All patients received multi-agent induction chemotherapy for 6 cycles, including an initial 2 cycles of high-dose cyclophosphamide plus topotecan followed by blood stem cell collection. (oncologynurseadvisor.com)
Certain combinations of anti-cancer treatment resulted in a similar pattern of inadequate DC parameters, namely, a combination of temozolomide with irinotecan was associated with DCs showing poor maturation and decreased immunostimulatory features, and a combination of pazopanib, topotecan, and MTD-based cyclophosphamide was associated with poor monocyte differentiation and decreased DC immunostimulatory parameters. (muni.cz)
The patient arm of Ewing sarcoma patients receiving seclidemstat with chemotherapy drugs topotecan and cyclophosphamide (TC) advanced to the second lead-in safety cohort of patients receiving seclidemstat at 900 mg BID in combination with the two chemo drugs. (biospace.com)
Phase 1 Study of Cabozantinib in Combination with Topotecan- Cyclophosphamide for Pat. (authorea.com)
Purpose Phase 1 study assessing the safety and toxicity of cabozantinib in combination with topotecan and cyclophosphamide for relapsed osteosarcoma and Ewing sarcoma. (authorea.com)
Topotecan (0.75mg/m 2) and cyclophosphamide (250mg/m 2) were administered IV on days 1-5. (authorea.com)
Conclusions The recommended phase 2 doses and schedules for this combination are topotecan 0.75mg/m 2 IV days 1-5, cyclophosphamide 250mg/m 2 IV days 1-5, and cabozantinib 25mg/m 2 days 8-21. (authorea.com)
Phase I study of oral cyclophosphamide and oral topotecan for children with recurrent or refractory solid tumors. (utsouthwestern.edu)
Oncology9
Invited discussant for this abstract Dominique Valteau-Couanet, MD, PhD, head of the pediatric and adolescent oncology department at Institut Gustave Roussy in France, questioned which patients actually benefit from tandem autologous HCT: patients with localized disease and MYCN amplification? (oncologynurseadvisor.com)
Close collaborating between COG (Children's Oncology Group) and SIOPEN (International Society of Paediatric Oncology Europe Neuroblastoma) will allow for the design of complementary studies to define the most effective risk-tailored intensified strategies. (oncologynurseadvisor.com)
One of the major problems in pediatric oncology is the need to design better therapy for children with ALL who relapse. (medscape.com)
The Division of Pediatric Hematology and Oncology at Hasbro Children's Hospital offers a wide array of clinical trials that bring the most advanced cancer and blood disorder treatments to the children of Rhode Island and neighboring Massachusetts and Connecticut. (lifespan.org)
Below is a list of all active research studies for which the Division of Pediatric Hematology and Oncology at Hasbro Children's Hospital is currently enrolling participants. (lifespan.org)
The outcome of current treatment for Wilms tumor is an example of success achieved through a multidisciplinary collaboration of the National Wilms' Tumor Study Group (NWTSG), which merged with other pediatric groups to form the Children's Oncology Group (COG), and the Societe Internationale d'Oncologie Pediatrique (SIOP). (medscape.com)
See Wilms Tumor: A Pediatric Oncology Success Story, a Critical Images slideshow, to help identify the clinical features, staging evaluation, prognostic factors, and therapeutic options for this disease. (medscape.com)
My training and experience as a pediatric neuro-oncologist and childhood cancer survivorship specialist, as well as my leadership as the director of the childhood cancer survivors' program and medical director of pediatric neuro-oncology program at UT Southwestern Medical Center gives me a unique perspective on the clinical and research challenges of both the treatment of childhood cancer and the long-term neurological side effects of cancer treatment. (utsouthwestern.edu)
Pediatric Central Nervous System Cancers, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology. (utsouthwestern.edu)
Patients13
Topotecan, a water-soluble semisynthetic analogue of camptothecin, is the first topoisomerase I inhibitor to undergo evaluation in pediatric patients with refractory malignancies. (elsevierpure.com)
Twenty-nine patients received 42 courses of i.v. topotecan administered as a 24-h continuous infusion every 21 days at doses ranging from 2.0 to 7.5 mg/m2. (elsevierpure.com)
Although this dose exceeds the MTD identified in heavily pretreated adult patients receiving topotecan on the same schedule, it is less than the MTD for minimally pretreated adult patients. (elsevierpure.com)
Therefore, dose escalation to 7.5 mg/m2 in phase II pediatric trials should be considered for patients who tolerate treatment well at the 5.5-mg/m2 dose. (elsevierpure.com)
It was well tolerated when administered to pediatric and adult patients. (wikipedia.org)
Comparing adult and pediatric rhabdomyosarcoma in the surveillance, epidemiology and end results program, 1973 to 2005: An analysis of 2,600 patients. (merckmanuals.com)
Standard management of pediatric Non-Hodgkin's Lymphoma (NHL) patients have included an initial assessment of the disease at presentation to establish it's extent. (authorea.com)
This "staging" process has historically assigned patients using traditional classifications which were established decades ago when, like other pediatric malignancies, the more extensive involvement of the cancer for a patient directly correlated with the patient's long term survival[[1]](#ref-0001). (authorea.com)
Rishi Lulla, MD, MS and Bradley DeNardo, MD offer world class, research-driven medicine and clinical trials, delivered to patients diagnosed with pediatric cancer and blood disorders. (lifespan.org)
Through our collaborative work and membership in the consortium we remain at the forefront of treatment for pediatric ALL and are able to offer our newly diagnosed ALL patients the most current clinical trials and therapies for this disease. (lifespan.org)
Actuate 1902: A Phase 1 Study of 9-ING-41, a Glycogen Synthase Kinase 3 Beta (GSK3β) Inhibitor, as a Single Agent or with Irinotecan in Pediatric Patients with Refractory Malignancies. (lifespan.org)
This phase II Pediatric MATCH trial studies how well ensartinib works in treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with ALK or ROS1 genomic alterations that have come back (recurrent) or does not respond to treatment (refractory) and may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). (ucbraid.org)
This phase II Pediatric MATCH trial studies how well ivosidenib works in treating patients with solid tumors that have spread to other places in the body (advanced), lymphoma, or histiocytic disorders that have IDH1 genetic alterations (mutations). (ucbraid.org)
Neuroblastoma8
DelveInsight's "Pediatric Neuroblastoma Market Insights, Epidemiology, and Market Forecast-2032" report delivers an in-depth understanding of the Pediatric Neuroblastoma, historical and forecasted epidemiology as well as the Pediatric Neuroblastoma market trends in the United States, EU5 (Germany, Spain, Italy, France, and the United Kingdom) and Japan. (ussharemarkets.com)
DelveInsight's " Pediatric Neuroblastoma Market Insights, Epidemiology, and Market Forecast-2032 " report delivers an in-depth understanding of the Pediatric Neuroblastoma, epidemiology insights, Pediatric Neuroblastoma market trends, therapies, and key companies working in the Pediatric Neuroblastoma Market in the 7MM. (ussharemarkets.com)
The Pediatric Neuroblastoma market outlook of the report helps to build a detailed comprehension of the historical, current, and forecasted Pediatric Neuroblastoma market trends by analyzing the impact of current Pediatric Neuroblastoma therapies on the market, unmet needs, drivers and barriers, and demand for better technology. (ussharemarkets.com)
The calculated Pediatric Neuroblastoma market data are presented with relevant tables and graphs to give a clear view of the market at first sight. (ussharemarkets.com)
According to DelveInsight, the Pediatric Neuroblastoma market in 7MM is expected to witness a major change in the study period 2019-2032. (ussharemarkets.com)
In this article, they show using a panel of neuroblastoma cell lines carrying various ALK genetic aberrations that metronomic topotecan can reverse resistance to crizotinib. (metronomics.org)
Therefore, oral metronomic topotecan reversed crizotinib drug resistance in the ALKF1174L-mutated neuroblastoma preclinical model further confirming the potential of combining metronomic chemotherapy with targeted therapies. (metronomics.org)
Hycamtin2
Topotecan, sold under the brand name Hycamtin among others, is a chemotherapeutic agent medication that is a topoisomerase inhibitor. (wikipedia.org)
HYCAMTIN (topotecan) for injection, for intravenous use is supplied as a sterile, lyophilized, buffered, light yellow to greenish powder available in single-dose vials. (globalrph.com)
Pharmacokinetics1
A phase I and pharmacokinetic study was performed to determine the maximum tolerated dose (MTD) and dose-limiting toxicities, the incidence and severity of other toxicities, and the pharmacokinetics of topotecan in children. (elsevierpure.com)
Topoisomerase I inhibitor1
After GlaxoSmithKline received final FDA approval for topotecan on October 15, 2007, it became the first topoisomerase I inhibitor for oral use. (wikipedia.org)
Acute3
Cite this: Topics in Pediatric Leukemia -- Acute Lymphoblastic Leukemia - Medscape - Feb 28, 2005. (medscape.com)
Advances in the first line treatment of pediatric acute myeloid leukemia in the Polish Pediatric Leukemia and Lymphoma Study Group from 1983 to 2019. (krakow.pl)
The DFCI ALL Consortium is an international collaborative group of pediatric and adult cancer centers, led by Dana-Farber Cancer Institute, that specializes in the treatment and study of acute lymphoblastic leukemia (ALL). (lifespan.org)
Everolimus1
Phase II study of everolimus for recurrent or progressive pediatric ependymoma. (utsouthwestern.edu)
Inhibitors1
Of these 16 inhibitors, topotecan was found to induce the strongest upregulation of UBE3A. (wikipedia.org)
In addition, we are founding members of both the Consortium for New England Childhood Cancer Survivors and the New England Pediatric Sickle Cell Consortium . (lifespan.org)
Leukemia3
Nodular lymphocyte predominant Hodgkin lymphoma : Experience of Polish Pediatric Leukemia/Lymphoma Study Group. (krakow.pl)
Retrospective Analysis of the Treatment Outcome in Myeloid Leukemia of Down Syndrome in Polish Pediatric Leukemia and Lymphoma Study Group From 2005 to 2019. (krakow.pl)
Mixed-lineage leukemia (MLL) rearrangements are found in 15-20% of pediatric AML cases [ 2 ]. (biomedcentral.com)
Liver1
Prevalence, management and efficacy of treatment in portal vein obstruction after paediatric liver transplantation: protocol of the retrospective international multicentre PORTAL registry. (childrensmercy.org)
Through these national and regional groups, we have novel therapies and new treatment protocols available for virtually every pediatric cancer patient, as well as for children dealing with chronic hematologic diseases or the long-term consequences of cancer treatment. (lifespan.org)
Phase2
The recommended starting dose for phase II pediatric trials is 5.5 mg/m2. (elsevierpure.com)
Statera Biopharma submitted its Phase III protocol for STAT-201 in pediatric Crohn's Disease to the FDA. (biospace.com)
Dose2
Pharmacokinetic studies revealed a linear relationship between the steady-state topotecan concentration and dose. (elsevierpure.com)
When tested on mice in vivo, topotecan affected the hippocampus, striatum and cerebral cortex but not the cerebellum unless a higher dose was administered (21.6 micrograms/hour for five days). (wikipedia.org)
Blood1
Standardizing Blood Pressure Measurements in Pediatric Hemodialysis: a Collaborative Journey. (childrensmercy.org)
Treatment4
Topotecan is often given in combination with paclitaxel as first line treatment for extensive-stage small-cell lung cancer. (wikipedia.org)
Combined treatment with crizotinib and LDM topotecan demonstrated a synergistic effect in ALKF1174L-mutated SH-SY5Y cells. (metronomics.org)
Provides financial assistance for transportation costs associated with pediatric cancer treatment. (oncolink.org)
Wilms tumor, treatment for which includes surgery (radical or partial nephrectomy), is the fifth most common pediatric malignancy and the most common type of renal tumor in children. (medscape.com)
Consortium3
Correction to: Radiotherapy for Atypical Teratoid/Rhabdoid Tumor (ATRT) on the Pediatric Proton/Photon Consortium Registry (PPCR). (mayo.edu)
Radiotherapy for Atypical Teratoid/Rhabdoid Tumor (ATRT) on the Pediatric Proton/Photon Consortium Registry (PPCR). (mayo.edu)
A Pediatric Colorectal and Pelvic Learning Consortium Study. (childrensmercy.org)
Drug1
Visit Lonza in Booth # 20 and don't miss our scientific presentations ranging in topics from pediatric and geriatric drug delivery to pulmonary delivery. (capsugel.com)
Department1
Diagnosis and Management of Pediatric Gastroesophageal Reflux in the Emergency Department. (childrensmercy.org)
Society1
Journal of the Pediatric Infectious Diseases Society. (elsevierpure.com)
Research1
I'm a pediatric oncologist with both clinical and research responsibilities. (chop.edu)
Form1
In physiological environments, topotecan is in equilibrium with its inactive carboxylate form. (wikipedia.org)
Cases1
We studied 5 consecutive cases of GCT involving the distal radius operated by en-bloc resection of tumor followed by reconstruction with ipsilateral non-vascularized fibular graft with a minimum 1 year follow-up. (jbstjournal.com)
Level2
abiraterone will increase the level or effect of topotecan by P-glycoprotein (MDR1) efflux transporter. (medscape.com)
bremelanotide will decrease the level or effect of topotecan by Other (see comment). (medscape.com)