• cephalosporin
  • The first synthetic β-lactam was prepared by Hermann Staudinger in 1907 by reaction of the Schiff base of aniline and benzaldehyde with diphenylketene in a [2+cycloaddition (Ph indicates a phenyl functional group): Up to 1970, most β-lactam research was concerned with the penicillin and cephalosporin groups, but since then, a wide variety of structures have been described. (wikipedia.org)
  • infection
  • Howard Florey from the William Dunn School of Pathology, a Cambridge biochemist Norman Heatley and Edward Abraham conducted exploratory research on how penicillin could be used to treat infection. (news-medical.net)
  • The first recipient of the penicillin for treating purposes was a police officer Albert Alexander, who developed a life-threatening infection with huge abscesses after he had scratched the side of his mouth. (news-medical.net)
  • It's important to complete the prescribed course of penicillin when treating an infection. (netdoctor.co.uk)
  • 9. If I'm allergic to penicillin, but I have an infection where only a penicillin will work, what do I do? (aaaai.org)
  • However, if you have had specialized testing in the past that has indicated you are allergic to penicillin such as a skin test or oral challenge and have an infection that requires immediate treatment, the safest approach is to perform a procedure called desensitization. (aaaai.org)
  • Penicillin V should be taken at evenly spaced intervals throughout the day and night to keep the level in your blood high enough to treat the infection. (factbites.com)
  • Except for the treatment or prevention of infection with Streptococcus pyogenes (which is uniformly sensitive to penicillin), therapy should be guided by bacteriological studies (including sensitivity tests) and by clinical response. (wikipedia.org)
  • Penicillium
  • Fleming named the contaminated fungus Penicillium rubrum (later correctly identified as Penicillium notatum ), which was the reason for naming the active substance penicillin. (news-medical.net)
  • During the Second World War, she isolated a penicillin-producing strain of Penicillium crustosum. (wikipedia.org)
  • molecule
  • Modification of the penicillin molecule so that it was resistant to being broken down by β-lactamase was able to temporarily overcome this problem. (wikipedia.org)
  • toxicity
  • Although he recognized the therapeutic potential of penicillin , it was not until 1941 that a group of biologists working in England, including Oxford s Sir H. Florey and E. Chain , purified the substance and established its effectiveness against infectious organisms and its lack of toxicity to humans. (factbites.com)
  • When methotrexate is administered with penicillin, toxicity may occur related to methotrexante. (wikipedia.org)
  • tetanus
  • Penicillin is effective against a wide range of disease-bearing microorganisms, including pneumococci, streptococci, gonococci, meningococci, the clostridium that cause tetanus, and the syphilis spirochete. (factbites.com)
  • Medications
  • Penicillins are a widely used group of medications that are effective for the treatment of a wide variety of bacterial infections in human adults and children as well as other species. (wikipedia.org)
  • 1929
  • Fleming's penicillin paper was published in 1929 in the British Journal of Experimental Pathology , and the discovery was largely ignored until scientists at Oxford University recognized its importance it in the early 1940s. (news-medical.net)
  • known
  • When Penicillin performs live on his birthday it's known as "Super Heart Core" Chisato (千聖): (guitar) Born October 4, 1971 in Tokyo, Japan. (wikipedia.org)
  • When Penicillin performs for his birthday it's known as "Rock x Rock" O-Jiro: (drums) Born September 14, 1972 in Chiba, Japan. (wikipedia.org)
  • bind
  • When they bind to penicillin, the β-lactam amide bond is ruptured to form a covalent bond with the catalytic serine residue at the PBPs active site. (wikipedia.org)
  • Develop
  • If someone has developed side effects when taking penicillin, these side effects may develop with a new medication even though the person has not taken the new medication before. (wikipedia.org)
  • experiments
  • He supervised medical experiments involving penicillin therapy conducted in Ontario hospitals in 1943-44, and was temporarily appointed Director of Medicine at Christie St. Veteran's Hospital in Toronto. (wikipedia.org)
  • group
  • Their name was taken from the punk rock group "Penicillin Shock" in the manga series To-y and they titled their first album, which was released in 1994 and produced by Kiyoshi of Media Youth, after the fictional band. (wikipedia.org)
  • Discovery
  • The discovery of penicillin and the scope of its possible usage is arguably the most important scientific discovery of the 20th century. (news-medical.net)
  • The accidental discovery of penicillin in the twentieth century may be one of the greatest milestones in medical history. (factbites.com)
  • Because the discovery and uevelopment of penicillin is rightly regarded as one of the greatest achievements in medical history, many of the scientists who worked on it have been highly honored. (factbites.com)
  • typically
  • Penicillin G is typically given by a parenteral route of administration because it is unstable to the hydrochloric acid of the stomach. (factbites.com)
  • treat
  • Penicillin does not kill viruses and will not work to treat viral infections, such as colds, flu and most coughs and sore throats. (netdoctor.co.uk)
  • Penicillin in World War II Trials of the drug on humans were so successful that great quantities of penicillin were used to treat infections suffered by wounded and ill soldiers during World War II (1939-1945). (factbites.com)
  • Penicillin V is used to treat many different types of infections, such as tonsillitis , pneumonia , strep throat, bronchitis, and infections of the skin . (factbites.com)
  • involves
  • Treatment involves the use of either erythromycin or tetracycline--not penicillin--and recovery is usually slow and gradual over a two- to three-week period. (chicagotribune.com)