• irritable bowel sy
  • Viberzi, a mu-opioid receptor agonist, is approved to treat irritable bowel syndrome with diarrhea (IBS-D). Since its approval in May 2015 through February 2017, the FDA has received 120 reports of serious cases of pancreatitis or death. (clinicaladvisor.com)
  • diabetic
  • RESEARCH DESIGN AND METHODS We studied a nationwide, population-based Finnish register of 10,737 patients diagnosed with type 1 diabetes during 1980-2005 and followed for 10 years and 2,544 adults with long-standing diabetes drawn from the Finnish Diabetic Nephropathy Study (FinnDiane). (diabetesjournals.org)
  • metabolism
  • Essentiale normalizes the metabolism of lipids and proteins, improves the detoxification function of the liver, restores the cellular structure of the liver and retards the producing of conjunctive tissue. (wikipedia.org)
  • necrosis
  • The balance between these two mechanisms of cellular death is mediated by caspases which regulate apoptosis and have important anti-necrosis functions during pancreatitis: preventing trypsinogen activation, preventing ATP depletion through inhibiting polyADP-ribose polymerase, and by inhibiting the inhibitors of apoptosis (IAPs). (wikipedia.org)
  • cardiovascular
  • The inflammatory response leads to the secondary manifestations of pancreatitis: hypovolemia from capillary permeability, acute respiratory distress syndrome, disseminated intravascular coagulations, renal failure, cardiovascular failure, and gastrointestinal hemorrhage. (wikipedia.org)
  • cancers
  • A study of 818 heavy drinkers found that those who are exposed to more acetaldehyde than normal through a defect in the gene for alcohol dehydrogenase are at greater risk of developing cancers of the upper gastrointestinal tract and liver. (wikipedia.org)
  • This is explained by the fact that ethanol is a proven mutagen and in addition, metabolite of ethanol (acetaldehyde) produced in the liver is highly carcinogenic, thus explaining both local (mouth, throat, esophageal cancers) as well as distant (skin, liver, breast) cancers. (wikipedia.org)
  • ultrasound
  • Metastatic lesion in a liver from a Wilms tumor, imaged by high-resolution laparoscopic ultrasound. (evaskills.eu)
  • Participants are admitted to the NIH Clinical Center for a complete medical history and examination, including blood and urine tests, chest X-ray, electrocardiogram, abdominal ultrasound, Fibroscan (ultrasound exam of the liver that measures the amount of scarring), bone mineral density scan and liver biopsy. (clinicaltrials.gov)
  • ethanol
  • Acetaldehyde is produced by the liver as it breaks down ethanol. (wikipedia.org)
  • An average liver can process 7 grams of ethanol per hour. (wikipedia.org)
  • It is well known that ethanol causes cell death at the concentrations present in alcoholic beverages. (wikipedia.org)
  • Yet, repeated ethanol intake, or chronic ethanol use, increases expression of the slow-inactivating L-type VGCCs known to sustain Ca2+ influx. (wikipedia.org)
  • While acute ethanol use increases the activity of AC, chronic use tends to desensitize AC such that more simulation, increased ethanol consumption, is required to elicit the same response. (wikipedia.org)
  • Withdrawal following chronic ethanol use as well as voluntary ethanol intake, consuming ethanol when both an ethanol solution and water are offered, in rats showed a decrease in CaMKIV and consequently p-CREB. (wikipedia.org)
  • affects
  • The lack of thiamine sometimes affects other major energy consumers, the myocardium, and also patients may have developed cardiomegaly. (wikipedia.org)
  • ascites
  • Patients with ascites generally will complain of progressive abdominal heaviness and pressure as well as shortness of breath due to mechanical impingement on the diaphragm. (wikipedia.org)
  • Those with ascites due to cancer (peritoneal carcinomatosis) may complain of chronic fatigue or weight loss. (wikipedia.org)
  • Most experts recommend a diagnostic paracentesis be performed if the ascites is new or if the patient with ascites is being admitted to the hospital. (wikipedia.org)
  • The autopsy revealed a severely cirrhotic and shrunken liver, of which ascites is a common consequence. (wikipedia.org)
  • drinks
  • When combined with other central nervous system (CNS) depressants such as alcoholic drinks and opioids, the potential for toxicity and fatal overdose increases. (wikipedia.org)
  • Signs
  • OBJECTIVE The current study investigated whether the risk of mortality in patients with type 1 diabetes without any signs of albuminuria is different than in the general population and matched control subjects without diabetes. (diabetesjournals.org)
  • Centre
  • And one thing that's cleared, according to the centre for health education, an alcoholic is not a bad, weak-willed person. (medindia.net)
  • clinical
  • During the treatment period, patients visit the Clinical Center for blood tests and a physical examination every 2 weeks for the first month and then every 4 to 12 weeks. (clinicaltrials.gov)
  • After 48 weeks, patients are readmitted to the Clinical Center for a complete evaluation that includes all the tests done at the start of therapy, including a liver biopsy. (clinicaltrials.gov)
  • Patients who seem to have improved with treatment may continue therapy for up to 192 weeks, when they are again admitted to the Clinical Center for a complete medical evaluation and liver biopsy. (clinicaltrials.gov)
  • drinkers
  • The high tolerance of chronic heavy drinkers may allow some of them to remain conscious at levels above 0.40%, although serious health hazards are incurred at this level. (wikipedia.org)
  • oral
  • Oral capsule FMT and colonoscopy delivery showed similar patient outcomes, low rate differences, and high success rates. (clinicaladvisor.com)
  • There are seven classes of medications associated with acute pancreatitis: statins, ACE inhibitors, oral contraceptives/hormone replacement therapy (HRT), diuretics, antiretroviral therapy, valproic acid, and oral hypoglycemic agents. (wikipedia.org)
  • kidney
  • In addition to the liver, the kidney is also responsible for eliminating herbs and drugs from the body. (evaskills.eu)
  • Diabetes
  • A Danish study also reported that mortality in patients with type 1 diabetes without nephropathy was only slightly increased compared with the background population ( 5 ). (diabetesjournals.org)