• Oxidative stress reflects an imbalance between reactive oxygen species (ROS) production and the biological systems ability to detoxify the reactive intermediates. (hindawi.com)
  • Thiobarbituric acid reactive substances (measure of lipid peroxidation), glutathionelinked detoxification enzymes, catalase, and superoxide dismutase were determined. (vitality101.com)
  • We therefore aimed to investigate peroxidation, measured as thiobarbituric the correlation between hypercholesterol- acid-reactive substance (TBARS). (who.int)
  • Hyperglycemia contributes to glycosylation of proteins and lipids, increases the production of reactive oxygen species, stimulates the synthesis and secretion of pro-inflammatory cytokines and acute phase proteins in various tissues, promoting thus inflammation processes in the vascular wall [ 2 , 3 ]. (medsci.org)
  • The exposure to these environmental and cosmetic substances, leads to generation of free radicals, reactive oxygen species in particular, leading to oxidative stress. (jru-b.com)
  • This review is focused on the effects of the reactive oxygenated species in disturbing the redox balance and inducing oxidative injury that leads to androgenic alopecia. (jru-b.com)
  • Oxidative stress, defined as an imbalance between reactive oxygen species (ROS) production and removal, results from the overproduction of ROS, decreased antioxidant defence or a combination of both. (iiarjournals.org)
  • Reactive oxygen species (ROS) induced lipid peroxidation is associated with sperm function. (ijbs.com)
  • Oxidant damage to cellular DNA, proteins (including the epigenome), and lipids can occur when reactive oxygen species escape cell antioxidant and repair mechanisms. (who.int)
  • In lung tissue, lipid peroxidation, reactive oxygen species, superoxide dismutase activity and reduced glutathione were all increased by WPS exposure. (who.int)
  • Serum MDA and total homocysteine concentration were significantly higher, but TAC, total bilirubin and direct bilirubin levels were lower in CAD patients when compared to the controls. (ajol.info)
  • Increased serum MDA concentration, as a biomarker of lipid peroxidation, low serum bilirubin and antioxidant capacity were observed in patients with angiographically defined CAD. (ajol.info)
  • In patients with obesity and type 2 diabetes, altered serum concentrations of Il-10 seems to be dependent on the degree of insulin resistance and proinflammatory status. (medsci.org)
  • We found that patients with rheumatoid arthritis have higher serum copper/zinc superoxide dismutase levels than control subjects. (indexindex.com)
  • In case of androgenic alopecia, copper and zinc was discovered in the disrupted metabolism form in serum, urine and hair of the patients, and data suggests rise in oxidative stress. (jru-b.com)
  • Serum vitamin C was significantly lower in diabetic cataract group when compared to senile cataract patients. (allresearchjournal.com)
  • The fasting serum lipid profile and MDA were assayed using routine laboratory methods . (bvsalud.org)
  • Clinical experience suggests that serum cholesterol levels are low in some HCV-infected patients and that such an abnormality is corrected by effective antiviral treatment. (natap.org)
  • Long-term intake of HPD improves the serum and hepatic lipid and cholesterol accumulation by suppressing hepatic squalene epoxidase (SQLE) expression, a key enzyme in cholesterol biosynthesis. (bvsalud.org)
  • The identification of genetic variants related to blood lipid levels within a large, population-based and nationally representative study might lead to a better understanding of the genetic contribution to serum lipid levels in the major race/ethnic groups in the U.S. population. (cdc.gov)
  • Using data from the second phase (1991-1994) of the Third National Health and Nutrition Examination Survey (NHANES III), we examined associations between 22 polymorphisms in 13 candidate genes and four serum lipids: high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TG). (cdc.gov)
  • Results from our study contribute to a growing body of literature identifying key determinants of plasma lipoprotein concentrations and could provide insight into the biological mechanisms underlying serum lipid and cholesterol concentrations. (cdc.gov)
  • Decades of research have demonstrated that serum concentrations of blood lipids are associated with increased risk for cardiovascular disease and mortality [ 1 - 4 ]. (cdc.gov)
  • Disturbed lipid and carbohydrate metabolism are manifested by enhanced inflammation and endothelial dysfunction in patients with simply obesity. (medsci.org)
  • In this review, we summarize some of the latest knowledge on mitochondrial dysregulation in major depression (depicted in Figure 1 ) and also discuss how mitochondrial dysfunction could instigate downstream changes in extracellular matrix proteins such as reelin, neuronal nitric oxide (nNOS), oxidative stress, and inflammation, and finally adult hippocampal neurogenesis. (frontiersin.org)
  • Lipid peroxidation, oxidative stress and inflammation are the postulated pathogenic mechanisms for dyslipidaemia during COVID-19 infection. (iium.edu.my)
  • Oxidative stress generates inflammation, and/or psycho-emotional stress, and also influences the ageing process, including the hair follicle. (jru-b.com)
  • Cell death on hair follicle (keratinocytes and its distinctive mesenchyme of dermal papilla) have been attributed to mechanisms of oxidative stress, including H2O2, nitric oxide and derivatives, ultraviolet rays, ionizing radiations, endotoxin-induced inflammation, photodynamic therapy and cigarette smoke. (jru-b.com)
  • Although the role of intraocular pressure (IOP) elevation in glaucoma has been established, the reduction of oxidative stress and inflammation has emerged as a promising target for neuronal tissue-supporting glaucoma management. (arvojournals.org)
  • At day 29, rats underwent electroretinogram (ERG) recordings, and retinas were analyzed for RGC density and markers of neural trophism, oxidative stress, and inflammation. (arvojournals.org)
  • When our sympathetic nervous system is over activated for days, weeks or months we experience more stress and our bodies experience more inflammation (Bellinger, 2018). (amysavagianmd.com)
  • Oxidative stress may contribute to the disease mechanisms in both the relapsing-remitting and progressive phases of MS through its involvement in inflammation and axonal degeneration, respectively. (neurology.org)
  • Recent experimental studies reported the occurrence of lung inflammation and oxidative stress following acute and subacute exposure to WPS. (who.int)
  • Here, we wanted to verify the extent of inflammation and oxidative stress in mice chronically-exposed to WPS and to evaluate, for the first time, its effect on alveolar injury and DNA damage and their association with impairment of lung function. (who.int)
  • CONCLUSION: We show the persistence of lung inflammation and oxidative stress in mice chronically-exposed to WPS and demonstrate, for the first time, the occurrence of DNA damage and enlargement of alveolar spaces and ducts associated with impairment of lung function. (who.int)
  • mtROS also causes oxidation of lipids and proteins identified in bleomycininduced mouse models of pulmonary fibrosis and in sufferers with IPF (80, 81). (namptinhibitor.com)
  • Functional analysis showed that cholesterol biosynthesis pathways and the cytochrome 450 family of proteins (specifically Cyp4A10 that is associated with oxidative stress and lipid peroxidation leading to hepatocyte injury) were increased in mice exposed to e-cigarette aerosol. (medscape.com)
  • Numerous markers of oxidative activity are present in persons with asthma. (namptinhibitor.com)
  • These compounds are accurate markers of lipid peroxidation in both animal and human models of oxidative stress. (wikipedia.org)
  • This study was designed to determine whether red-cell oxidative stress status and antioxidant enzyme levels can serve as markers in patients predisposed to in-stent stenosis. (vitality101.com)
  • During the same liest markers in patients with atherogenic period, 20 healthy age- and sex-matched risk factors (e.g. male sex, ageing, hyper- personnel whose medical records showed tension, diabetes mellitus, smoking, fam- total cholesterol and triglycerides were ily history) in the absence of angiographic within normal levels and who had no car- evidence of atherosclerosis [1]. (who.int)
  • Inflammatory markers and acute phase reactants found to have a relation with the disrupted lipid profile during COVID-19 infection. (iium.edu.my)
  • The objective of this short review is to outline the altered lipid profile in COVID-19 infected patient, and to highlight the relationship between dyslipidaemia, inflammatory markers, severity and morbidity of COVID infection. (iium.edu.my)
  • The eicosanoid family encompasses thromboxanes, prostacyclins, leukotrienes, hydroxyeicosatetraenoic acids (HETEs), epoxyeicosatrienic acids (EETs), lipoxins, and isoprostanes, the last of which can be generated by nonenzymatic oxidative mechanisms and may serve as markers of oxidative stress in humans. (jci.org)
  • We also evaluated total antioxidant capacity and lipid peroxidation in gastrocnemius muscle of diabetic rats treated with metformin and/or insulin. (hindawi.com)
  • Furthermore, the increase in 8-iso-PGF 2α correlated with other parameters of lipid peroxidation as well as with a decrease in the total antioxidant status in the MS CSF samples. (neurology.org)
  • Isoprostanes and their metabolites have also been shown to be elevated in the urine of cigarette smokers, and have been suggested as biomarkers of oxidative stress in smokers. (wikipedia.org)
  • 2011). "Biomarkers of oxidative damage in cigarette smokers: Which biomarkers might reflect acute versus chronic oxidative stress? (wikipedia.org)
  • It has been shown that H 2 S displayed an effective preservation of antioxidants enzymes activity [ 34 - 36 ] and also decreased the levels of different biomarkers of oxidative stress in vivo and in vitro [ 34 - 38 ]. (hindawi.com)
  • The results suggest the probable active participation of higher concentrations of C-peptide in the intensification of inflammatory and atherogenic processes in obese patients with type 2 diabetes. (medsci.org)
  • This study demonstrated an increased occurrence of atherogenic lipid profile and oxidative stress among hypertensive patients . (bvsalud.org)
  • SCOPE: Substituting plant protein for animal protein has emerged as a promising strategy for managing atherogenic lipids. (bvsalud.org)
  • Hepatocellular lipid accumulation is thought to simultaneously stimulate mitochondrial fatty acid oxidation and the production of ROS, thereby promoting lipid peroxidation and damage of mitochondrial DNA (mtDNA) ( 3 ). (spandidos-publications.com)
  • Progression as the final stage of carcinogenesis involves irreversible changes from the benign to the malignant cell phenotype by the continuous accumulation of genetic alterations with oxidative stress probably playing a similar role as in the previous stages ( 9 ). (iiarjournals.org)
  • Furthermore, in vivo studies demonstrate that 12,13-DiHOME significantly inhibits lipid accumulation, as well as SQLE expression induced by oleic acid in HepG2 cells. (bvsalud.org)
  • In liver samples, they observed that e-cigarette exposure led to hepatic lipid accumulation and oxidative stress, as well as a significant increase in hepatic expression of p53, a known inducer of insulin resistance and NAFLD. (medscape.com)
  • However, the impact of long-term intake of a high plant protein diet (HPD) on hepatic lipid disorder remains unclear. (bvsalud.org)
  • There is also growing evidence that FFA-mediated oxidative stress contributes significantly to mitochondrial dysfunction in the liver. (spandidos-publications.com)
  • In patients with Type 2 diabetes mellitus (T2DM) parameters characterizing the degree of obesity significantly positively correlated with levels of CRP and CCL2. (medsci.org)
  • For these patients, disease progression significantly slowed or reversed at 12 months and 24 months according to standard severity scales used in the measurement of the disease, including the PSPRS. (globenewswire.com)
  • Levels of copper, MDA were significantly higher, and vitamin C level was significantly lower in the lens of diabetic cataract patients when compared to senile cataract patients. (allresearchjournal.com)
  • Seventeen patients who manifested recurrence during the 49.6 months follow-up had significantly increased MDA compared to those staying in complete remission. (iiarjournals.org)
  • Results: Plasma analysis showed significantly decreased SOD and CAT activities, and UA level in RAS patients compared to control group. (bvsalud.org)
  • Plasma GSHPx activity was significantly higher in RAS patients. (bvsalud.org)
  • In saliva, SOD and CAT activities, and UA levels were significantly higher in RAS patients, while GSHPx activity was lower compared to control. (bvsalud.org)
  • Along with oxidative stress, WPS exposure significantly increased lung DNA damage index. (who.int)
  • We have reported that oxidative stress may play a role in the pathophysiology of FM. (nih.gov)
  • This group was retested to confirm important role in the pathophysiology of their blood lipid status before participating several vascular diseases, including athero- in the study. (who.int)
  • The present study investigated the effects of insulin and/or metformin treatment on oxidative stress levels in the gastrocnemius muscle of diabetic rats. (hindawi.com)
  • Despite metformin being widely used in T2D treatment [ 7 , 19 ], recent clinical studies evaluated dual therapy with insulin and metformin for type 1 diabetic (T1D) patients [ 20 , 21 ]. (hindawi.com)
  • We do not known studies that verified the role of metformin associated with insulin compared to insulin therapy alone in oxidative stress control in gastrocnemius muscle of streptozotocin-diabetic rats. (hindawi.com)
  • The purpose of the present study was to verify the action of metformin combined with insulin in oxidative stress control of streptozotocin-diabetic rats. (hindawi.com)
  • PURPOSE: To compare the efficacy and safety of subcutaneous insulin lispro with that of a standard low-dose intravenous infusion protocol of regular insulin in patients with uncomplicated diabetic ketoacidosis. (keyopinionleaders.com)
  • After iron infusion, transferrin saturation increased more markedly in non-diabetic subjects from 28% to 185% vs. from 33% to 101% in diabetic patients (P = 0.008). (sciensano.be)
  • This study is aimed at comparing the lipid peroxidation, copper and vitamin C levels in diabetic cataract and senile cataract patients. (allresearchjournal.com)
  • Study subjects were forty eight patients with senile cataract and twenty six patients with diabetic cataract. (allresearchjournal.com)
  • We observed oxidative stress in the lens of diabetic cataract patients indicated by increased lipid peroxidation and copper, and decreased vitamin C. Future studies with larger sample size and involving antioxidant treatment of cataract are required. (allresearchjournal.com)
  • Diabetic neuropathy - In experimental diabetic neuropathy, alpha-lipoic acid provides increased nerve blood flow, reduced oxidative stress and improves distal nerve conduction (24). (peoplesrx.com)
  • In humans, it has been demonstrated that oral administration of 600mg/day of lipoic acid can prevent or improve diabetic neuropathy, which may be due to a lowering of lipid peroxidation (25). (peoplesrx.com)
  • Peroxidized phospholipid-mediated cytotoxicity is involved in the pathophysiology of diseases [i.e., an abnormal increase of phosphatidylcholine hydroperoxide (PCOOH) in plasma of type 2 diabetic patients]. (elsevierpure.com)
  • When lipid extract from diabetic plasma was infused directly into the QTRAP, Amadori-PE molecular species could be screened out by neutral loss scanning. (elsevierpure.com)
  • The plasma Amadori-PE level was 0.08 mol% of total PE in healthy subjects and 0.15-0.29 mol% in diabetic patients. (elsevierpure.com)
  • 2004), such as retinopathy, neuropathy and vascular diseases, that are largely responsible for the morbidity and mortality observed in diabetic patients. (gotomydoctor.com)
  • 2 Iron and copper are oxidative (i.e., the opposite of antioxidants). (vitality101.com)
  • middle-chain triglyceride (MCT)/long-chain triglyceride (LCT)-containing fat emulsions have lower polyunsaturated fatty acid content, higher concentrations of antioxidants (alpha-tocopherol) and reduced susceptibility to peroxidation reactions compared with LCT-containing fat emulsions, which possess strong proinflammatory and oxidative damage potential [ 1 ]. (biomedcentral.com)
  • There is increasing awareness that oxidative stress may be implicated in the pathophysiology of autism spectrum disorder (ASD). (nature.com)
  • Therefore, it has been proposed that oxidative stress in the developing brains contributes to neuronal damage in genetically susceptible children, which is important in the pathophysiology of ASD. (nature.com)
  • Bilirubin may act as an antioxidant that suppresses lipid oxidation. (ajol.info)
  • The patients' oxidative (lipid, protein, and DNA oxidation) and antioxidative (antioxidant enzyme activities and compounds) profiles were examined before and after the treatment period. (nih.gov)
  • This condition can lead to lipid peroxidation in muscle cell membranes, which contributes to the development of insulin resistance [ 5 , 6 ]. (hindawi.com)
  • The genetic basis for elevation in lipid levels is not well understood, but substantial heritability has been demonstrated in twin [ 9 ] and family-based [ 10 - 12 ] studies, which have estimated that approximately 43% to 83% of the variance in blood lipid and lipoprotein levels is attributable to genetic factors. (cdc.gov)
  • Recent candidate gene studies [ 13 - 16 ], as well as genome-wide association studies [ 17 - 25 ], have identified polymorphisms that account for a portion of the variation in blood lipid levels. (cdc.gov)
  • 0.0001)) after adjustment for lipid status parameters and traditional risk factors in this study population. (ajol.info)
  • The aim of this study was to investigate the effect of olive oil on oxidative stress and health-related parameters in FM. (nih.gov)
  • Therefore, H 2 S pathway may be involved in Pb-induced hypertension and treatment with NaHS exerts antihypertensive effect, promotes non-NO-mediated relaxation, and decreases oxidative stress in rats with Pb-induced hypertension. (hindawi.com)
  • Spermatozoa are rich in polyunsaturated fatty acids as well as susceptible to be attacked by ROS or membrane lipid peroxide ion. (ijbs.com)
  • Spermatozoa are rendered dysfunctional by lipid peroxidation and altered membrane function, together with impaired metabolism, morphology, and motility [ 2 ]. (ijbs.com)
  • Lipid peroxidation triggers the loss of membrane integrity, causing increased cell permeability, enzyme inactivation, structural damage to DNA, and cell death [ 3 ]. (ijbs.com)
  • The PSPRS, which is a clinician-rated quantitative measure of disease severity for patients with PSP, is comprised of 28 items spanning the following six categories: daily activities (by history), behavior, bulbar, ocular motor, limb motor and gait/midline. (globenewswire.com)
  • Dyslipidaemia has been recognized as a common complication in COVID-19 infection exerting a significant effect on severity and mortality in COVID-19 infected patients. (iium.edu.my)
  • Our hypothesis is that the inhibition of complex I can minimize damage oxidative in muscles of hypoinsulinemic rats. (hindawi.com)
  • Differences between groups approached statistical significance for oxidative DNA damage and levels of the antioxidant compound zinc. (nih.gov)
  • Administration of intravenous iron preparations in haemodialysis patients may lead to the appearance of non-transferrin bound iron which can catalyse oxidative damage. (sciensano.be)
  • Despite the need for iron in the brain, its increase leads to toxic free radicals, oxidative stress, and nerve cell damage [ 1 ]. (springeropen.com)
  • The observed positive short-term metabolic effects of MCT/LCT-containing fat emulsions could have potential clinical applications in reducing oxidative damage, caused by a large inflammatory mass of the lung in ARDS patients. (biomedcentral.com)
  • 1 , - , 3 There is growing evidence of the involvement of oxidative stress in neural damage in MS. 3 , - , 6 Because of the high lipid content in neural tissue, oxidative stress, with its associated increased free radical production, leads to lipid peroxidation. (neurology.org)
  • Oxidative stress has been implicated in coronary artery disease (CAD). (ajol.info)
  • Blood was collected from patient groups undergoing coronary angiography for chest pain evaluation, namely, group A (without coronary artery disease), group B (previous coronary stents without in-stent stenosis), and group C (previous coronary stents with in-stent stenosis). (vitality101.com)
  • Polyunsaturated fatty acid in the phospholipids of the human spermatozooa is highly susceptible to peroxidation. (ijbs.com)
  • An increase in the IL-1 family of cytokines, in particular (IL-36 gamma), in skin lesions and peripheral blood of PMLE patients indicates an enhanced focal and systemic immune response. (medscape.com)
  • Steatosis affects the natural course of HCV infection: it is associated with fibrosis, a possible mediator of increased risk to develop type 2 diabetes, it impairs the response to antiviral treatment in HCV-3 patients and might constitute a risk factor for the development of hepatocellular carcinoma. (natap.org)
  • Consider that altered oxidative stress/antioxidant status is related to T1D complications [ 22 , 23 ] and metformin action in the decrease of mitochondrial ROS. (hindawi.com)
  • Insulin resistance occurs in almost all patients with non-alcoholic fatty liver disease (NAFLD), and mitochondrial dysfunction likely plays a pivotal role in the progression of fatty liver into non-alcoholic steatohepatitis (NASH). (spandidos-publications.com)
  • As detailed in the right side of the image, there are a series of mitochondrial alterations that have been observed both in depressed patients and in animal models of depression (red lines). (frontiersin.org)
  • In this study, we compared the safety and efficacy of a dipeptidyl peptidase-4 inhibitor (sitagliptin) plus basal insulin with a basal-bolus insulin regimen for the management of patients with type 2 diabetes in general medicine and surgery in hospitals. (keyopinionleaders.com)
  • GPx, a selenium-containing antioxidative enzyme scavenging system, act directly as an antioxidant and an inhibitor of lipid peroxidation. (ijbs.com)
  • Previous mouse studies suggest that electronic cigarette exposure plus a Western diet triggers oxidative stress leading to increased lipid peroxidation and hepatic steatosis, according to Dr. Theodore Friedman of Charles R. Drew University of Medicine & Science in Los Angeles. (medscape.com)
  • Patients with ADHD are more likely to develop allergies, and vice versa, which has led researchers to investigate potential IgE responses to foods in children with ADHD. (psychiatrictimes.com)
  • To investigate the potential of 8-iso-prostaglandin F 2α (8-iso-PGF 2α ) as a biomarker for disease activity and oxidative stress in the CSF of patients with multiple sclerosis (MS). (neurology.org)
  • But when blood sugar levels are chronically elevated, the pancreas becomes stressed and progressively more dysfunctional, unable to produce enough insulin to deal with the spikes. (vitalitymagazine.com)
  • Elevated levels of isoprostanes are suspected of contributing to increased risk of heart attack in patients taking Coxibs[citation needed]. (wikipedia.org)
  • For example, in addition to the four classes of F2-isoprostanes that can arise from arachidonic acid, peroxidation of eicosapentaenoic acid (EPA) is predicted to lead to the generation of six classes of F3 isoprostanes, α-linolenic and γ-linolenic acids to two classes of E1- and F1-isoprostanes, and docosahexaenoic acid to eight classes of D4-isoprostanes and eight classes of E4-isoprostanes. (wikipedia.org)
  • Isoprostanes are a class of lipid peroxidation products that are generated when free radicals attack the arachidonic acid esterified in phospholipid pools of cell membranes. (neurology.org)
  • RESEARCH DESIGN AND METHODS: This 52-week double-blind study randomized patients to subcutaneous dulaglutide 1.5 mg, dulaglutide 0.75 mg, or metformin. (keyopinionleaders.com)
  • Materials and methods: 29 patients (13 women, 16 men) aged 49 ±12.5 years with periodontal disease, chronic course were included to the study and divided into two groups. (medtourpress.pl)
  • Material and methods: Forty patients with RAS and 40 health controls were included into the study. (bvsalud.org)
  • Within any single patient, only one clinical form is consistently manifested. (medscape.com)
  • Late-stage bipolar [patients] present a higher number of episodes and clinical correlates of a more severe disorder in terms of ability to function, as well as in terms of bodily changes such as increased inflammatory states. (medscape.com)
  • Session chairman Antoine Pelissolo, MD, PhD, professor of psychiatry at Pitié-Salpˆtrière Hospital in Paris, France, who was not involved in the study, commented to Medscape Medical News that in general, it is important to study biomarkers in psychiatry "because biological psychiatry for the moment [does not have] many implications in clinical practice, but now I think that these approaches are very interesting to describe the evolution of patients. (medscape.com)
  • LOS ALTOS, Calif., June 30, 2021 (GLOBE NEWSWIRE) -- Retrotope, a clinical-stage biopharmaceutical company focused on the development of novel, first-in-class therapies for degenerative diseases, today announced that the first patient has been dosed in a multicenter Phase 2 clinical trial evaluating RT001, the company's lead development candidate, in patients with progressive supranuclear palsy (PSP). (globenewswire.com)
  • Clinical investigators have already reported significant patient interest for participation in the trial and expect enrollment to be completed rapidly. (globenewswire.com)
  • RT001, which is currently being evaluated in clinical trials across several neurodegenerative diseases, has been safely administered orally on a daily basis to more than 100 patients, spanning more than 1,000 patient months. (globenewswire.com)
  • This breadth of clinical research is a testament to the fundamental role that we believe the targeted down-regulation of LPO can play in staving off the cellular degeneration that is a hallmark of these diseases and, in turn, providing meaningful benefit to patients suffering with these conditions," said Mark G. Midei, M.D., Retrotope's vice president for medical affairs. (globenewswire.com)
  • These patients present with clinical symptoms in their late 40s or early 50s. (medscape.com)
  • The core literature for this review is the published clinical studies and the case reports that studied the effects of COVID-19 infection on lipid profile. (iium.edu.my)
  • Cerebral hypoperfusion is a pre-clinical event in AD and represents the most accurate indicator predicting the probable AD patients to develop AD in a future time. (iospress.com)
  • Our study demonstrates that CSF levels of 8-iso-PGF 2α may serve as a biomarker of oxidative stress in MS. Further investigation will help establish the pathologic and clinical significance of our preliminary findings. (neurology.org)
  • Among adults with a history of chronic stress , 300 mg ashwagandha extract reduces cortisol and anxiety and improves resistance to additional stress. (marksdailyapple.com)
  • In male infertility patients, ashwagandha improves semen quality and improves testosterone status by reducing the impact of oxidative stress. (marksdailyapple.com)
  • These data suggest that infusion of a MCT-containing fat emulsion could lead to a significant decrease of oxygen used by the lung for nonmetabolic purposes (i.e. free radical formation from lipid peroxidation). (biomedcentral.com)
  • In conclusion, our results reveal that dual therapy with metformin and insulin promotes more benefits to oxidative stress control in muscle of hypoinsulinemic rats than insulinotherapy alone. (hindawi.com)
  • Pb-intoxication increased oxidative stress in rats, while treatment with NaHS blunted increases in plasmatic MDA levels and increased antioxidant status of plasma. (hindawi.com)
  • An increase in oxidative stress is associated with hyperglycemia, development, and progression of diabetes complications [ 3 , 4 ]. (hindawi.com)
  • Metformin, a biguanide derivate, is mainly used to treat patients with type 2 diabetes mellitus (T2D) [ 7 ]. (hindawi.com)
  • Most of subjects felt healthier after consuming oxygenated water.Conclusion The consumption of oxygenated water could improve the healing process for patients with diabetes mellitus. (researchgate.net)
  • BACKGROUND: Outcome trials in patients with type 2 diabetes mellitus have demonstrated reduced hospitalizations for heart failure (HF) with sodium-glucose co-transporter-2 inhibitors. (keyopinionleaders.com)
  • Thus, the effects of sodium-glucose co-transporter-2 inhibitors in patients with established HF with reduced ejection fraction, including those with and without type 2 diabetes mellitus, remain unknown. (keyopinionleaders.com)
  • BACKGROUND: The role of incretin-based drugs in the treatment of patients with type 2 diabetes admitted to hospital has not been extensively assessed. (keyopinionleaders.com)
  • OBJECTIVE: To compare the efficacy and safety of two doses of once-weekly dulaglutide, a glucagon-like peptide 1 receptor agonist, to sitagliptin in uncontrolled, metformin-treated patients with type 2 diabetes. (keyopinionleaders.com)
  • We investigated this hypothesis by monitoring the oxidative stress of haemodialysis patients and the impact of iron and diabetes mellitus herein. (sciensano.be)
  • Diabetes is modifiable, and even reversible, with the implementation of holistic lifestyle modifications, such as changes in diet, exercise, stress reduction, and the use of nutraceuticals. (vitalitymagazine.com)
  • In the case of the IDDM, insulin is of crucial importance for the survival of the patients. (gotomydoctor.com)
  • Lipid peroxidation/antioxidant activity in patients with alopecia areata. (jru-b.com)
  • Aim: To study the functional activity and concentration of platelets in PRP-preparations with different anticoagulants (heparin, citrate) in patients with periodontitis associated with cardiovascular pathology and develop the protocol of PRPapplication for this category of patients. (medtourpress.pl)
  • Patients experience a decrease in quality of life owing to efforts to avoid sun exposure. (medscape.com)
  • Conclusion: Plasma and saliva antioxidant system is affected in RAS patients and both may be considered as an appropriate indicator of antioxidant status of body. (bvsalud.org)
  • These observations indicate the need to evaluate the efficacy of combined antiviral and 'metabolic' approaches vs standard antiviral regimes in patients with steatosis and HCV chronic infection. (natap.org)
  • Fifty-seven individuals were divided into 3 groups: 2 study groups (patients with chronic periodontitis, with or without coexisting coronary disease), and control group - without symptoms of chronic periodontitis and coronary disease. (medtourpress.pl)
  • The role of MDA and antioxidant capacity and their inter-relationship in patients with and without CAD was investigated. (ajol.info)
  • EVOO may protect women with FM against oxidative stress in addition to improving functional capacity and health-related psychological status. (nih.gov)