• Molecular genetics and immunopathologic analysis of bladder cancer have shown some abnormalities in a number of genes and proteins that have been implicated in the development and progression of such tumors, mainly in the p53 pathway. (ijpmonline.org)
  • There were 49 cases of smooth muscle tumors: 27 leiomyomas and 22 leiomyosarcomas. (bvsalud.org)
  • Nine thousand seven hundred and seventy histopathologic exams were accomplished during this period and only 64 (0,092%) were diagnosed as smooth muscle tumors, that corresponded to 49 cases, being 27 (55%) leiomyomas e 22 (45%) leiomyossarcomas. (bvsalud.org)
  • It is thought that leiomyoma is the result of either transformation of normal uterine muscle cells into abnormal cells through somatic mutations , or through the growth of abnormal uterine muscle cells into tumors. (wikidoc.org)
  • This myxoid neurothekeoma displays a lobulated, nonencapsulated but well-circumscribed proliferation of spindled and epithelioid cells embedded within a myxoid stroma. (medscape.com)
  • The myxoid subtype of neurothekeoma is characterized by a lobulated, nonencapsulated but well-circumscribed proliferation of spindled and epithelioid cells in varying proportions (see the first image below). (medscape.com)
  • In the differential diagnosis of UTROSCT, we considered ESTSCLE, low-grade endometrial stromal sarcoma, epithelioid leiomyoma, and endometrioid carcinoma with sex-cord-like elements. (turkjpath.org)
  • Cytology with a biphasic pattern can suggest the diagnosis of synovial sarcoma. (ochsnerjournal.org)
  • Microscopic examination of the pelvic mass showed a biphasic tumor composed of epithelial and mesenchymal components, suggestive of synovial sarcoma. (ochsnerjournal.org)
  • Uterine leiomyoma must be differentiated from other diseases that cause uterine mass, such as: uterine adenomyoma , pregnancy , hematometra , uterine sarcoma , uterine carcinosarcoma, and metastasis . (wikidoc.org)
  • The tumor was composed of sheets of pleomorphic, round to polygonal epithelioid cells with prominent eosinophilic cytoplasm, large nuclei, many multinucleated, and very prominent nucleoli. (biomedcentral.com)
  • If such a tumor does not stain for HMB-45 or Melan-A, a specific diagnosis of epithelioid pleomorphic angiomyolipoma cannot be made with certainty. (biomedcentral.com)
  • We present here what is, to the best of our knowledge, the first case of epithelioid/pleomorphic angiomyolipoma of the kidney in a 50-year-old Caucasian man with no history of tuberous sclerosis, and with a tumor marker profile negative for several premelanosome antigens. (biomedcentral.com)
  • Electron microscopic examination of tumor cells confirmed the presence of premelanosome-like granules. (biomedcentral.com)
  • Based on the characteristic microscopic appearance of this tumor, and its overall tumor marker profile, we concluded this was a renal epithelioid/pleomorphic angiomyolipoma with a negative premelanosome antigen phenotype. (biomedcentral.com)
  • The neoplasm had an infiltrative growth pattern, but there was no vascular invasion. (turkjpath.org)
  • The pathogenesis of leiomyoma is characterized by benign smooth muscle neoplasm . (wikidoc.org)
  • There are rare AMLs of epithelioid type that can exhibit malignant behavior. (pediagenosis.com)
  • Histologically, neurothekeomas consist of spindled and epithelioid cells with abundant eosinophilic, finely granular cytoplasm. (medscape.com)
  • The rare variant of renal epithelioid/pleomorphic angiomyolipoma has been reported in approximately 120 cases. (biomedcentral.com)
  • On gross pathology , round, well circumscribed, non-encapsulated, solid white or tan nodules , and whorled are characteristic findings of leiomyoma. (wikidoc.org)
  • On microscopic histopathological analysis, elongated and spindle-shaped cells with a cigar-shaped nucleus are characteristic findings of leiomyoma. (wikidoc.org)
  • Rare cases of AML, composed of a prominent epithelioid component, with spindle and giant cells, containing none or a minimal amount of adipose tissue, have been reported as the epithelioid variant of angiomyolipoma (EAML) [ 2 ]. (biomedcentral.com)
  • The epithelioid cells in EAML can be quite pleomorphic and the appearance of a carcinoma-like pattern is frequently observed. (biomedcentral.com)
  • From 27 leiomyomas, 21 (78%) were vascular type and only 6 (22%) were solid, no epithelioid was found. (bvsalud.org)
  • The histologic distinction between atypical leiomyoma and low grade leiomyosarcoma is difficult and is based on the following criteria: number of mitosis, cellular atypia and pattern of necrosis 5,6 . (bvsalud.org)
  • The aim of this study is to analyse and compare the clinical features of leiomyoma and leiomyosarcoma, because they help in the differential diagnosis. (bvsalud.org)
  • The aim of this retrospective study is to evaluate and compare clinical features, like gender, age, location and symptomatology of leiomyoma and leiomyosarcoma, and review the literature from 1970 to 2010, since there isn't any recent comparative article. (bvsalud.org)
  • Microscopic evaluation showed anastomosing cords, trabeculae, nests, and tubules of epithelial-like cells found in a fibroblastic stroma (Figure 1 ). (turkjpath.org)
  • Methods: Fixed number of Vero and Hep2 cells were preserved at -85ºC deep freezer in separate vials and were revived at one month interval to check the growth pattern. (ijpmonline.org)
  • Combination of analysis of fluorescence labeling and light scatter properties of cells allows rapid and better determination of target cell antigens. (ijpmonline.org)
  • 2] identified three sonographic PSTT patterns: it looks like a vascularized heterogeneous solid mass in uterine cavity (type 1), in the myometrium (type 2) or a lacunar like lesion with cystic areas within the myometrium with high vascularization (type 3). (peertechzpublications.org)
  • Records of oral leiomyoma and leiomyosarcoma from Oral Pathology Department of Dental School at University of São Paulo during the period 1962-2010 were analysed. (bvsalud.org)
  • The mainstay of therapy for uterine leiomyoma is oral contraceptive pills , either combination pills or progestin-only , Gonadotropin-releasing hormone analogs . (wikidoc.org)
  • The structure of this tissue is composed of septal (i.e. linear strands) and lobular compartments, which differ in microscopic appearance. (wikipedia.org)
  • Histological analysis confirmed the presence of melanoma in both patients. (bvsalud.org)
  • Leiomyoma is more commonly observed among patients aged 40 years and older. (wikidoc.org)
  • In the past, these tumors were presumed to have elements of smooth muscle (smooth muscle origin), so they were classified as leiomyomas, leiomyosarcomas and leiomyoblastomas [ 3 ]. (biomedcentral.com)
  • There were 49 cases of smooth muscle tumors: 27 leiomyomas and 22 leiomyosarcomas. (bvsalud.org)
  • Benign leiomyomas ( fibroids ) and ULMS often coexist in the same uterus, but are genetically distinct entities. (sarcomahelp.org)
  • Other than histologic and cytogenetic analysis, no specific laboratory tests exist for diagnosing soft-tissue tumors. (medscape.com)
  • The histologic distinction between atypical leiomyoma and low grade leiomyosarcoma is difficult and is based on the following criteria: number of mitosis, cellular atypia and pattern of necrosis 5,6 . (bvsalud.org)
  • Succinate dehydrogenase-deficient GISTs also arise in the stomach and are usually epithelioid, as are some KIT-mutant GISTs. (nih.gov)
  • The aim of this retrospective study is to evaluate and compare clinical features, like gender, age, location and symptomatology of leiomyoma and leiomyosarcoma, and review the literature from 1970 to 2010, since there isn't any recent comparative article. (bvsalud.org)
  • Retrospective analysis of 100 cases with 20 cases each of histologically normal cervical epithelium, CIN1, 2, 3 and invasive SCC for p16 expression was performed by immunohistochemistry using commercially available mouse monoclonal antibody to p16 (clone 6H12). (ijpmonline.org)
  • This study aimed to identify lymphedema symptom patterns and the association of such patterns with phenotypic characteristics and biomarkers using latent class analysis (LCA). (bvsalud.org)
  • To simulate and study the hypoxic microenvironment associated with intracerebral glioma in vivo, simple and reproducible methods are described and discussed for inducing hypoxia or chemical pseudohypoxia in glioma cell cultures and assessing their effects on the expression and nuclear translocation of hypoxia-inducible factor (HIF)-1α, a key transcriptional factor of oxygen homeostasis, by Western blot analysis and immunocytochemistry. (bvsalud.org)
  • Our study provides a biologic foundation for consolidating the Silva system into low-risk (pattern A + B without LVI) and high-risk (pattern B with LVI and pattern C) categories. (stanford.edu)