AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceNamed GroupsHealth CareGeographicals
Familial Mediterranean FeverArmeniaColchicineCytoskeletal ProteinsGout SuppressantsAmyloidosisJewsMevalonate Kinase DeficiencyHereditary Autoinflammatory DiseasesAfrica, NorthernChromosomes, Human, Pair 16ArabsAbdominal PainFeverAmyloidosis, FamilialTurkeyMutationTubulin ModulatorsSerum Amyloid A ProteinHeterozygoteHomozygoteCryopyrin-Associated Periodic SyndromesProteinsSacroiliitisIsraelImmunoglobulin DPericarditisBlood SedimentationConsanguinityInterleukin 1 Receptor Antagonist ProteinCaspase 1DNA Mutational AnalysisPedigreeAge of OnsetSerositisEncyclopedias as Topic
ColchicineSerositisSystemicAmyloidosisMutationsPolyserositisAbstractGoutInflammationCharacterized by recurrentMutationPediatric patientsPrevalenceAutoimmune diseasesAttacksSyndromeInflammatoryDiagnosisBouts of feverClinicalGeneticDiseases2016DisorderMethodsBenignArthritisCoexistenceAnakinraCardiovascular diseaseDiseaseSeverePeriodic fever synArthralgiaDiagnosticTreatmentAcuteTurkeyFebrileSymptomsProfuseChildrenAmyotrophic lateral s
Colchicine16
  • Colchicine to treat gout or familial Mediterranean fever. (who.int)
  • Patients with renal or hepatic impairment should not be given colchicine in conjunction with P-gp or strong CYP3A4 inhibitors ( 5.3 ). (nih.gov)
  • In these patients, life-threatening and fatal colchicine toxicity has been reported with colchicine taken in therapeutic doses ( 7 ). (nih.gov)
  • Treatment with prophylactic colchicine prevents acute attacks as well as amyloidosis in almost all patients. (msdmanuals.com)
  • Colchicine was successfully introduced in 1972 as a prophylactic therapy for eliminating FMF attacks and preventing amyloidosis, which could otherwise lead to renal failure in FMF patients. (testmenu.com)
  • Interferon-alpha for patients with colchicine-resistant disease. (lu.se)
  • A larger cohort of 6528 patients was initially included and underwent a one-month open-label use of colchicine. (acsh.org)
  • 2] Patients were randomized to treatment with 0.5 mg of colchicine daily or placebo. (acsh.org)
  • An early signal of the impact of colchicine on cardiovascular disease was identified in retrospective studies of patients with gout and Familial Mediterranean Fever who had a lower incidence of coronary disease than their untreated contemporaries. (acsh.org)
  • Polymorphonuclear leukocyte chemotaxis was investigated in 35 patients with recurrent polyserositis during attacks and during spontaneous or colchicine-induced remissions. (tau.ac.il)
  • Chemotaxis was found to be unchanged in the attack-free period in untreated patients, increased by about 50% during attacks, and decreased by about 50% during colchicine treatment. (tau.ac.il)
  • Early Predictors of Colchicine Resistance in Familial Mediterranean Fever. (cdc.gov)
  • En ce qui concerne le traitement, 97% des patients répondaient bien à la colchicine et une amyloïdose n'a été documentée chez aucun des patients après un suivi de 5 ans. (who.int)
  • 6. Patients not currently taking colchicine for other indications (e.g., gout arthritis, familial Mediterranean fever). (who.int)
  • 2. Patients with a history of hypersensitivity to colchicine. (who.int)
  • This design allows the researchers to observe the effects of colchicine in comparison to placebo in patients undergoing different timings of PCI while ensuring that all groups receive the standard care. (who.int)
Serositis6
  • Patients display attacks associating recurrent fever, arthritis, serositis and skin manifestations [1]. (efim.org)
  • Patients were questioned about cold exposure, emotional stress, tiredness, long-lasting standing, long-duration travel, starvation, high intake of food, trauma, and infection as triggering factors for the attacks with both serositis and musculoskeletal pain. (gazi.edu.tr)
  • Familial Mediterranean Fever (FMF), also inherited with autosomal recessive trait, is characterized by recurrent episodes of fever, arthritis, and serositis. (balkanmedicaljournal.org)
  • Patients with FMF type 1 have short episodes of inflammation and serositis including fever, peritonitis, synovitis, pleuritis, and rarely, pericarditis and meningitis. (lu.se)
  • Familial Mediterranean fever (FMF) is an autoinflammatory disorder characterized by recurrent fever and serositis. (turkiyeklinikleri.com)
  • Familial Mediterranean fever (FMF) is an autoinflammatory disorder characterized by recurrent short episodes of fever and serositis resulting in pain in the abdomen chest joints and muscles. (globalgenes.org)
Systemic4
  • We herein report three illustrative cases of heart failure due to cardiac sarcoidosis in patients who were or were not diagnosed with preceding systemic sarcoidosis. (go.jp)
  • Comparative study of serum surfactant protein-D and KL-6 concentrations in patients with systemic sclerosis as markers for monitoring the activity of pulmonary fibrosis. (jrheum.org)
  • This approach is particularly important for patients with systemic rheumatic diseases. (rambam.org.il)
  • Objectives Familial Mediterranean fever (FMF) and systemic juvenile idiopathic arthritis (sJIA) are chronic inflammatory diseases and anti-inflammatory agents are used in their treatment. (ogu.edu.tr)
Amyloidosis4
  • We present a rare case of 24 year old male patient who had liver and kidney transplantation due to Byler Syndrome and secondary amyloidosis related to FMF, diagnosed as rapidly growing large amyloid goiter. (balkanmedicaljournal.org)
  • Patients with FMF type 2 have amyloidosis, as the first clinical manifestation of disease in an asymptomatic individual. (lu.se)
  • AA-amyloidosis was noted in six patients. (biomedcentral.com)
  • Assessment of Surrogate Markers for Cardiovascular Disease in Familial Mediterranean Fever-Related Amyloidosis Patients Homozygous for M694V Mutation in MEFV Gene. (cdc.gov)
Mutations8
  • 149 FMF is an autoinflammatory disease caused by mutations in Mediterranean fever gene, which encodes a 781-amino acid protein called pyrin. (wikipedia.org)
  • This study is aimed to survey the factors regarded as triggering the attacks in patients with FMF and their relationship with MEFV gene mutations. (gazi.edu.tr)
  • The panel of 12 mutations offered in this test will pick up 80% to 90% of Mediterranean carriers, but less in other ethnic groups. (testmenu.com)
  • For individuals who are negative for mutations by targeted mutation testing, DNA sequence analysis of the entire MEFV gene coding region is available (offered as Familial Mediterranean Fever Full Gene Sequencing). (testmenu.com)
  • One hundred and fourteen patients (53 male, 61 female) with two MVK mutations were included in this study. (biomedcentral.com)
  • The aim of this study was to assess the frequency of MEFV gene mutations in periodic fever patients from CSEE countries. (biomedcentral.com)
  • Slovenia 6/15, Slovakia 1/3, Czech Republic 1/8 and 1 patient from Slovakia has had 3 mutations. (biomedcentral.com)
  • MEFV gene mutations were identified in 31/156 (20%) patients with periodic fevers from CSEE countries. (biomedcentral.com)
Polyserositis3
  • The disorder has been given various names, including familial paroxysmal polyserositis, periodic peritonitis, recurrent polyserositis, benign paroxysmal peritonitis, periodic disease or periodic fever, Reimann periodic disease or Reimann syndrome, Siegal-Cattan-Mamou disease, and Wolff periodic disease. (wikipedia.org)
  • Typical clinical manifestations are self -limiting attacks of recurrent fever , abdominal pain , arthralgia , and chest pain due to aseptic polyserositis. (bvsalud.org)
  • We reviewed the files of 56 patients with the autosomal recessive familial paroxysmal diagnosis of FMF who were followed up in polyserositis of unknown pathogenesis [ 1 ]. (who.int)
Abstract1
  • ABSTRACT Familial Mediterranean fever is quite prevalent among Arabs.We reviewed the files of 56 patients diagnosed with familial Mediterranean fever and followed up at King Hussein Medical Centre in Jordan over 4 years for their clinical profile, course, genotype, treatment and complications.There were 30 males and 26 females with a mean age at onset of 5.2 years. (who.int)
Gout2
  • In the presence of mild to moderate renal or hepatic impairment, adjustment of dosing is not required for treatment of gout flare, prophylaxis of gout flare and FMF, but patients should be monitored closely ( 8.6 ). (nih.gov)
  • In patients with severe renal impairment for prophylaxis of gout flares, the starting dose should be 0.3 mg/day for gout flares, no dose adjustment is required, but a treatment course should be repeated no more than once every two weeks. (nih.gov)
Inflammation2
  • The research shows that the same genetics underlie different clinical signs of inflammation, demonstrating that the periodic fevers are part of an autoinflammatory syndrome.The genetic information makes it possible to develop a DNA test to gauge individual dogs' risk of autoinflammatory disease - a test that may be commercially available in a matter of months. (vin.com)
  • NOMID is characterized by neonatal onset of cutaneous symptoms along with fever with inflammation in multiple organ systems. (exploremyplan.com)
Characterized by recurrent2
  • Etiology references Familial Mediterranean fever is an autosomal recessive disorder characterized by recurrent bouts of fever and peritonitis, sometimes with pleuritis, skin lesions, arthritis, and, rarely, pericarditis. (msdmanuals.com)
  • Patients with multiple sclerosis are classified according to their clinical phenotype, with ~85% following a relapsing-remitting course (relapsing-remitting multiple sclerosis) characterized by recurrent, acute neurological deficits punctuating periods of latency or remission (Lublin and Reingold, 1996). (medscape.com)
Mutation14
  • The Prevalence of the Mutation in Codon 249 of the P53 Gene in Patients with Hepatocellular Carcinoma (HCC) in Turkey. (acibadem.com.tr)
  • In the mutation found in PAAND patients, however, only a single copy of the mutation is needed to cause the disease, so it affects half of the children of patients. (edu.au)
  • The PAAND mutation causes the body to respond as if there is an infection, which leads to the skin making an inflammatory protein which causes fevers, pain and skin lesions," Dr Masters said. (edu.au)
  • The first study , published in 2011 in the journal PLOS Genetics , found that the same mutation that gives shar-pei their characteristic thick, wrinkled skin also predisposes the breed to a periodic fever syndrome. (vin.com)
  • Twenty-eight (31%) patients had M694V homozygous mutation, while 30 (33%) patients had M694V heterozygous mutation. (turkiyeklinikleri.com)
  • Ninety-six patients harboured at least one V377I mutation, fourteen of them had a homozygous V377I mutation. (biomedcentral.com)
  • The second most frequent mutation was I268T occurring in 29 patients. (biomedcentral.com)
  • 6 Jang SH.Long te rm therapeutic plan for patients with nonsmall cell lung cancer harboring EGFR mutation. (jcimjournal.com)
  • 31 patients (20%) were found to have at least one mutation. (biomedcentral.com)
  • Homozygous mutation was found only in one patient from Czech Republic. (biomedcentral.com)
  • 1 novel MEVF gene mutation was identified (S730F) in patient from Slovenia. (biomedcentral.com)
  • We are planning to evaluate genotype-phenotype correlation in MEFV mutation positive patients in CSEE countries in the future. (biomedcentral.com)
  • 2) CAPS syndrome is caused by a gain of function mutation in the NLRP3 gene leading to over secretion of fever causing cytokine IL-1B. (exploremyplan.com)
  • There has been a common homozygous mutation in the IL1RN gene detected in a number of patients. (exploremyplan.com)
Pediatric patients3
Prevalence2
  • The prevalence of Familial Mediterranean. (comu.edu.tr)
  • Prevalence of familial autoimmune diseases in juvenile idiopathic arthritis: results from the international Pharmachild registry. (contemporarypediatrics.com)
Autoimmune diseases3
  • The risk of juvenile idiopathic arthritis (JIA) is greater among children with familial autoimmune diseases (AD), according to a recent study published in Pediatric Rheumatology . (contemporarypediatrics.com)
  • The unit has extensive experience in treating patients with collagen diseases and internal organ complications (lung and heart involvement in collagen diseases, pulmonary hypertension due to collagen disease, Raynaud's syndrome, and gastrointestinal complications in autoimmune diseases). (rambam.org.il)
  • Autoimmune Registry, Inc., ARI, is a 501(c)(3) non-profit umbrella organization that provides a hub for research, statistics, and patient data on all autoimmune diseases. (globalgenes.org)
Attacks4
Syndrome13
  • Congenital Byler Syndrome (Progressive Familial Intrahepatic Cholestasis) inherited with autosomal recessive trait and characterized by defective secretion of bile acids. (balkanmedicaljournal.org)
  • Introduction: Psoriasis is not only a skin disease, is a chronic inflammatory disease associated with serious comorbidities: psoriatic arthritis, metabolic syndrome (obesity, dyslipidemia and insulin resistance), Crohn s disease, depression, ocular problems, cardio-vascular diseases (myocardial infarction), cancer.Methods: 1236 patients (male 54.13% and female 45.87%) with psoriasis were seen in an Outpatient Clinic over a period of 8 years (2004. (endocrine-abstracts.org)
  • Cerebellar syndrome (3%), mental retardation (4%) and seizures (5%) were noted in some patients. (biomedcentral.com)
  • One patient suffered from macrophage activation syndrome, a life-threatening complication characterized by high fever, pancytopenia and liver damage. (biomedcentral.com)
  • As news has grown about the hyperinflammation syndrome happening in some children possibly connected with COVID-19, we know many parents of kids with periodic fever syndromes are concerned. (saidsupport.org)
  • This 2016 study looked at how familial Mediterarrean fever (FMF), hyperimmunoglobulinemia D with periodic fever syndrome (HIDS), and tumor necrosis factor-associated periodic fever syndrome (TRAPS) affects patients' lives and their family's lives. (saidsupport.org)
  • Periodic Fever Syndrome in…Dogs? (saidsupport.org)
  • G-CSF levels are increased in peripheral blood of patients with active Sweet syndrome, suggesting that high levels of G-CSF may correlate with the activity of disease. (medscape.com)
  • [ 11 ] The functional properties of neutrophils, rather than the absolute number, is thought to be significant because patients with Sweet syndrome due to G-CSF develop lesions as the neutrophil count rapidly increases, despite a decreased absolute neutrophil count. (medscape.com)
  • 2) Familial cold autoinflammatory syndrome (FCAS) is the mildest form and more common in the United States. (exploremyplan.com)
  • Utility of a targeted next-generation sequencing-based genetic screening panel in patients with periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome. (cdc.gov)
  • However, recent reports suggest that vasculitis should not exclude the diagnosis since it has been shown to occur in many patients with Sweet syndrome, which may represent an epiphenomenon instead of a primary immune-mediated process. (medscape.com)
  • G-CSF levels in peripheral blood are increased in patients with active Sweet syndrome, suggesting that high levels of G-CSF may one day be a useful indicator of activity level of the disease. (medscape.com)
Inflammatory8
  • Familial Mediterranean Fever (FMF) is the most common monogenic auto-inflammatory disease [1]. (efim.org)
  • Familial Mediterranean fever (FMF) is a hereditary inflammatory disorder. (wikipedia.org)
  • Familial Mediterranean fever is a frequently seen chronic inflammatory disease that can lead to severe morbidity and mortality if left untreated. (uwi.edu)
  • This gene is known to cause an inflammatory disease called Familial Mediterranean Fever (FMF) in patients who inherit mutated copies from both their mother and father. (edu.au)
  • Ninety-nine of 114 patients had recurrent inflammatory episodes, while six patients suffered from a chronic course and nine patients had a chronic course with exacerbations. (biomedcentral.com)
  • Inflammatory parameters, such as erythrocyte sedimentation rates (98%), C-reactive protein (94%) and white blood count (66%), were abnormal in many patients. (biomedcentral.com)
  • Patients with JIA being treated with nonsteroidal anti-inflammatory drugs were included in the registry. (contemporarypediatrics.com)
  • Interleukin (IL)-1- beta inhibitors (anakinra, rilonacept, and canakinumab) have shown effectiveness in preventing and alleviating symptoms of CAPS and reducing levels of inflammatory indices, including serum amyloid A.(2) Treatment with non-steroidal anti-inflammatory drugs, disease modifying antirheumatic drugs, and glucocorticoids were offered only some patients partial symptom control. (exploremyplan.com)
Diagnosis7
  • This case is unique since two autosomal genetic disorders are together in the same patient and important as it emphasizes the consequences of consanguineous marriage, early diagnosis and treatment compliance of FMF and the awareness of amyloid goiter in patients followed by primary care physicians and healthcare professionals. (balkanmedicaljournal.org)
  • In these patients atypical presentation is the rule and it requires a high clinical suspicion for its diagnosis [ 8 ]. (hindawi.com)
  • Clinicians should be aware of in differential diagnosis of additional diseases that may develop in follow-up of FMF patients. (turkiyeklinikleri.com)
  • Here we review single gene disorders that have the potential to mimic multiple sclerosis, provide an overview of clinical and investigational characteristics of each disorder, and present guidelines for when clinicians should suspect an underlying heritable disorder that requires diagnostic confirmation in a patient with a definite or probable diagnosis of multiple sclerosis. (medscape.com)
  • Early, accurate diagnosis is critical to effective patient management and counselling, but assignment of an incorrect diagnosis of multiple sclerosis remains a frequent concern. (medscape.com)
  • In the absence of pathognomonic clinical findings or a definitive laboratory test, the diagnosis of multiple sclerosis remains challenging in many patients, and diagnostic criteria emphasize the caveat of 'no better explanation' for a patient's clinical presentation and MRI findings. (medscape.com)
  • Other opportunistic infections (eg, salmonellosis , histoplasmosis , toxoplasmosis ) can also present as FUO and elude rapid diagnosis in patients who are febrile with AIDS. (medscape.com)
Bouts of fever2
  • It is characterized by recurring bouts of fever, most commonly with severe abdominal pain due to peritonitis. (testmenu.com)
  • That's because in 1981, few in veterinary medicine knew that shar-pei are prone to bouts of fever, and no one knew why. (vin.com)
Clinical12
  • Clinical and genetic findings of familial Mediterranean fever (FMF) may vary in different populations. (uwi.edu)
  • In this study, we investigated demographic, clinical and mutational features of FMF patients treated in a single reference hospital in Turkey. (uwi.edu)
  • However, lowering LDL levels is a common clinical practice to reduce oxidation and the risk of major events in patients with cardiovascular diseases (CVD). (hindawi.com)
  • Clinical examination revealed a severely ill patient, a silent abdomen which was distended with painful percussion and palpation of the epigastrium. (endocrine-abstracts.org)
  • Background: It is disputable whether to repeat FNAB after the first one was nondiagnostic, or to submit the patient to operation.Methods: Indication for FNAB was a thyroid nodule of ≥1 cm or of a less size with clinical or ultrasound features of malignancy. (endocrine-abstracts.org)
  • Tuberculosis is a disease relatively frequent in renal transplant patients, presenting a wide variety of clinical manifestations, often involving various organs and potentially fatal. (hindawi.com)
  • An expert on MKD validated all patients on clinical and genetic criteria. (biomedcentral.com)
  • This study describes the clinical and genetic characteristics of 114 MKD patients, which is the largest cohort so far. (biomedcentral.com)
  • Several single gene disorders share clinical and radiologic characteristics with multiple sclerosis and have the potential to be overlooked in the differential diagnostic evaluation of both adult and paediatric patients with multiple sclerosis. (medscape.com)
  • We analyzed clinical, laboratory and genetic data of MEFV gene of all periodic fever patients who were followed at the University Children's Hospital Ljubljana from the beginning of 2006 to the beginning of 2013. (biomedcentral.com)
  • Clinical and genetic characterization of familial Mediterranean fever among a cohort of Egyptian patients. (cdc.gov)
  • Clinical and functional impact of central sensitization on patients with familial Mediterranean fever: a cross-sectional study. (cdc.gov)
Genetic5
  • People with genetic origins in the Mediterranean basin are more frequently affected than other ethnic groups. (msdmanuals.com)
  • Familial Mediterranean fever (FMF) is a disease of people with genetic origins in the Mediterranean basin, predominantly Sephardic Jews, North African Arabs, Armenians, Turks, Greeks, and Italians. (msdmanuals.com)
  • This study aims to describe the genetic and phenotypic characteristics of MKD in a large international patient cohort. (biomedcentral.com)
  • Recognition of a single-gene disorder as causal for a patient's 'multiple sclerosis-like' phenotype is critically important for accurate direction of patient management, and evokes broader genetic counselling implications for affected families. (medscape.com)
  • In addition, free genetic testing was provided for suspected FMF patients with periodic fevers from the countries of the CSEE region. (biomedcentral.com)
Diseases6
  • In this work, we present the results of calcium metabolism analysis in such patients.Subjects and methods: 3929 operations of patients with different thyroid diseases were performed during 2010 2012 years. (endocrine-abstracts.org)
  • However, unlike general population, in renal transplant (RT) patients, extrapulmonar (occurring in 15%) and disseminated diseases (33-49%) are very frequent [ 1 - 3 , 7 ]. (hindawi.com)
  • The medical records of 90 patients with coexistence diseases among 858 FMF patients were investigated retrospectively from their medical files. (turkiyeklinikleri.com)
  • In parents of the included JIA patients, 1366 ADs were reported, with psoriasis and ankylosing spondylitis being the most common diseases. (contemporarypediatrics.com)
  • We are leaders in advancing education, advocacy, and research for those impacted by autoimmune and autoinflammatory arthritis (AiArthritis) diseases through peer-led guidance, collaboration, and resources that are driven by patient-identified issues and patient-infused solutions. (globalgenes.org)
  • Rat-bite fever ( Spirillum minor ), Lyme disease ( Borrelia burgdorferi ), and syphilis ( Treponema pallidum ) are other spirochetal diseases that can cause FUO. (medscape.com)
20161
  • Since 2016 we have operated a database for patients who suffer from any autoimmune disease. (globalgenes.org)
Disorder3
  • Ordinarily, a hospitalized patient should be supplied with some information about the disorder and the medicines being used to treat it, including their advantages and side effects [url=https://dit.edu.ng/docs/purchase-online-sotalol-cheap-no-rx/] heart attack young squage order sotalol no prescription[/url]. (ehd.org)
  • Up to 50% of patients have a family history of the disorder, usually involving siblings. (msdmanuals.com)
  • Familial Mediterranean fever (FMF) is an inherited disorder. (testmenu.com)
Methods2
  • Methods: The Cochrane Library, CENTRAL, MEDLINE, LILACS, EMBASE, and CRD databases were searched based on the eligibility criteria for all types of studies on NIV use in patients with ALS published up to January 2022. (researchgate.net)
  • Methods The study population consisted of 85 SCI patients and 38 control subjects. (go.jp)
Benign2
  • We present a case report of a young female patient with hypercalcemia-induced acute necrotizing pancreatitis as first manifestation of a benign parathyroid adenoma.Case: A 46-year-old female presented at the emergency room with a sudden attack of severe epigastric pain and vomiting. (endocrine-abstracts.org)
  • Patients with undiagnosed FUO (5-15% of cases) generally have a benign long-term course, especially when the fever is not accompanied by substantial weight loss or other signs of a serious underlying disease. (medscape.com)
Arthritis9
  • Influence of serum folic acid levels on plasma homocysteine concentrations in patients with rheumatoid arthritis. (acibadem.com.tr)
  • There are 7 subtypes of arthritis under JIA, all of which appear in patients before they are aged 16 years, and last for over 6 weeks. (contemporarypediatrics.com)
  • Enthesitis-related arthritis, psoriatic arthritis, and undifferentiated arthritis were seen more often in patients with a family history of AD. (contemporarypediatrics.com)
  • Measuring patient health status in rheumatoid arthritis -- what is a minimal clinically important difference? (jrheum.org)
  • Expression of tristetraprolin (G0S24) mRNA, a regulator of tumor necrosis factor-alpha production, in synovial tissues of patients with rheumatoid arthritis. (jrheum.org)
  • Radiographic progression is getting milder in patients with early rheumatoid arthritis. (jrheum.org)
  • Effects of high dose methylprednisolone pulse therapy on bone mass and biochemical markers of bone metabolism in patients with active rheumatoid arthritis: a 12-month randomized prospective controlled study. (jrheum.org)
  • The efficacy of switching from etanercept to infliximab in patients with rheumatoid arthritis. (jrheum.org)
  • Effects of anakinra monotherapy on joint damage in patients with rheumatoid arthritis. (jrheum.org)
Coexistence1
  • Among 858 FMF patients, additional coexistence disease was identified in 90 (10.5%) patients. (turkiyeklinikleri.com)
Anakinra1
  • The FDA approved anakinra as treatment for DIRA and rilonacept as maintenance therapy once a patient has achieved remission of DIRA. (exploremyplan.com)
Cardiovascular disease1
  • Lodoco is indicated to reduce the risk of myocardial infarction (MI), stroke, coronary revascularization, and cardiovascular death in adult patients with established atherosclerotic disease or with multiple risk factors for cardiovascular disease. (acsh.org)
Disease6
  • The name of a patient or family with the condition (for example, amyotrophic lateral sclerosis is often called Lou Gehrig disease after the famous baseball player who was diagnosed with the condition). (medlineplus.gov)
  • The study by Agepha Pharma used by the FDA in its approval of this new indication for use ultimately involved 5478 patients between the ages of 35 and 82 with evidence of coronary artery disease upon imaging [1] and had been clinically stable for six months before enrollment. (acsh.org)
  • The time from disease onset until entry in the study for patients was a median 139 days. (contemporarypediatrics.com)
  • Sickle cell disease (SCD) patients aged 12 years and up can now be treated with exa-cel and lovo-cel, following simultaneous approval from the FDA on December 8, 2023. (contemporarypediatrics.com)
  • Approximately 15% of patients follow a primary progressive or progressive relapsing course from disease onset, usually characterized by symptoms of progressive myelopathy (gait instability, spasticity, bladder symptoms) and cognitive impairment. (medscape.com)
  • We are looking to speak to persons and caregivers of patients who suffer from different rare medical conditions, such as Acid sphingomyelinase deficiency (ASMD), Fabry disease, Gaucher disease, Pompe disease, Mucopolysaccharidoses 1 (MPS 1) and GM2 Gangliosidosis. (fieldscopeint.com)
Severe3
  • therefore, patients usually have moderate-severe left ventricular dysfunction when diagnosed with cardiac sarcoidosis, which may decrease the effectiveness of therapies. (go.jp)
  • Dr Seth Masters from the institute, working in conjunction with Dr Adrian Liston and Dr Carine Wouters from Belgium, studied families in France, Belgium and England who had been living with an unknown condition that caused severe skin lesions, fevers, pain and exhaustion. (edu.au)
  • 85% of patients had a history of an acute coronary event, severe chest pain, or myocardial infarction, two-thirds of which were more than two years previously. (acsh.org)
Periodic fever syn1
  • Note that "periodic fever" can also refer to any of the periodic fever syndromes. (wikipedia.org)
Arthralgia1
  • Seventy-one percent of all patients had arthralgia and 57 percent had myalgia. (biomedcentral.com)
Diagnostic2
  • Nous avons exa- miné les dossiers de 56 patients ayant eu un diagnostic de fièvre méditerranéenne familiale et suivis au Centre médical Roi Hussein en Jordanie sur une période de 4 ans afin d'étudier leur profil clinique, l'évolution de la maladie, le génotype, le traitement et les complications. (who.int)
  • 1. Patients diagnosed with STEMI for the first time, with the following diagnostic criteria: persistent typical chest pain >30 minutes lasting more than 12 hours, accompanied by ST-segment elevation in at least 2 contiguous leads, and an increase in cardiac enzymes, troponin I. (who.int)
Treatment4
  • What [HA565 trade name] is and what it is used for [HA565 trade name] is an antiretroviral medicine used in the treatment of HIV-1 infected patients. (who.int)
  • Although colchicines are the only effective treatment of familial Mediterranean fever (FMF), resistance to colchicines (CR) which is observed in up to 30% of the patients is still a problem. (omu.edu.tr)
  • The holistic approach embraced by the unit enables patients to receive comprehensive treatment by a multidisciplinary team (rheumatologist, rheumatology nurse, study coordinator, physiotherapist, occupational therapist, social worker, and psychologist) in the framework of the consulting clinic as well as during hospitalization. (rambam.org.il)
  • Prezcobix (darunavir and cobicistat) is a combination of a human immunodeficiency virus ( HIV -1) protease inhibitor and a CYP3A inhibitor and is indicated for the treatment of HIV-1 infection in adult patients. (rxlist.com)
Acute1
  • Serum 25-hydroxy vitamin D (25-OHD) concentration (ng/mL) was detected in all FMF patients who were not in an acute attack period. (omu.edu.tr)
Turkey1
Febrile1
  • Triggers inducing febrile episodes were mentioned in 108 patients, the most important ones were vaccination (n=39), infection (n=18) and stress (n=26). (biomedcentral.com)
Symptoms2
  • The patient had no diarrhea, urinary symptoms, graft pain or other complaints. (hindawi.com)
  • Typical and atypical mycobacteria and cytomegalovirus (CMV) are opportunistic infections in persons with HIV infection that frequently cause prominent constitutional symptoms, including fever, with few localizing or specific signs. (medscape.com)
Profuse1
  • Five years after RT, in February 2012, he was admitted with mild fever, profuse night sweating, and weight loss of 10% of his body weight, with three months of evolution. (hindawi.com)
Children4
Amyotrophic lateral s1
  • Background: Respiratory failure is the most common cause of death in patients with amyotrophic lateral sclerosis (ALS), and morbidity is related to poor quality of life (QOL). (researchgate.net)