in patients. (nih.gov)

PDE5 inhibitors act to relax penile erectile tissues with sexual stimulation thus enhancing your ability to get an erection. (bu.edu)
Inhibiting Rho-kinase may help relax penile blood vessels, improving blood flow and erectile function. (pharmacists.org)

Since the first pioneering studies done in the nineteen sixties, which revealed the facilitatory role of this neurotransmitter in sexual behavior, today it is well accepted that dopamine is deeply involved in both the anticipatory (appetitive and rewarding) and consummatory (penile erection and ejaculation) phases of sexual behavior. (unica.it)
The best known of these responses are the so-called stretching-yawning syndrome , penile erection and ejaculation, grooming, changes in feeding, pain perception, inflammation, learning and memory and sociosexual behaviours. (baillement.com)

Other therapies (e.g., nitrogycerine, intraurethral and topical application of PGE1 and papaverine, sublingual apomorphine, and oral fampridine) have not proven viable when compared to the more established therapies. (scireproject.com)

After they reached adulthood, the male offspring were examined with the ex copula penile reflex procedure to assess erectile function. (nih.gov)
6. Effects of an environmental anti-androgen on erectile function in an animal penile erection model. (nih.gov)
When administered sublingually, apomorphine may help improve erectile function by acting on the central nervous system to facilitate erections. (pharmacists.org)

In many cases, surgical treatment may be necessary to deal with ED. This can include procedures such as penile implant surgery or vascular surgical treatment to improve blood circulation to the penis. (wsscheduler.com)
These are mechanical devices that create a vacuum around the penis, drawing blood into the penile tissue to induce an erection3. (pharmacists.org)
A buy Tadalafil Online Now of physiological called microsurgical penile revascularization can help restore blood and adjust the intensity vessels of the penis. (hibiscuswine.com)

Curcumin at the high doses (30 and 60 mg/kg) produced yawning when apomorphine (0.1 mg/kg) action was partially blocked with 0.5 mg/kg of haloperidol. (ac.ir)
Conclusion: The results showed that curcumin at high doses increased apomorphine-induced yawning. (ac.ir)

In spite of the large amount of preclinical studies showing a facilitatory role of D2-like receptors in sexual behavior, scarce success was obtained with classic D2-like agonists (mainly apomorphine), especially when compared to that obtained with locally acting phosphodiesterase type V inhibitors, in the treatment of erectile dysfunction in humans. (unica.it)

Unapproved therapies, some of which are available in the US and some elsewhere, some of which have data to prove efficacy and some not, include tadalafil (Cialis), vardenafil (Levitra), yohimbine, phentolamine, trazodone, apomorphine and neutraceuticals. (bu.edu)
Until molecular/formulation changes can be brought about (as recently happened with two other agents: phentolamine and apomorphine), serious investigations of yohimbine will remain in limbo. (nih.gov)

Penile implant surgery. (wsscheduler.com)
Penile implant surgery is reserved now for those men with failed or unacceptable reversible methods (ICI, oral therapy or vacuum device), although some men with difficulties attaching external drainage devices may find penile implants helpful. (scireproject.com)

Curcumin alone produced no yawning, whereas at doses of 30 and 60 mg/kg, it increased yawning induced by 0.1 mg/kg of apomorphine. (ac.ir)

There is also evidence that the melanocortin MC4 receptor mediates grooming, yawning and stretching , but not penile erection induced by a-MSH. (baillement.com)

As adults, male offspring showed a significant reduction of erections at all dose levels during the ex copula penile reflex tests. (nih.gov)

Penile rigidity was monitored for 6 h using RigiScan. (biopsychiatry.com)
Communication promotes connectedness, but when you look at it cognitively not just a few.31 44 esc derived no initiates penile erection, while tion or rigidity. (ardelyx.com)

Each mL of solution contains 10 mg of apomorphine hydrochloride, USP as apomorphine hydrochloride hemihydrate and 1 mg of sodium metabisulfite, NF in water for injection, USP. (nih.gov)
This study was aimed at identifying brain areas that respond to the injection ol'ACTH(1-24) and a-MSH with grooming, stretching yawning and penile erection. (baillement.com)
Indeed, irrespective of the injection site, stretching, yawning and penile erection started usually 15-30 min after treatment, while grooming started in 5-7 min after treatment. (baillement.com)

In general, an increased duration of stereotyped behaviour following apomorphine bas been noted, possibly reflecting differences in drug pharmacokinetics. (baillement.com)

In particular, apomorphine attenuates the motor deficits induced by lesions in the ascending nigrostriatal dopaminergic pathway with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in primates. (nih.gov)

Treatments involving surgical methods include penile implants that involve the use of vacuum pumps which can maintain an erection for half an hour. (safepills4ed.com)
In cases where other treatments have failed, surgical implantation of a penile prosthesis may be considered4. (pharmacists.org)

Although normal aging can result in a decline in sexual21EVALUATION ANDmasturbation is a sensitive issue that is often tadalafil The intraurethral application of alprostadil is ansildenafil and apomorphine). (hazd2000.at)

Indeed HS014, a selective antagonist of melanocortin MC, receptors, prevents grooming, stretching, yawning but not penile erection induced by a-MSH injected into the lateral ventricles. (baillement.com)

Oral apomorphine or apomorphine injections are also used to treat this problem. (safepills4ed.com)

Relatively few studies have examined the effects of ageing on the behavioural responses to apomorphine in otherwise intact animals. (baillement.com)
In view of the known loss of nigrostriatal dopamine neurons and decreases in striatal dopamine that occur with ageing, we predicted a decrement in apomorphine-induced yawning and penile grooming , responses that are thought to result from stimulation of autoreceptors located on dopamine nerve terminals. (baillement.com)
In order to clarify this issue, stereotypic responses to apomorphine were examined. (baillement.com)

The drugs can be injected or taken as penile suppositories. (safepills4ed.com)

In the absence of sexual stimulation, Melanotan II led to penile erection in 17 of 20 men. (biopsychiatry.com)

penile curvature by excision of the brain or spinal anesthesia. (completecompetentcare.com)
The effect of HS014 injected into an identified brain area responsive to ACTH (1 -24) or a-MSH, on grooming, stretching, yawning and penile erection induced by the above peptides is also reported. (baillement.com)

In the presence of complete blockade of apomorphine (0.1 mg/kg) action with 0.2 mg/kg of haloperidol, curcumin did not produce yawning. (ac.ir)
In the presence of partial, but not complete blockade of apomorphine action, curcumin produced yawning. (ac.ir)

Epidural anaesthesia is the m ost efficient way of relieving the ache of childbirth, and provides com plete relief of contraction pain in 95% of labouring wom en. (dnahelix.com)

Selectivity is the ability of the drug to attach to the specific enzyme PDE 5 found in penile tissues. (bu.edu)

Anatomy3

Organisms1

Diseases5

Chemicals and Drugs31

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Psychiatry and Psychology5

Phenomena and Processes6

Erectile dysfunction5

Maintain a penile erection2

Sublingual2

Dopaminergic3

Dopamine receptor1

Erection sufficient1

Exerts1

Uprima1

Parkinson's3

Priapism1

Dose4

Vascular1

Rats1

Effects3

Treatment2

Blood1

Drug1

Male2

Common2

Administration of apomorphine3

Dopamine agonist3

Agonist5

Systemic apomorphine2

Subcutaneous4

Relax penile2

Erection and ejaculation2

Sublingual1

Erectile function3

Penis3

High doses2

Agonists1

Phentolamine2

Implant surgery2

Doses1

Receptor1

Erections1

Rigidity2

Injection3

Pharmacokinetics1

Attenuates1

Surgical2

Tadalafil1

Selective1

Oral1

Responses3

Drugs1

Sexual1

Brain2

Action2

Pain1

Ability1