Patients dapsone. Medical search. Frequent questions

Dapsone overdose is a well-known potent cause of methemoglobinemia and hemolytic anemia. (nih.gov)
Methemoglobinemia occurs in about 15 % of patients treated with long-term dapsone at standard doses (100 mg/day). (wikipedia.org)
Methemoglobinemia (MetHb), which is characterized by an increased methemoglobin level, is a rare but potentially fatal disorder caused by congenital enzyme deficiencies or exposure to oxidizing agents, including dapsone. (koreamed.org)
Methemoglobinemia may not resolve or may rebound after initial response to therapy with methylene blue in patients with methemoglobinemia associated with aryl amines (e.g., aniline) or sulfa drugs (e.g., dapsone). (drugs.com)
2010. Pathophysiologic mechanisms, diagnosis, and management of dapsone-induced methemoglobinemia. (cdc.gov)
2000. Acute dapsone exposure and methemoglobinemia in children: treatment with multiple doses of activated charcoal with or without the administration of methylene blue. (cdc.gov)

Evaluation of Prospective HLA-B*13:01 Screening to Prevent Dapsone Hypersensitivity Syndrome in Patients With Leprosy. (bvsalud.org)
Here we are reporting a rare case so called dapsone syndrome or DHS (Dapsone Hypersensitivity Syndrome), which include skin eruption (rash), fever and internal organ involvement like hepatobiliary, pulmonary, hematological and neurological and others. (longdom.org)
Dr. Adam Friedman, director of the Supportive Oncodermatology Clinic at George Washington School of Medicine and Health Sciences in Washington, DC, said, "While the findings are interesting, and certainly in line with where we are heading with personalized medicine, the incidence of dapsone hypersensitivity syndrome is quite low, ranging from 0.5%-3% of those on the medication. (medscape.com)

Standard treatment for leprosy is multidrug therapy with dapsone, rifampin, and clofazimine ( 1 ). (cdc.gov)
Dapsone, also known as 4,4'-sulfonyldianiline (SDA) or diaminodiphenyl sulfone (DDS), is an antibiotic commonly used in combination with rifampicin and clofazimine for the treatment of leprosy. (wikipedia.org)
Dapsone is commonly used in combination with rifampicin and clofazimine for the treatment of leprosy. (wikipedia.org)
What are rifampicin, dapsone and clofazimine? (thehindu.com)

Systemic exposure to dapsone in PK patients was low. (mssm.edu)
ABSTRACT The study was designed to determine the acetylator status in patients with systemic lupus erythematosus (SLE) and compare it to a matched group of healthy volunteers. (who.int)
All patients were on systemic immunosuppression at the time of surgery (dapsone, azathioprine, cyclophsophamide, or combinations) and were treated with peri-operative oral corticosteroids. (uveitis.org)
TPP Canada authorized the sale of this biologic therapy in October 2004, for the treatment of patients with moderate-to severe chronic plaque psoriasis who are candidates for systemic therapy or phototherapy. (skintherapyletter.com)
Pneumocystis jirovecii is a common cause of pneumonia in immunosuppressed patients, especially in those infected with human immunodeficiency virus (HIV) and in those receiving systemic corticosteroids. (msdmanuals.com)
Patients with PaO2 70 mm Hg receive systemic corticosteroids. (msdmanuals.com)
OR, 60.8 for dapsone-induced drug rash, eosinophilia and systemic symptoms. (medscape.com)

OBJECTIVE: This study looked at whether oral vitamin C and vitamin E would protect the erythrocyte from oxidant damage caused by dapsone in patients with dermatitis herpetiformis. (mcmaster.ca)
RESULTS: Statistical analysis of the results suggests that oral administration of 800 units of vitamin E daily for 4 weeks confers partial protective effect against dapsone-induced hemolysis in patients with dermatitis herpetiformis. (mcmaster.ca)
Dermatitis herpetiformis, an intensively itching and blistering skin disease related to gluten-sensitive enteropathy, is such an excellent example of IgA-mediated neutrophil-directed skin disease highly responsive to dapsone treatment [1]. (scirp.org)

Avoid coadministration of dapsone topical with oral dapsone or antimalarial medications because of the potential for hemolytic reactions. (medscape.com)
Dapsone is the recommended treatment for erythema elevatum diutinum, as a review found that using oral dapsone alone was effective in 80% of early cases of the disease. (wikipedia.org)

ACZONE (dapsone) Gel, 7.5%, contains dapsone, a sulfone, in an aqueous gel base for topical dermatologic use. (rxlist.com)
Dapsone Tablets, USP 100 mg contains dapsone. (who.int)

The treatment for this variation is a combination of two antibiotics (dapsone and rifampicin). (drdrew.com)

The side-effect is more common and severe in those with glucose-6-phosphate dehydrogenase deficiency, leading to the dapsone-containing antimalarial combination Lapdap being withdrawn from clinical use. (wikipedia.org)

Dapsone, a sulfone class of medication developed in 1908, has been extensively and confidently utilized by dermatology physicians over a century. (scirp.org)

Hemolysis is the most prominent side-effect, occurring in about 20 % of patients treated with dapsone, although it is dose-related. (wikipedia.org)
The DDS and MADDS levels and different pharmacokinetic parameters after a single dose of dapsone and at steady state in leprotic patients have been studied. (leprosy-information.org)
From these results, it could be concluded that 100 mg daily dose is sufficient to maintain plasma therapeutic concentration in leprotic patients in Indian population. (leprosy-information.org)
Note: may need higher dose in patients with central nervous system disease. (cdc.gov)
Need to decrease dose in patients with renal impairment. (cdc.gov)
Patient tolerated dapsone with no reported adverse effects and continues on low dose dapsone, as he will remain on afatinib indefinitely. (cdlib.org)
After an overnight fast, each participant received a single oral dose of 100 mg dapsone. (who.int)
Après un jeûne d'une nuit, chaque participant s'est vu administrer une dose unique de 100 mg de dapsone par voie orale. (who.int)
Therapy with high-dose dexamethasone (HD-DXM) in previously untreated patients affected by idiopathic thrombocytopenic purpura: a GIMEMA experience. (medscape.com)
The mean dose of dapsone was 94.5 mg/d and the mean duration of dapsone-induced cADRs was 30.4days. (medscape.com)

Dapsone treatment was partly effective but complete healing of the EED lesions was achieved only after the introduction of a strict gluten-free diet. (gastrolab.net)

SEE NAMCS PATIENT DATASET NAMES FOR DSN ABSTRACT General Information This material provides documentation for users of the Micro-Data tapes of the National Ambulatory Medical Care Survey (NAMCS) conducted by the National Center for Health Statistics. (cdc.gov)

Aczone ( dapsone ) Gel, 5% is a sulfone drug indicated for the topical treatment of acne vulgaris . (rxlist.com)
ACZONE ® (dapsone) Gel, 7.5%, is indicated for the topical treatment of acne vulgaris in patients 12 years of age and older. (rxlist.com)
A topical form of dapsone is also effective with potentially less side effects. (wikipedia.org)
OBJECTIVE: We sought to evaluate efficacy, safety, tolerability, and pharmacokinetics (PK) of once-daily topical dapsone 7.5% gel. (mssm.edu)
CONCLUSION: Once-daily topical dapsone 7.5% gel used for 12 weeks was safe, effective, and well tolerated in preadolescent patients with acne. (mssm.edu)
The patient was treated with topical steroids plus daily Dapsone 100 mg and weekly steroid injections (40 mg). (bvsalud.org)
This case of MMP in a young female patient was effectively managed with a combination therapy of topical steroids, Dapsone and steroid injections. (bvsalud.org)
A comparison of oral and topical corticosteroids in patients with bullous pemphigoid. (bvsalud.org)
Dapsone is the first newmolecule in a decade approvedby the FDA for the topical treatment of acne vulgaris,and Aczone Gel 5% combines dapsone in a SolventMicroparticulate gel, enabling dapsone to be appliedtopically. (pharmacytimes.com)

There are no clinical trials but there are many case reports that dapsone is effective at doses of 25 mg/day to 200 mg/day for treatment of relapsing polychondritis. (wikipedia.org)
In addition, results of a small clinical trial showed efficacy of dapsone in patients suffered with severe COVID-19 infection. (scirp.org)
The medical community recognized not only the clinical usefulness of dapsone for the treatment of IgA-mediated neutrophil-directed skin diseases, but also delineated the mechanism of how dapsone stops the destructive effects of neutrophils. (scirp.org)
With the need to prevent complications leading to hospital admissions and the absence of proven effective treatments for COVID-19 outpatients, showing that dapsone has a net clinical benefit should be a public health priority. (biospace.com)
A perilesional excisional biopsy was done, and the histologic and immunohistochemical analysis confirmed the clinical diagnosis of MMP as the cause of desquamative gingivitis in this patient. (bvsalud.org)
The efficacy and safety profile of dapsone is well established based on the clinical experience in the treatment of HIV related condition as detailed above. (who.int)
We have conducted a retrospective study of clinical features and treatment response of LV in 24 Chinese patients. (medicaljournals.se)
Data were collected from medical records and clinical photographs of the patients. (medicaljournals.se)
[1] We report two cases of PG in a child and an adult patient, with variations in clinical presentation. (e-ijd.org)
Objective: This study evaluated the clinical usefulness of mean platelet volume (MPV) for predicting functional outcomes in subarachnoid hemorrhage (SAH) patients. (koreamed.org)

Methylene blue is contraindicated in patients with G-6-PD deficiency due to risk of hemolytic anemia. (drugs.com)
Berlin G, Brodin B, Hilden J. 1985.Acute dapsone intoxication: a case treated with continuous infusion of methylene blue, forced diuresis, and plasma exchange. (cdc.gov)

Dapsone is effective and safe in persons with moderate, severe, or refractory cutaneous lupus erythematosis. (wikipedia.org)
Patients with this uncommon, self-limited condition usually present with fever and nonspecific cutaneous lesions. (medscape.com)
Some patients experience recurrences of the cutaneous eruption upon reintroduction of the chemotherapeutic regimens. (medscape.com)
Chorzelski et al in 1999[7] described paraneoplastic pemphigus with cutaneous and serologic features of pemphigus foliaceus in a patient with an underlying lymphoma. (medscape.com)
In a systematic review and meta-analysis, Dr. Manupat Lohitnavy of Naresuan University in Phitsanulok and colleagues found that HLA-B*1301 is associated with dapsone-induced cutaneous drug reactions (cADRs) in Chinese and Thai patients. (medscape.com)

An August 2015 review notes that dapsone is reported to be effective against generalized granuloma annulare. (wikipedia.org)

The most frequent adverse events observed during treatment with dapsone were nausea, vomiting, anorexia and headache. (who.int)
Dapsone can cause several adverse reactions ranging from simple rashes to multiorgan involvement. (longdom.org)

CONCLUSION: Partial protection against dapsone-induced hemolysis by orally administered vitamin E, if confirmed as being clinically relevant by further trials, may allow clinicians to continue dapsone therapy orally in patients who develop significant hemolysis. (mcmaster.ca)
Clinicians diagnosed the patient as having lepromatous leprosy (also known as Hansen disease). (medpagetoday.com)
A genetic screening in these populations may benefit patients," he added, and clinicians should be cautious about using dapsone in these individuals. (medscape.com)

Resistance to dapsone and rifampin has been observed in many leprosy-endemic regions of the world ( 2 - 5 ). (cdc.gov)
With this program, 9 cases of dapsone resistance and 1 case of rifampin resistance were found among 72 leprosy relapse patients from 8 participating countries in 2010 ( 7 ). (cdc.gov)
Of 39 patients with origins in the Pacific Islands (n = 18), Central or South America (n = 5), Asia (n = 2), and the United States (n = 14), 1 patient had dapsone-resistant Mycobacterium leprae and 1 had dapsone- and rifampin-resistant M. leprae ( 9 ). (cdc.gov)
We expanded this previous survey by evaluating an additional 11 US leprosy patients from American Samoa and US patients from other geographic origins for susceptibility to dapsone and rifampin. (cdc.gov)
Combining these results with our previously published data, 4 of 6 US patients from American Samoa had dapsone-resistant M. leprae , and 1 of these was also resistant to rifampin. (cdc.gov)
Biopsy results of 20 US leprosy patients known to be originally from other locations given diagnoses during this time interval did not demonstrate dapsone or rifampin resistance. (cdc.gov)

Other therapies include azathioprine, mycophenolate mofetil, dapsone and vinca alkaloids. (mja.com.au)

However, dapsone can potentially cause severe side effects, meaning that sometimes steroids or other antibiotics should be used instead, although these alternative treatments are much less effective. (wikipedia.org)

Dapsone was first studied as an antibiotic in 1937. (wikipedia.org)
Initially used as an antibiotic for leprosy, dapsone has been subsequently adapted to treat several skin diseases that are pathologically characterized by tissue deposition of immunoglobulin A (IgA) and infiltration of one type of white blood cells termed neutrophils. (scirp.org)
250mg/5ml dosing option of this antibiotic for use in pediatric patients 6 months to 12 years of age. (skintherapyletter.com)

Prophylactic vitamin E to minimize potential hemolysis at the initiation of dapsone therapy may also be appropriate. (mcmaster.ca)
A case of hemolysis in a neonate from dapsone in breast milk has been reported. (wikipedia.org)
may induce or exacerbate hemolysis in these patients. (drugs.com)

These conditions are more common among patients with a history of delirium, prolonged sedation, mechanical ventilation, and acute respiratory distress syndrome. (aafp.org)
Chorioretinitis in a patients with acquired immunodeficiency syndrome (AIDS). (medscape.com)
[ 14 ] suggest that the condition is in the spectrum of other neutrophilic dermatoses that have been observed in patients with cancer: erythema elevatum diutinum, intraepidermal immunoglobulin A (IgA) pustulosis, pyoderma gangrenosum, subcorneal pustular dermatosis, Sweet syndrome (and it localized variant, neutrophilic dermatosis/pustular vasculitis of the dorsal hand), and vasculitis. (medscape.com)
It is the most common opportunistic infections classifying patients infected with human immunodeficiency virus (human immunodeficiency virus +) at the stage acquired immune deficiency syndrome. (centerwatch.com)

Dapsone is effective and safe for treatment of second-line therapy for people with chronic spontaneous urticaria in those for whom antihistamines and other first-line agents have failed. (wikipedia.org)
More recently, the critical care community has begun to recognize the need for more detailed analyses of the chronic issues that confront patients in the months to years following an ICU stay. (aafp.org)
Pneumocystis jirovecii pneumonia also increasingly concerns immunocompromised human immunodeficiency virus negative patients, due to the increasing use of immunosuppressive therapies (including corticosteroids), of anticancer cytostatics and biotherapies, in the context of grafts, transplants, but also from autoimmune or inflammatory chronic diseases. (centerwatch.com)
Indicated for thrombocytopenia associated with chronic idiopathic thrombocytopenic purpura in patients experiencing inadequate response to corticosteroids, immunoglobulins, or splenectomy. (medscape.com)

Plasma dapsone and its metabolite monoacetyldapsone levels in leprotic patients. (leprosy-information.org)
After 3 hours, plasma dapsone/monoacetyldapsone ratio was determined. (who.int)

Skin biopsies from US leprosy patients were tested for mutations associated with drug resistance. (cdc.gov)
Previously, we performed a survey of drug resistance among US leprosy patients referred to the National Hansen's Disease Programs (Baton Rouge, Louisiana, USA) during 2010-2012 ( 8 ). (cdc.gov)
A total of 305 leprosy patients consisting of tuberculoid (TT), borderline tuberculoid (BT), borderline lepromatous (BL), lepromatous leprosy (LL), as well as 200 healthy controls were enrolled in the study. (vitamindwiki.com)
The allelic frequency distribution of T and t allele (p = 0.0037), F and f allele (p = 0.0024) was significantly higher in leprosy patients and healthy controls. (vitamindwiki.com)
Leprosy patients are significantly associated with t-F-a haplotype. (vitamindwiki.com)
Paradoxically, we noted no difference in the levels of vitamin D between leprosy patients and healthy controls. (vitamindwiki.com)
Present study was carried out to find out the association of vitamin D receptor (VDR) gene polymorphism, mRNA gene expression of VDR gene and level of vitamin D with leprosy reactions and leprosy patients. (vitamindwiki.com)
Surprisingly, level of vitamin D in leprosy patients was not found to be associated with the disease and its manifestations. (vitamindwiki.com)
VDR genotypes (Fok1 and Taq1) were found to be associated with leprosy patients. (vitamindwiki.com)
Gene expression of vitamin D receptor was lower in leprosy patients in comparison to healthy controls. (vitamindwiki.com)

The Dapsone Coronavirus SARS-CoV-2 Trial (DAP-CORONA) COVID-19 study is a randomized, triple blind, placebo-controlled, parallel, multicentre trial which will evaluate the efficacy and safety of a new version of dapsone developed and patented by Pulmonem , a Canadian biotech start-up. (biospace.com)

Has been used as diagnostic (visualizing) dye † [off-label] in a variety of procedures, including sentinel lymph node biopsy in cancer patients (e.g., breast cancer patients), endoscopic evaluation of lesions in patients with GERD or Barrett's esophagus, urologic evaluation in patients with ureteral or renal pelvis injury, and thoroscopic procedures in patients with pulmonary nodules. (drugs.com)
We reported the results of our experience with cataract surgery in 20 patients (26 eyes) with biopsy-proven cicatricial pemphigoid. (uveitis.org)

Each gram of ACZONE Gel, 7.5% contains 75 mg of dapsone in an off-white to yellow gel with suspended particles. (rxlist.com)

dapsone and a caffeine metabolite [ 1 ]. (who.int)

PCP was diagnosed for 1,080 (39%) of the 2,786 pediatric AIDS patients reported to CDC through 1990. (cdc.gov)

At that time, the patient received a regimen of narrowband UV-B phototherapy and triamcinolone cream -- treatment he continued for 4 years. (medpagetoday.com)

In addition, all patients with resistance seemed to have primary resistance to dapsone because biopsies were taken before known treatment with antileprosy drugs. (cdc.gov)
Haemolytic anemia can be triggered by certain foods (fava beans) and drugs (sulphones such as dapsone, primaquines, salicylates). (lu.se)
a list of oxidative drugs should be delivered to the affected patient. (lu.se)

Post-ICU patients at higher risk of posttraumatic stress disorder include those who are younger, have received sedatives, have been on prolonged mechanical ventilation, and have a history of acute lung injury or traumatic brain injury. (aafp.org)

Hypersensitivity reactions occur in 1.4% of persons treated with dapsone, and can be fatal in medical settings with low resources. (wikipedia.org)

Dapsone resistance in American Samoa could have developed before implementation of multidrug therapy in this population, when dapsone was used as a monotherapy for leprosy. (cdc.gov)
Abnormalities in white blood cell formation, including aplastic anemia, are rare, yet are the cause of the majority of deaths attributable to dapsone therapy. (wikipedia.org)
For many years before the development of effective antiretroviral therapy (ART), these infections inflicted significant morbidity and mortality on patients living with AIDS. (medscape.com)
The patient was treated with dapsone and his acneiform eruption resolved within two months of initiating therapy. (cdlib.org)
Dapsone can be an effective therapy for refractory or severe cases of EGFR-induced acneiform eruptions. (cdlib.org)
As in this case, dapsone may improve patient adherence to EGFR inhibitors, thereby allowing for effective therapy of underlying malignancy. (cdlib.org)
The strategic approach that had been taken had also resulted in significant improvements in work to prevent and control leprosy, such as simplification of diagnosis and multidrug therapy through provision of blister packs free to all new patients. (who.int)
Since 1985, more than 15 million patients have been cured through multidrug therapy. (who.int)
At the beginning of 2010, that figure had fallen further to 212 000 cases, corresponding to the number of patients on multidrug therapy at that time. (who.int)
Preliminary results of an ongoing trial raise the prospect of reducing the duration of multidrug therapy currently recommended by WHO to six months for patients with multibacillary leprosy but it is still too early to draw final conclusions. (who.int)
When data are from a reference laboratory that is likely to receive referral isolates from patients who are intolerant of therapy or for whom therapy has failed, there is a potential for bias in their interpretation. (antimicrobe.org)
The dental management of these medically compromised patients can be problematic in terms of oral complications, dental therapy, and emergency care. (medscape.com)
Dr. Lohitnavy told Reuters Health, "Prior to commencing dapsone therapy for patients with Asian ancestry, a genetic screening for HLA-B*1301 gene may be beneficial. (medscape.com)

Recommending exposure avoidance is always appropriate, but is usually difficult to implement except in the most compulsive patients. (medscape.com)
Evaluation of a patient after leaving the intensive care unit involves a review of the hospital stay, including principal diagnosis, exposure to medications, period spent in the intensive care unit, and history of prolonged mechanical ventilation. (aafp.org)

Dapsone by mouth was one of the first medications used to treat moderate to severe acne vulgaris, and is still occasionally prescribed for the treatment of severe cases. (wikipedia.org)
BACKGROUND: Acne vulgaris in patients aged younger than 12 years is increasingly common and primarily noninflammatory (i.e., comedonal). (mssm.edu)
Propionibacterium levels in patients with and without acne vulgaris. (bmj.com)

All 4 dapsone-resistant isolates had distinct mutations (P55L, P55R, T53I, and T53A) in the drug resistance-determining region of the M. leprae folP 1 gene. (cdc.gov)
The data strongly suggest that these M. leprae isolates are not clonal in origin (i.e., did not originate from a single dapsone-resistant clone). (cdc.gov)
Findings indicate that at least 4 (17%) of these 23 patients were infected with dapsone-resistant M. leprae . (cdc.gov)

This is when the patient has skin lesions that, when cultured, show evidence of little or no bacteria. (drdrew.com)
The patient had been treated with ivermectin four years earlier, and reported that the lesions resolved at that time. (aafp.org)
Approximately one half of patients experience spontaneous resolution without scarring, whereas, in other patients, lesions may last for years. (aafp.org)

Our patient presented with fever, skin eruption, jaundice, and anaemia which responded to withdrawn of dapsone and intravenous steroids. (longdom.org)

Dapsone is effective and safe for adjunctive glucocorticoid-sparing treatment of persons with idiopathic thrombocytopenic purpura and is preferred over danazol or interferon alpha in those people with antinuclear antibodies. (wikipedia.org)

Specifically, in our previous study on the mechanism of dapsone in inhibiting neutrophil binding of skin we utilized a modified neutrophil adherence assay. (scirp.org)

Monitor patients for potential loss of efficacy of atovaquone if coadministration of tetracycline is necessary. (nih.gov)

Beyond the platelet count, the decision to treat is affected by individual bleeding risk, disease stage, side effects of treatment, concomitant medications, and patient preference. (mja.com.au)

Our patient is a 64-year-old Malay man who first presented in July 1993 with a history of rash starting on the hands 1½ years. (annals.edu.sg)

In this concept paper, we examine the possible use dapsone, a century-old and safe medication, to treat patients with severe cases of pulmonary COVID-19 infection. (scirp.org)
Immunosuppression resulting from HIV places a patient at risk for infection from organisms that are otherwise relatively mildly hazardous and that would normally be cleared by a competent immune system. (medscape.com)
[ 3 ] As observed in patients with hemophilia who experienced presumed transfusion-related transmission during the 1980s to 1990s, OI generally developed an average of 7 to 10 years after initial HIV infection. (medscape.com)
Cryptococcosis is a well-recognised infection in immunocompromised patients, although its prevalence varies with the type of immune defect. (annals.edu.sg)
Pneumocystis jirovecii pneumonia is a serious and frequent infection in immunocompromised patients, whose evolution is potentially fatal if untreated. (centerwatch.com)
Most patients have fever, dyspnea, and a dry, nonproductive cough that evolves over several weeks (HIV infection) or over several days (other causes of compromised cell-mediated immunity). (msdmanuals.com)

incidence of certain spontaneous disorders, The patients were diagnosed and evalu- including cancer [ 1 ]. (who.int)
For example, the patient with a significant bleeding problem or thrombocytopenia arising as a primary condition or secondary to medication, radiation, or leukemia is best managed in an in-patient environment where replacement of platelets can be provided before the procedure or afterwards if spontaneous bleeding occurs (eg, following a tooth extraction). (medscape.com)

Since dapsone is effective in treating IgA-mediated skin diseases by blocking the binding of neutrophils to the tissue site, it could also be an effective treatment for severe cases of COVID-19 lung injury, which has a similar pathological mechanism. (scirp.org)
Research conducted in our laboratory and in others has demonstrated that dapsone inhibits the binding of neutrophils to IgA. (scirp.org)
This IgA complex model system allowed us to examine the effects of neutrophil chemokine GM-CSF and dapsone on the binding of neutrophils to the IgA complex. (scirp.org)

The metabolic, pharmacokinetic and toxicological properties of dapsone have been well documented, so we understand its mechanism of action, how it's absorbed by the body and how it might minimize the inflammatory process in the lungs and reduce COVID-19 complications that lead to hospital admissions, intubation, intensive care and mortality. (biospace.com)

Patients in the PK cohort applied dapsone 7.5% gel under maximal-use conditions for eight days and a thin layer for the remaining 11 weeks. (mssm.edu)
Plasma concentrations of dapsone and metabolites were evaluated after one week in the PK cohort. (mssm.edu)

Dapsone Tablets, USP 100 mg, manufactured at Jacobus Pharmaceutical Company, Inc. was submitted to be considered for prequalification in 2014 when the product was licensed / registered in USA and subsequently accepted for the WHO list of prequalified products for the treatment of HIV/AIDS related conditions on 13 Jan 2015. (who.int)

Risk factors for lethal outcome in patients with bullous phemphigoid: low serum albumin level, high dosage of glucocorticosteroids, and old age. (bvsalud.org)
Decrease dosage in patients with impaired renal function. (cdc.gov)

Patients with gastrointestinal disorders may have limited absorption resulting in suboptimal atovaquone concentrations. (nih.gov)

In severe cases, patients may refuse treatment with EGFR inhibitors because of the significant impact on the quality of life and aesthetic discomfort. (cdlib.org)

We will first delineate the established knowledge of the therapeutic effects and the molecular mechanism of dapsone on skin diseases. (scirp.org)

The rapid resolution of this group of skin diseases, which could occur as fast as within 1 - 3 days of dapsone treatment, is well documented. (scirp.org)
Psychological morbidities, posttraumatic stress disorder, anxiety disorder, and depression also often occur in the post-intensive care unit patient. (aafp.org)
6-8 This is particularly important in children because most fatalities from malaria (∼ 85%) occur in patients younger than 5 years of age. (ashpublications.org)
The dental clinician needs to understand the potential complications that can occur as a consequence of dental treatment of a medically compromised patient and when pretreatment or post-treatment medication or emergency care is indicated. (medscape.com)

According to Dr. Bourbeau, immunomodulatory agents such as dapsone could turn out to be a significant advancement in COVID-19 therapeutics. (biospace.com)

A novel mutation of the ITGB2 gene in a Chinese Zhuang minority patient with leukocyte adhesion deficiency type 1 and glucose-6-phosphate dehydrogenase deficiency. (cdc.gov)
Therefore, a genetic screening for the HLA-B*1301 gene in patients with Asian ancestry - particularly Chinese and Thai - should be conducted. (medscape.com)

Neutrophilic eccrine hidradenitis (NEH) was initially described in acute myelogenous leukemia (AML) patients undergoing chemotherapy. (medscape.com)
More than 70% of oncology patients who develop neutrophilic eccrine hidradenitis do so after their first course of chemotherapy. (medscape.com)
Neutrophilic eccrine hidradenitis (NEH) is a neutrophilic dermatosis primarily affecting the eccrine glands and occurs most commonly in patients undergoing chemotherapy for a malignancy. (annals.edu.sg)

Organisms1

Diseases6

Chemicals and Drugs7

Methemoglobinemia6

Hypersensitivity Syndrome3

Clofazimine4

Systemic7

Dermatitis Herpetiformis3

Oral dapsone2

Contains dapsone2

Rifampicin1

Antimalarial1

Sulfone class1

Dose10

Gluten-free1

Abstract1

Topical9

Clinical10

Methylene2

Cutaneous5

Granuloma annulare1

Adverse2

Clinicians3

Rifampin6

Azathioprine1

Antibiotics1

Antibiotic3

Hemolysis3

Syndrome4

Chronic4

Monoacetyldapsone2

Leprosy patients10

Efficacy and safety1

Biopsy2

ACZONE Gel1

Metabolite1

Pediatric1

Phototherapy1

Drugs3

Acute lung i1

Reactions1

Therapy13

Exposure2

Acne Vulgaris3

Leprae3

Lesions3

Steroids1

Idiopathic1

Adherence1

Coadministration1

Medications1

Rash1

Infection6

Spontaneous2

Neutrophils3

Pharmacokinetic1

Cohort2

Jacobus Pharmaceutical Company1

Dosage2

Atovaquone1

Severe cases1

Mechanism1

Occur4

Immunomodulatory1

Gene2

Neutrophilic eccrine hidradenitis3