Patients immune sera. Medical search. Frequent questions

Classic serum sickness can be induced by antithymocyte globulin (ATG), a heterologous serum protein generated by immunization of horses or rabbits with human thymic tissue. (medscape.com)
Post-exposure prophylaxis with antirabies serum immune globulin was prescribed in 9% of the cases ( n = 90). (rrh.org.au)
All pregnant women in the United States should be screened for hepatitis B. If infected, the baby will need to receive specific hepatitis B immune globulin and be vaccinated at birth. (healthywomen.org)
In December 2012, the Food and Drug Administration (FDA) approved VariZIG, a varicella zoster immune globulin preparation (Cangene Corporation, Winnipeg, Canada) for use in the United States for postexposure prophylaxis of varicella for persons at high risk for severe disease who lack evidence of immunity to varicella * and for whom varicella vaccine is contraindicated ( 1 ). (cdc.gov)
Previously available under an investigational new drug (IND) expanded access protocol, VariZIG, a purified immune globulin preparation made from human plasma containing high levels of anti-varicella-zoster virus antibodies (immunoglobulin G), is the only varicella zoster immune globulin preparation currently available in the United States. (cdc.gov)
This report summarizes data on the timing of administration of varicella zoster immune globulin in relation to exposure to varicella-zoster virus and provides the CDC updated recommendations for use of VariZIG that replace the 2007 ACIP recommendations. (cdc.gov)
Studies conducted in the late 1960s indicated that clinical varicella was prevented in susceptible, healthy children by administration of zoster immune globulin (ZIG) (prepared from patients recovering from herpes zoster) within 72 hours of household exposure ( 4 ). (cdc.gov)
The first commercial varicella zoster immune globulin preparation available in the United States, VZIG, was prepared from plasma obtained from healthy, volunteer blood donors identified by routine screening to have high antibody titers to varicella-zoster virus, and became available in 1978. (cdc.gov)
Octagam, Immune Globulin Intravenous (Human) 5% Liquid Preparation Initial U.S. Approval: 2004 - These highlights do not include all the information needed to use Octagam, Immune Globulin Intravenous (Human), safely and effectively. (nih.gov)
Octagam is an immune globulin intravenous (human), 5% liquid, indicated for treatment of primary humoral immunodeficiency (PI) (1). (nih.gov)

Symptoms in affected patients indicate the crucial involvement of MHC proteins in the immune recognition of self and nonself. (medscape.com)
Classic serum sickness is now rarely seen because the use of foreign proteins is limited to antitoxins such as those used to treat botulism, diphtheria, rabies , and snake, scorpion, and spider venom. (medscape.com)
The classic syndrome is caused by immunization of the host by heterologous serum proteins. (medscape.com)
[ 14 ] However, ATG, as well as other immunosuppressive foreign proteins, such as chimeric monoclonal antibodies that consist of murine-derived antigen-binding fragment (Fab) and human-derived crystallizable fragment (Fc) portions of antibodies, have been reported to be sufficiently immunogenic to cause serum sickness. (medscape.com)
The immune system is a complex network of cells, proteins and tissues that protects multicellular organisms against invading pathogens. (ugent.be)
Serum samples were analysed using human multiplex panels (Meso Scale Discovery, Rockville, MD, USA ) which quantifies 54 discrete inflammatory proteins. (ecco-ibd.eu)
Serum immune proteins which demonstrated a significant week 0 to 6 change were evaluated as candidate biomarkers of week 14 and 30 SFR. (ecco-ibd.eu)
There was no association between any of these 7 immune proteins and VDZ therapy outcome at week 14 or 30. (ecco-ibd.eu)
Glycans are found on many serum proteins, including those that play an important role in the immune response. (drexel.edu)
When it comes to proteins involved in the immune response, the glycans can make the proteins either more or less efficient at clearing the infection. (drexel.edu)
The increased intestinal permeability was accompanied by augmented expression of genes marking immune cell infiltration and encoding key proteins for immune cell adhesion, antigen presentation, and cytokine signaling in the orbital tissue. (frontiersin.org)
Comparison of the DNA profiles of the eluted phage using pre-immunotherapy and post-immunotherapy patient sera will reveal emergence of new antibodies (post-immunotherapy gain of antibodies) against proteins of potential interest for melanoma targeting. (mayo.edu)

They have poor antibody responses to polysaccharide antigens but elevated levels of serum immunoglobulin A (IgA) and immunoglobulin E (IgE) with low levels of immunoglobulin M (IgM). (medscape.com)
During autoimmune reactions, self-antigens are recognized as non-self and a T and/or B cell immune response is initialized. (ugent.be)
To assess the presence of antigen-specific immune responses to a broad panel of candidate tumor antigens. (bcan.org)
Conjugates were characterized by native gel electrophoresis and matrix-assisted laser desorption/ionization-mass spectrometry, and used as antigens in ELISA assays for serum specific-IgE and IgG. (cdc.gov)

Heterologous polyclonal antibodies are obtained from the serum of animals (e.g., rabbit, horse), and injected with the patient's thymocytes or lymphocytes. (wikipedia.org)
However, the use of equine and murine antisera as antilymphocyte or antithymocyte globulins and murine monoclonal antibodies for immunomodulation and cancer treatment has created a new group of medications that may cause serum sickness. (medscape.com)
Since the development of serum sickness is dependent on the host's ability to produce antibodies to the inciting antigen, patients who are incapable of producing antibodies, such as patients with Bruton agammaglobulinemia, will not develop serum sickness. (medscape.com)
Their research unexpectedly revealed that the patients with no clinical signs had a controlled immune response with increased antigen presentation, and T lymphocyte activation and more limited production of antibodies, compared with the patients presenting with symptoms. (pasteur.fr)
Immunotherapy with monoclonal antibodies may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. (bcan.org)
Graves' disease (GD), characterized by TSH-receptor stimulating antibodies and increased thyroid hormone serum levels, is an autoimmune disease affecting roughly 3% of the general population ( 1 ). (frontiersin.org)
In this approach, we isolate and affinity-column immobilize the IgG fraction from patient serum before and after immune therapy for melanoma, and expose the immobilized antibodies to bacteriophage expressing approximately 2x109 overlapping cDNA sequences of paired (same patient derived plasma and cancer cells) melanoma genomic RNA. (mayo.edu)
IgA deficient patients with antibodies against IgA are at greater risk of developing severe hypersensitivity and anaphylactic reactions Epinephrine should be available immediately to treat any acute severe hypersensitivity reactions. (nih.gov)
Previous clinical evidence suggested that high levels of serum CA125 have a negative impact on the effectiveness of the experimental therapeutic antibodies farletuzumab and amatuximab ( 13 - 15 ). (spandidos-publications.com)
In an observational study we investigated the pathobiology and extent of this potential cause of MGN by examining the association of antibodies against CNTN1 with the clinical features of a cohort of 468 patients with suspected immune-mediated neuropathies, 295 with idiopathic MGN, and 256 controls. (lu.se)
We identified 15 patients with immune-mediated neuropathy and concurrent nephrotic syndrome (biopsy proven MGN in 12/12), and 4 patients with isolated MGN from an idiopathic MGN cohort, all seropositive for IgG4 CNTN1 antibodies. (lu.se)
CNTN1-containing immune complexes were found in the renal glomeruli of patients with CNTN1 antibodies, but not in control kidneys. (lu.se)
In an immunochemical reaction, Apolipoprotein B in the human serum sample form immune complexes with specific antibodies. (cdc.gov)

Fc receptor function and circulating immune complexes in gluten sensitive enteropathy--possible significance of serum IgA. (bmj.com)
The capacity to clear IgG containing immune complexes from the circulation was studied in patients with coeliac disease (n = 13), dermatitis herpetiformis (n = 8), and coeliac disease with concomitant serum IgA deficiency (n = 4). (bmj.com)
C1q binding and C3, IgG, and IgA containing immune complexes. (bmj.com)
C1q binding immune complexes were detected only in IgA deficient gluten sensitive enteropathy. (bmj.com)
Patients with coeliac disease and dermatitis herpetiformis had higher values of C3, IgG, and IgA containing immune complexes than control subjects and serum IgA deficient patients with coeliac disease. (bmj.com)
The clearance rate was inversely correlated to the amount of immune complexes for the subgroups of gluten sensitive enteropathy. (bmj.com)
When the antigen and antibody molecules are present in approximately equal molar ratios (slight antigen excess), known as the zone of equivalence, cross-linking and lattice formation occur forming intermediate and large immune complexes. (medscape.com)
however, this is not the case in the presence of a high concentration of immune complexes or if the removal system is not functioning well. (medscape.com)
This results in a large mass of aggregates of immune complexes deposited in various tissues, such as the internal elastic lamina of arteries and in perivascular regions. (medscape.com)
These tissue-deposited immune complexes activate complements, which lead to the clinical manifestation of the disease (eg, inflammatory changes in the renal glomeruli and in the skin). (medscape.com)
Large amounts of antigen exposure can lead to widespread deposition of complement-fixing immune complexes and the clinical presentation of serum sickness. (medscape.com)
Therefore, we focus on the immune complexes in serum and synovial fluid of RA patients. (ugent.be)
Autoimmune anti-HIV-1gp120 antibody with antiidiotype-like activity in sera and immune complexes of HIV-1-related immunologic thrombocytopenia. (jci.org)

Delivery is accompanied by increases in anxiety levels that are significantly related to an activation of the inflammatory response system (IRS), as indicated by increases in the serum concentrations of interleukin-6 and the interleukin-1 receptor antagonist (IL-1RA) and increases in the activity of prolyl endopeptidase (PEP), a cytosolic endopeptidase that cleaves peptide bonds on the carboxyl side of proline in behaviorally active neuropeptides involved in anxiety. (psychiatrist.com)
We administered the Spielberger State-Trait Anxiety Inventory (STAI) to and assessed serum IL-1RA and soluble CD8 (sCD8) concentrations and serum PEP activity in 48 primiparae and 48 multiparae at the end of term and 1 and 3 days after delivery. (psychiatrist.com)
Changes in serum immune protein concentrations with pro-inflammatory, immunoregulatory and chemotactic functions are observed following VDZ induction therapy. (ecco-ibd.eu)
GO patients displayed significantly higher LBP serum concentrations than healthy controls. (frontiersin.org)
High triglycerides are associated with increased risk for CAD in patients with other risk factors, such as low HDL-cholesterol, some patient groups with elevated apolipoprotein B concentrations, and patients with forms of LDL that may be particularly atherogenic. (cdc.gov)
LDL-cholesterol is measured to assess risk for CHD and to follow the progress of patients being treated to lower LDL-cholesterol concentrations. (cdc.gov)

3] Nearly all patients with NBS are homozygous for the same founder mutation, ie, deletion of 5 bp (657del5) in the NBS1 gene, which encodes the protein nibrin. (medscape.com)
Autoimmunity and immune system dysregulation in schizophrenia: IgGs from sera of patients hydrolyze myelin basic protein. (nature.com)
P102 Changes in serum immune protein profiles following vedolizumab therapy in Inflammatory Bowel Disease. (ecco-ibd.eu)
We aimed to characterise changes in serum immune protein profiles following VDZ induction therapy and evaluate the association between serum immune protein profiles and outcome of VDZ therapy. (ecco-ibd.eu)
Changes in serum immune protein profile were compared between baseline(week 0) and following two VDZ infusions(week 6). (ecco-ibd.eu)
Compared with the control group, patients with COVID-19 expressed increased levels of several proinflammatory markers, including interleukin 6 (IL-6), interleukin 10 (IL-10), C-reactive protein (CRP), and growth-regulated oncogene-alpha (GRO/CXCL-1). (renalandurologynews.com)
Intestinal permeability was assessed by measuring serum lipopolysaccharide-binding protein (LBP), zonulin, TLR5, and TLR9 ligands. (frontiersin.org)
In the current proposal, we hypothesize that reacting COVID serum from patients that have recovered from COVID infection and compare to non-infected self-serum (if available) and control healthy volunteer serum (available in our lab) may identify protein targets that have developed as a result of the COVID infection and could be useful in the development of a COVID vaccine as well as a serologic test for anti-COVID immunity. (mayo.edu)
Neuronal and glomerular binding of patient IgG, serum CNTN1 antibody and protein levels, as well as immune-complex deposition were. (lu.se)
BACKGROUND: Toluene diisocyanate (TDI), a widely used aromatic diisocyanate with the potential to cause asthma, reacts with albumin in the airway fluid, which acts as a carrier protein for chemical presentation to the immune system. (cdc.gov)

Autoimmune antiidiotype-like antibody (Ab2) directed against anti-HIV-1gp120 (Ab1) was found in high titer in the sera of 10 consecutive homosexual and 11 narcotic addict HIV-1-related immunologic thrombocytopenia (HIV-1-ITP) patients, was barely detectable in 10 nonthrombocytopenic HIV-1 sero-positive individuals, and was not detectable in 5 normal subjects by use of a solid-phase RIA. (jci.org)
Titers of 64 for IgG and 32 for IgM analysis, and a negative control was created by using an in patient serum specimens were considered evidence of irrelevant monoclonal mouse antibody. (cdc.gov)
Rituximab (RTX) is a CD20‑targeting antibody that is the standard‑of‑care for patients with non‑Hodgkin Lymphoma (NHL) cases. (spandidos-publications.com)
Taken together, these findings warranted further investigation on NAV‑006 as a next generation anti‑CD20 antibody that could improve the efficacy of parent RTX in NHL patients with high levels of CA125. (spandidos-publications.com)
This strategy includes the monoclonal anti-CD20 antibody, rituximab (RTX), alone or in combination with chemotherapy for patients who have advanced-stage disease. (spandidos-publications.com)

The investigators used serum proteomics and immune cell phenotyping to compare the two groups' systemic immune responses and identify potential disease severity drivers that could predict which patients were most at risk and guide new treatment protocols. (mountsinai.org)
Translational science analysis shows that peak expansion of cytokine-secreting cNeT at day 21 was coincident with signs of systemic immune activation including increased serum IL-6. (itbusinessnet.com)
For the purposes of this workshop, immune mediated ear disease was defined to include both primary autoimmune sensorineural hearing loss (ASNHL) originating in the inner ear and secondary immune mediated ear disease/hearing loss (IMED) from systemic immune/autoimmune disease originating outside the inner ear. (nih.gov)

The role of innate immune responses and neuroinflammation in amyloid accumulation and progression of Alzheimer's disease. (nature.com)
We will build further on these results and continue to study immune responses in asymptomatic Cambodian children in detail. (pasteur.fr)
Febrile responses by patients have been observed since medical observations of the infection process as far back as the 6th century BC. (pharmaceuticalonline.com)
2 A great deal of interest evolved as studies of gram‑negative bacteria were found to induce a variety of responses in patients exposed to portions of their cell walls. (pharmaceuticalonline.com)
Serum and urine will be obtained as well to characterize circulating immune responses. (bcan.org)
GRO/CXCL1 reflects heightened immune responses, they noted, and serum CRP correlates with COVID-19 outcome. (renalandurologynews.com)
The transition from innate to adaptive immune responses in IMED. (nih.gov)
Characterization of inner ear-specific immune responses in normal and ASNHL individuals. (nih.gov)

Further study is required to identify serum biomarkers of VDZ therapy response. (ecco-ibd.eu)
COVID-19 associated cystitis (CAC): increased urinary symptoms and biomarkers of inflammation in urine in patients with acute COVID-19. (renalandurologynews.com)
Many serum biomarkers have been evaluated in melanoma but their clinical significance remains a matter of debate. (hindawi.com)
In this paper, a review of the serum biomarkers for melanoma will be detailed and will be discussed from the point of view of their practical usefulness. (hindawi.com)
New serum biomarkers of melanoma progression and metastatic disease are still awaited in order to provide efficient rationale for followup and treatment choices. (hindawi.com)

At the conclusion of today's session the participant will be able to describe the risk factors, endemic areas, and incubation period of hantavirus infection, identify the clinical presentation and methods to identify a patient with hantavirus in the clinical setting, and understand the parameters of clinical management and critical care for patients with hantavirus. (cdc.gov)
In were classified as definite cases of R. africae infection if patients, ATBF manifests as an acute, febrile, and influen- this rickettsia was isolated from clinical specimens or a zalike illness, frequently accompanied by severe headache, positive PCR detection was associated with a positive prominent neck muscle myalgia, inoculation eschars serologic test result. (cdc.gov)
Scientists from the Institut Pasteur in Paris and the Institut Pasteur in Cambodia, in collaboration with teams from the CNRS and Inria, have demonstrated that asymptomatic dengue infection in children is associated with activation of the immune system via control mechanisms, resulting in the elimination of viral infection without excessive immune activation. (pasteur.fr)
To identify the internal mechanisms used to control dengue virus infection in asymptomatic patients, scientists from the Institut Pasteur in Paris, the Institut Pasteur in Cambodia, the CNRS and Inria examined the composition of blood serum, immune cells and the gene expression profile in asymptomatic Cambodian children infected with the dengue virus and compared them to those of patients presenting with clinical signs. (pasteur.fr)
By looking at infected but asymptomatic patients, this study can help us understand the mechanisms that prevent the development of symptoms following infection. (pasteur.fr)
College of Medicine researchers have proposed a way to detect the bacterial infection by looking for a unique indicator that occurs before the immune system is able to launch a specific response. (drexel.edu)
As a further complication, people can become reinfected, but diagnostic tests will not work on subsequent infections because there is no way to know if an immune response is from the first infection or a new one. (drexel.edu)
Thus, SARS-CoV-2 infection leaves an inflammatory imprint in the monocyte/ macrophage compartment that drives aberrant macrophage effector functions and eicosanoid metabolism, resulting in long-term immune aberrations in patients recovering from mild COVID-19. (nature.com)
Serum and airway prostanoid- and LT levels are increased in severe COVID-19 10 , 11 , suggesting a role for eicosanoids in the immune response to SARS-CoV-2 infection. (nature.com)
Pro-inflammatory 5-LOX metabolites were selectively increased in post COVID-19 MDM, suggesting that SARS-CoV-2 infection drives a pro-inflammatory eicosanoid reprogramming that contributes to long-term alterations in innate immune cell function. (nature.com)
During the pandemic in Spain there was a downward trend in the number of patients registered across the waves, as well as in the severity of the infection. (unav.edu)
Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. (mims.com)
If a patient develops a serious infection, RAPTIVA (efalizumab) should be discontinued and appropriate therapy instituted. (rxlist.com)

We assessed serum and fecal markers of intestinal inflammation/injury and immune activation, and indices of fatigue. (medscape.com)
Second, inflammation, toxins, and pathogens rob the body of nutrients, disrupt nutrient recycling and synergy networks, and add to the demands of the immune system's cells and other tissues to fight the illness and repair damages. (vitalitymagazine.com)
However, not all depressed patients have increased inflammation. (psychiatrictimes.com)
4 Remarkably, we still do not know the factors that lead to increased inflammation in these depressed patients. (psychiatrictimes.com)
Results from our research show increased inflammation not only in depressed patients who have a history of childhood maltreatment but also in persons who have experienced maltreatment but who are not depressed. (psychiatrictimes.com)
In a subsequent study, we found that inflammation is increased also in depressed patients with lower socioeconomic status in childhood or adulthood, and in patients with more cardiovascular risk factors, such as being overweight or having high blood pressure, high total cholesterol, and high glycated hemoglobin. (psychiatrictimes.com)
The findings, published in the September 14 edition of Science Translational Medicine, suggest that lung damage is linked to the loss of immune cells called macrophages that normally reside in the lung and organize tissue repair, followed by an influx of new macrophages from the blood into the lung that cause inflammation. (mountsinai.org)
Our recent work had shown that patients suffering from chronic airway inflammation exhibit transcriptional reprogramming of MDM 14 , a cell type implicated in COVID-19 pathogenesis 7 . (nature.com)
Moreover, serum LBP levels significantly correlated with the abundance of specific Gram-negative gut bacteria, linking the gut to local orbital inflammation. (frontiersin.org)
Neopterin has been extensively used as a clinical marker of immune activation during inflammation in a wide range of conditions and stresses. (mdpi.com)

Serum sickness is a type III hypersensitivity reaction mediated by immune complex deposition with subsequent complement activation. (medscape.com)
Reported complications include peripheral corneal infiltrate and ulcer, eyelid eczema, microbial keratitis, ocular discomfort or epitheliopathy, bacterial conjunctivitis, scleral vasculitis and melting in patients with rheumatoid arthritis, and immune complex deposition with 100% serum. (aao.org)

Within the MicroGO cohort, patients with high serum LBP levels also showed higher levels of zonulin and TLR5 and TLR9 ligands in their circulation. (frontiersin.org)
Recent clinical evidence suggests that high serum levels of the tumor‑produced mucin 16 (MUC16) and cancer antigen 125 (CA125) have a negative impact on the effectiveness of RTX clinical activity in up to 40% of patients with follicular lymphoma. (spandidos-publications.com)
High serum level of CA125 is used as an indicator of tumor abdominal involvement, advanced staging, relapse rates and survival in NHL patients ( 8 - 12 ). (spandidos-publications.com)

Moreover, sex, tissue, and putative cell type were systematically evaluated for immune alterations in different neuropsychiatric disorders. (nature.com)
Immunization is coded 3E0134Z Introduction of Serum, Toxoid and Vaccine into Subcutaneous Tissue, Percutaneous Approach. (fortherecordmag.com)
Two distinct cohorts of GO patients were studied, one of which was a unique cohort consisting of blood, fecal, and retro-orbital tissue samples. (frontiersin.org)
GD is the most common form of hyperthyroidism ( 1 ) and up to 40% [CI 0.32 - 0.48] of GD patients have clinically apparent abnormalities of orbit soft tissue, known as Graves' orbitopathy (GO) or thyroid eye disease (TED) ( 2 ). (frontiersin.org)
In patients with chronic peripheral arterial disease, this increases blood flow to the affected microcirculation and enhances tissue oxygenation. (drugs.com)
Tissue oxygen levels have been shown to be significantly increased by therapeutic doses of pentoxifylline in patients with peripheral arterial disease. (drugs.com)

COHORT A: Patients receive atezolizumab intravenously (IV) over 30-60 minutes on day 1. (bcan.org)
Together with co-senior authors Alex Charney, MD, PhD, and Sacha Gnjatic, PhD we are now following our COVID-19 cohort described in this study and will compare extensive immune profiling of the patients who develop long COVID with those who fully recover, in order to identify drivers and treatment strategies for long COVID. (mountsinai.org)
Association of postoperative covert stroke and cognitive dysfunction among elderly patients undergoing non-cardiac surgery: protocol for a prospective cohort study (PRECISION study). (quanterix.com)

6 The favorable attributes of endotoxins as therapy (tumor destruction and immune enhancement) were being explored into the 1970s, but potency testing was limited to the RPT. (pharmaceuticalonline.com)
Expansion cohorts) V. To assess the intratumoral immune response of neoadjuvant by comparing pre-treatment transurethral resection of bladder tumor (TURBT) with post-treatment cystectomy tumor specimens. (bcan.org)
The best clinical response was a partial response (ongoing at week 33) in a NSCLC patient that showed an investigator-reported 57% total tumor reduction at week 24. (itbusinessnet.com)
Background The Spanish Melanoma Group (GEM) developed a national registry of patients with melanoma infected by SARS-CoV-2 ( GRAVID ).Methods The main objective was to describe the COVID-19 fatality rate in patients with melanoma throughout the pandemic, as well as to explore the effect of melanoma treatment and tumor stage on the risk of COVID-19 complications. (unav.edu)
Patients are mostly young and late diagnosis, which means thicker tumors (thicker than 1 mm, or Breslow index ≥1 mm: the Breslow index is the measurement in mm of the vertical thickness of the primary tumor) and/or involvement of regional lymph nodes, causes a greater risk of developing a disseminated disease. (hindawi.com)
Previous studies have established CA125 as a tumor-microenvironment factor that can be detected and found elevated (above normal 35 U/ml levels) in the serum of up to 40% of FL patients and other NHL patients. (spandidos-publications.com)

These updates were reflected in the withdrawal of the 1987 FDA guidance and publication in 2012 of a question and answer (Q&A) document intended to explain how to use the LAL assay in support of patient safety assays for product release and process development. (pharmaceuticalonline.com)

At the AUA2021 Virtual Experience, the first US group to identify this complication reported that patients with COVID-19, especially those with CAC, have increased levels of inflammatory cytokines in their urine. (renalandurologynews.com)
Michael Chancellor, MD, of the Beaumont Health System and Oakland University Beaumont School of Medicine in Royal Oak, Michigan, and colleagues asked 53 patients with COVID-19 (discharged from the hospital with normal kidney function) and 12 uninfected patients (control group) to provide a urine sample and complete the AUA/Urology Care Foundation Overactive Bladder (OAB) assessment tool. (renalandurologynews.com)
Most patients with COVID-19 did not display virus in their urine upon PCR testing, according to the investigators. (renalandurologynews.com)
Monitor renal function, including blood urea nitrogen and serum creatinine, and urine output in patients at risk of developing acute renal failure. (nih.gov)

The best known dysregulation of the adaptive immune response in autoimmune diseases is the production of autoantibodies. (ugent.be)

IgE reactivity and basophil activation studies were performed in clinically defined mugwort-allergic patients. (nih.gov)
Serum sickness-like reaction (SSLR) is clinically similar to the classic or primary form described above and is attributed to many nonprotein drugs, including beta-lactam antibiotics, ciprofloxacin, sulfonamides, bupropion, streptokinase, metronidazole, and others. (medscape.com)
Clinically available immune tests are very limited, which is unfortunate because understanding the composition of immune cells circulating in the blood, and the inflammatory molecules they produce, can be extremely informative and help identify new treatments for many different diseases," says Dr. Merad. (mountsinai.org)

Actually, with the emergence of new targeted therapies for cancer and the increasing range of therapeutic options, the challenge for the clinician is to assess the unique risk/response ratio and the prognosis for each patient. (hindawi.com)

Patients and Methods: To this end, blood samples were collected from 30 osteoporotic patients, cytokines, chemokines and MMP-3 were measured with the help of ELISA and CBA. (authorea.com)
Data on risk factors, brain MRI, cognitive function evaluation and serum immune-inflammatory cytokines will be collected and analysed. (quanterix.com)

Hyperproteinemia, increased serum viscosity and hyponatremia occur in patients receiving IGIV therapy. (nih.gov)

Von Pirquet and Schick first described and popularized the term serum sickness at the turn of the 20th century, using it to describe patients who had received injections of heterologous (nonhuman) antitoxins for the treatment of diphtheria and scarlet fever . (medscape.com)

Serum sickness is an immune complex-mediated hypersensitivity reaction characterized by fever, rash, arthritis, arthralgia, and other systemic symptoms. (medscape.com)

Data on 14 heavily pre-treated patients (eight patients from CHIRON with advanced NSCLC and six patients from THETIS with recurrent melanoma) that received cNeT as monotherapy and had completed at least one post-treatment scan six weeks following dosing by the abstract cut-off date will be presented. (itbusinessnet.com)
COVID-19 was resolved in 119 cases, including 85 (57%) patients cured, 15 (10%) that died due to melanoma, and 20 (13%) that died due to COVID-19. (unav.edu)
LDH as well as S100B levels have been correlated with poor prognosis in AJCC stage III/IV melanoma patients. (hindawi.com)
In the 7th revision of the American Joint Committee on Cancer (AJCC) for melanoma staging and classification (2009), patients can be divided in four stages, from stage I and II (local disease) to stage III (locoregional disease) and stage IV (metastatic disease). (hindawi.com)
Indeed many arguments emphasize that early detection of melanoma metastasis could improve the prognosis of patients, at least for a part of them. (hindawi.com)
High-risk melanoma patients can be defined by a 50% risk of relapse despite initial optimal surgical treatment. (hindawi.com)

For the treatment of ocular surface diseases such as persistent epithelial defects, superior limbic keratoconjunctivitis, keratoconjunctivitis sicca, and neurotrophic keratopathy, autologous serum eyedrops are beneficial. (aao.org)

Two hundred and eighty-three patients out of 726 (38.98%) underwent complete vaccine prophylaxis. (rrh.org.au)

With regard to patient education on serum sickness, the patient and his or her family should be advised of the nature of the offending agent. (medscape.com)
The mechanism of many of the drugs responsible for serum sickness-like reaction is not well known. (medscape.com)

Mitochondria, endoplasmic reticulum and innate immune dysfunction in mood disorders: Do Mitochondria-Associated Membranes (MAMs) play a role? (nature.com)
The role of the innate immune system in ASNHL. (nih.gov)

Two autosomal recessive syndromes involving DNA repair indicate some interaction between the immune system and neurologic function. (medscape.com)
Immunosuppressive drugs, also known as immunosuppressive agents, immunosuppressants and antirejection medications, are drugs that inhibit or prevent the activity of the immune system. (wikipedia.org)
Meltzer A, Van de Water J. The Role of the Immune System in Autism Spectrum Disorder. (nature.com)
Many parents decide not to have their children vaccinated despite a child's immune system being more vulnerable without vaccinations. (fortherecordmag.com)
With 7 meta-analyses published on this topic between 2009 and 2017, there is little doubt that patients with major depression have, on average, have increased activity of the inflammatory system. (psychiatrictimes.com)
The researchers emphasize that the study highlights the need to improve measurements of the immune system in patients. (mountsinai.org)
Inadequate diet weakens the human immune system. (rense.com)
Dr. Meyer uses Serum Bio-Compatibility and Biofeedback testing while trying to optimize the patient's immune system. (ihealthtube.com)
CONCLUSION: Biophysics of TDI exposure substantially affects formation of TDI-albumin conjugates recognized by the immune system in association with exposure and asthma. (cdc.gov)

Primiparae showed significantly higher serum IL-1RA levels than multiparae 1 (p = .003) and 3 (p = .02) days after delivery, but not before delivery. (psychiatrist.com)

By preventing the clonal expansion of lymphocytes in the induction phase of the immune response, it affects both the cell and the humoral immunity. (wikipedia.org)
A crucial point of the immune response is the ability to distinguish between self and non-self. (ugent.be)
3 Further studies showed this response was the same as those reactions following injections of drugs into patients. (pharmaceuticalonline.com)
I. To assess the intratumoral immune response associated with increasing numbers of atezolizumab (MPDL3280A) treatments. (bcan.org)
BCG-refractory disease is defined as the absence of a complete response by 6 months in patients who have received induction and maintenance OR two induction courses of BCG. (bcan.org)
We recently reviewed the effects of immune gene variants on depression's severity and response to antidepressant treatment. (psychiatrictimes.com)
We are encouraged by the partial response and stable disease we have seen thus far with our cNeT monotherapy in heavily pre-treated patients with advanced NSCLC. (itbusinessnet.com)
The criteria should not include a specific immune test or a response to therapy. (nih.gov)
Adaptive immune response in the ear over time. (nih.gov)
Key evidence showing that ADCC plays an important role in the clinical effect of RTX was provided by the analysis of Fc gamma RIIIa (CD16a) polymorphisms, where patients carrying CD16a 158V/V genotype (associated with high affinity Fc gamma receptor) showed significantly improved objective response rates compared with FL patients carrying at least one 158F allele (associated with low affinity Fc gamma receptor) ( 20 ). (spandidos-publications.com)
This means beef-eating, especially the gristle as in the knuckles, makes for stronger artery walls and also helps protect your immune-response function in the subcutaneous 'fat' immediately below the skin, the largest organ of the human body. (rense.com)
The physician universe, sample size, and response rates by physician specialty are shown in table I. Of the participating physicians, 237 saw no patients during their assigned reporting period because of vacations, illness, or other reasons for being temporarily not in practice. (cdc.gov)
Structural elucidation of TDI-albumin conjugates is crucial to understanding the human immune response to TDI exposure. (cdc.gov)

Week 0 and week 6 pre-infusion serum samples were collected from each patient. (ecco-ibd.eu)

A drug-induced reaction should be considered in any patient who is taking medications and who suddenly develops a symmetric cutaneous eruption. (medscape.com)

The aims of this study were to examine whether there are differences in anxiety levels, the IRS, and serum PEP values between primiparae and multiparae before and after delivery. (psychiatrist.com)
The results suggest that primiparae suffer greater anxiety and have a different neuroimmune responsivity than multiparae and that the increased anxiety levels in primiparae may be related to changes in the IRS and serum PEP activity. (psychiatrist.com)
The transcriptome alterations at gene and network levels may clarify the immune-related pathophysiology and help to better define neuropsychiatric and neurological disorders. (nature.com)
High levels of serum triglycerides help mark conditions that are associated with increased risk for CHD and peripheral atherosclerosis. (cdc.gov)
Elevated levels of Apo B are frequently found in patients withatherosclerotic vascular changes and are a risk factor for atheroscelerosis. (cdc.gov)

Gene- and variant-specific efficacy of serum/glucocorticoid-regulated kinase 1 inhibition in long QT syndrome types 1 and 2. (nih.gov)

Fig. 1: Differential expression of immune genes in six disorders. (nature.com)

The immune system's lymphocyte component is divided into B cells and T cells. (medscape.com)
In the study, blood and lung fluid samples of healthy controls and 583 COVID-19 patients admitted to Mount Sinai were collected as part of the Health System's COVID-19 Biobank. (mountsinai.org)

9 Based largely on candidate-gene studies, findings indicate that common genetic variants are involved in both immune activation and depression. (psychiatrictimes.com)

Diabetes patients (n = 39) were examined by direct binding ELISA and their results were compared with healthy age-matched controls (n = 22). (scialert.net)

The mean T1/2 of clearance was prolonged in both coeliac disease (86 (24) minutes) and dermatitis herpetiformis (111 (35) minutes), compared with healthy subjects (20 (5) minutes) and coeliac patients with concomitant serum IgA deficiency (T1/2 = 17 (6) minutes). (bmj.com)
MA144 trade name] is contraindicated in patients with: · hypersensitivity to any of the active ingredients, to sulfonamide drugs or to any of the excipients (see section 6.1) · premature or newborn infants in the first 2 months of life, because of the immaturity of their enzyme systems · documented megaloblastic anaemia due to folate deficiency. (who.int)

Recent studies have shown that GD/GO patients have a disturbed gut microbiome composition, which has been associated with increased intestinal permeability. (frontiersin.org)
These results indicate that GO patients have enhanced intestinal permeability. (frontiersin.org)

For patients at risk of renal dysfunction or thrombotic events, administer Octagam 5% liquid at the minimum infusion rate practicable (2.4). (nih.gov)
The pharmacokinetics and metabolism of TRENTAL have not been studied in patients with renal and/or hepatic dysfunction. (drugs.com)

In patients over age 65 or in any person at risk of developing renal insufficiency, do not exceed the recommended dose, and infuse Octagam 5% liquid at the minimum infusion rate practicable (8.5). (nih.gov)

We sought to characterize IgE epitopes of Art v 1-sensitized patients and humanized mice for molecular immunotherapy of mugwort allergy. (nih.gov)

Induction of SGK1 via glucocorticoid-influenced clinical outcome of triple-negative breast cancer patients. (nih.gov)
Microarray technology and proteomic research will surely provide new candidates in the near future allowing more accurate definition of the individual prognosis and prediction of the therapeutic outcome and select patients for early adjuvant strategies. (hindawi.com)
CNTN1 seropositive patients were largely resistant to first-line neuropathy treatments but achieved a good outcome with escalation therapies. (lu.se)

Dr. Harkins has served as Division Chief Pulmonary Critical Care in Sleep Medicine for the last 3 years in the Department of Internal Medicine at the University of New Mexico and has been on faculty since 1999 and she has taken care of numerous hantavirus patients in the University of New Mexico ICU. (cdc.gov)

Some patients infected with SARS-CoV-2, the coronavirus that causes COVID-19, report severe de novo genitourinary symptoms that investigators have termed COVID-19-associated cystitis (CAC). (renalandurologynews.com)

A patient may experience a stinging sensation after eyedrop use because of a mismatch between the pH of the instilled eyedrops and that of the patient's tear. (aao.org)

The study hypothesized that oxidative by-product like hydrogen peroxide (H 2 O 2 ), would reacts with hemoglobin (Hb) and help to initiate autoimmunity in patients with type 1 diabetes. (scialert.net)
In view of these, the present study was hypothesized that oxidative by-products like hydrogen peroxide, would react with Hb and help to initiate autoimmunity in patients with type 1 diabetes mellitus. (scialert.net)

Immune activation: A link between food insecurity and chronic disease in people living with HIV. (uc.edu)
TRENTAL is indicated for the treatment of patients with intermittent claudication on the basis of chronic occlusive arterial disease of the limbs. (drugs.com)

CDC also has revised the patient groups recommended by the Advisory Committee on Immunization Practices (ACIP) to receive VariZIG by extending the period of eligibility for previously recommended premature infants from exposures to varicella-zoster virus during the neonatal period to exposures that occur during the entire period for which they require hospital care for their prematurity. (cdc.gov)

Patients with COVID-19 reported severe de novo symptoms on the questionnaire, including an increase in urinary urgency, frequency, and nocturia, and noted pain or pressure upon voiding. (renalandurologynews.com)
As shown in a new study out of China discloses that COVID-19 patients show an extremely low level of cholesterol inside their arteries. (rense.com)

Dr. Meyer has been trained in the mouth-body connection and she feels the patient must address the body's nutritional needs in order to experience the best overall health. (ihealthtube.com)

Despite significant recent improvements in the field of immunotherapy, cancer remains a heavy burden on patients and healthcare systems. (mdpi.com)

Thrombotic events have occurred in patients receiving IGIV therapy. (nih.gov)

Z28.03 Immunization not carried out because of immune compromised state of patient. (fortherecordmag.com)
A patient could decide not to receive the immunization for reasons of belief or group pressure, including religious belief. (fortherecordmag.com)
Sometimes a patient is delinquent in immunization status or has a lapsed schedule. (fortherecordmag.com)

The enhanced liver fibrosis (ELF)-Index predicts hepatic fibrosis superior to FIB4 and APRI in HIV/HCV infected patients. (uc.edu)
Caution is advised in repeated administration of [MA144 trade name] to patients with blood dyscrasias and those with renal hepatic failure, in whom the drugs accumulate. (who.int)

Anatomy35

Organisms18

Diseases22

Chemicals and Drugs91

Analytical, Diagnostic and Therapeutic Techniques and Equipment44

Phenomena and Processes49

Information Science3

Health Care4

Globulin10

Proteins12

Antigens4

Antibodies13

Complexes13

Concentrations6

Protein10

Antibody5

Systemic immune3

Responses8

Biomarkers5

Infection13

Inflammation10

Complex deposition2

High serum3

Tissue6

Cohort3

Tumor6

Assays1

Urine4

Dysregulation1

Clinically3

Emergence of new1

Cytokines2

Viscosity1

Heterologous1

Hypersensitivity reaction1

Melanoma6

Autologous1

Vaccine1

Sickness2

Innate immune2

System9

Significantly higher1

Response13

Samples were collected1

Reaction1

Levels5

Inhibition1

Differential1

System's2

Gene1

ELISA1

Deficiency2

Intestinal2

Dysfunction2

Octagam1

Characterize1

Outcome3

19991

Investigators1

Patient's1

Autoimmunity2

Chronic2

Occur1

COVID2

Body's1

Immunotherapy1

IGIV1

Immunization3

Hepatic2