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  • drug
  • The most commonly reported (≥2%) drug-related clinical adverse reactions of moderate to severe intensity in treatment-naïve adult patients receiving ISENTRESS compared with efavirenz were headache (4% vs 5%), insomnia (4% vs 4%), nausea (3% vs 4%), dizziness (2% vs 6%), and fatigue (2% vs 3%), respectively. (merckconnect.com)
  • Immediate discontinuation of Liptruzet is recommended in patients that become pregnant while taking this drug. (wikipedia.org)
  • counts
  • Despite the potency of boosted regimens, many HIV-infected patients receiving these regimens have incomplete viral suppression and yet maintain clinical stability and CD4 counts above nadir levels: the so called 'CD4/HIV disconnect' state. (clinicaltrials.gov)
  • kidney
  • AGE free adducts are the major form through which AGEs are excreted in urine, with AGE-peptides occurring to a lesser extent but accumulating in the plasma of patients with chronic kidney failure. (wikipedia.org)
  • Activation of RAGE induces production of a variety of cytokines, including TNFβ, which mediates an inhibition of metalloproteinase and increases production of mesangial matrix, leading to glomerulosclerosis and decreasing kidney function in patients with unusually high AGE levels. (wikipedia.org)
  • total
  • However, in contrast to FH patients, sitosterolemia patients usually have normal to moderately elevated total sterol levels and very high levels of plant sterols (sitosterol, campesterol, stigmasterol, avenosterol) and 5α-saturated stanols in their plasma. (wikipedia.org)
  • hepatic
  • No dosage adjustment of ISENTRESS is necessary for patients with mild to moderate hepatic impairment. (merckconnect.com)
  • Patients have markedly reduced whole-body cholesterol biosynthesis associated with suppressed hepatic, ileal, and mononuclear leukocyte hydroxymethylglutaryl-coenzyme A reductase (HMG-CoA reductase), the rate-controlling enzyme in the cholesterol biosynthetic pathway. (wikipedia.org)
  • Liptruzet is not safe to use in patients with active liver disease or unexplained persistent elevations in hepatic transaminase. (wikipedia.org)
  • atorvastatin
  • Anacetrapib is the fourth CETP inhibitor being tried for cardiovascular benefit In a 2014 study in 165 Japanese patients Evacetrapib decreased CETP activity alone or in combination with atorvastatin. (wikipedia.org)
  • plasma
  • Plasma sitosterol levels in sitosterolemia patients are 10-25 times higher than in normal individuals (8-60 mg/dl). (wikipedia.org)
  • blood
  • Patients will have blood samples collected at 5 time points (screening, baseline, Week 4, Week 8, and Week 12). (clinicaltrials.gov)
  • Boston)--Despite current guidelines that recommend newly diagnosed high-cholesterol patients have a TSH blood test done to make sure they do not have hypothyroidism, researchers from Boston University School of Medicine (BUSM) and Boston Medical Center (BMC) have found that only about half of these patients were screened for thyroid dysfunction. (bio-medicine.org)
  • Current guidelines recommend that patients newly diagnosed with high cholesterol should have a TSH blood test done to make sure they do not have hypothyroidism. (bio-medicine.org)
  • dysfunction
  • We performed this retrospective study to see how many patients with newly diagnosed high cholesterol were having their thyroid function checked and found that only about half of these patients were screened for thyroid dysfunction, despite current guidelines," explained corresponding author Elizabeth Pearce, MD, associate professor of medicine at BUSM and endocrinologist at BMC. (bio-medicine.org)
  • risk
  • Use with caution in patients at increased risk of myopathy or rhabdomyolysis, such as patients receiving concomitant medications known to cause these conditions and patients with a history of rhabdomyolysis, myopathy or increased serum creatine kinase. (merckconnect.com)
  • Whilst there are clear advantages to pharmaceutical companies in pursuing the licensing of repurposed drugs there are risks and costs associated with this, for example the introduction of thalidomide for multiple myeloma was seen by many analysts at the time as high risk and even dangerous but has been hugely successful for patients and the company. (wikipedia.org)