• Neutrophil-to-lymphocyte ratio in bronchoalveolar lavage from IPF patients: a novel prognostic biomarker? (minervamedica.it)
  • BACKGROUND: THIS is the first time that a bronchoalveolar lavage (BAL) neutrophil-to-lymphocyte ratio (NL-ratio) has been demonstrated in sarcoidosis and chronic hypersensitivity pneumonitis (cHP) than in idiopathic pulmonary fibrosis (IPF) patients. (minervamedica.it)
  • CONCLUSIONS: This is the first time that a lower NL-ratio has been demonstrated in sarcoidosis and cHP than in IPF patients. (minervamedica.it)
  • The present preliminary report indicates a relationship between BAL NL-ratio and lung function parameters in patients with IPF: this ratio may help to optimize management of IPF patients and to improve follow-up and outcome. (minervamedica.it)
  • The neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are used as a diagnostic marker, disease activity marker, and prognostic marker in patients with Crohn's disease and ulcerative colitis. (ecco-ibd.eu)
  • Neutrophil-lymphocyte ratio (NLR) is a marker of systemic inflammation that has been shown to predict mortality in patients with malignancies, ischemic heart disease and peripheral vascular disease. (edu.au)
  • We evaluated the clinical impact of the preoperative platelet-to-lymphocyte ratio (PLR) in patients with resectable esophageal cancer who received curative treatment. (iiarjournals.org)
  • Median survival was 45.81 months and patients of increased Tc cells, activated T helper cells(CD4 + CD25 + T cells or activated Th cells), activated Tc cells and normal CD4 + /CD8 + ratio presented encouraging outcomes (p = 0.007;0.016;0.028;0.016 respectively). (researchsquare.com)
  • Platelet to Lymphocyte ratio (PLR) is thought to be associated with a worse outcome in multiple types of cancer. (biomedcentral.com)
  • PLR was calculated as the ratio of platelet count to lymphocyte count. (biomedcentral.com)
  • Similarly, platelet to lymphocyte ratio (PLR) is also a systemic inflammation-based parameter. (biomedcentral.com)
  • Conclusion In patients with resected left-sided pancreatic cancer, a tumour microenvironment characterized by a high CD4/CD3 lymphocyte ratio along with a low αSMA/vimentin ratio is correlated with poorer survival. (hal.science)
  • The aim of this study was to explore the validity and accuracy of the neutrophil-to-lymphocyte ratio (NLR) in predicting sHT in patients with AIS undergoing revascularization. (univpm.it)
  • Moreover, for 435 patients who underwent a series of blood and endoscopic examination, we performed Kaplan-Meier (K-M) analyses to identify the NLR and PLR as a marker of prognosis in intestinal BD. (ecco-ibd.eu)
  • The patient prognosis after complete resection for pathologic stage IIIA(N2) non-small cell lung cancer (NSCLC) remains a significant concern. (oncotarget.com)
  • Although the survival rate after curative treatment gradually improves, more than half of patients develop recurrent disease, even after curative treatment, and the prognosis of patients with recurrence is poor ( 5 , 6 ). (iiarjournals.org)
  • Dynamic monitoring of serum lymphocyte subsets can be used as an auxiliary indicator for prognosis judgment. (researchsquare.com)
  • Some observations even suggest that the presence of particular reactive lymphocytes in some of the infected patients could be an indicator of a better prognosis of the disease. (wikipedia.org)
  • PLR might play a significant role in the prognosis of PCa patients treated with ADT. (biomedcentral.com)
  • Abstract Background The prognosis of patients with pancreatic cancer remains poor and novel therapeutic targets are required urgently. (hal.science)
  • Low albumin levels and low lymphocyte counts are intra hospital conditions that exert a negative influence on prognosis, healing and length of hospitalization. (biomedcentral.com)
  • According to recent studies low albumin levels and low lymphocyte counts are the frequent in hospitalized patients, representing negative conditions with a negative impact on prognosis and length of stay (LOS) [ 1 , 2 ]. (biomedcentral.com)
  • TNBC remains a poor-prognosis breast cancer subtype, with limited treatment options for patients with advanced, recurrent disease. (prnewswire.com)
  • Immunohistochemistry was performed to identify neutrophils (neutrophil- elastase), macrophages (CD68), and T-lymphocyte subpopulations (CD4 and CD8) in the submucosa. (unife.it)
  • Flow cytometric estimation of the apoptotic marker CD95 in peripheral neutrophils, lymphocytes and monocytes was done for 18 infants with non-oedematous protein energy malnutrition (PEM) and 12 oedematous ones, on hospital admission and after supervised nutritional rehabilitation, and compared with 12 matched controls. (who.int)
  • In some cases, T cells may present, as a result of residual autologous cells or transplacentally acquired maternal lymphocytes [ 1 ]. (hindawi.com)
  • They could not be absorbed out with platelets or erythrocytes, and did not react with autologous lymphocytes. (ox.ac.uk)
  • The authors report on advanced refractory melanoma patients treated in a compassionate use trial of ipilimumab at the Memorial Sloan-Kettering Cancer Center. (nih.gov)
  • Patients with advanced refractory melanoma were treated in a compassionate use trial with ipilimumab 10 mg/kg every 3 weeks for 4 doses. (nih.gov)
  • The results confirm that ipilimumab is clinically active in patients with advanced refractory melanoma. (nih.gov)
  • Methods We analyzed infused TIL products from metastatic melanoma patients previously treated with ACT for the presence of neoantigen-specific T cells. (bmj.com)
  • The company has completed dosing in pivotal programs in patients with metastatic melanoma and cervical cancer. (biospace.com)
  • To determine the immunologic characteristics of tumor infiltrating lymphocytes (TILs) in comparison with the corresponding peripheral blood lymphocytes (PBLs) of patients with ovarian cancer in order to detect specific antitumor-reactive-immunocompetent cells. (nih.gov)
  • Peripheral blood lymphocytes had a higher proliferative activity and cytotoxicity against natural killer-sensitive tumor cells than the corresponding TILs. (nih.gov)
  • Peripheral blood lymphocytes showed more potentially valuable behavioral characteristics than TILs. (nih.gov)
  • We aimed to investigate the prognostic value of tumor-infiltrating lymphocytes (TILs) in a uniform cohort of patients with completely resected stage IIIA(N2) NSCLC. (oncotarget.com)
  • Our data suggest a potential role of TILs in predicting the survival of patients with completely resected stage IIIA(N2) NSCLC. (oncotarget.com)
  • The beneficial effects of TILs were more pronounced in the prediction of the DMFS and the OS in patients with SCC. (oncotarget.com)
  • Background Adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs) is a promising immunotherapeutic approach for patients with advanced solid tumors. (bmj.com)
  • TILs were enriched on reactivity to neoantigen peptides derived and prioritized from patient sample-directed mutanome analysis. (bmj.com)
  • Treatment resistance could be due to the tumour microenvironment, a desmoplastic stroma consisting of cancer-associated fibroblasts and tumour-infiltrating lymphocytes (TILs). (hal.science)
  • ImmunoPulse™ IL-12, which employs intratumoral electroporation to enhance delivery of DNA-based interleukin-12 (IL-12), is designed to enhance tumor immunogenicity, leading to increased tumor infiltrating lymphocytes (TILs) and pro-inflammatory cytokines. (prnewswire.com)
  • Previous studies have demonstrated that breast cancer patients whose tumors are associated with markers of inflammation, such as the presence of TILs, have better clinical outcomes. (prnewswire.com)
  • Platelet and lymphocyte counts are routinely performed in most clinical laboratories worldwide, therefore we evaluated whether pretreatment PLR could predict the clinical outcome of PCa patients treated with ADT. (biomedcentral.com)
  • There were no differences in cell counts between patients with primary and those with secondary Sjogren's syndrome and between symptomatic and asymptomatic patients. (unife.it)
  • The guidelines describe single-platform technology (SPT), a process in which absolute counts of lymphocyte subsets are measured from a single tube by a single instrument. (cdc.gov)
  • Compared to these patients, also statistically significant higher CD4+ CD103+ counts in HP patients were observed (p = 0.007). (anma.it)
  • Counts lower than 1,000 lymphocytes per microliter (μl) of blood usually correspond to severe disease. (medicalnewstoday.com)
  • In the whole sample, low albumin levels and low lymphocyte counts were directly correlated to longer hospitalizations. (biomedcentral.com)
  • The main objective is to verify the correlation between serum albumin levels, lymphocyte counts and length of stay in a vast hospital population, together with various blood parameters and patient history. (biomedcentral.com)
  • Tumor infiltrating lymphocytes and PBLs were phenotyped by their surface markers, cytokine pattern, proliferation rate, and cytotoxic ability. (nih.gov)
  • Ipilimumab is a monoclonal antibody that antagonizes cytotoxic T lymphocyte antigen-4, a negative regulator of the immune system. (nih.gov)
  • In immunology, reactive lymphocytes, variant lymphocytes, atypical lymphocytes, Downey cells or Türk cells are cytotoxic (CD8+) lymphocytes that become large as a result of antigen stimulation. (wikipedia.org)
  • These antibodies exhibited a maximal cytotoxic activity at +4 degrees C. They reacted mainly with B lymphocytes as assessed by microlymphocytotoxicity assays using B- or T-cell enriched subpopulations and T- or B-cell lines as targets. (ox.ac.uk)
  • Retrospective data of 481 systemically untreated, N0, young TNBC patients showed that increasing stromal tumour infiltrating lymphocytes (TIL) have a prognostic value for improved outcome [1]. (medicom-publishers.com)
  • The stratification of the results by department and diagnosis suggests that there is a higher correlation in certain subpopulations, and albumin shows a greater correlation with length of stay than lymphocytes. (biomedcentral.com)
  • Conclusion: Our findings support that the SP142 and 22C3 IHC assays, with their respective clinically applied scoring algorithms, are not analytically equivalent where they identify partially non-overlapping subpopulations of TNBC patients and cannot be substituted with one another regarding PD-L1 detection. (lu.se)
  • If the complete blood count reveals lymphocytopenia, testing for immunodeficiency and analysis of lymphocyte subpopulations should follow, usually after the patient has recovered from any acute event. (msdmanuals.com)
  • This study retrospectively analyzed serum lymphocyte subsets and survival outcomes in intracranial germ cell tumors (iGCTs) patients. (researchsquare.com)
  • Iovance Biotherapeutics aims to improve patient care by making T cell-based immunotherapies broadly accessible for the treatment of patients with solid tumors and blood cancers. (biospace.com)
  • There is increasing evidence that breast cancer patients with tumors characterized by a 'pro-inflammatory phenotype,' including those with TNBC, have better responses to chemotherapy and experience longer disease-free and overall survival rates," said Mai H. Le , MD, Chief Medical Officer at OncoSec. (prnewswire.com)
  • Thus, this study investigated the effects of masturbation-induced orgasm on lymphocyte circulation and cytokine production in healthy young males. (karger.com)
  • METHODS: Consecutive BAL samples from the 167 interstitial lung disease (ILD) patients were retrospectively enrolled in the study and clustered into three diagnostic categories: IPF, cHP and sarcoidosis. (minervamedica.it)
  • Patients and Methods: This study included 168 patients who underwent curative surgery followed by perioperative adjuvant chemotherapy for esophageal cancer between 2005 and 2018. (iiarjournals.org)
  • Methods: We identified the cases of 114 consecutive patients who underwent the surgery at our Hospital between January 2006 and December 2012 by using the multivariate analysis, the Cox proportional-hazard regression model. (scirp.org)
  • Methods: Consecutive patients hospitalized for AIS who underwent intravenous thrombolysis, mechanical thrombectomy or both were identified. (univpm.it)
  • Current methods used to predict or monitor the activity of infused T cells in patients provide limited data on treatment efficacy ( 6 , 7 ). (snmjournals.org)
  • To assure the accuracy and reliability of CD4+ T-lymphocyte test results obtained within individual laboratories and to assure the comparability of results between laboratories, standard methods for performing the test, as well as guidelines for quality control and quality assurance, are desirable. (cdc.gov)
  • The aim of our research was to determine how immunotherapy changes the proportion of lymphocyte subsets in dog peripheral blood and the levels of cytokines secreted by these cells during therapy. (mdpi.com)
  • Blood samples for further analyses were collected from patients in the third and sixth month of immunotherapy. (mdpi.com)
  • Now-a-days, the market of immunotherapy is more attributed towards developing Tumor-Infiltrating Lymphocytes for causing complete remission of the tumor cells from the cancer patients. (researchandmarkets.com)
  • As per "Global Tumor Infiltrating Lymphocytes Immunotherapy Market Opportunity & Clinical Trials Insight 2025" report findings, it is estimated that the innovative research and development sector has excited the oncology researchers for driving the overall oncology pharmaceutical industry. (researchandmarkets.com)
  • In March 2021, we became the first center in the world to use NK therapy, a type of immunotherapy, in a patient with advanced lymphoma. (ohsu.edu)
  • The Knight Cancer Institute was among the first in the nation to treat patients who have advanced prostate cancer with the immunotherapy medication Provenge. (ohsu.edu)
  • In infectious mononucleosis, the atypical lymphocytes are one component of a normal immune system that helps to control potentially fatal Epstein-Barr virus-induced B-cell lymphoma in human. (wikipedia.org)
  • Nodular lymphocyte-predominant Hodgkin lymphoma is characterized by the presence of lymphocyte-predominant cells, sometimes termed "popcorn cells," which are a variant of Reed-Sternberg cells. (lls.org)
  • Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) affects about 5 percent of Hodgkin lymphoma patients. (lls.org)
  • The LLS mission: Cure leukemia, lymphoma, Hodgkin disease and myeloma, and improve the quality of life of patients and their families. (lls.org)
  • Our team became the first in the world to use an NK therapy from Artiva Biotherapeutics in a patient with advanced lymphoma. (ohsu.edu)
  • For therapeutic purposes, nodular lymphocyte-predominant HL is managed in the same way as indolent non-Hodgkin lymphoma (see Follicular Lymphoma [non-Hodgkin Lymphoma] ). (medscape.com)
  • It is common to evaluate lymphocytes subsets in virus infection, immunodeficiency diseases and cancer. (researchsquare.com)
  • Data obtained demonstrated that IFN-γ-expressing T lymphocytes, mostly CD8+ cells, were present in HIV-1-infected patients, and that their percentage, always higher in HIV-1-infected patients than in healthy subjects (p ≤ 0.001), increased with progressive stages of HIV-1 infection. (unibs.it)
  • The presence in the HIV-1-infected patients of activated CD8+ T cells, which are resistant to HIV-1 infection, may suggest that these cells are able to respond to continuous and progressive viral expression (HIV or/and other viruses) and may be a component of the specific response to HIV-1. (unibs.it)
  • Patients who had non-elective surgery, pre-operative radiotherapy and chemotherapy and showed clinical evidence of infection or other inflammatory conditions were excluded from the study. (scirp.org)
  • The ALS assay, however, tested positive in all patients with documented or highly suspicious typhoid, suggesting that such a response could be the basis of improved diagnostic point-of-care-assay for serovar Typhi infection. (wustl.edu)
  • Rapid increases in lymphocyte numbers can indicate an infection or underlying health condition. (medicalnewstoday.com)
  • Enhanced apoptosis in the leukocytes of peripheral blood of PEM patients may be a marker of increased infection and immune disturbances. (who.int)
  • Human Immunodeficiency Virus (HIV) Infection Human immunodeficiency virus (HIV) infection results from 1 of 2 similar retroviruses (HIV-1 and HIV-2) that destroy CD4+ lymphocytes and impair cell-mediated immunity, increasing risk of certain. (msdmanuals.com)
  • In acute viremia due to HIV or other viruses, lymphocytes may undergo accelerated destruction from active infection with the virus, may be trapped in the spleen or lymph nodes, or may migrate to the respiratory tract. (msdmanuals.com)
  • The patient had no known pet or but the infection has been diagnosed in animal exposures but many pigeons were areas lacking eucalyptus, indicating that reported to live near his home. (who.int)
  • Two days demonstrated by the present case, where the later, due to lack of clinical improvement, patient is infected with HIV, the fungus can an aliquot of the admission CSF was tested cause an infection regardless of the immune and found to have a cryptococcal antigen status of the patient. (who.int)
  • The genomic sequences from nine patients who were among the first cases of this serious infection (COVID-19) are almost genetically identical, which suggests the very recent appearance of this Coronavirus in humans 3 . (bvsalud.org)
  • Therefore, the PLR might be a promising prognostic factor for patients with esophageal cancer. (iiarjournals.org)
  • We discovered that, in mouse models, activated B-lymphocytes infiltrate infarcted tissue in the weeks after stroke. (jneurosci.org)
  • The process of measuring the percentage of CD4+ T-lymphocytes in the whole blood sample is referred to as ``immunophenotyping by flow cytometry'' (9-14). (cdc.gov)
  • Our findings thus show that the in vitro activation of lymphocytes by PSK can help identify the candidates with either gastric or colorectal cancer who are the best suited to undergo immunochemotherapy including treatment with PSK. (unboundmedicine.com)
  • It was originally described by W. Türk in 1907 in the peripheral blood of patients with infectious mononucleosis. (wikipedia.org)
  • Determine the feasibility and efficacy of a reduced-intensity conditioning regimen comprising alemtuzumab, fludarabine, melphalan, and thiotepa followed by allogeneic peripheral blood stem cell transplantation (PBSCT) in patients with hematologic malignancies. (knowcancer.com)
  • Background: Perioperative systemic inflammation affects the long-term oncological outcomes of patients with malignancies. (iiarjournals.org)
  • Characterization of antibodies reacting with husband's lymphocytes in sera from patients with trophoblastic malignancies. (ox.ac.uk)
  • For example, patients suffering from Li-Fraumeni syndrome have an almost 100% chance of developing a wide range of malignancies before the age of 70 years. (nature.com)
  • The main focus has been on tumor cell PD-L1 expression, but its assessment alone is insufficient for patient selection in most malignancies. (lu.se)
  • To date, six patients have relapsed and died, two after a second hematopoietic stem cell transplantation without T-cell depletion or administration of unmodified T-cells. (frontiersin.org)
  • Progressive depletion of CD4+ T-lymphocytes is associated with an increased likelihood of clinical complications. (cdc.gov)
  • The study aimed to analyze the correlation between low blood levels of albumin, low lymphocytes, and length of stay. (biomedcentral.com)
  • Lymphocyte count and co-morbidities were evaluated in the whole cohort, albumin levels in 1437 patients. (biomedcentral.com)
  • A routine check of albumin, lymphocytes and a spectrum of significant variables can provide precious information which can eventually lead to a shorter hospital stay. (biomedcentral.com)
  • Low levels of albumin and lymphocytes are highly correlated with prolonged hospitalizations. (biomedcentral.com)
  • Actually, albumin and lymphocyte count are biochemical parameters successfully used in common clinical practices for highlighting and monitoring certain specific diseases [ 3 ]. (biomedcentral.com)
  • The ultimate goal of this study is to raise awareness among physicians about the health status of hospitalized patients, based on lymphocyte count and albumin levels at admission. (biomedcentral.com)
  • We would like to create an innovative, economical and standardized screening method, based on albumin, lymphocyte count and an analysis of co-morbidities, in order to assess the organic status of patients and predict the length of recovery at admission. (biomedcentral.com)
  • Additionally, a direct correlation between DEB and FOM toxicity was observed in lymphocytes from FA patients , indicating similar susceptibility to both agents. (bvsalud.org)
  • Therefore, the NLR and PLR might be effective, readily available, and low-cost biomarkers for inflammation in intestinal BD patients. (ecco-ibd.eu)
  • In contrast, patients with self-reactive cells have significant autoimmune features in addition to their clinical and molecular immunodeficient state. (hindawi.com)
  • Conclusion: The PLR had a clinical impact on the long-term oncological outcomes of patients with esophageal cancer treated with curative intent. (iiarjournals.org)
  • Clinical studies are also underway to evaluate TIL in earlier stage cancers in combination with currently approved treatments, and to investigate Iovance peripheral blood lymphocyte (PBL) T cell therapy for blood cancers. (biospace.com)
  • These patients present with clinical symptoms in their late 40s or early 50s. (medscape.com)
  • Also, the market is adjoined with various clinical stage biotechnology companies focusing on the development as well as commercialization of the TIL therapy for the cancer patients. (researchandmarkets.com)
  • Some of these therapies have been approved by the Food and Drug Administration, and others are available to eligible patients through clinical trials. (ohsu.edu)
  • Germline variants such as BRCA1/2 play an important role in tumorigenesis and clinical outcomes of cancer patients. (nature.com)
  • The challenge remains in using these inherited germline variants to predict clinical outcomes of cancer patient population. (nature.com)
  • 9 Here we reasoned that the collective impact of germline variants in cancer patients might largely determine tumorigenesis, evolution, and even clinical outcomes. (nature.com)
  • Knowledge of the general health status of a patient and the possibility to estimate his/her length of hospital stay are essential information for Clinical Governance, and for the improvement of internal services of hospitals on a large scale. (biomedcentral.com)
  • T cell preparation: Patients and donors undergo apheresis to obtain peripheral blood mononuclear cells (PBMCs), which are expanded in culture. (knowcancer.com)
  • Allogeneic peripheral blood stem cell (PBSC) transplantation: Patients undergo allogeneic PBSC transplantation on day 0. (knowcancer.com)
  • B-lymphocytes undergo isotype switching, and IgM, IgG, and IgA antibodies are found in the neuropil adjacent to the lesion. (jneurosci.org)
  • Two-hundred-ninety prostate cancer patients who had undergone ADT as first-line therapy were retrospectively analyzed. (biomedcentral.com)
  • After obtaining approval from the Ethics Committee at the Renji Hospital, Shanghai Jiao Tong University School of Medicine, and informed consent from patients, medical records of 325 prostate cancer patients who had undergone ADT as first-line therapy at the Renji Hospital between January 2010 and December 2014 were retrospectively reviewed. (biomedcentral.com)
  • Patients with severe combined immunodeficiency (SCID) may present with residual circulating T cells. (hindawi.com)
  • The latter includes patients with autoreactive clonal expanded T cell and patients with alloreactive transplacentally maternal T cells. (hindawi.com)
  • In contrast, patients with reactive T cells exhibited poor T-cell differentiation and activity. (hindawi.com)
  • While the autoreactive cells displayed significantly reduced Tregs numbers, the alloreactive transplacentally acquired maternal lymphocytes had high functional Tregs. (hindawi.com)
  • SCID patients presenting with circulating T cells show different patterns of T-cell activity and regulatory T cells enumeration that dictates the immunodeficient and autoimmune manifestations. (hindawi.com)
  • The origin of the reactive cells in such patients are either thymic release of T-cells that expand at the periphery or transplacentally transfers of maternal T lymphocytes. (hindawi.com)
  • A distinctive feature of SCID patients, which sometimes can clinically resemble Omenn, [ 6 ] is the presence of alloreactive cells originated from transplacentally maternal T lymphocytes. (hindawi.com)
  • Thymus derived lymphocytes (T cells) in patients with genital warts. (bmj.com)
  • Cultured lymphocytes with PSK at 100 micrograms/ml increased the level of DNA synthesis, as determined by the 3H-thymidine uptake, from 0.9 to 3.0 fold, compared to the PSK non-treated cells. (unboundmedicine.com)
  • Since no significant differences were found between AD patients and age-matched controls with regard to the fraction of CD45RA+ or CD45RO+ CD4+ T cells nor the ability of peripheral blood mononuclear cells to produce IL-2 or IL-4, it is unlikely that the difference in DEX sensitivity is due to a changed lymphokine profile or a changed composition of the CD4+ T cell population. (eur.nl)
  • Determine the safety of LMB-2 immunotoxin-treated, selectively-depleted donor T cells, administered after allogeneic PBSCT, in these patients. (knowcancer.com)
  • LMB-2 immunotoxin-treated, selectively-depleted donor T cells: Patients receive LMB-2 immunotoxin-treated, selectively-depleted donor T cells IV over 30-60 minutes on approximately day 28. (knowcancer.com)
  • Cohorts of 3-6 patients receive escalating dose of LMB-2 immunotoxin-treated, selectively-depleted donor T cells until the maximum tolerated dose (MTD) is determined. (knowcancer.com)
  • As dramatically demonstrated in AIDS patients, without helper T cells we cannot defend ourselves even against many microbes that are normally harmless. (nih.gov)
  • Atypical lymphocyte population often express features of activated CD8+ T cells, such as CD29, CD38, HLA-DR, CD45RO and CD95. (wikipedia.org)
  • Some pathogen-related causes include: Epstein-Barr virus Cytomegalovirus Toxoplasma gondii Treponema pallidum (syphilis) Streptococcus agalactiae (group B streptococci) Hepatitis C Hantavirus The presence of Downey cells were observed in many COVID-19 cases, together with the atypical plasmacytoid lymphocytes (which could be one of the less usual atypical lymphocyte types). (wikipedia.org)
  • The aim of these trials was to provide patients with the protection of T-cells after T-cell-depleted allo-HSCT in the matched or mismatched donor setting with an option to delete transduced T-cells, if severe aGvHD occurred within the trial period. (frontiersin.org)
  • Donor chimerism was stabilized after transfusion of the transduced cells in all patients treated. (frontiersin.org)
  • Tumor infiltrating lymphocyte (TIL) therapy uses a patient's own immune cells to attack cancer. (biospace.com)
  • TIL cells are extracted from a patient's own tumor tissue, expanded through a proprietary process, and infused back into the patient. (biospace.com)
  • They're also called CD4 T lymphocytes or "helper T cells. (medlineplus.gov)
  • CD4+ T-cells and other lymphocyte subsets in persons infected with human immunodeficiency virus (HIV). (cdc.gov)
  • We examined the properties of peripheral blood CD8 + lymphocytes from asbestos-exposed patients with pleural plaque (PL) and MM. The percentage of CD3 + CD8 + cells in PBMCs did not differ among the three groups, although the total numbers of PBMCs of the PL and MM groups were lower than those of the healthy volunteers (HV). (elsevierpure.com)
  • The percentage of IFN-γ + and CD107a + cells in PMA/ionomycin-stimulated CD8 + lymphocytes did not differ among the three groups. (elsevierpure.com)
  • Percentages of perforin + cells and CD45RA - cells in fresh CD8 + lymphocytes of PL and MM groups were higher than those of HV. (elsevierpure.com)
  • Percentages of granzyme B + and perforin + cells in PMA/ionomycin- stimulated CD8 + lymphocytes were higher in PL group compared with HV. (elsevierpure.com)
  • The MM group showed a decrease of perforin level in CD8 + lymphocytes after stimulation compared with patients with PL. These results indicate that MM patients have characteristics of impairment in stimulation-induced cytotoxicity of peripheral blood CD8 + lymphocytes and that PL and MM patients have a common character of functional alteration in those lymphocytes, namely, an increase in memory cells, possibly related to exposure to asbestos. (elsevierpure.com)
  • Percentages of perforin+ cells and CD45RA- cells in fresh CD8+ lymphocytes of PL and MM groups were higher than those of HV. (elsevierpure.com)
  • These white blood cells include B lymphocytes or B cells and T lymphocytes or T cells. (medicalnewstoday.com)
  • It begins in B cells and causes an increase in abnormal lymphocytes. (medicalnewstoday.com)
  • The treatment regimen associated with the TIL therapy comprises of collection of lymphocytes that have the ability to engage themselves in the tumor cells destruction. (researchandmarkets.com)
  • The therapy is completely dependent on the tumor biopsy extracted from the patients rather than circulating T cells in the blood. (researchandmarkets.com)
  • NK cells can also be collected from donor blood or umbilical cord blood and given, unchanged, to patients. (ohsu.edu)
  • and the percentage of lymphocytes that are CD4+ T-cells. (cdc.gov)
  • about 75% of the lymphocytes are T cells, 20% B cells, and 5% NK cells. (msdmanuals.com)
  • Thus, most patients with lymphocytopenia have a reduced absolute number of T cells, particularly in the number of CD4+ T cells. (msdmanuals.com)
  • PD-L1 was expressed mainly by macrophages (not by tumor cells) and PD-1 by lymphocytes. (lu.se)
  • Analysis of the cerebral spinal fluid (CSF) disease in immunocompromised patients, revealed a white cell count of 30 cells/mm3 especially patients with HIV [ 7 ]. (who.int)
  • Therefore, if physicians manage and control perioperative systemic inflammation using optimal screening tools, they may be able to improve patient survival. (iiarjournals.org)
  • Reactive lymphocytes have been found to accumulate in areas of inflammation like the liver and pharynx of individuals with infectious mononucleosis and skin window preparations. (wikipedia.org)
  • To investigate the degree and the type of inflammation in the bronchial mucosa in patients with Sjogren's syndrome, we examined lobar bronchial biopsies obtained from 10 patients with Sjogren's syndrome (six with primary and four with secondary) and eight control subjects. (unife.it)
  • We aimed to compare CD103+ expression in BALF T-lymphocytes between patients with HP, sarcoidosis and other interstitial lung diseases (ILD). (anma.it)
  • After a final diagnosis established according to international criteria, three patient subgroups-HP, ILD (which included idiopathic interstitial pneumonia and connective tissue disease-associated lung disorders) and sarcoidosis-were considered for further analysis. (anma.it)
  • We mapped the presence of macrophages (CD68 and CD163) and lymphocytes (CD3) located within the tumor epithelium, the cell type-specific expression of PD-L1 and PD-1, and their impact on 5-year overall survival (OS) in a consecutive cohort of 130 women diagnosed with advanced HGSC between 2011 and 2015. (lu.se)
  • This document has been developed by CDC to give guidance to laboratories performing lymphocyte immunophenotyping assays in human immunodeficiency virus-infected persons. (cdc.gov)
  • companion IHC diagnostic assays for atezolizumab and pembrolizumab, respectively) in a population-based cohort of 232 early-stage TNBC patients. (lu.se)
  • Micronuclei frequency began to rise in lymphocytes of subjects with polyps, suggesting a systemic genomic instability condition. (oncotarget.com)
  • We suggest that a high-tolerance capacity of the alloreactive transplacentally acquired maternal lymphocytes represents a toleration advantage, yet still associated with severe immunodeficiency. (hindawi.com)
  • Lymphocytes expressing interferon-γ (IFN-γ) on their surface were evaluated in 61 patients, all IV drug abusers, infected with human immunodeficiency virus type 1 (HIV-1), and in 85 healthy subjects (61 of whom were blood donors and 24 HIV-1 seronegative IV drug abusers). (unibs.it)
  • Single-platform technology (SPT) is designed to enable de- system and managing the health care of persons infected with terminations of both absolute and percentage lymphocyte sub- human immunodeficiency virus (HIV) ( 1-4 ). (cdc.gov)
  • The pathogenesis of acquired immunodeficiency syndrome (AIDS) is largely attributable to the decrease in T-lymphocytes bearing the CD4 receptor (CD4+) (1-5). (cdc.gov)
  • CD4+ T-lymphocyte levels are also used as prognostic indicators in patients with human immunodeficiency virus (HIV) disease (8). (cdc.gov)
  • Therefore, we tested the hypothesis that a B-lymphocyte response to stroke could contribute to the onset of dementia. (jneurosci.org)
  • A total of 1712 diagnostic tests with 621 intestinal BD patients who underwent both blood examination and endoscopic examination at the Inflammatory Bowel Disease Clinic of Severance Hospital, Seoul, Korea between March 2005 to November 2020 were analyzed in our study. (ecco-ibd.eu)
  • From 2005 to 2012, consecutive patients with pathologic stage IIIA(N2) NSCLC who underwent complete resection at our institution were reviewed. (oncotarget.com)
  • In this study, we extended the prognostic analysis to CRC patients with metastasis who underwent surgery in order to select the predictive factors from these available and inexpensive laboratory data. (scirp.org)
  • This patient series included those who underwent primary tumor resection, a bypass or a proctostomy and those who underwent the simultaneous resection of metastases with curative intent. (scirp.org)
  • The PSK-reactive group demonstrated no relation to the age and sex of the patients, tissue differentiation type or tumor advancement. (unboundmedicine.com)
  • Under a magnification of 100X, this hematoxylin-eosin-stained (H&E) photomicrograph depicts the cytoarchitectural changes found in a liver tissue specimen extracted from a Lassa fever patient. (cdc.gov)
  • Lymphocytes from FA patients have hypersensitivity to alkylating agents , particularly to diepoxybutane (DEB). (bvsalud.org)
  • However, no specific genotoxic evaluation directed to patients with hypersensitivity to alkylating agents was performed. (bvsalud.org)
  • In colorectal biopsies and peripheral blood lymphocytes of patients with IBD, polyps and CRC, we evaluated 1) genomic instability using the γH2AX assay as marker of DSB and micronuclei in mononuclear lymphocytes kept under cytodieresis inhibition, and 2) cellular stress through expression and cellular localization of glutathione-S-transferase omega 1 (GSTO1). (oncotarget.com)
  • PD-L1 IHC positivity and abundance of tumor infiltrating lymphocytes were of positive prognostic value in univariable regression analyses in patients treated with (neo)adjuvant chemotherapy, where it was strongest for 22C3 CPS ≥ 10 and distant relapse-free interval (HR = 0.18, p = 0.019). (lu.se)
  • The effect of PSK, a protein-bound polysaccharide and an immunomodulator, on lymphocytes was examined in vitro for 36 patients with gastric cancer and 26 with colorectal cancer. (unboundmedicine.com)
  • When the 1.3 fold increase of 3H-thymidine uptake was defined as the PSK-reactive group, 52.8% (19/36) of the patients with gastric cancer and 50.0% (13/26) for colorectal cancer were found in the PSK-reactive group. (unboundmedicine.com)
  • Objectives: Our aim is investigating the predictive potential of these available and convenient laboratory dates in stage IV colorectal cancer (CRC) patients. (scirp.org)
  • The number of colorectal cancer (CRC) patients has been increasing rapidly worldwide in recent decades, and the survival rates of CRC patients have increased in the past few years, possibly as a result of progress in diagnostic faculty and improved chemotherapy. (scirp.org)
  • Because lymphocytes account for only 20 to 40% of the total white blood cell (WBC) count, lymphocytopenia may go unnoticed if the WBC count is checked without a differential. (msdmanuals.com)
  • In addition, the company's TIL therapy is being investigated in a registration-supporting study for the treatment of patients with locally advanced, recurrent or metastatic non-small cell lung cancer. (biospace.com)
  • It is important to note that the lymphocytes in the blood represent only a small proportion of the total lymphocyte pool, and the lymphocyte count may not always correlate with the composition and numbers of lymphocytes in other lymphoid (eg, nodes, spleen) and non-lymphoid (eg, lung, liver) tissues. (msdmanuals.com)
  • Later in 1923 the features of the reactive lymphocytes were characterized in greater detail by Hal Downey and C.A. McKinlay, who also discovered the association with EBV and CMV. (wikipedia.org)
  • Downey type II cell is the most common type of reactive lymphocyte. (wikipedia.org)
  • now it is more suggested that reactive lymphocytes are activated T-lymphocytes produced in response to infected B-lymphocytes. (wikipedia.org)
  • Reactive lymphocytes are usually associated with viral illnesses, but they can also be present as a result of drug reactions (such as phenytoin), immunizations, radiation, and hormonal causes (such as stress and Addison's disease), as well as some autoimmune disorders (such as rheumatoid arthritis). (wikipedia.org)
  • With CD45 gating, the relative numbers of beads and lymphocyte subsets are enumerated, and their absolute numbers and percentage values are calculated. (cdc.gov)
  • The aims of this study were to: (i) explore the relationship between NLR and other biochemical parameters and (ii) to examine the value of NLR as a predictor of cardiovascular and all-cause mortality in hemodialysis patients. (edu.au)
  • NLR is a practical, cost-efficient and easy to use predictor of cardiovascular and all-cause mortality in incident hemodialysis patients. (edu.au)
  • Despite prophylactic treatment of the patients with immunosuppressive drugs after allo-HSCT, GvHD is still associated with non-relapse mortality (NRM) and contributes around 25% of NRM. (frontiersin.org)
  • Conclusions: NLR is not only simple and convenient for classification of patients, but also one of the important predictors of mortality for stage IV incurable CRC patients. (scirp.org)
  • In the present study we evaluated the putative genotoxic effect of FOM in cultured lymphocytes from FA patients , compared to cultured lymphocytes from healthy donors (HD). (bvsalud.org)
  • Thus, women with greater lymphocyte tumor infiltration had better outcome and PD-L1/PD-1 expression, regardless of PD-1/PD-L1 being markers for immune suppressive pathways, conferred a survival benefit in our cohort. (lu.se)
  • For example, CD57 expression seems to be significantly decreased only in patients with EBV infections. (wikipedia.org)
  • Lymphocytes play an essential role in the immune system and can spike during infections. (medicalnewstoday.com)
  • The spike in lymphocytes is necessary for the body to fight infections. (medicalnewstoday.com)
  • As FA patients are very susceptible to infections and may be submitted to several surgeries, FOM can eventually be prescribed to them during their lifetime. (bvsalud.org)
  • The day infections throughout the world, including prior to admission, the patient developed the United States and Europe, have been a cough, neck stiffness and tonic-clonic reported [ 3,4 ]. (who.int)
  • However, it is possible to observe that 17% of patients confirmed with COVID-19 have severe infections and about 2.5% of these patients die. (bvsalud.org)
  • Young patients with high TIL have an excellent outcome without (neo)adjuvant chemotherapy. (medicom-publishers.com)
  • Androgen deprivation therapy (ADT) is the mainstay of therapy for patients with locally advanced or metastatic PCa or patients with early-stage disease who are ineligible for local regional treatments due to health disparity [ 2 ]. (biomedcentral.com)
  • Nonetheless, approximately 20% - 25% of CRC patients have metastatic disease at the time of first presentation. (scirp.org)
  • Most patients carry a missing or damaged p53 gene, a tumor suppressor whose activity is impaired in almost 50% of all cancers. (nature.com)
  • We propose that the growing genomic instability found in our patients is connected with the alteration of cellular environment. (oncotarget.com)
  • Fosfomycin increases chromosome instability in lymphocytes from Fanconi Anemia patients. (bvsalud.org)