• 2016
  • On April 3, 2016 at the American College of Cardiology cardiologists first saw the data for Eli Lilly's ACCELERATE trial of Evacetrapib involving 12,000 patients. (wikipedia.org)
  • counts
  • Despite the potency of boosted regimens, many HIV-infected patients receiving these regimens have incomplete viral suppression and yet maintain clinical stability and CD4 counts above nadir levels: the so called 'CD4/HIV disconnect' state. (clinicaltrials.gov)
  • kidney
  • Based on TCM theory, the generation of hyperlipidemia has a close relationship with the liver, spleen, kidney, and diet. (biomedcentral.com)
  • AGE free adducts are the major form through which AGEs are excreted in urine, with AGE-peptides occurring to a lesser extent but accumulating in the plasma of patients with chronic kidney failure. (wikipedia.org)
  • Activation of RAGE induces production of a variety of cytokines, including TNFβ, which mediates an inhibition of metalloproteinase and increases production of mesangial matrix, leading to glomerulosclerosis and decreasing kidney function in patients with unusually high AGE levels. (wikipedia.org)
  • criteria
  • Patients who satisfy the entry criteria at screening visit will have a 4-week Therapeutic Lifestyle Changes (TLC) diet control period during which all lipid-lowering medications will be discontinued. (clinicaltrials.gov)
  • atorvastatin
  • Anacetrapib is the fourth CETP inhibitor being tried for cardiovascular benefit In a 2014 study in 165 Japanese patients Evacetrapib decreased CETP activity alone or in combination with atorvastatin. (wikipedia.org)
  • levels
  • The importance of plasma TG as an independent risk factor for CAD was recognized after the publication of a meta-analysis by Austin et al 19,20 in 2000, which provided support for the earlier observation that plasma TG levels predict relative risk in relatives of FCHL patients. (ahajournals.org)
  • However, in contrast to FH patients, sitosterolemia patients usually have normal to moderately elevated total sterol levels and very high levels of plant sterols (sitosterol, campesterol, stigmasterol, avenosterol) and 5α-saturated stanols in their plasma. (wikipedia.org)
  • Plasma sitosterol levels in sitosterolemia patients are 10-25 times higher than in normal individuals (8-60 mg/dl). (wikipedia.org)
  • coenzyme
  • Patients have markedly reduced whole-body cholesterol biosynthesis associated with suppressed hepatic, ileal, and mononuclear leukocyte hydroxymethylglutaryl-coenzyme A reductase (HMG-CoA reductase), the rate-controlling enzyme in the cholesterol biosynthetic pathway. (wikipedia.org)
  • blood
  • Patients will have blood samples collected at 5 time points (screening, baseline, Week 4, Week 8, and Week 12). (clinicaltrials.gov)
  • Boston)--Despite current guidelines that recommend newly diagnosed high-cholesterol patients have a TSH blood test done to make sure they do not have hypothyroidism, researchers from Boston University School of Medicine (BUSM) and Boston Medical Center (BMC) have found that only about half of these patients were screened for thyroid dysfunction. (bio-medicine.org)
  • Current guidelines recommend that patients newly diagnosed with high cholesterol should have a TSH blood test done to make sure they do not have hypothyroidism. (bio-medicine.org)
  • Yirui capsules are an innovative Chinese Medicine which are designed to improve the blood lipid state in patients with hyperlipidemia. (biomedcentral.com)
  • high
  • Between one and 13 percent of patients with high cholesterol are thought to have hypothyroidism. (bio-medicine.org)
  • Thyroid function was checked within six months of the high cholesterol diagnosis in 49.5 percent of the patients. (bio-medicine.org)
  • We performed this retrospective study to see how many patients with newly diagnosed high cholesterol were having their thyroid function checked and found that only about half of these patients were screened for thyroid dysfunction, despite current guidelines," explained corresponding author Elizabeth Pearce, MD, associate professor of medicine at BUSM and endocrinologist at BMC. (bio-medicine.org)
  • Whilst there are clear advantages to pharmaceutical companies in pursuing the licensing of repurposed drugs there are risks and costs associated with this, for example the introduction of thalidomide for multiple myeloma was seen by many analysts at the time as high risk and even dangerous but has been hugely successful for patients and the company. (wikipedia.org)
  • strongly
  • This could strongly impact medical practice by placing many patients on statin prophylaxis who otherwise would have been untreated. (wikipedia.org)