Patients lymphopenia. Medical search. Frequent questions

Conclusion Our study found a significant association between lymphopenia, thrombocytopenia and elevated levels of CRP, PCT, LDH, D-dimer and COVID-19 severity. (bmj.com)
According to the complete blood count, 54.3% had lymphopenia, 26% thrombocytopenia, and 27% anemia. (bvsalud.org)
Clinical laboratory findings can include lymphopenia, thrombocytopenia, and elevated creatinine. (cdc.gov)

Compared to normal lymphocyte count, the adjusted hazard ratio (HR) for mortality was 1.31 (95% confidence interval [CI] 1.21-1.41) and 1.97 (95% CI 1.75-2.22) for relative and severe lymphopenia, respectively. (viamedica.pl)
Lymphocyte Count Kinetics and the Effect of Different Radiotherapy Techniques on Radiation-Induced Lymphopenia in Patients with Breast Cancer Receiving Hypofractionated Postmastectomy Radiotherapy. (bvsalud.org)
It was shown that low absolute lymphocyte counts are predictive of postoperative sepsis and a better predictor of bacteremia than conventional markers in patients admitted in emergency care units [ 13 , 14 ]. (springeropen.com)
It is unknown whether the low lymphocyte count contributed to the development of PML in this patient, or if low lymphocyte counts are a risk factor for PML development in Tecfidera-treated patients. (fda.gov)
Even though circulating lymphocytes only present ~2-5% of the total lymphocyte population in the body, a correlation of lymphopenia and treatment outcome, due to dose to circulating lymphocytes, has been demonstrated. (iomp.org)
Based on lymphocyte count at week 4, patients received another 0-3 doses at week 5. (lu.se)
Lung lesions in COVID-19 patients are significantly correlated with the peripheral blood lymphocyte and neutrophil levels, both of which could serve as prognostic indicators that provide warning implications, and contribute to clinical interventions in patients. (biomedcentral.com)
Diagnosis is by detecting lymphopenia, absence or a very low number of T cells, and impaired lymphocyte proliferative responses to mitogens. (msdmanuals.com)

Most radiation therapy patients develop radiation-induced lymphopenia. (iomp.org)

We aimed to determine the association between lymphopenia and mortality in patients presenting to coronary angiography and investigate whether elevated red blood cell distribution width (RDW), an established cardiovascular prognostic marker, further refines risk stratification. (viamedica.pl)

Diagnostics for Coronavirus Disease 2019 (COVID-19) Patients: What is the incubation period for coronavirus disease 2019 (COVID-19)? (medscape.com)
The specialist rehabilitation needs of a third group, covid-19 patients whose acute illness required intensive care, have been covered elsewhere. (bmj.com)
COVID-19 patients having IHD develop worse disease with excess early in-hospital mortality. (medrxiv.org)
Cases with Different severity of COVID-19 patients were classified according to institutional SOP, as per guidance from MOHFW [ 4 ] . (medrxiv.org)
Results 32 studies with 10 491 confirmed COVID-19 patients were included. (bmj.com)
The results have the potential to be used as an early biomarker to improve the management of COVID-19 patients, by identification of high-risk patients and appropriate allocation of healthcare resources in the pandemic. (bmj.com)
CT is recommended for clinical screening and observation of COVID-19 patients due to its high efficiency and objectivity. (biomedcentral.com)
Features of COVID-19 patients and comparative analysis according to AF development. (elsevier.es)

Often patients present with similar manifestations to Hyperimmunoglobulin E syndrome (HIES), including severe atopic dermatitis, chronic sinusitis or otitis, cutaneous vasculitis, severe pulmonary infections and pneumonia, and very high concentrations of the serum antibody IgE levels. (wikipedia.org)
Patients are susceptible to reoccurring pulmonary infections that may lead to bronchiectasis in the future. (wikipedia.org)
In addition to increased susceptibility to infections, patients with CID often manifest immune dysregulation, with autoimmune cytopenias and organ-specific autoimmunity. (nih.gov)
Patients treated with Olumiant are at risk for developing serious infections that may lead to hospitalization or death. (nationaleczema.org)
Most patients who developed these infections were taking concomitant immunosuppressants such as methotrexate or corticosteroids. (nationaleczema.org)
Patients with invasive fungal infections may present with disseminated, rather than localized, disease. (nationaleczema.org)
Avoid Olumiant in patients with an active, serious infection, including localized infections. (nationaleczema.org)
Over time, these patients develop progressive immunodeficiency and if not treated, succumb to opportunistic infections, hemophagocytosis, multiorgan failure, or EBV-positive lymphomas. (frontiersin.org)
Infection with SARS-Cov-2 is very similar to other viral infections in terms of clinical manifestations (7,11), and patients show a wide range of clinical symptoms from mild and asymptomatic to very severe including viral pneumonia, respiratory failure and even death (12). (who.int)
Various infections, lymphopenia, flushing, and gastrointestinal side effects were more frequent in the dimethyl fumarate group. (ku.dk)
Загальні відомості про імунодефіцити Immunodeficiency disorders are associated with or predispose patients to various complications, including infections, autoimmune disorders, and lymphomas and other cancers. (msdmanuals.com)

Mild cytokine release syndrome occurred in two patients receiving teplizumab and resolved within 7 days. (medscape.com)
So just as an overview, some-- one very large study of cases in China reported that the vast majority of patients with COVID-19 do in fact have mild to moderate illness, however, 19% had severe or critical illness. (cdc.gov)
Patients were classified in Mild, Moderate, Severe & Critical categories of COVID cases. (medrxiv.org)
Results A total 204 (N) patients were clinically classified into different severity groups, as per MOHFW and qCSI(quick Covid Severity Index) guidelines, as Mild (34), Moderate (56), Severe (39) and Critical (75). (medrxiv.org)
A retrospective case series of 2135 Chinese children with suspected or confirmed acute SARS-CoV-2 infection found that more than 90% of patients were asymptomatic or had mild to moderate illness. (bmj.com)
The World manifestations (7,11) , and patients show a wide range of Health Organization (WHO) declared the outbreak a clinical symptoms from mild and asymptomatic to very public health emergency of international concern on 30 severe including viral pneumonia, respiratory failure and January 2020 (3) . (who.int)

[ 1 ] In one study, 97.5% of symptomatic patients developed symptoms within 11.5 days of becoming infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (medscape.com)
Severe hypoglycemia occurred in 13.4% of patients receiving teplizumab and 16.2% of patients receiving placebo. (medscape.com)
Background: Related to the SARS-CoV-2 pandemic leading to COVID-19 illness, patients with cancer comorbidity are known to have a higher risk of developing severe viral-related events, including death. (mdpi.com)
Severe COVID-19 illness is seen more in patients more than 50 years of age. (medrxiv.org)
Severe lymphopenia has been associated with poor overall survival, occurrence of distant metastases, and disease recurrence. (iomp.org)
By modeling human T-cell differentiation in an artificial thymic organoid system, our lab is interested in defining the stages at which T-cell development is blocked in patients with known and novel forms of severe combined immune deficiency. (nih.gov)
Furthermore, this system also allows to distinguish between hematopoietic cell autonomous and non-hematopoietic (mostly, thymus-intrinsic) causes of severe congenital T-cell lymphopenia. (nih.gov)
It is also approved in over 40 countries for the treatment of adults with moderate to severe AD who are candidates for systemic therapy and approved in Japan for the treatment of certain hospitalized patients with COVID-19. (nationaleczema.org)
3 Males and patients with later age of onset tend to have more severe disease and poorer prognosis. (lww.com)
Management of patients infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is challenging due to the scarce scientific information and treatment guidelines. (ecancer.org)
There can also be surprises though: the author's own data shows that patients with asthma were less likely to present with severe pulmonary or systemic disease when exposed to H1N1pdm09. (nature.com)

Because glycosylation is known to be critical for numerous immune-related proteins, these patients likely present with additional abnormalities including hemolytic anemia, hepatosplenomegaly, and neutropenia. (wikipedia.org)
The main grade 3/4 toxicity was neutropenia, which occurred in about one-third of patients. (cancernetwork.com)

SARS-CoV in the pathogenesis of clinical manifestations and laboratory test abnormalities in SARS patients. (cdc.gov)
Teplizumab, a humanized monoclonal antibody to CD3 on T cells, was approved by the US Food and Drug Administration in November 2022 to delay the onset of clinical type 1 diabetes in patients aged 8 years or older with preclinical (stage 2) disease. (medscape.com)
1 Clinical management requires a whole-patient perspective. (bmj.com)
Broadly, such patients can be divided into those who may have serious sequelae (such as thromboembolic complications) and those with a non-specific clinical picture, often dominated by fatigue and breathlessness. (bmj.com)
The TITAN final analysis further confirms that treatment with apalutamide can prolong overall survival and offer a clear long-term clinical benefit and established safety profile for patients with metastatic prostate cancer who are starting androgen deprivation therapy," said Dr. Kim Chi, Medical Oncologist at BC Cancer - Vancouver and principal investigator of the TITAN study. (jnj.com)
Initial results from the TITAN study presented at the 2019 American Society of Clinical Oncology Genitourinary Cancers Symposium (ASCO GU) and simultaneously published in The New England Journal of Medicine showed the addition of ERLEADA ® (apalutamide) to ADT compared to placebo plus ADT significantly improved the dual primary endpoints of OS and radiographic progression-free survival (rPFS) in patients with mCSPC. (jnj.com)
To date, published results on ERLEADA ® include data from more than 2,000 patients across Phase 3 clinical studies. (jnj.com)
Approximately 4,000 patients have taken Tecfidera in MS clinical trials, including 1,000 patients treated for at least 4 years. (fda.gov)
Chimeric antigen receptor T (CART) cell therapy targeting the B cell specific differentiation antigen CD19 has shown clinical efficacy in a subset of relapsed/refractory (r/r) diffuse large B cell lymphoma (DLBCL) patients. (frontiersin.org)
Blood cell and serum markers, along with clinical data of DLBCL patients who were scheduled for CART cell therapy were evaluated to search for biomarkers predicting CART cell responsiveness. (frontiersin.org)
In addition, the analysis found that patients with lower rates of brain atrophy showed the highest probability of remaining free from disability progression at two years.1 This supports existing findings that increased brain volume loss over time is associated with worse clinical outcomes such as increased disability progression and cognitive changes, in patients with multiple sclerosis. (disabled-world.com)
IgG subclass determination is of limited value in assessing patients with clinical immunodeficiency because functional antibody deficiency may be present despite normal IgG subclass levels. (medscape.com)
We aimed to provide the clinical features, treatment, and prognosis of the critically ill patients with SARS-CoV-2 infection in Guangdong Province. (medrxiv.org)
A cross-sectional study method was carried out to explore the differences among the proportions of lung lobe infection and to correlate the percentage of infection (POI) of the whole lung in all patients with clinical laboratory examination values. (biomedcentral.com)
This study aimed to investigate the epidemiological and clinical characteristics of patients with COVID-19 in Saveh city, Islamic Republic of Iran in 2020. (who.int)
Data on sociodemographic, epidemiological and clinical characteristics of the patients were collected using a validated form through interviews and medical records. (who.int)
The chi-squared, t and Fisher exact tests were used to assess differences in sociodemographic, epidemiological and clinical characteristics between patients with positive and negative polymerase chain reaction results. (who.int)
After clinical evaluation, 74 patients went into rituximab maintenance and the primary endpoint was assessed in the final analysis at 3 years of follow-up. (haematologica.org)
Although national data indicate that the number of malnutrition diagnoses among hospital discharges has been steadily rising, an in-depth examination of the demographic and clinical characteristics of these patients has not been conducted. (researchgate.net)
From April 16, 2003, through May 1, 2003, during a 2-week period of the SARS outbreak in Taipei ( 16 ), 17 adult patients, who were admitted to the emergency department of the National Taiwan University Hospital and met the clinical case definitions for probable SARS ( 15 ), were included in this study. (cdc.gov)
For patients with suspected chikungunya disease, it is important to rule out dengue virus infection because proper clinical management of dengue can improve the outcome. (cdc.gov)

Majority of patients presented with lymphopenia and elevated lactate dehydrogenase. (medrxiv.org)

We analyzed the hematological and coagulation parameters of hospitalized patients with COVID-19 at admission, and two and three weeks during hospitalization. (bvsalud.org)

The most clinically relevant adverse reactions are lymphopenia and herpes zoster (shingles). (acnr.co.uk)

In elderly or high-risk patients with pulmonary symptoms, perform chest radiography to exclude pneumonia. (medscape.com)
Methods In this multi-centered, retrospective, observational study, we enrolled critically ill patients with SARS-CoV-2 pneumonia who were admitted to the intensive care unit (ICU) in Guangdong Province. (medrxiv.org)
Results Forty-five critically ill patients with SARS-CoV-2 pneumonia were identified in 7 ICUs in Guangdong Province. (medrxiv.org)
Two patients died (one pneumonia, one encephalitis). (lu.se)
53.4% of the patients were male, mean age of 62.3±15.4 years, and 43.6% were admitted due to pneumonia. (bvsalud.org)

Lymphopenia is associated with adverse prognosis in chronic disease states that are related to immune dysregulation. (viamedica.pl)
however, patients who experience early relapse, or who are refractory to initial immunochemotherapy have a poor prognosis ( 3 ). (frontiersin.org)
The advent of immunosuppressive therapy (cyclophosphamide plus glucocorticoids) has revolutionised the prognosis for patients with AAV, transforming the course of the disease from fatal to one that can be managed, though not without significant treatment-related toxicity. (smw.ch)
Most patients have a comparatively good prognosis, and a few quickly progress to acute respiratory distress syndrome (ARDS), sepsis shock, and multiple organ failure, which heralds a poor prognosis. (biomedcentral.com)
F. R. Carvalho - fabianarc@ affects the treatment and prognosis of patients. (bvsalud.org)

Severely ill patients might develop an alteration of their immune system called post-aggressive immunosuppression. (springeropen.com)

E-mail: [email protected], severity and mortality in patients with COVID-19. (bvsalud.org)

Signs/symptoms in pediatric patients are similar to those of adults but are usually milder, with most children presenting with symptoms of upper respiratory infection. (medscape.com)
Lymphopenia at ICU admission and its persistence at day 3 were associated with an increased risk of ICU-acquired infection, while only persisting lymphopenia predicted increased 28-day mortality. (springeropen.com)
One of these case-patients might have acquired infection either abroad or from her spouse, who was one of the other seven SARS-CoV-positive cases. (cdc.gov)
Except for this one person with possible transmission from a household contact, no evidence of SARS-CoV infection was detected by serologic testing of household contacts of SARS cases or of healthcare workers who cared for SARS patients. (cdc.gov)
Some studies showed that malnutrition is a significant problem among patients hospitalized due to COVID-19 infection, and the outcome of patients with SARS-CoV-2 is strongly associated with their nutritional status. (mdpi.com)
The U.S. Food and Drug Administration (FDA) is warning that a patient with multiple sclerosis (MS) who was being treated with Tecfidera (dimethyl fumarate), developed a rare and serious brain infection called PML, and later died. (fda.gov)
This is the only confirmed case of this rare and serious brain infection reported in patients taking Tecfidera. (fda.gov)
A patient with multiple sclerosis (MS) who was being treated with Tecfidera (dimethyl fumarate) developed a rare and serious brain infection called progressive multifocal leukoencephalopathy (PML) and later died. (fda.gov)
Information about critically ill patients with SARS-CoV-2 infection outside of Wuhan is scarce. (medrxiv.org)
Carefully consider the risks and benefits of Olumiant prior to initiating therapy in patients with chronic or recurrent infection. (nationaleczema.org)
Closely monitor patients for the development of signs and symptoms of infection during and after treatment with Olumiant including the possible development of TB in patients who tested negative for latent TB infection prior to initiating therapy. (nationaleczema.org)
Studies have shown that cardiac injury occurred in up to 28% of patients hospitalized with a SARS-CoV-2 infection [ 4 ], which can increase the risk of death later on. (jmir.org)
1 2 3 A recent prospective multicentre study of four French hospitals screened all admitted patients for SARS-CoV-2 infection by polymerase chain reaction testing and found that 45% of the 438 positive paediatric cases hospitalised were asymptomatic. (bmj.com)
Some of these patients develop fulminant infectious mononucleosis and die within days or weeks of primary infection. (frontiersin.org)
These patients are unable to control EBV infection and have infiltration of tissues by EBV positive T, NK, or less often B cells. (frontiersin.org)
Cancer patients are at higher risk of infection and severity of Coronavirus Disease-19 (COVID-19). (ecancer.org)
Paediatric patients had better outcomes than adult populations, and a high number of asymptomatic carriers and nosocomial infection, early diagnosis are recommended. (ecancer.org)
The serologic test of an indirect immunofluorescence assay performed on serum specimens collected 28 days after onset confirmed SARS-CoV infection in 13 of the 17 patients. (cdc.gov)

Furthermore, a very recent study showed that persistent lymphopenia on the fourth day after bacteremia diagnosis predicts early and late mortality in those patients, including in the subgroup of patients with sepsis [ 15 ]. (springeropen.com)
Consecutively hospitalised patients were recruited at diagnosis and followed-up at 8-12 weeks with a face-to-face medical review, spirometry, exercise test, blood tests, chest radiograph and assessment of the health-related quality of life (HRQoL). (bmj.com)
Relative to patients without a malnutrition diagnosis, those with the diagnosis were older, had longer lengths of stay and incurred higher costs. (researchgate.net)
Finally, discharge to home care was twice as common among malnourished patients, and a discharge of death was more than 5 times as common among patients with a malnutrition diagnosis. (researchgate.net)
Taken together, these nationally representative, cross-sectional data indicate that hospitalized patients discharged with a diagnosis of malnutrition are older and sicker and their inpatient care is more expensive than their counterparts without this diagnosis. (researchgate.net)
This finding, with the high detection rate a median of 4 days after disease onset and before the development of lung lesions in four patients, suggests that throat wash and saliva should be included in sample collection guidelines for SARS diagnosis. (cdc.gov)
A retrospective study using the medical charts of 103 patients admitted to the hospital due to a diagnosis of COVID-19 was carried out. (bvsalud.org)

Clinically, PGM3 deficient patients are marked with a group of immunologic and neurologic impairments. (wikipedia.org)
These findings reinforce and expand on the consistent and positive effect of Cladribine Tablets in improving clinically relevant outcomes, such as reducing relapse rate and disability, and further our resolve to make this investigational therapy available for patients living with RRMS," said Steven Hildemann, MD, PhD, Global Chief Medical Officer and Head of Global Medical Affairs and Safety, Merck KGaA, Darmstadt, Germany. (disabled-world.com)

We also aim to define the mechanisms underlying immune dysregulation in patients with CID of known genetic etiology. (nih.gov)

The final results of the LNH-PRO-05 study showed that a combination of antiproliferative and immunomodulatory agents with chemo had good outcomes in follicular lymphoma patients. (cancernetwork.com)
Objective To evaluate association between biomarkers and outcomes in COVID-19 hospitalised patients. (bmj.com)
English full text observational studies describing the laboratory findings and outcomes of COVID-19 hospitalised patients were identified searching PubMed, Web of Science, Scopus, medRxiv using Medical Subject Headings (MeSH) terms COVID-19 OR coronavirus OR SARS-CoV-2 OR 2019-nCoV from 1 December 2019 to 15 August 2020 following Meta-analyses Of Observational Studies in Epidemiology (MOOSE) guidelines. (bmj.com)
Patients who have HIV and are using antiretroviral therapy did not have adverse outcomes when using nivolumab for cancer treatment. (eatg.org)
Limited studies exist on the longer-term outcomes of patients admitted to the hospital due to COVID-19. (bmj.com)

Patients were studied for baseline characteristics, laboratory and radiological characteristics. (medrxiv.org)
Chest high-resolution computer tomography (CT) images and laboratory examination data of 31 patients with COVID-19 were extracted, and the lesion areas in CT images were quantitatively segmented and calculated using a deep learning (DL) system. (biomedcentral.com)
Relevant laboratory parameters in patients at hospital admission between July 2020 and Oct. (bvsalud.org)
to describe the alterations of laboratory parameters of patients diagnosed with COVID-19 at admission to Tesãi Foundation Hospital in Ciudad del Este-Paraguay between July 2020 to October 2021. (bvsalud.org)

Tecfidera is a drug used to treat relapsing forms of multiple sclerosis (MS), a brain and spinal cord disease in which patients experience multiple episodes of weakness, numbness, and other nervous system signs and symptoms that partially or completely resolve overs weeks or months. (fda.gov)
Post hoc analysis of Phase III CLARITY study data recently published in Multiple Sclerosis Journal showed statistically significant reduction in brain atrophy in patients on a short course of investigational Cladribine Tablets over two years compared with patients receiving placebo. (disabled-world.com)
The post hoc analysis showed that Cladribine Tablets reduced the annualised rate of brain volume loss - also known as brain atrophy - compared with placebo in patients with relapsing remitting multiple sclerosis (RRMS). (disabled-world.com)
Objective: To report on safety and effectiveness of subcutaneous cladribine (Litak ® ) in multiple sclerosis (MS) patients. (lu.se)
in multiple sclerosis (MS) patients. (lu.se)
This is a first of its kind in multiple sclerosis, which can also be a benchmark for the future, bringing together the NHS, government and industry to achieve faster access for patients, in line with the UK's Life Sciences Industrial Strategy. (acnr.co.uk)
METHODS: In the double-blind, placebo-controlled phase 2 study dimethyl FUMArate treatment in Progressive Multiple Sclerosis (FUMAPMS), patients with PPMS were randomly assigned to treatment with 240 mg dimethyl fumarate or placebo in a 1:1 ratio for 48 weeks. (ku.dk)

Patients were confirmed with COVID-19 using polymerase chain reaction testing. (who.int)

Some patients have experienced gastrointestinal symptoms such as diarrhea and nausea prior to developing fever and lower respiratory tract signs and symptoms. (medscape.com)

This association was even more pronounced when patients were stratified for complete remission (CR versus non-CR: 13.7 ± 11.7% versus 37.7 ± 17.4%, P=0.001). (frontiersin.org)

AZEDRA is a radioactive therapeutic agent indicated for the treatment of adult and pediatric patients 12 years and older with iobenguane scan positive, unresectable, locally advanced or metastatic pheochromocytoma or paraganglioma who require systemic anticancer therapy. (drugs.com)

Patients may develop persistent symptoms and disability over time. (fda.gov)

Association between radiation dose to organs at risk and acute patient reported outcome during radiation treatment for head and neck cancers. (dana-farber.org)
In this study, we analyzed the outcome of 84 patients at 3 years of follow-up after first-line treatment with fludarabine, cyclophosphamide and rituximab (FCR) induction followed by 36 months of rituximab maintenance thearpy. (haematologica.org)
Surprisingly, the outcome in this population was similar to that observed in patients who received the full six cycles of the induction regimen. (haematologica.org)

On admission, the patient had a fever up to 39 °C, but no dyspnoea. (thieme-connect.de)
All patients who survived were offered follow-up at a respiratory outpatient clinic (except for nursing home residents or current hospital inpatients) 8-12 weeks after their hospital admission. (bmj.com)

A recent study showed that patients with CAEBV or infectious mononucleosis have a decrease in the TCR-beta repertoire and expanded T cell clones in their peripheral blood compared with healthy carriers of EBV ( 14 ). (frontiersin.org)

The were prospectively collected during patients' illness. (cdc.gov)
What is the range of illness severity of patients with coronavirus disease 2019 (COVID-19)? (medscape.com)
In a Chinese study of over 44,000 patients, all deaths occurred among patients with critical illness, with a 2.3% overall case fatality rate but a 49% case fatality rate among patients with critical disease. (medscape.com)
Patients with coronavirus disease 2019 (COVID-19) have varying signs and symptoms at the onset of illness. (medscape.com)

Twenty-six patients were infused with CART cells (median 81 days after leukapheresis) and were analyzed for the overall response (OR) 3 months later. (frontiersin.org)
Low frequency of differentiated CD3 + CD27 - CD28 - T cells at leukapheresis represents a novel pre-infusion blood biomarker predicting a favorable response to CART cell treatment in r/r DLBCL patients. (frontiersin.org)
Patients with CAEBV in the United States most often present with disease involving B or T cells, while in Asia, the disease usually involves T or NK cells. (frontiersin.org)
Some patients with CAEBV have been reported to have impaired NK cell ( 8 ) or T cell activity ( 9 - 13 ) against EBV-infected cells. (frontiersin.org)
In addition, reduced numbers of EBV-specific T cells have been described in patients with CAEBV disease ( 10 ). (frontiersin.org)
Unlike healthy persons with infectious mononucleosis, patients with CAEBV disease often have low numbers of EBV-specific CD8 cells ( 10 ). (frontiersin.org)
Individuals with this condition often have low numbers of white blood cells (lymphopenia), particularly B cells and T cells . (medlineplus.gov)

Thirty-seven patients (82.2%) had developed acute respiratory distress syndrome, and 13 (28.9%) septic shock. (medrxiv.org)

Tell patients taking Tecfidera to contact you if they develop any symptoms that may be suggestive of progressive multifocal leukoencephalopathy (PML). (fda.gov)

This exploratory analysis assessed the efficacy of abemaciclib plus fulvestrant across subgroups of patients receiving study therapy as first- or second-line treatment for metastatic disease. (aacrjournals.org)
In the wide and changing therapeutic scenario for FL patients, it is desirable to focus on minimizing both early and long-term toxicity while maintaining efficacy, in order to achieve the long-expected survival," wrote researchers led by Jimena Cannata-Ortiz, of the Hospital Universitario La Princesca in Madrid. (cancernetwork.com)
The efficacy/toxicity profile of this treatment stands out as a good option for these patients," the researchers concluded. (cancernetwork.com)
Fifteen patients had KS, 12 had other solid tumors, and 9 had cancers where PD-1 agents had shown efficacy. (eatg.org)
DISCUSSION: Dimethyl fumarate treatment for 48 weeks had no effect on any of the investigated efficacy measures in patients with PPMS. (ku.dk)

The association of lymphopenia with mortality remained significant after additional adjustment to RDW. (viamedica.pl)
RARITAN, N.J., February 8, 2021 - The Janssen Pharmaceutical Companies of Johnson & Johnson announced today results from the final analysis of the Phase 3 TITAN study, which demonstrated the continued statistically significant benefit of the addition of ERLEADA ® (apalutamide) to androgen deprivation therapy (ADT) in overall survival (OS) in patients with metastatic castration-sensitive prostate cancer (mCSPC), regardless of extent of disease, when compared to placebo plus ADT. (jnj.com)
Compared to healthy controls (n=24), DLBCL patients (n=33) showed significant lymphopenia, due to low CD3 + CD4 + T helper and CD3 - CD56 + NK cell counts, while cytotoxic CD3 + CD8 + T cell counts were similar. (frontiersin.org)
Phase III CLARITY study data revealed significant reduction in brain atrophy in patients on short course of investigational Cladribine Tablets over two years. (disabled-world.com)

Prior to developing PML, the patient had a very low number of lymphocytes, a type of white blood cell, in her blood. (fda.gov)

Treatment with antiviral drugs was initiated in all the patients. (medrxiv.org)

Patients were recruited from the Diagnostic and Severity markers of COVID-19 to Enable Rapid triage (DISCOVER) study, a single-centre prospective study (Bristol, UK) recruiting consecutive patients (≥18 years of age) admitted with COVID-19. (bmj.com)

The apparent volume of distribution averaged 0.31 L/kg following a single 0.2 mg/kg oral dose of chlorambucil in 11 cancer patients with chronic lymphocytic leukemia. (nih.gov)
About half the patients (48.3%) had a history of chronic disease. (who.int)
Diabetes (16.2%), high blood pressure (14.8%) and cardiovascular disease (12.4%) were the most prevalent chronic diseases among patients who were confirmed positive for COVID-19. (who.int)
It has been postulated that monitoring measurable residual disease (MRD) could be used as a surrogate marker of progression-free survival (PFS) in chronic lymphocytic leukemia (CLL) patients after treatment with immunochemotherapy regimens. (haematologica.org)

Patients who have demonstrated hypersensitivity to chlorambucil should not be given the drug. (nih.gov)
TRIZIVIR is contraindicated in patients with a prior hypersensitivity reaction to abacavir and in HLA B*5701-positive patients [see CONTRAINDICATIONS , WARNINGS AND PRECAUTIONS ]. (rxlist.com)

Retrospective analysis of patients undergoing coronary angiography for evaluation or treatment of coronary artery disease between 2003 and 2018. (viamedica.pl)
Combination treatment with rituximab, interferon alfa-2b, and dose-dense cyclophosphamide/vincristine/prednisone (CVP) was safe and effective for patients with follicular lymphoma (FL) and an FL International Prognostic Index (FLIPI) score of 2 or greater, according to the final results of the LNH-PRO-05 study published as correspondence in the British Journal of Haematology . (cancernetwork.com)
Results: In all, 208 patients received at least one course of treatment. (lu.se)
Thirty-six patients were enrolled between October 21, 2015, and January 6, 2020, who received at least 1 dose of the treatment. (eatg.org)
OLUMIANT ® (baricitinib) 2-mg is indicated for the treatment of adult patients with moderately to severely active rheumatoid arthritis who have had an inadequate response to one or more tumor necrosis factor (TNF) antagonist therapies. (nationaleczema.org)
We are delighted with the NHS England decision on this commercial agreement, which will see patients in England access the treatment immediately. (acnr.co.uk)
Patients can take cladribine tablets at home from the first dose as treatment does not require hospital administration. (acnr.co.uk)
CLASSIFICATION OF EVIDENCE: This study provides Class I evidence that for patients with PPMS, dimethyl fumarate treatment has no effect on CSF NFL levels compared with placebo treatment. (ku.dk)

Additionally, 40% of patients experienced grade 3/4 lymphopenia. (cancernetwork.com)

Methods: Litak ® was offered to MS-patients irrespective of disease course. (lu.se)

The range of symptom prevalence is reported from three large meta-analyses, one with 131 studies and 7780 paediatric patients, 1 the second with 28 studies and 1614 patients, 2 and the third with 46 studies and 551 patients 3 and summarised in table 1 . (bmj.com)

Patients with SJS/TEN will have fever and pain, typically, and the primary lesions are atypical targets with a positive Nikolsky sign . (moviecultists.com)

Around 10% of patients who have tested positive for SARS-CoV-2 virus remain unwell beyond three weeks, and a smaller proportion for months (see box 1 ). (bmj.com)
We conducted a cross-sectional study of the first 100 patients hospitalised at the Instituto Nacional de Enfermedades Neoplasicas (Lima, Peru) who were positive for SARS-CoV-2 by reverse transcriptase (RT)-PCR during the period 30 March to 20 June. (ecancer.org)
We examined oral specimens, including throat wash and saliva, and found large amounts of SARS-CoV RNA in both throat wash (9.58 x 10 2 to 5.93 x 10 6 copies/mL) and saliva (7.08 x 10 3 to 6.38 x 10 8 copies/mL) from all specimens of 17 consecutive probable SARS case-patients, supporting the possibility of transmission through oral droplets. (cdc.gov)

lymphopenia is associated with increased risk of mortality during long-term follow-up in patients undergoing coronary angiography, regardless of the coronary presentation. (viamedica.pl)
According to Federico, the results achieved in patients with advanced and high-risk FL using a combination of three "simple ingredients" such as rituximab, IFN alfa-2b, and dose-dense CVP, were probably beyond even the expectations of the investigators. (cancernetwork.com)

In MONARCH 2, abemaciclib plus fulvestrant significantly prolonged progression-free survival (PFS) and overall survival (OS) versus placebo plus fulvestrant in patients with hormone receptor positive (HR + ), HER2 − advanced breast cancer. (aacrjournals.org)
The mean percentage brain volume loss per year was significantly reduced in patients treated with Cladribine Tablets 3.5 mg/kg (--0.56%±0.68, p=0.010, n=336) and 5.25 mg/kg (--0.57%±0.72, p=0.019, n=351) compared with patients treated with placebo (--0.70%±0.79, n=338). (disabled-world.com)
Thrombosis, including deep venous thrombosis (DVT) and pulmonary embolism (PE), has been observed at an increased incidence in patients treated with Olumiant compared to placebo. (nationaleczema.org)
BACKGROUND AND OBJECTIVE: To study whether dimethyl fumarate is superior to placebo in decreasing CSF concentrations of neurofilament light chain (NFL) in patients with primary progressive MS (PPMS). (ku.dk)
Twenty-six patients (96%) in the dimethyl fumarate group and 24 patients (89%) in the placebo group completed the randomized phase. (ku.dk)

The brain atrophy analysis evaluated the effect of Cladribine tablets on brain volume loss (BVL) over 2 years in RMS and the association of BVL with confirmed disability progression in 1,025 (77.3%) of the patients in CLARITY. (disabled-world.com)
Effectiveness in relapsing MS appeared similar to cladribine tablets and was encouraging in progressive MS. Our data suggest cladribine may be safe and effective in MS-patients irrespective of their disease stage. (lu.se)
1 NHS England and Merck, the manufacturer of cladribine tablets, have partnered on the commercial access agreement, representing an example of a "win-win-win" for the NHS, patients and industry at a time of intense financial pressure on the NHS. (acnr.co.uk)
Cladribine tablets should not be taken by certain people, including immunocompromised patients and pregnant women. (acnr.co.uk)

Serum Ig levels are consistently depressed but are generally higher in patients with common variable immunodeficiency than in patients with X-linked agammaglobulinemia. (medscape.com)

What are the signs and symptoms of patients with coronavirus disease 2019 (COVID-19)? (medscape.com)
Here we present the case with CT imaging of a Caucasian patient with coronavirus disease 2019 (COVID-19) in Berlin, Germany. (thieme-connect.de)

We study both patients with yet genetically undefined forms of CID and patients with known gene defects. (nih.gov)

In critically ill patients, especially those with septic shock, after an initial phase of immune system hyperstimulation, dysfunction could appear secondarily. (springeropen.com)
The patient who died was not taking any other drugs that affect the immune system or drugs that are thought to be associated with PML. (fda.gov)
The JC virus is a common virus that is harmless in most people but can cause PML in some patients who have weakened immune systems. (fda.gov)

In a study of 12 patients given single oral doses of 0.2 mg/kg of LEUKERAN, the mean dose-adjusted (±SD) plasma chlorambucil C max was 492 ± 160 ng/mL, the AUC was 883 ± 329 ng.h/mL, the mean elimination half-life (t½) was 1.3 ± 0.5 hours, and the T max was 0.83 ± 0.53 hours. (nih.gov)
Radiotherapy Dose in Patients Receiving Immunotherapy. (dana-farber.org)

Patient characteristics at baseline. (archbronconeumol.org)

Patient Nutrition and Probiotic Therapy in COVID-19: What Do We Know in 2021? (mdpi.com)
Patients were scheduled to receive 8 cycles of therapy with granulocyte colony-stimulating factor support. (cancernetwork.com)
The number of radiation therapy options for cancer patients has increased significantly in recent years. (iomp.org)
Test patients for latent TB before initiating Olumiant and during therapy. (nationaleczema.org)
All patients should be screened for the HLAï¿½B*5701 allele prior to initiating therapy with TRIZIVIR or reinitiation of therapy with TRIZIVIR, unless patients have a previously documented HLA B*5701 allele assessment. (rxlist.com)
Thirty-seven patients (44%) did not have detectable residual disease in the BM prior to maintenance therapy. (haematologica.org)
Interestingly, 29 patients with detectable residual disease in the BM after induction no longer had detectable disease in the BM following maintenance therapy. (haematologica.org)
After a median followup of 6.30 years, the median overall survival (OS) and PFS had not been reached in patients with either undetectable or detectable residual disease in the BM, who had achieved a complete response at the time of starting maintenance therapy. (haematologica.org)
As per protocol, 15 patients (17.8%), who achieved a complete response and undetectable peripheral blood and BM residual disease after four courses of induction, were allowed to stop fludarabine and cyclophosphamide and complete two additional courses of rituximab and continue with maintenance therapy for 18 cycles. (haematologica.org)

Of n = 13 patients whose CSF-NfL at baseline was elevated, 77% were normalised within 12 months. (lu.se)
An objective response was found in 25% (95% CI, 12.1%-42.2%) of patients, all of whom had baseline CD4 count of 200 or more. (eatg.org)

Based on these data, ADT alone should no longer be considered sufficient for patients with advanced, castration-sensitive disease. (jnj.com)
Data were compared between patients with and without intubation. (medrxiv.org)
Screening for extranodal extension in HPV-associated oropharyngeal carcinoma: evaluation of a CT-based deep learning algorithm in patient data from a multicentre, randomised de-escalation trial. (dana-farber.org)
At 18 months, 64% of patients with relapsing MS and BaFU data (n = 39) had NEDA. (lu.se)
At 19 months, 62% of patients with progressive MS and BaFU data (n = 13) had NEPAD. (lu.se)
These data show that, compared to historic controls, patients treated with FCR followed by rituximab maintenance have high-quality responses with fewer relapses and improved OS. (haematologica.org)

In either case, the patient is not able to produce functional PGM3 protein Patients have significantly increased levels of serum IgE, IgG, and IgA. (wikipedia.org)

Anatomy12

Organisms4

Diseases11

Chemicals and Drugs11

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Phenomena and Processes10

Thrombocytopenia3

Lymphocyte8

Radiation-Induced Lymphopenia1

Association between lymphopenia1

COVID-19 Patients8

Infections11

Mild6

Severe11

Neutropenia2

Clinical21

Lactate dehydrogenase1

Hospitalized patients with COVID-191

Herpes zoster1

Pneumonia5

Prognosis5

Immunosuppression1

Mortality in patients1

Infection18

Diagnosis7

Clinically2

Etiology1

Outcomes5

Laboratory4

Multiple sclerosis7

Confirmed with COVID-191

Gastrointestinal symptoms1

0.0011

Systemic1

Persistent1

Outcome3

Admission2

Recent study showed1

Illness4

Cells7

Acute1

Leukoencephalopathy1

Efficacy5

Significant4

Lymphocytes1

Antiviral drugs1

Severity1

Chronic4

Hypersensitivity2

Treatment8

Additionally1

Methods1

Paediatric patients1

Fever1

SARS-CoV3

Risk2

Placebo5

Cladribine Tablets4

Immunodeficiency1

Coronavirus disease 20192

Defects1

Immune3

Dose2

Characteristics1

Therapy9

Baseline2

Data6

Significantly1