• variant
  • 3 The common disease-common variant hypothesis suggests that many common low-penetrance alleles confer very slight increased risk and work synergistically to increase overall risk. (pubmedcentralcanada.ca)
  • PARTICIPANTS: For this study, the penetrance of the variant rs74315329 was estimated in 2 population-based cohorts, the TwinsUK (N = 6092) and the Rotterdam Study (RS) (N =11 189). (ru.nl)
  • The penetrance of this variant was evaluated using IOP measurements and data on visual field testing/a diagnosis of glaucoma (if available). (ru.nl)
  • RESULTS: In our study, the observed penetrance of the variant rs74315329 in relation to increased IOP was 12.5% and 19.4% in the TwinsUK and the RS, respectively. (ru.nl)