• Thyrotropin-releasing hormone (TRH) is a hypophysiotropic hormone produced by neurons in the hypothalamus that stimulates the release of thyroid-stimulating hormone (TSH) and prolactin from the anterior pituitary. (wikipedia.org)
  • thyrotropin-releasing hormone receptor thyroid-stimulating hormone hypothalamic-pituitary thyroid axis hypothalamic-pituitary-prolactin axis Urayama A, Yamada S, Kimura R, Zhang J, Watanabe Y (December 2002). (wikipedia.org)
  • Thyrotropin releasing hormone stimulation showed blunt response of TSH but good response for prolactin. (medassocthai.org)
  • The prolactin response to thyrotropin-releasing hormone (TRH) gives evidence of the dynamics of prolactin secretion. (portlandpress.com)
  • These studies dealt with the physiology and pathophysiology of the thyroid hormone feedback regulation of TSH using thyrotropin-releasing hormone as a tool in both humans and animals. (harvard.edu)
  • Thyrotropin-releasing hormone (TRH) released from the hypothalamus stimulates secretion of thyrotropin-stimulating hormone, TSH, from the anterior pituitary. (nih.gov)
  • 4. These results suggest an abnormal regulation of the prolactin secretion in young hypertensive patients with evidence of increased sympathetic tone, supporting the concept that central dopaminergic mechanisms may be involved in the development or maintenance of essential hypertension. (portlandpress.com)
  • For most patients with symptoms of Graves disease, first-line treatment can begin with antithyroid drugs to reduce the synthesis and secretion of excess thyroid hormone. (medscape.com)
  • Minimal excess doses of T4 suppress thyrotropin (TSH) secretion from the pituitary. (medscape.com)
  • Moreover, TSH secretion was normally suppressed by T3 in 40% of the patients. (nih.gov)
  • Levothyroxine is also effective in the suppression of pituitary TSH secretion in the treatment or prevention of various types of euthyroid goiters, including thyroid nodules, Hashimoto's thyroiditis, multinodular goiter and, as adjunctive therapy in the management of thyrotropin-dependent well-differentiated thyroid cancer (see INDICATIONS AND USAGE, PRECAUTIONS, DOSAGE AND ADMINISTRATION). (nih.gov)
  • In the present study we examined the clinical value of a differential response of thyroglobulin (Tg) concentration after recombinant human thyrotropin (rhTSH) stimulation (rhTSH Tg testing) and its correlation with (131)I uptake and whole-body scanning (rhTSH-WBS) in 104 patients who had previously undergone near-total thyroidectomy and (131)I ablation for differentiated thyroid carcinoma (DTC). (unife.it)
  • The patient was given a high dose of PTU combined with lugol s solution for controlling hyperthyroidism preoperatively. (medassocthai.org)
  • While waiting for the remote effect of radiotherapy, the patient was given an antithyroid drug to control hyperthyroidism. (medassocthai.org)
  • Evidence shows that RAI treatment cures hyperthyroidism for more than 90% of patients with Graves disease or autonomous thyroid nodules. (medscape.com)
  • Treatment for subclinical hyperthyroidism is recommended for patients who are at highest risk of osteoporosis and cardiovascular disease, including those older than 65 years or with persistent serum thyrotropin level less than 0.1 mIU/L. (medscape.com)
  • Background: Autoantibody mimicry of hormone action at the thyrotropin receptor (TSH-R) and aberrant signaling of TSH-R by autoantibodies (TSH-R-Ab) causes autoimmune thyroid disease (AITD), hyperthyroidism and hypothyroidism, both of which affect millions of patients worldwide. (endocrine-abstracts.org)
  • Patients present usually with underlying hyperthyroidism or immune mediated cellular infiltration. (standardofcare.com)
  • Graves' ophthalmopathy is potentially sight threatening eye disease generally occurring in patients with hyperthyroidism or a history of hyperthyroidism due to Graves' disease . (standardofcare.com)
  • in 11 of the patients the GHRH test was repeated following methimazole-induced remission of hyperthyroidism. (curehunter.com)
  • 76 patients had persistent disease--66 unremitting/relapsing hyperthyroidism, 10 stable hypothyroidism--36 or more months after onset of disease. (curehunter.com)
  • Various sources of high iodine concentrations, such as kelp tablets, some cough medicines, amiodarone (Cordarone, Pacerone - medications used to treat certain problems with heart rhythms) and x-ray dyes may occasionally cause hyperthyroidism in patients with thyroid nodules. (aace.com)
  • Approximately 1-2% of patients with hyperthyroidism progress to thyroid storm. (medscape.com)
  • The onset of the ophthalmopathy is in aimed to investigate the prevalence and most cases concomitant with the onset severity of ophthalmopathy in Graves of hyperthyroidism, but eye disease may patients in our area (north-east of the precede or follow hyperthyroidism [ 3 ]. (who.int)
  • Monoclonal antibodies to the thyrotropin receptor: stimulating and blocking antibodies derived from the lymphocytes of patients with Graves disease. (unipi.it)
  • Human monoclonal antibodies have been generated from heterohybridomas obtained by fusing mouse myeloma cells with peripheral lymphocytes from patients with active Graves disease. (unipi.it)
  • This report characterizes four antibodies as presumptive thyrotropin receptor antibodies because they specifically inhibit thyrotropin binding and competitively inhibit thyrotropin-induced cAMP levels in human thyroid cells. (unipi.it)
  • These two antibodies do not react with human thyroid gangliosides but are strong inhibitors of thyrotropin binding to liposomes containing the high-affinity glycoprotein component from human, bovine, and rat thyroid membranes. (unipi.it)
  • We report a patient with late onset Rasmussen´s encephalitis with anti-ganglioside IgGQ1b and anti-GAD antibodies positivity, who failed immunotherapy with cytostatics, immunoglobulins and steroids. (nel.edu)
  • The biological treatment with monoclonal antibodies might be the way to stabilize patients with Rasmussen´s encephalitis, mainly late-onset, to prevent them from harmful and devastating hemispherectomy. (nel.edu)
  • Thyrotropin receptors in orbital tissues such as fibroblasts and adipocytes are the targets of such antobodies and cause the ophthalmopathy. (standardofcare.com)
  • The data unequivocally establish the pluritopic nature of the immunoglobulins in Graves disease and relate individual components or determinants of the thyrotropin receptor structure with specific autoimmune immunoglobulins. (unipi.it)
  • To test the hypothesis that, a low Se intake could protect against goiter development in autoimmune thyroiditis, we analysed the Se concentration in 20 patients with the atrophic variant of lymphocytic thyroiditis, 23 patients with Hashimoto's thyroiditis and 23 patients with non-toxic nodular (colloid) goiter. (lu.se)
  • The human leukocyte antigen (HLA) genotype may be important, since it was observed that autoimmune conditions in the APECED cohort showed HLA associations that were similar to those found in non‐APECED patients with respective autoimmune disorders 4 . (ersjournals.com)
  • Gastrin and chromogranin A (CgA) levels have been tested for the diagnosis of enterochromaffin-like cell hyperplasia (ECLH) in patients with type 1 diabetes and autoimmune atrophic gastritis but not for patients with Hashimoto's thyroiditis (HT). (karger.com)
  • Graves' ophthalmopathy, also known as thyroid-associated ophthalmopathy or thyroid eye disease may sometimes occur in patients with euthyroid or hypothyroid chronic autoimmune thyroiditis. (standardofcare.com)
  • their ability to inhibit thyrotropin-induced cAMP increases in thyroid cells competitively is complemented by more than additive agonism at low (10 pM) thyrotropin concentrations. (unipi.it)
  • Seventeen patients with a TSH-secreting adenoma, diagnosed on the basis of detectable TSH levels in the face of high free thyroid hormone concentrations and pituitary lesion at neuroimaging, underwent pituitary surgery. (nih.gov)
  • The majority (86%) of hyperthyroid patients normalized thyroid hormone concentrations and regained euthyroidism, although pituitary imaging, alpha-subunit, and alpha-subunit/TSH molar ratio normalized in only 47%, 54%, and 58% of patients, respectively. (nih.gov)
  • On examination, the patient had no clinical features of Graves disease. (cmaj.ca)
  • Critically important Graves disease occurs in 25% of patients, however sub clinical involvement with extreme ocular muscle enlargement is seen radiographically it up to 70% of patients. (standardofcare.com)
  • Approximately half the patients with GD have ocular involvement, Graves' orbitopathy. (standardofcare.com)
  • A family history of thyroid dysfunction is found in approximately half the patients with Graves' disease and the pathogenesis is strongly influenced by genetics. (standardofcare.com)
  • Kochupillai, Narayana (1998) Prevalence and significance of steatorrhea in patients with active Graves' disease American Journal of Gastroenterology, 93 (7). (ias.ac.in)
  • Objective: The aim of this study was to determine the prevalence of steatorrhea in patients with Graves' disease and to assess its significance and correlation with changes in body mass index (BMI), coefficient of fat absorption (COFA), and pancreatic exocrine function in these patients. (ias.ac.in)
  • Methods: Daily dietary fat intake, 24 h fecal fat, COFA, fecal chymotrypsin activity (as an index of pancreatic exocrine function), and total T3, T4, and TSH levels were assessed in 28 patients with active Graves' disease. (ias.ac.in)
  • Conclusion: Steatorrhea associated with a decrease in COFA can occur in a reversible manner in 46% of patients with Graves' disease. (ias.ac.in)
  • Case report This patient is a 50-year-old white woman with a past medical history of Graves' disease with significant extrathyroidal manifestations including ophthalmopathy, acropachy, and biopsy-proven PTM predominately affecting her distal anterior and lateral legs. (unscburma.org)
  • RÉSUMÉ Cette étude a évalué la prévalence et la gravité des manifestations ophtalmologiques chez les patients atteints de la maladie de Graves-Basedow (n = 68) qui se sont présentés au service de consultations externes d'endocrinologie de l'Université des Sciences médicales de Mashad entre décembre 2002 et septembre 2005. (who.int)
  • There have been few studies to evaluate with Graves disease will develop GO and the prevalence and severity of GO in Iranian severe forms affect 3% to 5% of patients. (who.int)
  • All patients with regarding the pathogenesis, pathophysio- confirmed diagnosis of Graves disease logy, and management of this disease attending the endocrine clinics of the [ 6,7 ]. (who.int)
  • It stimulates proliferation, cytokine, and hyaluronan production, and thyrotropin receptor expression by orbital fibroblasts. (eur.nl)
  • PURPOSE: Thyroglobulin (Tg) may be released from damaged residual thyroid tissues after radioactive iodine (RAI) therapy in patients with differentiated thyroid carcinoma (DTC). (koreamed.org)
  • Pacini F, Lippi F, Formica N, Elisei R, Anelli S, Ceccarelli C, Pinchera A. Therapeutic doses of iodine131 reveal undiagnosed metastases in thyroid cancer patients with detectable serum thyroglobulin levels. (rusmedserv.com)
  • This multicenter study compares the sensitivity and specificity of five immunoassays for the measurement of TBAb and introduces a novel and ultra-rapid TBAb bioassay.Methods: Serum samples from AITD patients were tested with two TSH-R binding immunoassays (Cobas e411. (endocrine-abstracts.org)
  • Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. (medscape.com)
  • Clinician feedback using a shared decision-making tool for the evaluation of patients with thyroid nodules-an observational study. (mayoclinic.org)
  • Patients with benign nodules are usually advised to have periodic follow-up examinations. (cdc.gov)
  • Prevalence of Hypothyroidism in Patients With Erdheim-Chester Disease. (nih.gov)
  • The sHT patients may present signs and characteristic symptoms of hypothyroidism such as: fatigue, weight gain, dyslipidemia, psychological disorders, cardiovascular disorders, and increased risk of coronary artery disease and mortality ( 3 3. (scielo.br)
  • Compared to patients with HFpEF, those with HFmrEF were more likely to have comorbid acute myocardial infarction, infection and coronary artery disease, had higher level of N-terminal pro B-type natriuretic peptide (NT-proBNP), cardiac troponin, blood urea nitrogen (BUN), white blood cell (WBC). (researchsquare.com)
  • And patients with HFpEF were more frequently to be female, to be older, and to have comorbid peripheral artery disease, but less frequently had AMI, CAD and kidney disease than those with HFrEF. (researchsquare.com)
  • Resultant factitious thyrotoxicosis can create diagnostic and therapeutic confusion, particularly in patients with thyroid disease. (second-opinions.co.uk)
  • A recent study demonstrated an absence of mutations in BMPR‐II in patients with PPH and connective tissue disease, thus suggesting that PPH associated with immune deregulation may have a different pathogenesis from the familial form 13 . (ersjournals.com)
  • Quality of life in patients with benign nontoxic goiter: impact of disease and treatment response, and comparison with the general population. (medscape.com)
  • Patients are often diagnosed when the disease has spread locally giving symptoms such as shortness of breath, difficulties in swallowing or changes in the voice. (europa.eu)
  • Approximately 3-5% of patients have severe disease with pain, inflammation, corneal ulceration or compressive optic neuropathy. (standardofcare.com)
  • While most patients diagnosed with DTC have a good prognosis, a significant proportion has persistent or recurrent disease. (hindawi.com)
  • Management of DTC has undergone major changes in recent years-it is now known that DTC is not a homogeneous condition and rather than employ an aggressive approach for all patients, and the trend is to risk, stratify, and individualize the treatment according to the disease characteristics. (hindawi.com)
  • TSH-suppressive therapy has been shown to be effective not only in those with persistent metastatic disease but also in "disease-free" patients to reduce the risk of recurrence. (hindawi.com)
  • In higher stage patients (stages III and IV), overall survival and disease-specific survival were improved in patients who maintained subnormal to undetectable serum TSH levels. (hindawi.com)
  • However, the potential benefits of reaching the therapeutic goal must always be balanced against possible adverse effects of subclinical thyrotoxicosis including exacerbation of angina in patients with ischemic heart disease, increased risk for atrial fibrillation in older patients, and increased risk of osteoporosis in postmenopausal women. (hindawi.com)
  • Aim This study used swept-source optical coherence tomography (SS-OCT) to investigate subfoveal choroidal thickness (SFCT) in patients with thyroid-associated ophthalmopathy (TAO) who displayed different levels of disease activity and severity. (bmj.com)
  • Undiagnosed chronic kidney disease is present in 49% of patients with type 2 diabetes mellitus in the United States, a study found. (renalandurologynews.com)
  • In a large study of patients with chronic kidney disease, metabolic acidosis independently increased the risk of progressing to end-stage renal disease and death. (renalandurologynews.com)
  • The interdependence of trajectories in patient parameters, such as albumin and white blood cell count, may suggest certain disease processes. (renalandurologynews.com)
  • In type 2 diabetes patients, a dementia diagnosis preceded vascular events such as kidney disease progression by a mean 2998 days or roughly 8 years. (renalandurologynews.com)
  • Nearly half of patients with autosomal dominant polycystic kidney disease receive at least 1 CT scan over 2 years, study finds. (renalandurologynews.com)
  • The electroencephalographic pattern is distinctive in many but not in all patients with Creutzfeldt-Jakob disease (CJD). (annals.edu.sg)
  • Visit our Journey for Patients with Thyroid Disease to learn more about Hashimoto's disease diagnosis. (aace.com)
  • Older patients who may have underlying heart disease are usually started on a low dose of levothyroxine and gradually increased, while younger, healthy patients can be started on full replacement doses at once if the blood work shows that it's necessary. (aace.com)
  • The treatment of thyroid disease depends on many factors, including the type and severity of the thyroid disorder and the age and overall health of the patient. (cdc.gov)
  • The comorbidities associated with acromegaly are known to lead to an impaired quality of life and an average 10-year reduction in life expectancy in untreated patients compared with the general population, mainly due to cardiovascular disease. (medscape.com)
  • Late in the progression of disease, patients may become stuporous or comatose with hypotension. (medscape.com)
  • Patients whose thyroid cancer has developed following radiation to the head and neck area may present with more extensive disease. (medscape.com)
  • Some 5-10% of patients with thyroid cancer will die of their disease. (medscape.com)
  • The NCCN recommends total thyroidectomy as the initial procedure only if invasive cancer or metastatic disease is apparent at the time of surgery, or if the patient wishes to avoid a second, completion thyroidectomy should the pathologic review reveal cancer. (medscape.com)
  • Patients with minimally invasive disease have an excellent prognosis with a limited need for nodal surgery, according to this study. (medscape.com)
  • A total of 83(46.9%) of the patients had appendicitis related diagnosis, 16(9.0%) of the cases resulted from trauma, 25(14.1%) had intestinal obstruction from post-operative bands, 28(15.8%) had intestinal obstruction from colonic tumours and 17(9.6%) had perforated peptic ulcer disease. (bvsalud.org)
  • Clinical presentation, thyroid function tests, and thyrotropin-receptor antibody status are key in establishing etiology. (medscape.com)
  • A patient with a high-titer GAD antibody does not always have progressive glucose intolerance. (nel.edu)
  • Levothyroxine, at doses individualized according to patient response, is effective as replacement or supplemental therapy in hypothyroidism of any etiology, except transient hypothyroidism during the recovery phase of subacute thyroiditis. (nih.gov)
  • In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction. (nih.gov)
  • 4 cm or that are diffusely spreading require total or near-total thyroidectomy with postoperative radioiodine ablation of residual thyroid tissue with appropriately large doses of iodine-131 administered when the patient is hypothyroid or after recombinant thyroid-stimulating hormone (TSH) injections. (msdmanuals.com)
  • In some patients, swelling of the muscles and other tissues around the eyes may develop, causing eye prominence, discomfort or double vision. (aace.com)
  • 10% of patients, particularly older than 60 years have atrial fibrillation. (standardofcare.com)
  • Consequently, many patients who take levothyroxine sodium for hypothyroidism are encouraged to take an over-the-counter (OTC) calcium supplement, such as calcium carbonate. (ispub.com)
  • found a positive association between hypothyroidism and cognitive impairment in a sample of elderly patients, as well as a positive association among participants with high-normal FT 4 levels and cognitive impairment after two year follow-up [ 8 ]. (biomedcentral.com)
  • Abramowicz MJ, Duprez L, Parma J, Vassart G, Heinrichs C. Familial congenital hypothyroidism due to inactivating mutation of the thyrotropin receptor causing profound hypoplasia of the thyroid gland. (medlineplus.gov)
  • Patients were randomized (1 : 1) to receive treatment of hypothyroidism with liquid L-T4 or tablet form. (hindawi.com)
  • Methods: We included 106 patients (92 females and 14 males) with CAT and 70 control subjects (53 females andm17 males) without clinical, biochemical, and ultrasonographic evidence of thyroid and neck diseases. (unipa.it)
  • We did not find any significant difference in serum selenium (S-Se) levels between the patients with the various thyroid disorders or between patients and controls. (lu.se)
  • 3. Basal prolactin, noradrenaline and normetadrenaline levels were higher in the hypertensive patients as compared with normotensive controls. (portlandpress.com)
  • Treatment with bromocriptine, a centrally acting dopaminergic agonist, lowered the blood pressure and suppressed the elevated prolactin and noradrenaline levels in the hypertensive patients. (portlandpress.com)
  • The aim of the study was to develop receiver operating characteristic (ROC) curves for gastrin and CgA levels and other clinical and biochemical parameters, as means for pretest probability of gastric ECLH in patients with HT. (karger.com)
  • Two and 4 patients with ECLH had normal gastrin and CgA levels, respectively. (karger.com)
  • Gastrin levels have high diagnostic accuracy for ECLH identification in patients with HT, and are highly specific when combined with low B 12 levels. (karger.com)
  • However, they should be interpreted with caution, as some patients may harbor gastric ECLH even if gastrin levels are not increased, necessitating further follow-up. (karger.com)
  • In addition, a β-blocker can be used initially to control tachycardia and palpitations for symptomatic patients and can be discontinued once thyroid hormone levels improve. (medscape.com)
  • Patients who do not separate these two medications by at least four hours, or who take calcium sporadically, may not consistently achieve therapeutic levels of levothyroxine. (ispub.com)
  • Serum levels of the hormone reach steady state after six weeks of therapy, and most patients continue to take the medication once a day for the rest of their lives ( 3 ). (ispub.com)
  • In a study in which patients were given a single 20 mg dose of oral hydrocortisone, peak supraphysiologic levels of cortisol were shown to occur at 2 hours in serum, saliva, and urine. (ndnr.com)
  • Serum Thyrotropin and Triiodothyronine Levels in Levothyroxine-treated Patients. (uchicago.edu)
  • Both the GMFCS levels and FMS scores improved from the third month to one-year post-surgery, after which a few patients had a worsening of their scores at the two years follow-up visit. (bvsalud.org)
  • Of the 67 dialysis patients entered in the the serum levels of thyroid hormones T3 study, full data were obtained for 57 pa- and T4 with blood urea nitrogen (BUN) tients (31 males and 26 females). (who.int)
  • However, there is a lack of analysis on the clinical characteristics of different types of elderly HF patients in geriatrics of Northeastern China.We conducted this single-center, retrospective study to evaluate the clinical characteristics of HF patients with mid-range(HFmrEF), preserved (HFpEF) and reduced ejection fraction (HFrEF) in a Chinese cohort. (researchsquare.com)
  • Heart failure (HF) is a complex clinical syndrome caused by any structural or functional impairment of ventricular filling orejection of blood[1].It has been considered as one of the major public health concerns with high mortality and economic burden of the patients all over the world. (researchsquare.com)
  • At the time of submission of the application for orphan designation , clinical trials with the medicine in patients with papillary thyroid cancer were ongoing. (europa.eu)
  • Conclusions SFCT was strongly associated with Clinical Activity Score in patients with TAO. (bmj.com)
  • This work led to Bob's single-authored landmark publication "Radioimmunoassay of Human Plasma Thyrotropin," published in the Journal of Clinical Investigation in 1965. (harvard.edu)
  • Depending on clinical stage, clinical risk factors, and the treatment given, 60% to 90% of all patients can be cured of their malignancy long-term. (ascopost.com)
  • The elevated level of thyroid hormones can result in clinical manifestations ranging from mild to severely toxic with resultant morbidity and mortality for affected patients. (medscape.com)
  • Clinical data (RECIST 1.1) were collected and patients were classified as having either durable clinical benefit (DCB) or no durable benefit (NDB). (insulin-receptor.info)
  • Open in a separate window Physique 4 Overview of the clinical and molecular features associated with DCB and NDB in NSCLC patients treated with ICIs. (insulin-receptor.info)
  • In addition, was 16 cases per 100 000 population per the clinical presentation of our patients year for females and 2.9 cases per 100 000 was compared and contrasted with that of population per year for males. (who.int)
  • The patient had received radioiodine treatment (asterisk) 12 weeks preceding coronary angioplasty with iodinated contrast (week 0, arrow). (cmaj.ca)
  • Some patients with papillary thyroid cancer have genetic mutations (changes) called NTRK gene fusions which result in the production of altered TRK proteins that can cause cancer. (europa.eu)
  • The value of the targeted agent crizotinib (Xalkori) may not be restricted to the 5% of patients with non-small cell lung cancer who have abnormalities in the ALK gene. (ascopost.com)
  • Interleukin-6 gene variation in Spanish patients with immunoglobulin-A deficiency. (cdc.gov)
  • Role of polymorphisms in the TNFRSF13B (TACI) gene in Spanish patients with immunoglobulin A deficiency. (cdc.gov)
  • Patients were randomized to receive either selenium (SE), an antioxidant (as selenium selenite, 100 (g b.i.d), or pentoxifylline (PF), an anti-inflammatory and antifibrotic agent (6. (endocrine-abstracts.org)
  • Biphasic effect of thyrotropin on invasion and growth of papillary and follicular thyroid cancer in vitro. (rusmedserv.com)
  • Overall, about 5% of patients with thyroid cancer have metastases beyond the cervical or mediastinal area on initial presentation, as do 2-3% of patients with papillary thyroid cancer and 11% of patients with follicular thyroid cancer. (medscape.com)
  • Current National Comprehensive Cancer Network (NCCN) guidelines recommend lobectomy plus isthmusectomy as the initial surgery for patients with follicular neoplasms, with prompt completion of thyroidectomy if invasive FTC is found on the final histologic section. (medscape.com)
  • Detection of BRAFV600E in Liquid Biopsy from Patients with Papillary Thyroid Cancer Is Associated with Tumor Aggressiveness and Response to Therapy. (nih.gov)
  • In addition, the medicines Nexavar (sorafenib), Lenvima (lenvatinib), Thyrogen (thyrotropin alfa) and doxorubicin were authorised for the treatment of papillary thyroid cancer. (europa.eu)
  • The sponsor has provided sufficient information to show that larotrectinib might be of significant benefit for patients with papillary thyroid cancer. (europa.eu)
  • Patients with FTC are more likely to develop lung and bone metastases than are patients with papillary thyroid cancer. (medscape.com)
  • Many patients also receive further treatment with iodine-131. (cdc.gov)
  • Lack of evidence of a role of XBP1 and PRDM1 polymorphisms in Spanish patients with immunoglobulin A deficiency. (cdc.gov)
  • Thyrotropin receptor and insulin-like growth factor-1 receptor crosstalk, orbital inflammatory infiltration and activation of orbital fibroblasts lead to perpetuation of orbital inflammation a. (endocrine-abstracts.org)
  • Orbital fibroblasts from five healthy controls and nine GO patients were collected. (eur.nl)
  • The authors report the first description of a case of primary pulmonary hypertension (PPH) in patient with APECED, caused by R257X mutation in AIRE. (ersjournals.com)
  • We measured the choroidal thickness of thyroid-associated ophthalmopathy (TAO) patients in different stages using swept-source optical coherence tomography (SS-OCT) and found that the choroidal thickness of TAO patients in the active phase increased significantly. (bmj.com)
  • in contrast, they are poor inhibitors of 125I-labeled thyrotropin binding to liposomes containing the glycoprotein component of the human thyrotropin receptor. (unipi.it)
  • 2. To evaluate further the role of dopaminergic mechanisms in hypertension three groups of young male hypertensive patients were studied and compared with healthy male volunteers. (portlandpress.com)
  • In the hypertensive patients the prolactin response to TRH was significantly attenuated. (portlandpress.com)
  • The questionnaire included details on treating hypertensive patients, cardiopulmonary resuscitation training, accessibility of medical emergency equipments in the dental clinics, prevalence of medical emergency cases in the dental office and the self-assessed competence to handle medical emergency situations in the dental clinics. (bvsalud.org)
  • Cryptococcosis is a well-recognised infection in immunocompromised patients, although its prevalence varies with the type of immune defect. (annals.edu.sg)
  • Interestingly, our data showed that diabetes was the only comorbidity different with a higher prevalence in patients in remission versus a general population of a similar median age (21.6% vs 6.9%, respectively). (medscape.com)
  • Here we examine outcomes in these 2 cohorts.Methods: Data from the EU and US sites for patients in the teprotumumab group (n =121) from the in. (endocrine-abstracts.org)
  • Patients and Methods. (hindawi.com)
  • Methods Thirty patients with TAO (60 eyes) and 38 healthy controls (67 eyes) in Shanghai, China, were recruited for this study. (bmj.com)
  • Methods Our retrospective monocentric study was based on 130 patients followed on a regular basis, with acromegaly controlled by medical treatments or cured by surgery or radiation technique. (medscape.com)
  • Ultrasonographic studies have shown a decrease in thyroid volume after 131 I therapy in the majority of patients with nontoxic goiter. (medscape.com)
  • Bahn RS, Castro MR. Approach to the patient with nontoxic multinodular goiter. (medscape.com)
  • Seven patients had low positive rhTSH Tg testing and no (131)I uptake, but 2 of these patients had cervical lymph node metastases. (unife.it)
  • Older patients have an increased risk of developing bone and lung metastases. (medscape.com)
  • In a study by Asari et al of 207 patients with FTC, the 127 patients with minimally invasive growth had no lymph node metastases. (medscape.com)
  • According to the authors, total thyroidectomy is recommended for all patients with FTC, but patients with widely invasive FTC need more aggressive surgery because of a higher tendency toward lymph node metastases. (medscape.com)
  • In another study from the National Thyroid Cancer Cooperative Study Group Registry in 1548 patients, TSH suppression improved overall survival in stage II patients with subnormal TSH versus normal or elevated serum TSH [ 2 ]. (hindawi.com)
  • L-carnitine is an amino acid that is low in the blood of depressed patients. (bipolarnews.org)
  • There are two standard blood tests of thyroid function: the measurement of thyroid hormone, usually T4, and the measurement of thyrotropin (TSH). (cdc.gov)
  • Effects of thyrotropin-releasing hormona on blood pressure and Herat rate in phobic and panic patients: A pilot study. (bvsalud.org)
  • Two blood samples was taken from Studies have shown that patients with urae- each patient, 1 immediately before and 1 mia may manifest some varie-ties of hor- immediately after haemodialysis. (who.int)
  • However, the proportion of patients having at least one metabolic complication of acromegaly at last follow-up (mean, 72 months after remission) was 27% for altered glucose tolerance or diabetes, 39% for hypertension, 34.3% for hypercholesterolemia, and 13.3% for hypertriglyceridemia. (medscape.com)
  • The aim of our study was to try to give insights on this point, based on 130 patients with acromegaly in remission or controlled and followed in a single French center, in comparison with French epidemiological data. (medscape.com)
  • The incidence of papillary thyroid carcinoma has risen over the last several decades, primarily due to the incidental discovery of small cancers in patients undergoing neck ultrasonography, MRI, CT scans, or PET scans that include the neck in the imaging field. (msdmanuals.com)
  • thus, radioactive iodide treatment, which is the most useful nonsurgical therapy for recurrent well-differentiated thyroid carcinoma, is not always useful in patients with Hürthle cell carcinoma. (medscape.com)
  • Jillard et al reported that post-thyroidectomy 131 I therapy improves survival in patients with Hürthle cell carcinoma. (medscape.com)
  • [ 35 , 36 ] Retinoic acid therapy also may be considered in patients with Hürthle cell carcinoma that does not take up radioactive iodide, although this is not yet a standard form of therapy. (medscape.com)
  • Three months after radioiodine therapy, at another centre, the patient underwent elective coronary angioplasty with 2 drug-eluting stents to the proximal left anterior descending artery, with no immediate complications. (cmaj.ca)
  • Studies have shown that T4 therapy is most effective in decreasing the size of small diffuse goiters in patients with a basal TSH within the reference range. (medscape.com)
  • Commonly used in Europe and Latin America but is not standard therapy in the United States unless the patient has contraindication for surgery. (medscape.com)
  • In 24 patients, reassessment was done after attaining a euthyroid state with carbimazole therapy. (ias.ac.in)
  • It is challenging for CKD patients to stay on spironolactone therapy because it can increase the risk of hyperkalemia, according to researchers. (renalandurologynews.com)
  • Papillary thyroid carcinoma: the impact of therapy in 576 patients. (rusmedserv.com)
  • Olanzapine (Zyprexa), an FDA-approved antipsychotic, effectively controlled chemotherapy-induced nausea and vomiting (CINV) in patients who failed to respond to guideline-recommended antiemetic therapy in a phase III trial presented at the ASCO Annual Meeting. (ascopost.com)
  • In advanced melanoma, combination therapy with two investigational drugs-one targeting BRAF and the other the MEK pathway-achieved a median progression-free survival of 7.4 months, which rose to 10.8 months in patients who were optimally dosed, reported Jeffrey S. Weber, MD, PhD , Director of the. (ascopost.com)
  • We present a patient with treatment-refractory PTM who had improved outcomes with teprotumumab therapy. (unscburma.org)
  • Four patients were initially misdiagnosed and treated with thyroid surgery or radioiodine therapy. (nih.gov)
  • in 76 NSCLC patients receiving ICI therapy. (insulin-receptor.info)
  • Furthermore, we recognized seven patients presenting mutations (five of which together with mutations) in the high and intermediate TMB group who did not respond to therapy (Physique?4). (insulin-receptor.info)
  • However, performing a multivariate analysis with the two markers yielded increased overall performance for predicting therapy response (Physique?5D), confirming other reports that suggest a combinatorial approach for stratifying patients for ICI therapy 14, 15, 17. (insulin-receptor.info)
  • He served a fellowship with William Daughaday, a world-class researcher on growth hormone, and from 1961 to 1963, worked at the Endocrinology Branch, National Cancer Institute, with Drs. William D. Odell and Peter G. Condliffe on immunologic studies of purified human and bovine thyrotropin (TSH). (harvard.edu)
  • This prospective study aimed to test the association between renal cortical perfusion (RCP) estimated in color Doppler sonographic dynamic tissue perfusion measurement (DTPM) with thyroid hormones in 36 patients treated with levothyroxine following total thyroidectomy for resectable thyroid cancer. (medscimonit.com)
  • Ensure the patients' samples, calibrators, and controls are at ambient temperature (20-25°C) before measurement. (cdc.gov)