• Conclusions In patients with severe AS and non-obstructive coronary artery disease, with the progression of LV hypertrophy, the compensatory mechanism of increased resting flow maintains adequate perfusion at rest, but not during hyperaemia. (bmj.com)
  • Cardiotoxicity is commonly associated with the presence of cardiovascular risk factors, such as a history of hypertension or coronary artery disease. (biomedcentral.com)
  • Several authors have concluded that LVEF dysfunction and/or CHF is more frequent in patients with a history of hypertension or coronary artery disease. (biomedcentral.com)
  • Only three cases of coronary artery disease related to sorafenib treatment have been described in the literature. (biomedcentral.com)
  • In 2007, a 58-year-old white male with no history of tobacco use, hypertension, diabetes, or hypercholesterolemia, and no family history of coronary artery disease, was found to have a large solid right renal mass and associated tumor thrombus of the inferior vena cava and right atrium. (biomedcentral.com)
  • Treatment led to complete disease response within a few months, and was very well tolerated by the patient, who did not experience any of the typical adverse effects of the drug. (biomedcentral.com)
  • Coronary artery disease severity and aortic stenosis: clinical outcomes according to SYNTAX score in patients undergoing transcatheter aortic valve implantation. (ox.ac.uk)
  • AIM: The aim of this study was to evaluate whether coronary artery disease (CAD) severity exerts a gradient of risk in patients with aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI). (ox.ac.uk)
  • Background:Noonan syndrome is a rare disease, mainly presenting with malformations such as dysplasia and stenosis of the pulmonary valve, atrial septal defect and a typical pattern of hypertrophic cardiomyopathy. (medscimonit.com)
  • To test the relation between FGF21 and stable coronary artery disease and to test the FGF21 in the role of a marker for the presence of hemodynamically significant coronary artery stenosis. (cardiologyjournal.in)
  • 203 subjects were divided into subgroups based on the presence of stable coronary artery disease and hemodynamically significant coronary artery stenosis. (cardiologyjournal.in)
  • FGF21 is a clinically useful marker of hemodynamically significant coronary artery stenosis only among non - smoking stable coronary artery disease patients. (cardiologyjournal.in)
  • FGF21 cannot be used as a marker of stable coronary artery disease in general population. (cardiologyjournal.in)
  • Twenty two patients with left coronary artery disease were included in this study. (edu.au)
  • Coronary artery disease is the leading cause of death in advanced countries. (edu.au)
  • Coronary artery disease tends to develop at locations where disturbed flow patterns occur, such as the left coronary artery. (edu.au)
  • Background: Atherosclerosis is the most common cause of coronary artery disease which is formed by plaque presence inside the artery wall leading to blockage of the blood supply to the heart muscle. (edu.au)
  • It seems that reduced paraoxonase activity in human may increase risk of coronary artery disease. (ac.ir)
  • In this study serum paraoxonase phenotypes in Iranian subjects were determined and the association between paraoxonase activity and its phenotypes with coronary artery disease risk factors were estimated. (ac.ir)
  • The placebo-controlled SELECT trial tested it as a disease-modifying agent in patients with obesity and established atherosclerotic cardiovascular disease (ASCVD). (medscape.com)
  • For patients with established vascular disease who are overweight or obese, semaglutide is a disease-modifying drug. (medscape.com)
  • Preoperative CCAs were evaluated for the presence of significant coronary artery disease (CAD). (who.int)
  • Actual FFR value predicts natural history of stenoses in patients with stable coronary disease. (ox.ac.uk)
  • Polymorphic markers Ala455Val of the THBD gene and Arg353Gln of the F7 gene and association with unfavorable outcomes of coronary atherosclerosis in patients with a history of acute ischemic heart disease]. (nih.gov)
  • For several decades, coronary artery bypass grafting (CABG) has been considered as the gold standard treatment of unprotected left main coronary artery (LMCA) disease. (amrita.edu)
  • The treatment goals for patients with coronary artery atherosclerosis are to relieve symptoms of coronary artery disease (CAD) and to prevent future cardiac events, such as unstable angina, AMI, and death. (medscape.com)
  • Coronary artery disease (CAD) often oc- to any of the bilirubin forms, including curs in the absence of traditional risk fac- free unconjugated bilirubin, protein-bound tors. (who.int)
  • Accordingly, we sought to investigate the impact of arterial remodeling of intermediate lesions on long-term prognosis in patients with stable coronary artery disease. (hindawi.com)
  • Consecutive patients with stable coronary heart disease who received IVUS examination between January 2011 and January 2014 were retrospectively screened. (hindawi.com)
  • Other clinical scenarios requiring IVUS examination (restenosis, acute coronary syndrome, left main disease, and chronic total occlusion) were excluded. (hindawi.com)
  • 2014 AHA/ACC guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. (acpjournals.org)
  • The Research Unit is also performing a prospective study in patients with aortic valve disease evaluating what genes might be important in the development of narrowed heart valves in older persons. (otago.ac.nz)
  • These changes in heart function occur early on in the progression of diabetes, putting patients with diabetes at increased risk of cardiovascular disease and heart failure. (otago.ac.nz)
  • The presence of CRP, complement, and oxLDL in a high proportion of plaque tissue from patients with unstable coronary artery disease implies that these surrogate markers have important proinflammatory effects inside atherosclerotic plaques. (bmj.com)
  • Peripheral vascular disease (PVD ), or atherosclerosis of peripheral vessels, is the most common cause of symptomatic stenosis in the human vascular tree. (medscape.com)
  • The pathogenetic mechanisms that lead to PVD are similar to those of coronary artery disease (CAD). (medscape.com)
  • The program remains committed to bringing as many Parkinson's disease clinical trials and studies to Overlook Medical Center as possible, understanding the complexity of the condition and the diverse needs of these patients. (atlantichealth.org)
  • Ceramides-lipids that accumulate in tissues during hyperlipidemia and inflammation-are significantly associated with increased cardiovascular disease events, even among individuals with low low-density lipoprotein cholesterol (LDL-C) levels and no evidence of coronary stenosis. (aacc.org)
  • The researchers defined coronary artery disease (CAD) as 50% stenosis in at least one coronary artery. (aacc.org)
  • Patients with chronic kidney disease (CKD) is a very high risk cardiovascular disease population and should be treated aggressively. (medsci.org)
  • 65 years, asymptomatic cardiac stenosis, diabetes, moderate renal failure and smoking, as well as heart failure, ischaemic stroke and peripheral artery disease). (thrombosisadviser.com)
  • Objective To explore acute and late coronary outcomes and their risk/modifiers in patients with Kawasaki disease (KD). (bmj.com)
  • With intravenous immunoglobulin therapy, the risk of coronary arterial lesions for patients with Kawasaki disease has been reduced from 20-25% to 5-10% during the acute stage. (bmj.com)
  • The anatomical SYNTAX (Synergy between percutaneous coronary intervention with taxus and cardiac surgery) score (SxS) is an angiographic scoring system for assessing the complexity of coronary artery disease (CAD) [ 1 ] advocated for decision making in the latest ESC/EACTS guidelines on myocardial revascularization [ 2 ]. (hindawi.com)
  • Originally, the SxS was introduced to predict clinical outcomes in stable patients with 3-vessel and/or left main disease undergoing percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG), respectively, based on data from the SYNTAX trial [ 3 , 4 ]. (hindawi.com)
  • Therefore, in order to account for the variability of clinical parameters affecting long-term outcomes and hence better classification of patients' risk, the SYNTAX score II (SxSII) was developed by complementing SxS with 7 prognostic variables including age, creatinine clearance, left ventricular ejection fraction (LVEF), presence of unprotected left main coronary artery (ULMCA) disease, peripheral vascular disease (PVD), female gender, and chronic obstructive pulmonary disease (COPD) [ 9 ]. (hindawi.com)
  • So far, the SxSII was validated in patients with left main and multivessel disease showing more accurate patient stratification than SxS [ 10 , 11 , 12 ]. (hindawi.com)
  • Rather, relief of angina is the main reason for performance of PCI in patients with stable coronary artery disease, and this effect is frequently noted. (the-hospitalist.org)
  • Abstract Clinical research in the treatment of patients with congenital heart disease (CHD) is limited by the wide variety of CHD manifestations and therapeutic options as well as the generally low incidence of CHD. (techscience.com)
  • Mortality was 19% lower with revascularization for asymptomatic stable coronary artery disease (CAD) than with medication alone over more than 4 years' follow-up (11.9% vs 18.6%, HR 0.81, 95% CI 0.69-0.96), according to researchers led by Andrew Czarnecki, MD, MSc, of Sunnybrook Health Sciences Centre in Toronto, Ontario. (medpagetoday.com)
  • Several scoring systems have tried to determine the severity of coronary artery disease (CAD) to investigate the connection between CAD severity and laboratory parameters. (dovepress.com)
  • Since the late 1960s, the severity of coronary stenosis was suspected to be a prognostic factor for patients with coronary artery disease (CAD), 1 - 3 and this hypothesis was proven in several clinical studies with long follow-up periods. (dovepress.com)
  • Aortic stenosis (AS) is the most common valvular heart disease among Western populations and severe AS has an estimated prevalence of 3-4% among people older than 75 years of age. (cardiologyonline.com)
  • The DEFINE PCI study, which took place at centers throughout the US and Europe, shows that the current approach to PCI has limitations for identifying the locations of physiologically significant arterial lesions in patients suffering from coronary artery disease (CAD). (philips.com)
  • Dr. Joseph Schoepf and colleagues enrolled 59 patients without a history of coronary artery disease who had chest pain or abnormal cardiac blood flow exams. (diagnosticimaging.com)
  • Comparison of early and late outcomes of TAVI alone compared to TAVI plus PCI in aortic stenosis patients with and without coronary artery disease. (bvsalud.org)
  • The presence of coronary artery disease (CAD) negatively impact procedural outcomes and long-term survival after (TAVI). (bvsalud.org)
  • Risk of coronary heart disease halved, Quitting achieves immediate and long-term benefits. (who.int)
  • The patient underwent triple coronary artery bypass surgery, and sorafenib treatment was discontinued. (biomedcentral.com)
  • Patients and Methods: This study was a prospective cohort analysis of hypertensive patients who underwent cardiac catheterization at a tertiary care referral center from July 1998 to March 1999. (elsevierpure.com)
  • n = 18) underwent directional coronary atherectomy for coronary lesions. (bmj.com)
  • To assess the incremental prognostic value of SYNTAX score II (SxSII) as compared to anatomical SYNTAX Score (SxS) and GRACE risk score in patients with acute coronary syndromes who underwent percutaneous coronary intervention. (hindawi.com)
  • In patients with ACS who underwent PCI, SxSII is an independent predictor of mortality during 1-year follow-up. (hindawi.com)
  • In Group A, 127 patients underwent an initial attempt at device closure. (techscience.com)
  • Patients with severe symptomatic aortic stenosis (AS) (n = 249) that underwent TAVI were divided into two groups patients with CAD (subdivided to patients treated with TAVI alone and to patients that underwent PCI before TAVI) and patients with isolated AS. (bvsalud.org)
  • Of a cohort of 249 consecutive patients with mean age of 83.2 ± 5.5 years, 83 patients with AS + CAD were treated with TAVI alone, 61 patients with AS + CAD underwent PCI before TAVI and 105 patients underwent TAVI for isolated AS. (bvsalud.org)
  • We describe a patient who experienced an unusual cardiac event after 2 years of sorafenib treatment. (biomedcentral.com)
  • Further investigation of a larger patient population is needed to better understand cardiac damage due to TKI treatment. (biomedcentral.com)
  • These studies documented normal cardiac function and normal morphology of the coronary arteries. (biomedcentral.com)
  • A patient presenting with uncontrolled heart failure should be treated supportively with oxygen, cardiac and oximetry monitoring, intravenous access, loop diuretics, nitrates (keep in mind the potential nitrate sensitivity of patients with aortic stenosis), morphine (as needed and tolerated), and noninvasive or invasive ventilatory support (as indicated). (medscape.com)
  • Initially, these compensatory changes allow the LV to maintain cardiac output, and patients are asymptomatic. (medscape.com)
  • As the stenosis progresses, patients are unable to increase stroke volume, and as a result, they are unable to increase cardiac output so as to compensate for increases in myocardial oxygen demand. (medscape.com)
  • Acute coronary syndrome is quite chalanging to diagnose when clinical appearance or ECG pattern is not spesific and cardiac marker is not available. (researchgate.net)
  • Typically, patients with CAD are first seen after they present with a cardiac event. (medscape.com)
  • The past 4 decades have witnessed tremendous progress in the areas of acute cardiac care, coronary care unit expansion, thrombolytic usage, and PCI. (medscape.com)
  • To understand why, we will compare the function of individual human right atrial and left ventricular cardiac cells (cardiomyocytes) from coronary bypass patients who have diabetes and those who do not. (otago.ac.nz)
  • Imaging has revealed that Valerie has stenosis of the cardiac artery, although she has no symptoms associated with this. (thrombosisadviser.com)
  • Competency-based cardiac imaging for patient-centred care. (researchgate.net)
  • However, subanalyses of the SYNTAX trial and results from different studies have implied that the purely anatomy-based risk stratification of the SxS score made it prone to misclassification of patient's true risk, particularly for all-cause mortality and cardiac death in patients with stable CAD or ACS treated by PCI [ 7 , 8 ]. (hindawi.com)
  • The primary safety endpoint of freedom from cardiac death, MI, or target vessel revascularization at 30 days was achieved in 92.2% of patients in the intravascular lithotripsy trial, versus 84.4% in ORBIT II. (medscape.com)
  • CT-QCA identified 25 plaques in infarct-related coronary arteries. (escardio.org)
  • Also, 53% of patients had normal renal arteries, 28% had stenoses less than 50%, and 19.2% had stenoses of 50% or more. (elsevierpure.com)
  • The PRECISE (Percutaneous Robotically-Enhanced Coronary Intervention) study showed the efficacy and safety of robotic-assisted procedures for relatively low-risk lesions in single coronary arteries. (nih.gov)
  • Acute coronary syndrome (ACS) refers to any group of symptoms attributed to obstruction of the coronary arteries. (researchgate.net)
  • Recently, CRP was identified within early atherosclerotic lesions in human coronary arteries obtained at necropsy. (bmj.com)
  • In another study, 1 they used a more precise system by classifying the coronary vessels as non/slightly/moderately/severely/totally obstructed depending on the grade of obstruction in percental gradations from no to total stenosis, but they concentrated on the major arteries and branches. (dovepress.com)
  • For computer simulation, I develop 3D mathematical models to simulate the blood flows in human atherosclerotic arteries, to study the blood flow pattern in curved arteries with or without stenosis, and to investigate the effect of the stenosis on the wall shear stress, the pressure drop, and the flow disturbance. (monmouth.edu)
  • We report 4 cases of patients in whom we used the transradial approach to treat complex lesions in the left anterior descending coronary artery with bifurcation balloon angioplasty reconstruction (2 cases), in the ostium of the first diagonal branch, and in the right coronary artery. (nih.gov)
  • As basis for their quantification, they measured the remaining lumina in the right coronary artery, main left coronary artery and its anterior descending and circumflex branches. (dovepress.com)
  • There was no evidence of coronary obstruction, and no patient had more than mild paravalvular leak. (medscape.com)
  • Local research includes assessment of biomarkers as predictors of coronary stent re-stenosis after implantation. (otago.ac.nz)
  • Stepwise multiple regression analysis with backward elimination revealed diabetes status, sex, and fibrinogen Clauss as significant predictors of coronary score. (dovepress.com)
  • Aortic stenosis is the obstruction of blood flow across the aortic valve (see the image below). (medscape.com)
  • Regardless of the etiology, calcification of the aortic valve leads to stenosis, inevitably resulting in a fixed obstruction to LV emptying. (medscape.com)
  • 2-4 CAL may persist and even progress to stenosis or obstruction. (bmj.com)
  • Intentional laceration of the aortic leaflet during transcatheter aortic valve replacement (TAVR) may prevent the rare but fatal complication of coronary artery obstruction, a first-in-humans study suggests. (medscape.com)
  • The procedure, called BASILICA, involves an electrified guidewire that traverses and lacerates the aortic leaflet in front of the coronary artery at risk for obstruction, so that the split leaflet splays out of the way once the valve is deployed. (medscape.com)
  • High-risk features for coronary obstruction included a median coronary height of only 6.8 mm, left sinus Valsalva width of 24.3 mm, and a virtual transcatheter valve to coronary distance of 2.8 mm. (medscape.com)
  • in which delayed coronary obstruction was identified in 0.22% of 17,092 TAVRs and was associated with a 50% in-hospital death rate. (medscape.com)
  • Both Latib and Khan note that prediction of coronary obstruction is still suboptimal and that preventive strategies, such as "chimney" stenting, or extending a stent beyond the coronary ostium, have shown poor long-term outcomes and can make reengaging a coronary artery extremely difficult after TAVR. (medscape.com)
  • Richard Jabbour, MD, Imperial College London, United Kingdom, lead author of the recent study by Latib, said BASILICA could be a potential solution to delayed coronary obstruction but that it requires expertise. (medscape.com)
  • Risk Factors and Clinical Outcomes of COVID-19 Infection in Multiple Sclerosis Patients: A Retrospective St. (medscimonit.com)
  • Patient selection for both the techniques directly impacts clinical outcome. (amrita.edu)
  • tween March 2003 and August 2003 for noted that patients with early familial CAD whom clinical data were available were had a mean total serum bilirubin of 8.9 (SD included in our study. (who.int)
  • The aim of this study was to investigate the impact of arterial remodeling of intermediate coronary lesions on long-term clinical outcomes. (hindawi.com)
  • IVUS-derived negative remodeling is associated with adverse long-term clinical outcome in stable patients with intermediate coronary artery stenosis. (hindawi.com)
  • However, data regarding the long-term clinical outcomes of IVUS-guided deferral of coronary revascularization are limited. (hindawi.com)
  • The Cardiology Research Unit's areas of research involve contributing to multi-centre trials, including trials of new devices for coronary angioplasty, and clinical trials of new drugs for management of heart attacks, cholesterol levels, and arrhythmia. (otago.ac.nz)
  • Current clinical practice guidelines in Europe recommend both beta-blockers and/or CCBs as first-line therapy for symptom relief in patients with stable CAD, a class IA indication. (tctmd.com)
  • Later on, the SxS was applied to a variety of patient populations with diverse clinical presentations including those with acute coronary syndromes (ACS) undergoing primary PCI [ 5 , 6 ]. (hindawi.com)
  • The addition of clinical variables was a promising step in improving risk stratification by reclassifying patients into more accurate risk categories. (hindawi.com)
  • Unfortunately, little evidence is available to guide clinical decision-making in asymptomatic patients, as only small subsets of these patients were included in previous studies," they wrote. (medpagetoday.com)
  • For example, in one of their studies, Proudfit et al 3 concentrated on the number of severe stenoses and correlated them to clinical characteristics such as duration of the history of angina pectoris, distribution of pain, and serum cholesterol. (dovepress.com)
  • Sponsored by Philips, the DEFINE PCI study involved approximately 500 patients, and was led by investigators from the Cardiovascular Research Foundation (US), Duke Clinical Research Institute (US) and the Imperial College London (UK). (philips.com)
  • To thoroughly describe the clinical, laboratory, and electrodiagnostic features of this paralysis syndrome, we evaluated acute flaccid paralysis that developed in seven patients in the setting of acute WNV infection, consecutively identified in four hospitals in St. Tammany Parish and New Orleans, Louisiana, and Jackson, Mississippi. (cdc.gov)
  • Because understanding the clinical characteristics and underlying etiology of WNV-induced acute flaccid paralysis is critical for therapeutic decisions as well as prognosis, we describe the detailed clinical, laboratory, and electrophysiologic findings from these six patients and from one additional patient. (cdc.gov)
  • Clinical characteristics of octogenarian patients under- going percutaneous coronary intervention. (bvsalud.org)
  • Multislice computed tomography (CT) can noninvasively identify the presence of coronary plaques even in the absence of significant coronary artery stenosis. (escardio.org)
  • Hierarchical regression was performed to test the FGF21 as a marker of the hemodynamically significant coronary artery stenosis. (cardiologyjournal.in)
  • Methods Absolute coronary flow and microvascular resistance were measured by continuous thermodilution in 29 patients with AS and 29 controls, without AS, matched for age, gender, diabetes and functional severity of epicardial coronary lesions. (bmj.com)
  • Treatment of coronary intermediate lesions remains a controversy, and the role of arterial remodeling patterns determined by intravascular ultrasound in intermediate lesion is still not well known. (hindawi.com)
  • Arterial remodeling patterns were assessed in 212 deferred intermediate lesions from 162 patients after IVUS examination. (hindawi.com)
  • 72 intermediate remodeling lesions were present in 66 patients, whereas 77 negative remodeling lesions were present in 71 patients, and 63 positive remodeling lesions were present in 55 patients. (hindawi.com)
  • As a rule, percutaneous coronary intervention (PCI) with drug-eluting stent implantation for every intermediate lesion could increase the risk of stent thrombosis or restenosis, whereas deferral revascularization of high-risk intermediate lesions might be associated with a higher risk of long-term events [ 5 , 6 ]. (hindawi.com)
  • Patients were enrolled if they had de novo lesions with a visual estimation of lumen DS of 50-70% and without revascularization (balloon angioplasty and/or stent implantation) after IVUS examination. (hindawi.com)
  • Results Coronary arterial lesions occurred in 40.6% of cases at their acute febrile stages, and persisted beyond 1 month in 196 (18.3%, M/F=138/58) patients: 125 (11.6%) had small aneurysms, 44 (4.1%) had medium aneurysms, and 27 (2.5%) had giant aneurysms. (bmj.com)
  • Although IVIG use improves the initial severity of coronary lesions, it does not further modify the long-term fate of coronary aneurysms. (bmj.com)
  • 1 Despite receiving intravenous immunoglobulin (IVIG) therapy, coronary arterial lesions (CALs) occurred in 5-20% of patients with KD during the acute stage. (bmj.com)
  • Intravascular lithotripsy proved highly effective, safe, and user friendly as an adjunct to stenting for severely calcified coronary lesions at 30 days of follow-up in the pivotal Disrupt CAD III study aimed at gaining U.S. regulatory approval. (medscape.com)
  • In so doing, the intravascular lithotripsy device developed by Shockwave Medical successfully addressed one of the banes of contemporary interventional cardiology: heavily calcified coronary lesions. (medscape.com)
  • Severely calcified coronary lesions complicate percutaneous coronary intervention. (medscape.com)
  • The fact that nearly one-quarter of patients had residual ischemia despite an angiographically successful result, mostly due to focal lesions that can easily be treated, has important implications for improving outcomes of patients undergoing stent implantation globally," said Gregg W. Stone, MD, Professor of Medicine at Columbia University Medical Center. (philips.com)
  • Total LV myocardial mass and LAD-specific myocardial mass were significantly higher in patients with AS (p=0.001). (bmj.com)
  • Hyperaemic myocardial perfusion (calculated as the ratio between the absolute coronary flow subtended to the LAD, expressed in mL/min/g), but not resting, was significantly lower in the AS group (p=0.035). (bmj.com)
  • A meta-analysis of nearly 5000 patients found that statins administered before invasive procedures significantly reduced the risk for postprocedural myocardial infarction. (medscape.com)
  • MUNICH, Germany-Another study has concluded that beta-blockers have no impact on mortality beyond 1 year in post-MI stable CAD patients and offer no survival benefit in stable patients who have not had a myocardial infarction. (tctmd.com)
  • Meta--analyses have demonstrated no impact of PCI on rates of death and myocardial infarction in patients with stable angina. (the-hospitalist.org)
  • Ellis SG "How should we treat patients with silent myocardial ischemia? (medpagetoday.com)
  • METHODS AND RESULTS: A total of 445 patients with severe AS undergoing TAVI were included into a prospective registry between 2007 and 2012. (ox.ac.uk)
  • Among symptomatic patients with medically treated moderate-to-severe aortic stenosis, mortality from the onset of symptoms is approximately 25% at 1 year and 50% at 2 years. (medscape.com)
  • In severe aortic stenosis, the carotid arterial pulse typically has a delayed and plateaued peak, decreased amplitude, and gradual downslope (pulsus parvus et tardus). (medscape.com)
  • Transcatheter Aortic Valve Replacement Versus Surgical Aortic Valve Replacement: How Would You Manage This Patient With Severe Aortic Stenosis? (acpjournals.org)
  • All patients experienced severe aortic regurgitation after leaflet laceration, but no patient required hemodynamic support in the 8 to 30 minutes between BASILICA and valve deployment, or afterward, Khan reported. (medscape.com)
  • Giant coronary artery aneurysm in association with systemic arterial ectasia. (minervamedica.it)
  • The marked improvement in technique and technology makes percutaneous coronary interventions (PCIs) feasible for patients with unprotected LMCA stenosis. (amrita.edu)
  • Amsterdam, the Netherlands and New Orleans, U.S. - At the American College of Cardiology's (ACC) annual meeting in New Orleans, U.S., Royal Philips (NYSE: PHG, AEX: PHIA), a global leader in health technology, today announced the results of the DEFINE PCI [1] study, which assessed the level of residual ischemia found in patients after percutaneous coronary interventions (PCI). (philips.com)
  • The glucagon-like peptide (GLP-1) agonist semaglutide has been shown to reduce outcomes in patients with diabetes. (medscape.com)
  • Gene IL6 G(-174)C and gene IL10 G(-1082)A polymorphisms are associated with unfavourable outcomes in patients with acute coronary syndrome]. (nih.gov)
  • For scientists and clinicians who carry out research about the genesis of atherosclerosis, it has always been compelling to somehow quantify the grade of severity of coronary artery calcification and stenosis. (dovepress.com)
  • It's staggering, the level of calcification these patients had. (medscape.com)
  • The procedural success rate, defined as successful stent delivery with less than a 50% residual stenosis and no in-hospital MACE, was 92.4% in Disrupt CAD III, compared to 83.4% for orbital atherectomy in ORBIT II. (medscape.com)
  • The mean diameter stenosis preprocedure was 65.1%, dropping to 37.2% post lithotripsy, with a final in-stent residual stenosis diameter of 11.9%, with a 1.7-mm acute gain. (medscape.com)
  • Chest pain: Angina pectoris in patients with aortic stenosis is typically precipitated by exertion and relieved by rest. (medscape.com)
  • Does PCI provide symptom relief in patients with stable angina? (the-hospitalist.org)
  • More than 500,000 PCIs are done yearly worldwide in patients with stable angina. (the-hospitalist.org)
  • The Objective Randomized Blinded Investigation With Optimal Medical Therapy of Angioplasty in Stable Angina (ORBITA) trial was designed to evaluate the effect of PCI, compared with placebo, on exercise time in patients with stable angina. (the-hospitalist.org)
  • Percutaneous coronary intervention in stable angina (ORBITA): A double--blind, randomised controlled trial. (the-hospitalist.org)
  • The cohort study included patients in an Ontario registry with the Canadian Cardiovascular Society class 0 angina and substantial stenosis in a major coronary vessel (n=9,897). (medpagetoday.com)
  • Several studies [2, 3] have revealed that a significant portion of patients treated with coronary stents continue to experience chest pain (angina) following PCI, leading to an increased rate of repeat procedures and corresponding higher costs. (philips.com)
  • This article describes the results of a recently published study [1] evaluating a novel, rapid magnetocardiography (MCG) system for the assessment of coronary artery stenois in non-high risk chest pain patients under observation. (dieurope.com)
  • 22 receive less complete revascularization and have a higher risk of cardiovascular death, stroke, or MI than patients without CAD or low SS. (ox.ac.uk)
  • However, these findings should be considered hypothesis generating and not be used as justification for routine revascularization of all coronary stenosis in asymptomatic patients. (medpagetoday.com)
  • Blood oxygenation varies greatly from one patient to another depending on the severity of the anatomic defects. (wikipedia.org)
  • Male patients and intravenous γ-immunoglobulin (IVIG) therapy were independent risk factors of initial coronary severity but were not associated with the late coronary outcomes, even in severity stratified subgroups. (bmj.com)
  • Conclusions The coronary severity 1 month after KD onset is most crucial to the late coronary outcomes. (bmj.com)
  • The points were added and should represent the severity of patients' CAD. (dovepress.com)
  • The coronary score delivers a quite simple but very precise tool for the quantification of CAD severity. (dovepress.com)
  • These results show plainly the connection between CAD severity and the lipid, glucose, coagulation, and immunologic status of CAD patients, and substantiate the importance of sufficient treatment in this group of patients - in particular, CAD patients suffering from type 2 diabetes mellitus. (dovepress.com)
  • CLARIFY is a prospective, longitudinal registry tracking stable CAD patients in 45 countries. (tctmd.com)
  • Ultimately, more of these stable CAD patients should be enrolled in trials, Ellis urged. (medpagetoday.com)
  • These patients represent a diagnostic and therapeutic challenge. (escardio.org)
  • Non spesific/classic marker in diagnostic acute coronary syndrome. (researchgate.net)
  • Our physicians are conducting ongoing research to offer the most advanced diagnostic and therapeutic services available for stroke patients and those who have brain tumors, movement disorders or other neurological diseases. (atlantichealth.org)
  • One test for all: whole exome sequencing significantly improves the diagnostic yield in growth retarded patients referred for molecular testing for Silver-Russell syndrome. (cdc.gov)
  • The present study, published in the April 9 issue of JACC Cardiovascular Interventions , involved compassionate use of BASILICA in seven patients considered unsuitable for surgery and turned down for TAVR in CoreValve (Medtronic) and Sapien (Edwards Lifesciences) trials. (medscape.com)
  • Freitas1 coronary interventions (PCI) in octogenarians are increasingly indicated. (bvsalud.org)
  • Main outcome measures The acute coronary severities and late outcomes (survival free of coronary aneurysm persistence and ischaemia) were assessed. (bmj.com)
  • Among the patients with KD with coronary aneurysms, 10-year ischaemia event-free and aneurysm persistence probability was 87.5% and 20.6%, respectively. (bmj.com)
  • The only definitive treatment for aortic stenosis in adults is aortic valve replacement (surgical or percutaneous). (medscape.com)
  • Surgical aortic valve replacement (SAVR) was the standard of care until transcatheter aortic valve replacement (TAVR) was shown to have lower mortality rates in patients at the highest surgical risk and was recommended for this group in the 2014 American Heart Association/American College of Cardiology (AHA/ACC) guidelines. (acpjournals.org)
  • Transcatheter versus surgical aortic-valve replacement in high-risk patients. (acpjournals.org)
  • Currently there are no medications available to slow the progression of aortic stenosis and treatment is based on careful observation until aortic valve replacement ( AVR ), which is an invasive procedure. (otago.ac.nz)
  • We report a case of Noonan syndrome with giant coronary aneurysms.Case Report:A young woman with the phenotypic characteristics of Noonan's syndrome presented with severe pulmonary stenosis and giant coronary aneurysms. (medscimonit.com)
  • In addition to the usual abnormalities of the pulmonary valve and the ventricular myocardium, the patient showed a wide spectrum of previously unreported coronary aneurysms.Conclusions:These additional findings support the hypothesis that a vasculitic process has been superimposed on the connective tissue defect associated with Noonan's syndrome. (medscimonit.com)
  • Tetralogy of Fallot (TOF) with pulmonary stenosis is the common form of tetralogy of Fallot, and it is the focus of this article. (medscape.com)
  • Thus, a more precise evaluation of coronary plaque might be obtained. (escardio.org)
  • In the semaglutide arm, 6.5% of patients experienced a first primary outcome event vs 8.0% in the placebo arm. (medscape.com)
  • Further studies are needed to investigate the correlation of the coronary score with outcome parameters (eg, death). (dovepress.com)
  • This study investigates the hemodynamic changes to various types of coronary stenosis in the left coronary artery bifurcation, based on a patient-specific analysis. (edu.au)
  • SUSTAIN-6 showed that semaglutide reduced MACE in patients with diabetes. (medscape.com)
  • After 1 year following an MI, or in patients without prior MI, both beta-blockers and calcium antagonists may be used for symptom relief, but a mortality benefit should not be assumed," Emmanuel Sorbets, MD (Imperial College London, England), said in a late-breaking science session here at the European Society of Cardiology Congress 2018. (tctmd.com)
  • Transient lithotripsy-induced left ventricular capture occurred in 41% of patients, but they were benign events with no lasting consequences. (medscape.com)