ThyrogenInterferon AlfaPapillary thyroiHypothalamusProteinIodineRecurrentMetastasesPituitaryHormoneFollicularLiverPediatric patientsThyroidectomyGravesProgression-free surChemotherapyTabletsTumorCancersEuthyroidImproves survivalChronicPrognosisOutcomesIodideFormClinicalSignificantlyDistantTreatment of patientsGeneticSymptomsDataQuality of life in patieTherapyCancerMainDiseaseDrugsCombinationEvaluationBodyStudyMultipleCare
Thyrogen10
- In addition, the medicines Nexavar (sorafenib), Lenvima (lenvatinib), Thyrogen (thyrotropin alfa) and doxorubicin were authorised for the treatment of papillary thyroid cancer. (europa.eu)
- Genzyme Corp. recently announced that the US Food and Drug Administration (FDA) has approved a supplemental indication for thyrotropin alfa for injection (Thyrogen) to be used in combination with radioiodine to ablate, or destroy, the remaining thyroid tissue in patients who have had their cancerous thyroids removed. (cancernetwork.com)
- Thyrogen is an exogenous source of human TSH that offers an additional diagnostic tool in the follow-up of patients with a history of well-differentiated thyroid cancer. (pharmacycode.com)
- Each patient was scanned first using THYROGEN, then scanned using thyroid hormone withdrawal. (thyrogen.com)
- Two prospective, randomized, phase clinical trials with a cross-over, nonblinded design, were conducted in patients with well differentiated thyroid cancer to compare 131-I WBS's obtained after Thyrogen injection to 131-I WBS's after THW. (thyrogen.com)
- Patients with residual thyroid tissue at risk for Thyrogen-induced hyperthyroidism include the elderly and those with a known history of heart disease. (thyrogen.com)
- There have been reports of death in non-thyroidectomized patients and in patients with distant metastatic thyroid cancer in which events leading to death occurred within 24 hours after administration of Thyrogen. (thyrogen.com)
- Hospitalization for administration of Thyrogen and post-administration observation in patients at risk should be considered. (thyrogen.com)
- There are post marketing reports of stroke in young women with risk factors for stroke, and neurological findings suggestive of stroke (e.g., unilateral weakness) occurring within 72 hours of Thyrogen administration in patients without known central nervous system metastases. (thyrogen.com)
- Patients should be well-hydrated prior to treatment with Thyrogen. (thyrogen.com)
Interferon Alfa1
- Hypothyroidism may also occur in patients taking amiodarone or other iodine-containing drugs, in patients taking interferon-alfa, and in patients being treated for cancer with checkpoint inhibitors or some tyrosine kinase inhibitors. (msdmanuals.com)
Papillary thyroi5
- Patients with FTC are more likely to develop lung and bone metastases than are patients with papillary thyroid cancer. (medscape.com)
- The sponsor has provided sufficient information to show that larotrectinib might be of significant benefit for patients with papillary thyroid cancer. (europa.eu)
- Some patients with papillary thyroid cancer have genetic mutations (changes) called NTRK gene fusions which result in the production of altered TRK proteins that can cause cancer. (europa.eu)
- At the time of submission of the application for orphan designation , clinical trials with the medicine in patients with papillary thyroid cancer were ongoing. (europa.eu)
- Overall, about 5% of patients with thyroid cancer have metastases beyond the cervical or mediastinal area on initial presentation, as do 2-3% of patients with papillary thyroid cancer and 11% of patients with follicular thyroid cancer. (medscape.com)
Hypothalamus2
- The hypothalamus, in the base of the brain, produces thyrotropin-releasing hormone (TRH). (wikipedia.org)
- Secondary hypothyroidism occurs when the hypothalamus produces insufficient thyrotropin -releasing hormone (TRH) or the pituitary produces insufficient TSH. (msdmanuals.com)
Protein2
- Jedna studija je pokazala da se eptakog beta veže za EPCR sa 25% do 30% većim afinitetom od eptakog alfa, istiskujući protein C sa EPCR vezivnih mjesta i smanjujući aktivaciju proteina, što doprinosi njegovom hemostatskom učinku. (wikipedia.org)
- Plasma concentrations of protein Z and protein Z-dependent protease inhibitor in patients with essential thrombocythemia. (edu.pl)
Iodine5
- Binding of thyrotropin alfa to TSH receptors on normal thyroid epithelial cells or on well-differentiated thyroid cancer tissue stimulates iodine uptake and organification. (pharmacycode.com)
- However, when the patient has been exposed to iodine in the form of medication or radiocontrast agents prior to therapy, the thyroid radioactive iodine is often too low for successful ablation. (johnshopkins.edu)
- In addition, 0.01 to 0.03 mg rhTSH administered 24 hours prior to 131 I in patients with a history of non-toxic multinodular goiter residing in an area of modestly low iodine intake, has also been shown to increase the 24-hour thyroid radioactive iodine uptake. (johnshopkins.edu)
- Conclusion: Recombinant TSH moderately increased the thyroid RAIU in subjects with depressed thyroid RAIU's during iodide administration and thus may be useful in preparing patients with non-toxic or toxic goiters and low thyroid RAIU's due to excess iodine for radioactive iodine treatment. (johnshopkins.edu)
- If iodine deficiency is severe, the patient becomes hypothyroid, a rare occurrence in the United States since the advent of iodized salt. (msdmanuals.com)
Recurrent3
- thus, radioactive iodide treatment, which is the most useful nonsurgical therapy for recurrent well-differentiated thyroid carcinoma, is not always useful in patients with Hürthle cell carcinoma. (medscape.com)
- Nevertheless, radioactive iodide treatment is used for most patients with Hürthle cell cancers after total and near-total thyroidectomy and in the treatment of patients with recurrent and metastatic Hürthle cell carcinoma. (medscape.com)
- Chemotherapy may be considered in symptomatic patients with recurrent or progressive disease. (medscape.com)
Metastases5
- Older patients have an increased risk of developing bone and lung metastases. (medscape.com)
- It could improve quality of life in patients with bone metastases. (medscape.com)
- In a study by Asari et al of 207 patients with FTC, the 127 patients with minimally invasive growth had no lymph node metastases. (medscape.com)
- According to the authors, total thyroidectomy is recommended for all patients with FTC, but patients with widely invasive FTC need more aggressive surgery because of a higher tendency toward lymph node metastases. (medscape.com)
- Caution should be exercised in patients who have substantial thyroid tissue still in situ or functional thyroid cancer metastases, specifically in the elderly and those with a known history of heart disease. (thyrogen.com)
Pituitary2
- Thyroid-stimulating hormone (also known as thyrotropin, thyrotropic hormone, or abbreviated TSH) is a pituitary hormone that stimulates the thyroid gland to produce thyroxine (T4), and then triiodothyronine (T3) which stimulates the metabolism of almost every tissue in the body. (wikipedia.org)
- The thyroid gland secretes T3 (triiodothyronine) and T4 (levothyroxine) under stimulation by TSH, the pituitary synthesis of which is downregulated with feedback loop mechanism by T3 and T4, and upregulated from hypothalamic synthesis of thyrotropin releasing hormone (TRH). (encyclopedia.pub)
Hormone3
- No thyroid hormone treatment is administered to the patient in the interim. (medscape.com)
- Hypothyroidism may occur in patients taking lithium , perhaps because lithium inhibits hormone release by the thyroid. (msdmanuals.com)
- Thyroid hormone (TH) signaling is a relevant component of the adaptive response of the myocardium to stress, and plays a critical role in regulating both heart rate and contractility of myocytes: hyperthyroidism is correlated with atrial arrhythmias, hypertension, and heart failure, and increases the risk of heart failure and mortality in cardiopathic patients [ 1 ] . (encyclopedia.pub)
Follicular2
- Current National Comprehensive Cancer Network (NCCN) guidelines recommend lobectomy plus isthmusectomy as the initial surgery for patients with follicular neoplasms, with prompt completion of thyroidectomy if invasive FTC is found on the final histologic section. (medscape.com)
- Recent trials have demonstrated improvements in progression-free and overall survival with the inclusion of the chimeric anti-CD20 monoclonal antibody rituximab (Rituxan) in chemotherapy regimens for treatment-naive and relapsed patients with advanced-stage follicular non-Hodgkin's lymphoma (NHL). (cancernetwork.com)
Liver2
- METHODS AND MATERIALS: A review of clinical data was performed to describe outcomes associated with the use of systemic therapy and/or locoregional therapies for patients with oligometastatic gastrointestinal cancers including esophagus, gastric, liver, biliary, pancreas, colorectal, and anal canal. (bvsalud.org)
- Monthly reviews were performed, including those who developed TD (as defined below) with thyrotropin (TSH) levels, full blood counts, renal and liver function tests as previously described [ 10 ]. (biomedcentral.com)
Pediatric patients1
- EBANGA (ansuvimab-zykl) is a Zaire ebolavirus glycoprotein (EBOV GP)-directed human monoclonal antibody indicated for the treatment of infection caused by Zaire ebolavirus in adult and pediatric patients, including neonates born to a mother who is RT-PCR positive for Zaire ebolavirus infection. (biologicshq.com)
Thyroidectomy3
- Jillard et al reported that post-thyroidectomy 131 I therapy improves survival in patients with Hürthle cell carcinoma. (medscape.com)
- The NCCN recommends total thyroidectomy as the initial procedure only if invasive cancer or metastatic disease is apparent at the time of surgery, or if the patient wishes to avoid a second, completion thyroidectomy should the pathologic review reveal cancer. (medscape.com)
- In a prospective, randomized, phase 3 clinical trial with a cross-over, nonblinded design, 229 patients with well-differentiated thyroid cancer who had undergone total or near-total thyroidectomy were studied to compare whole body scans. (thyrogen.com)
Graves2
- Cytoflorymetric analysis of chosen markers of apoptosis CD95/CD95L (Fas/FasL) in thyroid tissues from young patients with Graves' disease and Hashimoto's thyroiditis. (edu.pl)
- Soluble intercellular adhesion molecule-1 concentrations in patients with subacute thyroiditis and in patients with Graves disease with or without ophthalmopathy. (endokrinoloji.org)
Progression-free sur3
- Trials have demonstrated prolonged progression-free survival in patients treated with maintenance rituximab using a variety of schedules following treatment with single-agent rituximab, induction or salvage chemotherapy, or salvage therapy with rituximab and chemotherapy combinations. (cancernetwork.com)
- In advanced melanoma, combination therapy with two investigational drugs-one targeting BRAF and the other the MEK pathway-achieved a median progression-free survival of 7.4 months, which rose to 10.8 months in patients who were optimally dosed, reported Jeffrey S. Weber, MD, PhD , Director of the. (ascopost.com)
- CONCLUSIONS: These data emphasize the importance of multidisciplinary collaboration and consideration of radiation therapy for patients with oligometastatic gastrointestinal cancers to improve locoregional control and progression-free survival. (bvsalud.org)
Chemotherapy2
- Olanzapine (Zyprexa), an FDA-approved antipsychotic, effectively controlled chemotherapy-induced nausea and vomiting (CINV) in patients who failed to respond to guideline-recommended antiemetic therapy in a phase III trial presented at the ASCO Annual Meeting. (ascopost.com)
- Berndt E, Kallich J, McDermott A, Xu X, Lee H, Glaspy J. Reductions in anaemia and fatigue are associated with improvements in productivity in cancer patients receiving chemotherapy. (facit.org)
Tablets1
- Information on stability for tablets and capsules to help create MCAs for patients. (sps.nhs.uk)
Tumor2
- 3] In another study by Pisanu et al,[4] in a series of 23 patients, the mean tumor size was significantly greater for carcinomas than adenomas (3.1 cm vs 1.9 cm). (medscape.com)
- Pretreatment with glucocorticoids should be considered for patients in whom tumor expansion may compromise vital anatomic structures. (thyrogen.com)
Cancers3
- Thyroid cancers are found more often in patients with a history of low-dose or high-dose external irradiation to the cervical or thyroid area. (medscape.com)
- PURPOSE: The purpose of this critical review is to provide an overview of the role and outcomes associated with the use of local therapy for patients with oligometastatic gastrointestinal cancers. (bvsalud.org)
- RESULTS: This review describes outcomes associated with current first line systemic therapy and oligometastasis directed locoregional therapy for patients with gastrointestinal cancers. (bvsalud.org)
Euthyroid1
- Most patients with goiters not caused by Hashimoto thyroiditis are euthyroid or have hyperthyroidism. (msdmanuals.com)
Improves survival1
- Pharmion Corporation announced final data from a randomized, double-blind, placebo-controlled phase III trial demonstrating that the addition of thalidomide (Thalomid) to standard treatment improves survival by 17.6 months in patients over age 75 newly diagnosed with multiple myeloma compared to standard treatment, consisting of melphalan and prednisone (MP) alone. (cancernetwork.com)
Chronic3
- Genta Incorporated announced the release of new survival analyses based on extended follow-up of patients in a randomized phase III trial of oblimersen sodium (Genasense) for relapsed or refractory chronic lymphocytic leukemia (CLL). (cancernetwork.com)
- Concentrations of soluble factors participating in regulation of apoptosis of lymphocyte from patients with chronic Lyme arthritis (preliminary report). (edu.pl)
- Plaque Psoriasis (Ps): Treatment of adult patients with moderate to severe chronic plaque psoriasis who are candidates for systemic therapy or phototherapy, and when other systemic therapies are medically less appropriate. (biologicshq.com)
Prognosis2
- the prognosis is better for younger patients than for patients who are older than 45 years. (medscape.com)
- Patients with minimally invasive disease have an excellent prognosis with a limited need for nodal surgery, according to this study. (medscape.com)
Outcomes1
- In another study done at Memorial Sloan-Kettering Cancer center,[5] outcomes of 56 patients with Hürthle cell cancer were analyzed. (medscape.com)
Iodide1
- [ 35 , 36 ] Retinoic acid therapy also may be considered in patients with Hürthle cell carcinoma that does not take up radioactive iodide, although this is not yet a standard form of therapy. (medscape.com)
Form3
- New data from the largest clinical trial in newly diagnosed patients with a life-threatening form of leukemia showed that long-term use of imatinib mesylate (Gleevec) can halt progression to advanced disease stages in the 6th year of treatment. (cancernetwork.com)
- The appendixes contain sampling errors, instructions and definitions for completing the patient record form, and lists of codes used in the survey. (cdc.gov)
- Patient visit data were obtained through use of a patient encounter form (figure 1) completed by physicians for a sample of their patient visits. (cdc.gov)
Clinical2
- Depending on clinical stage, clinical risk factors, and the treatment given, 60% to 90% of all patients can be cured of their malignancy long-term. (ascopost.com)
- 2021) conducted a prospective clinical trial to evaluate the efficacy and safety of ERT in MLD patients. (creativebiomart.net)
Significantly1
- The aim of this study is to investigate the hypothesis that the development of TD in patients treated for HCV is associated with a significantly increased likelihood of attaining SVR. (biomedcentral.com)
Distant1
- PURPOSE: In patients with extracranial oligometastatic disease, distant failure (DF) after local ablative therapies is common. (bvsalud.org)
Treatment of patients2
- Millennium Pharmaceuticals, Inc, recently announced the presentation of results from three phase III investigations of bortezomib used in various combinations, for initial treatment of patients with multiple myeloma. (cancernetwork.com)
- The treatment of patients with Hodgkin lymphoma is one of the major success stories in medical oncology. (ascopost.com)
Genetic1
- conducted a comprehensive mutational analysis of the ARSA gene in MLD patients, revealing specific genetic variants associated with disease severity. (creativebiomart.net)
Symptoms1
- Patients are often diagnosed when the disease has spread locally giving symptoms such as shortness of breath, difficulties in swallowing or changes in the voice. (europa.eu)
Data6
- Disclaimer: For the purpose of the designation, the number of patients affected by the condition is estimated and assessed on the basis of data from the European Union (EU 28), Norway, Iceland and Liechtenstein. (europa.eu)
- Early data indicate that patients in whom other treatments had failed responded to treatment with this medicine. (europa.eu)
- Data published in the New England Journal of Medicine show that oral capecitabine (Xeloda) and oxaliplatin (Eloxatin) in combination with epirubicin (Ellence) is a comparable alternative to infused fluorouracil (5-FU) and cisplatin with epirubicin in patients with previously untreated, advanced esophagogastric cancer. (cancernetwork.com)
- Available data suggest that for well-selected patients among each gastrointestinal disease subsite, the use of local therapy is associated with favorable disease control and possible survival benefit. (bvsalud.org)
- Please don't share patient identifiable data with us by email. (sps.nhs.uk)
- Documentation of the 1989 NAMCS Micro-Data Tape for Patient visits is contained in a separate report. (cdc.gov)
Quality of life in patie1
- Alexander M, Kewalramani R, Agodoa I, Globe D. Association of anemia correction with health related quality of life in patients not on dialysis. (facit.org)
Therapy3
- Ongoing trials are evaluating the optimal use of rituximab (maintenance vs retreatment) and the benefit of rituximab maintenance following treatment of therapy-naive patients treated with rituximab-containing chemoimmunotherapy induction regimens. (cancernetwork.com)
- We enrolled 19 patients who developed TD while receiving combination therapy in a major tertiary referral hospital, New South Wales (NSW), Australia. (biomedcentral.com)
- Sequential changes in serum TPO following radioiodine therapy of patients witrh differentiated thyroid carcinoma. (endokrinoloji.org)
Cancer8
- For patient education information, see the Thyroid Cancer Directory . (medscape.com)
- Patient education information on thyroid cancer is also available on the American Cancer Society Web site . (medscape.com)
- The value of the targeted agent crizotinib (Xalkori) may not be restricted to the 5% of patients with non-small cell lung cancer who have abnormalities in the ALK gene. (ascopost.com)
- Patients whose thyroid cancer has developed following radiation to the head and neck area may present with more extensive disease. (medscape.com)
- Some 5-10% of patients with thyroid cancer will die of their disease. (medscape.com)
- It was developed in the mid-1990's to meet a growing demand for more precise evaluation of fatigue associated with anemia in cancer patients. (facit.org)
- May 17, 2023 · The medications cannot be given to patients with certain medical conditions, including medullary thyroid cancer , pancreatitis, or gallstones. (gartenwerkstatt-leipzig.de)
- Fierro-Renoy F., DeGroot LJ: Serum thyroglobulin in the follow-up of patients with treated differentiated thyroid cancer. (endokrinoloji.org)
Main1
- Surgical excision is the main treatment for patients with Hürthle cell carcinoma. (medscape.com)
Disease2
- We performed a tertiary hospital-based retrospective nested case-control analysis of 19 patients treated for hepatitis C who developed thyroid disease, and 76 controls (matched for age, weight, gender, cirrhosis and aminotransferase levels) who did not develop TD during treatment. (biomedcentral.com)
- Levels of L-ascorbic acid and cadmium in the saphenous vein of patients with coronary artery disease are negatively correlated. (edu.pl)
Drugs1
- This tape, called the drug mention tape, contains information on 38,948 drugs mentioned in the national sample of 38,384 patient visits. (cdc.gov)
Combination1
- Consequently, a large and growing number of patients will be expected to undergo treatment for hepatitis C. Of those receiving combination treatment with interferon (IFN)-α and ribavirin (RBV), approximately 5-10% will develop thyroid-related complications [ 6 ]. (biomedcentral.com)
Evaluation1
- Evaluation of central motor conduction in hypothyroid and Hyperthyroid patients. (endokrinoloji.org)
Body1
- Patients were matched for age, gender, viral load, body weight, alanine and aspartate aminotransferase levels, cirrhotic state and individualised IFN-α2 treatments (either α2a or α2b). (biomedcentral.com)
Study1
- The aim of this study is to assess the chance of achieving sustained virologic response (SVR) in patients who developed TD during treatment when compared with those who did not. (biomedcentral.com)
Multiple1
- Translations must undergo a rigorous methodology under the guidance of FACIT.org which includes multiple translators, QA steps and cognitive interviews with patients. (facit.org)
Care2
- Description of the National Ambulatory Medical Care Survey Introduction The (NAMCS) is a national survey of patient visits to physicians' offices. (cdc.gov)
- Only visits in the offices of nonfederally employed physicians classified by the American Medical Association (AMA) or the American Osteopathic Association (AOA) as 'office-based, patient care' were included in the 1989 NAMCS. (cdc.gov)