• There are 18 alleles, with 14 amino acid sequence variants in B52. (wikipedia.org)
  • The three HLA-DQß1 amino acid positions are located together at the peptide binding groove, suggesting their functional importance in antigen presentation. (bvsalud.org)
  • At present, the most widely used ICIs in clinical immunotherapy for a variety of solid tumors are monoclonal antibodies against cytotoxic T lymphocyte antigen-4 (CTLA-4), programmed cell death protein 1 (PD-1) and their ligand PD-L1. (biomedcentral.com)
  • However, given the relatively hidden clinical features of irAE, the immature mechanism of occurrence and lack of identification of sensitive markers that may occur irAE, which makes early prediction of patients susceptible to irAE particularly difficult [ 9 ]. (biomedcentral.com)
  • The serotype identifies the more common HLA-B*52 gene products. (wikipedia.org)
  • Such as excessive activation of autoreactive T cells, excessive release of inflammatory cytokines, elevated levels of autoantibodies, and common antigens between tumors and normal tissues. (biomedcentral.com)
  • RESULTS: Using genetic, genomic, and transcriptomic high-throughput sequencing data, we established common buzzards have at least three loci that produce functional alleles at both MHC classes. (bvsalud.org)
  • In total, we characterize 91 alleles from 113 common buzzard chicks for MHC-I exon 3 and 41 alleles from 125 chicks for MHC-IIB exon 2. (bvsalud.org)
  • A recent study showed that patients with CAEBV or infectious mononucleosis have a decrease in the TCR-beta repertoire and expanded T cell clones in their peripheral blood compared with healthy carriers of EBV ( 14 ). (frontiersin.org)
  • Here, we conduct a genome-wide association study of 144 patients with HIC and 41,516 controls of Japanese ancestry. (bvsalud.org)
  • Our study reveals genetic contributions to HIC risk that may be associated with class II MHC molecule antigen presentation. (bvsalud.org)
  • Sensorineural hearing loss and vertigo have been described in adult patients with BD, but are exceptionally rare in paediatric age [ 7 ]. (biomedcentral.com)
  • Rare patients who become infected with EBV, or reactivate EBV, develop disease that does not resolve. (frontiersin.org)
  • Thus, understanding irAE and developing predictive biomarkers for their occurrence are crucial for achieving the maximum benefit-risk ratio for ICI-treated patients. (biomedcentral.com)
  • Takayasu's arteritis appears to have an independent link to B52 associated disease. (wikipedia.org)
  • Patients with CAEBV in the United States most often present with disease involving B or T cells, while in Asia, the disease usually involves T or NK cells. (frontiersin.org)
  • In addition, reduced numbers of EBV-specific T cells have been described in patients with CAEBV disease ( 10 ). (frontiersin.org)
  • Unlike healthy persons with infectious mononucleosis, patients with CAEBV disease often have low numbers of EBV-specific CD8 cells ( 10 ). (frontiersin.org)
  • The association of human leukocyte antigen (HLA) alleles and Takayasu arteritis (TA) is not fully understood. (nih.gov)
  • The frequency of HLA-B39, an allele reportedly associated with TA in Asian populations, was not higher than controls in the present study (P=0.86, OR=1.07). (nih.gov)
  • HLA-B*51 allelic and carrier frequency in Kazakhstan: insights into Behçet's disease prevalence in Central Asia. (cdc.gov)
  • Objective: To describe the demographic and clinical features, as well as the frequency of the HLA-B*51 allele in Behçet disease (BD) patients in Latin American countries. (bvsalud.org)
  • Conclusions: The prevalence of BD in the Latin American countries seems to be low, as well as the frequency of HLA-B*51 allele. (bvsalud.org)
  • B52 had higher prevalence than B67 but the OR was higher for B67. (nih.gov)
  • The HLA-B67 allele could be a new and important marker of TA because of its high OR compared to HLA-B52, although its prevalence in TA is lower. (nih.gov)
  • The serotype identifies the more common HLA-B*52 gene products. (wikipedia.org)
  • B*5201 likely formed as a result of a gene conversion event between another HLA-B allele and HLA-B*5101. (wikipedia.org)
  • HLA-DRB1 gene polymorphisms in Iranian children with Henoch-Schönlein purpura. (cdc.gov)
  • did not find IL-4 in mucocutaneous lesions of patients with BD. (medscape.com)
  • BACKGROUND: This study aimed to identify new characteristics of elderly onset large-vessel vasculitis (EOLVV) by focusing on human leucocyte antigen (HLA) genotype, polymyalgia rheumatica (PMR), and affected vascular lesions observed on positron emission tomography/computed tomography (PET/CT) imaging. (bvsalud.org)
  • METHODS: We retrospectively studied 65 consecutive Japanese patients with large-vessel vasculitis (LVV) who had extracranial vasculitis lesions and underwent PET/CT imaging. (bvsalud.org)
  • Cranial and extracranial giant cell arteritis share similar HLA-DRB1 association. (cdc.gov)
  • HLA Class I in Egyptian patients with Behçet's disease: new association with susceptibility, protection, presentation and severity of manifestations. (cdc.gov)
  • However, the strength of association between HLA-B*51 and BD remains high in our population. (bvsalud.org)
  • A total of 96 patients diagnosed with TA according to the Guideline for Management of Vasculitis Syndrome (Japanese Circulation Society 2008) and 371 healthy controls were enrolled in the present study. (nih.gov)
  • PR3-ANCA-associated vasculitis is associated with a specific motif in the peptide-binding cleft of HLA-DP molecules. (cdc.gov)