Patient cardiomyopathy dilated. Medical search. Frequent questions

The study objectives were 1) to assess the long-term outcome of patients with biopsy-proved lymphocytic myocarditis (Dallas criteria), and 2) to compare the outcome of these patients with that of patients with idiopathic dilated cardiomyopathy. (nih.gov)
Study group survival was compared with that for a cohort of patients with idiopathic dilated cardiomyopathy seen at the Mayo Clinic from 1976 to 1987 who had endomyocardial biopsy findings negative for myocarditis. (nih.gov)
Fifty-eight patients with a diagnosis of idiopathic dilated cardiomyopathy who underwent endomyocardial biopsy served as the comparison cohort. (nih.gov)
Ejection fraction was lower in patients with idiopathic dilated cardiomyopathy ([mean +/- SD] 25 +/- 11%) than in those with myocarditis (38 +/- 19%, p = 0.001), even though a higher proportion of myocarditis group patients were in New York Heart Association functional class III or IV (63%) than patients in the dilated cardiomyopathy group (30%, p = 0.005). (nih.gov)
There was no difference in 5-year survival rate between the myocarditis and idiopathic dilated cardiomyopathy groups (56% vs. 54%, respectively). (nih.gov)
This study demonstrates that the long-term outcome of patients with biopsy-proved myocarditis seen in a referral setting is poor, although no different from that of patients with idiopathic dilated cardiomyopathy. (nih.gov)
This study was designed to assess the relation between cardiac MIBG uptake and circulating levels of proinflammatory cytokines in patients with idiopathic dilated cardiomyopathy (IDC). (nih.gov)
Dilated cardiomyopathy associated with lamin A /C (LMNA) gene variants (LMNA-related dilated cardiomyopathy [DCM]) is a life -threatening condition with a high unmet need, accounting for approximately 6% of idiopathic DCM cases. (bvsalud.org)
Anti-{beta} 1-adrenoceptor ({beta} 1AR) autoantibodies have been shown to be pathophysiologically important in idiopathic dilated cardiomyopathy (DCM). (mdc-berlin.de)
We analyzed our 10‐year cumulative experience of 40 consecutive patients with idiopathic dilated Cardiomyopathy and associated ventricular tachyarrhythmias, treated with implantable Cardioverter defibrillators. (johnshopkins.edu)
Range and colleagues analyze myocardial perfusion PET results from patients with nonischemic dilated cardiomyopathy with and without idiopathic atrial fibrillation. (snmjournals.org)
Prognosis for idiopathic dilated cardiomyopathy. (ptca.org)
Therapy for idiopathic restrictive cardiomyopathy (RCM) is limited to symptomatic treatment and is often ineffective in improving outcome. (medscape.com)
Most cases of RCM (including idiopathic ones) are not known to be inherited, although there have been reports of families in whom multiple members are affected by a combination of hypertrophic and restrictive cardiomyopathies. (medscape.com)
This photograph depicts a sectioned human heart, extracted at the time of this patient's autopsy, revealing the gross pathologic changes caused by a case of idiopathic cardiomyopathy. (cdc.gov)

Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy. (ca.gov)
Several mutations identified in phospholamban (PLN) have been linked to familial dilated cardiomyopathy (DCM) and heart failure, yet the underlying molecular mechanism remains controversial. (elifesciences.org)
The work will be of interest to investigators of mechanisms of substrate recruitment by protein kinases, and particularly to those who are trying to understand the mechanisms of familial dilated cardiomyopathy. (elifesciences.org)
Whole exome sequencing identifies a KCNJ12 mutation as a cause of familial dilated cardiomyopathy. (nih.gov)

Autoimmune mechanisms Thiamine deficiency Recent studies have shown that those subjects with an extremely high occurrence (several thousands a day) of premature ventricular contractions (extrasystole) can develop dilated cardiomyopathy. (wikipedia.org)
About 10% of people who develop dilated cardiomyopathy are older than 65. (msdmanuals.com)

T1 mapping and myocardial extracellular volume assessed by cardiac magnetic resonance in diabetic patients with stable coronary artery disease. (escardio.org)
Autoantibodies against the {beta} 1AR was analysed in sera from patients with DCM (n = 16) and coronary artery disease (CAD) (n = 21) treated with IVIG or placebo before, 6 and 12 months. (mdc-berlin.de)
Presence of other form(s) of cardiomyopathy contributing to HF (eg, inflammatory or infiltrative cardiomyopathy), clinically significant cardiac anatomic abnormality (eg,LV aneurysm), clinically significant coronary artery disease (eg, coronary revascularization, exercise induced angina) or uncorrected, hemodynamically significant (ie, moderate-severe) primary structural valvular disease not due to HF, per investigator judgment. (stanfordhealthcare.org)
Invasive therapy versus conservative therapy for patients with stable coronary artery disease: An updated meta-analysis. (yumaregional.org)
AIMS: To examine the relevance of genetic and cardiovascular magnetic resonance (CMR) features of dilated cardiomyopathy (DCM) in individuals with coronary artery disease (CAD). (imperial.ac.uk)

Dilated cardiomyopathy is myocardial dysfunction causing heart failure in which ventricular dilation and systolic dysfunction predominate. (msdmanuals.com)

Biopsy specimens from 41 patients met the Dallas criteria for a diagnosis of myocarditis (n = 28) or borderline myocarditis (n = 13). (nih.gov)
Therefore, the aim of this study was to test the diagnostic accuracy of ECVCCT in patients with a recent diagnosis of dilated cardiomyopathy, having ECVCMR as the reference technique. (cardiologicomonzino.it)
Patient 14 had a diagnosis of myopericarditis. (cdc.gov)
All patients who underwent CMR for further evaluation of DCM during the period of 2011-2019 and in whom CMR confirmed the diagnosis of DCM, were included in the study. (aku.edu)
Read this case highlighting the importance of early etiologic diagnosis of dilated cardiomyopathy. (escardio.org)
Algorithm for the diagnosis of patients with neurodevelopmental disorders and suspicion of a genetic syndrome. (cdc.gov)

RV dysfunction is an important predictor of morbidity and mortality in cardiac patients, especially those having dilated cardiomyopathy (DCM). (springeropen.com)
Patients were followed up in the year 2020 for all-cause mortality and cardiovascular hospitalizations. (aku.edu)
Most patients (40, 65.6%) experienced all-cause major adverse cardiovascular events (MACE) during the follow-up and mortality was observed in 10 (16.4%) patients. (aku.edu)
Pulmonary hypertension predicts mortality and morbidity in patients with dilated cardiomyopathy. (nature.com)

Although NIDCM is characterized by genetic and clinical heterogeneity, few studies have explored the pathogenesis of VA in patients with NIDCM. (hindawi.com)
Heart failure due to genetic mutation is one of the most common ailment and is a major contributor to the large number of patients on the heart transplant. (ca.gov)
Received ARRY-371797 as treatment for a genetic dilated cardiomyopathy secondary to LMNA mutations in a clinical study sponsored by Array BioPharma. (cmdir.org)
Researchers have made a significant finding in determining the genetic background of dilated cardiomyopathy in Dobermanns. (news-medical.net)
Researchers from the University of Helsinki and the Folkhälsan Research Center, together with their international partners, have identified the genetic background of dilated cardiomyopathy, a disease that enlarges the heart muscle, in dogs and humans. (news-medical.net)
Although dozens of genes underlying cardiomyopathy in humans have been identified, the hereditary nature and genetic background of the disease in dogs have remained unclear. (news-medical.net)
With the help of genetic mapping, two adjacent gene loci in chromosome 5 were associated with dilated cardiomyopathy. (news-medical.net)
The identical genetic background suggests that, to a degree, similar problems with the functioning of the heart muscle lead to dilated cardiomyopathy in both humans and dogs. (news-medical.net)
How to conduct genetic testing for patients with DCM? (escardio.org)
Researchers achieved a significant milestone in uncovering the genetic basis of dilated cardiomyopathy in Dobermanns. (medindia.net)
Groundbreaking gene therapy for genetic beta thalassemia is now accessible as a treatment to a patient post-FDA approval. (medindia.net)
patients underwent genetic sequencing as part of the research protocol and long-term follow-up. (imperial.ac.uk)
Adolescents with congenital heart defects: a patient and parental perspective of genetic information and genetic risk. (cdc.gov)
Genetic analysis in patients with left ventricular noncompaction and evidence for genetic heterogeneity. (lu.se)

These might include: Shortness of breath Syncope (fainting) Angina, but only in the presence of ischemic heart disease A person who has dilated cardiomyopathy may have an enlarged heart, with pulmonary edema and an elevated jugular venous pressure and a low pulse pressure. (wikipedia.org)

How well do you know the 2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death? (escardio.org)

This is a rollover study designed to investigate the safety and effectiveness of investigational study drug ARRY-371797 in patients who previously received ARRY-371797 in a study for patients with LMNA-related dilated cardiomyopathy sponsored by Array BioPharma and may, in the Investigator's opinion, derive benefit from continued treatment. (cmdir.org)
ARRY-371797 (PF-07265803), a potent, selective, oral, small-molecule inhibitor of the p38α mitogen-activated protein kinase pathway, improved 6-minute walk test (6MWT) distance in 12 patients with symptomatic LMNA-related DCM in a 48-week, open-label, phase 2 study. (bvsalud.org)
This is a randomized, double-blind, placebo-controlled study in patients with dilated cardiomyopathy (DCM) due to a mutation of the gene encoding the lamin A/C protein (LMNA). (stanfordhealthcare.org)
Patients with symptomatic lamin A/C protein (LMNA)-related cardiomyopathy Class II/III/ or Class IV defined as: - Gene positive for a pathogenic, likely pathogenic, or VUS mutation in the LMNA gene as determined by an accredited clinical laboratory. (stanfordhealthcare.org)

Treatment with beta-adrenergic blockers or overexpression of sarcoplasmic reticulum Ca(2+) adenosine triphosphatase (Serca2a) improved the function of iPSC-derived cardiomyocytes from DCM patients. (ca.gov)
Thus, iPSC-derived cardiomyocytes from DCM patients recapitulate to some extent the morphological and functional phenotypes of DCM and may serve as a useful platform for exploring disease mechanisms and for drug screening. (ca.gov)
Troponin destabilization impairs sarcomere-cytoskeleton interactions in iPSC-derived cardiomyocytes from dilated cardiomyopathy patients. (ox.ac.uk)

Characterized by ventricular dilatation, systolic dysfunction, and progressive heart failure, dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy in patients. (ca.gov)
Echo-Doppler parameters of RV and LV function including RV global longitudinal strain, basal & apical RV strain, LV ejection fraction and LV global longitudinal strain were evaluated in 42 DCM patients & 28 normal subjects, aiming to assess the value of apical versus basal RV strain in detection of RV dysfunction in patients with dilated cardiomyopathy. (springeropen.com)
RV apical but not basal strain reflects the status of RV function, and it represents a valuable measure to diagnose RV dysfunction in patients with DCM. (springeropen.com)

Tomasulo CE, Chen JM, Smith CL, Maeda K, Rome JJ, Dori Y. Lymphatic disorders and management in patients with congenital heart disease. (chop.edu)

Earlier studies have found that this disease is caused by mutation in a cardiac muscle gene call troponin T. In this study a special stem cell was generated from the skin cell of a family of patients with this mutation as well as their non-diseased sibling. (ca.gov)
Here, we generated cardiomyocytes from iPSCs derived from patients in a DCM family carrying a point mutation (R173W) in the gene encoding sarcomeric protein cardiac troponin T. Compared to control healthy individuals in the same family cohort, cardiomyocytes derived from iPSCs from DCM patients exhibited altered regulation of calcium ion (Ca(2+)), decreased contractility, and abnormal distribution of sarcomeric alpha-actinin. (ca.gov)
We previously reported that induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) from patients with a dilated cardiomyopathy (DCM) mutation, troponin T (TnT)-R173W, display sarcomere protein misalignment and impaired contractility. (ox.ac.uk)
Novel missense mutation (R94S) in the TAZ ( G4.5) gene in a Japanese patient with Barth syndrome. (lu.se)
Mutation analysis of the G4.5 gene in patients with isolated left ventricular noncompaction. (lu.se)
A novel intronic mutation of the TAZ ( G4.5) gene in a patient with Barth syndrome: creation of a 5' splice donor site with variant GC consensus and elongation of the upstream exon. (lu.se)

A variety of factors can cause cardiomyopathy, but genetics play a significant role. (news-medical.net)
This study, carried out by researchers at the Massachusetts General Hospital (MGH) and collaborators, has implications for patients who experience fatigue due to genetics-related musculoskeletal diseases as well as other types of illness-induced fatigue. (medindia.net)

Restrictive cardiomyopathy (RCM) is a rare disorder in children that is characterized by restrictive filling and reduced diastolic volume of one or both ventricles with normal or near-normal systolic function and wall thickness. (medscape.com)
1] The heart is grossly normal, although histologic abnormalities are often present, depending on the etiology of the restrictive cardiomyopathy. (medscape.com)
RCM may manifest as a solitary abnormality, although restrictive filling patterns of the left ventricle can also be seen in patients with dilated or hypertrophic cardiomyopathy. (medscape.com)
Some investigators have divided RCM into the following subtypes: (1) pure restrictive cardiomyopathy, (2) hypertrophic-restrictive cardiomyopathy, and (3) mildly dilated restrictive cardiomyopathy. (medscape.com)
6] Additionally, some inherited infiltrative disorders can cause restrictive cardiomyopathy. (medscape.com)
DMD patients are at risk for the development of restrictive lung disease, dilated cardiomyopathy, mitral regurgitation, and recurrent pulmonary infections secondary to aspiration. (medscape.com)

They also reviewed recent studies investigating genotype-phenotype associations in DCM patients with titin (TTN) mutations. (wikipedia.org)
This paper describes results on the association between protein kinase A and peptides corresponding to wild-type PLN (residues 8-22) and peptides bearing mutations (R9C and A11E) which in the context of full-length PLN (52 residues) result in dilated cardiomyopathy. (elifesciences.org)
Strande, J. L. Haploinsufficiency MYBPC3 mutations: another stress induced cardiomyopathy? (nature.com)
To understand the clinical impact of RBM20 mutations, we have generated induced pluripotent stem cells (iPSCs) from adult patients and healthy controls. (stanford.edu)
Using the patient heart cells we have engineered in the lab (Figure 2), we have set up a platform to test drugs that may counteract the harmful effects of RBM20 mutations. (stanford.edu)
Novel gene mutations in patients with left ventricular noncompaction or Barth syndrome. (lu.se)

The genes we identified are only associated with a dilated heart and affected cardiac function. (news-medical.net)

Enteroviruses are associated with diverse clinical syndromes ranging from minor febrile illness to severe, potentially fatal conditions (e.g., aseptic meningitis, encephalitis, paralysis, myocarditis, and neonatal enteroviral sepsis) and could be linked with the development of some chronic diseases (e.g., type 1 diabetes and dilated cardiomyopathy) ( 1,2 ). (cdc.gov)
Goland and colleagues assess the feasibility of 11 C-DTBZ PET quantification of pancreatic vesicular monoamine transporter type 2 binding in healthy subjects and patients with long-standing type 1 diabetes. (snmjournals.org)

ventricular arrhythmia (VA) is a major cause of clinical deterioration and demise in patients with NIDCM [ 3 - 6 ]. (hindawi.com)
Objectives: The objectives of the study were to evaluate the clinical presentation, cardiac magnetic resonance (CMR) features, and outcomes of patients with dilated cardiomyopathy (DCM). (aku.edu)
Guidelines have been established in Europe for the clinical management of patients with new-onset and long-term AF. (medscape.com)
8) Contrast-enhanced ultrasound (CEUS) for the characterization of focal liver lesions in clinical practice (DEGUM Multicenter Trial): CEUS vs. MRI--a prospective comparison in 269 patients. (bracco.com)
Hereditary Ataxias in Cuba: A Nationwide Epidemiological and Clinical Study in 1001 Patients. (cdc.gov)

The hallmark of psoriasis is chronic and systemic inflammation, which is a major contributor to the atherosclerosis, cardiomyopathy, and other cardiovascular manifestations seen in the disease. (medscape.com)
In general, these patients have a higher rate of cardiovascular risk factors and cardiovascular diseases. (medscape.com)
The most important cardiovascular diseases (CVDs) in the African Region are those related to atherosclerosis, cardiomyopathies and rheumatic heart disease. (who.int)

0.001) compared to patients without NI-LGE, with no significant difference in the burden of rare protein altering variants in DCM-associated genes between groups (9.7% vs 6.7%, odds ratio 1.5, 95% CI 0.5-4.4, p=0.41). (imperial.ac.uk)

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a form of heart disease that usually appears in adulthood. (medlineplus.gov)
Corrado D, Link MS, Calkins H. Arrhythmogenic Right Ventricular Cardiomyopathy. (medlineplus.gov)
Even so, the dispute considering Brugada syndrome as an independent entity or forming part of the spectrum of arrhythmogenic right ventricular cardiomyopathy is still controversial. (bvsalud.org)

Alcohol use disorder (alcoholic cardiomyopathy) Non-alcoholic toxic insults include administration of certain chemotherapeutic agents, in particular doxorubicin (Adriamycin), and cobalt. (wikipedia.org)

To reduce this risk, MG patients should be medically optimized before elective surgery. (medscape.com)

Thus, it is important to evaluate the prognostic value of positive endomyocardial biopsy findings in patients presenting with dilated cardiomyopathy, using standardized criteria for lymphocytic myocarditis. (nih.gov)
With the current lack of proved effective treatment for lymphocytic myocarditis and no demonstration of survival benefit for patients with myocarditis, these data suggest that endomyocardial biopsy performed to exclude myocarditis is of limited prognostic value in the routine evaluation of dilated cardiomyopathy. (nih.gov)
Prevalence and prognostic impact of sarcopenia identified according to Asia Working Group for Sarcopenia definition in non-dependent elderly patients with heart failure. (escardio.org)

17 NIDCM patients (6 patients suffered VA included) with complete survival time (time period of each patient from symptoms to heart transplantation) information were selected for the study. (hindawi.com)
In some cases, treating the underlying cause of dilated cardiomyopathy can reduce DCM symptoms and improve the health and function of the left ventricle. (healthline.com)
Dilated cardiomyopathy develops insidiously, and may not initially cause symptoms significant enough to impact on quality of life. (wikipedia.org)
Because the number of patients who have subclinical RCM is unknown, the natural history can be determined only when symptoms develop. (medscape.com)

Endomyocardial biopsy is frequently performed in patients presenting with dilated cardiomyopathy to identify lymphocytic myocarditis. (nih.gov)
Pre-analytical variables for the genomic assessment of the cellular and acellular fractions of the liquid biopsy in a cohort of breast cancer patients. (cdc.gov)

Dilated Cardiomyopathy was defined as left ventricular ejection fraction (EF) ≤50% with no defineable etiology. (johnshopkins.edu)
Up to 45% of patients with a left ventricular ejection fraction of ≤40% may suffer from this breathing disorder during sleep 1 , 2 . (ersjournals.com)

Most important are hypertension, stroke, cardiomyopathies and coronary heart disease. (who.int)

When Should Anticoagulation for Stroke be Initiated in Patients With Atrial Fibrillation? (medscape.com)
Potential major cardiac embolic sources (e.g. atrial fibrillation, thrombi of left ventricle/atrium, vegetation, myxoma, dilated cardiomyopathy) have a causal relationship to embolism. (lu.se)
The most common major potential embolic source was atrial fibrillation, detected in 22/121 patients. (lu.se)
Eleven left atrial thrombi were found (four of these patients had atrial fibrillation and seven had sinus rhythm). (lu.se)
Certain changes (e.g. atrial septal aneurysm) might have a potential embolic role in younger stroke patients but in our study no difference was found between older stroke patients and controls. (lu.se)

Objectives To determine the efficacy and tolerability of β blockers in a broad age range of women and men with heart failure with reduced ejection fraction (HFrEF) by pooling individual patient data from placebo controlled randomised trials. (bmj.com)

Long-Term Efficacy and Safety of ARRY-371797 (PF-07265803) in Patients With Lamin A/C-Related Dilated Cardiomyopathy. (bvsalud.org)

Differentially expressed genes (DEGs) were identified by comparing the gene expression of NIDCM patients with or without VA in the gene expression profile of GSE135055. (hindawi.com)
We established a prediction model on two-gene ( TOMM22 , PPP2R5A ) signature for the survival time of NIDCM patients. (hindawi.com)
Based on the regression coefficient and the expression value of each selected gene obtained by the multivariate Cox regression model, the risk score of each patient was calculated, then we separated 17 patients into high-risk and low-risk groups using the median risk score as the cutoff. (hindawi.com)
The significance of the gene discovery in dogs was investigated in human patients diagnosed with dilated cardiomyopathy using Dutch, English (UK Biobank) and Finnish (FinnGen) cohorts. (news-medical.net)
This study provides preliminary answers to at least two questions: How effective should scientists expect gene therapy for this disease will be in actual patients? (medindia.net)
The X-linked gene G4.5 is responsible for different infantile dilated cardiomyopathies. (lu.se)

A total of 228 DEGs were obtained, and 3 genes were screened out to be significantly related to the survival time of NIDCM patients. (hindawi.com)
In order to reveal the inherent molecular mechanism, NIDCM patients were divided into sinus rhythm (SR) group and VA group and differentially expressed genes (DEGs) were identified via bioinformatic methods. (hindawi.com)
The study revealed that these same risk genes cause heart muscle disease in human patients. (news-medical.net)
Altered expression of genes for Kir ion channels in dilated cardiomyopathy. (nih.gov)

Although in many cases no cause is apparent, dilated cardiomyopathy is probably the result of damage to the myocardium produced by a variety of toxic, metabolic, or infectious agents. (wikipedia.org)

After excluding subjects with a major potential cardiac embolic source and/or carotid artery stenosis, no differences in the prevalence of minor potential cardiac embolic sources were found between patients (55%) and control subjects (47%) (p = NS). (lu.se)
74 years) the prevalence of potential minor cardiac embolic sources did not differ between patients and controls. (lu.se)
However, potential minor cardiac embolic sources did not differ in prevalence in the patients compared with controls. (lu.se)
This high HCV prevalence (17.3 %) represents a substantial health burden in HD patients from Kinshasa, DR Congo. (bvsalud.org)

This is the most common infectious cause of dilated cardiomyopathy in Latin America Pregnancy: Dilated cardiomyopathy occurs late in gestation or several weeks to months postpartum as a peripartum cardiomyopathy. (wikipedia.org)

Diabetic cardiomyopathy-What do we know about it? (scirp.org)

In this study, cytokinesis-block micronucleus cytome (CBMN Cyt) assay was employed to evaluate the extent of chromosomal instability or DNA damage in lymphocytes of patients suffering from dilated cardiomyopathy (DCM), a serious cardiac muscle disorder. (vit.ac.in)

In stroke patients several cardiac changes associated with embolism can be detected with transoesophageal echocardiography. (lu.se)
One hundred and twenty-one patients with first-ever stroke were. (lu.se)

Asif T, Kassab K, Iskander F, Alyousef T. Acute Pericarditis and Cardiac Tamponade in a Patient with COVID-19: A Therapeutic Challenge. (yumaregional.org)

Recent epidemiological studies have shown a significantly worse survival for patients with left heart insufficiency and CSAS 7 , 8 . (ersjournals.com)

Echocardiography was diagnostic of dilated cardiomyopathy. (who.int)

Anatomy22

Organisms10

Diseases69

Chemicals and Drugs56

Analytical, Diagnostic and Therapeutic Techniques and Equipment60

Phenomena and Processes32

Anthropology, Education, Sociology and Social Phenomena1

Information Science3

Health Care16

Idiopathic15

Familial4

Develop dilated cardiomyopathy2

Coronary artery5

Myocardial1

Diagnosis6

Mortality4

Genetic14

Ischemic heart d1

Arrhythmias1

LMNA4

IPSC-derived cardiomyocytes3

Dysfunction3

Congenital1

Mutation6

Genetics2

Restrictive6

Mutations6

Cardiac Function1

Type 1 diabet2

Clinical5

Cardiovascular3

Variants1

Arrhythmogenic3

Alcoholic cardiomyopathy1

Medically1

Prognostic3

Symptoms4

Biopsy2

Left ventricu2

Hypertension1

Atrial5

Placebo-controlled1

Lamin1

Gene6

Genes4

Myocardium1

Prevalence4

Occurs1

Diabetic1

Disorder1

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Acute1

Significantly1

Echocardiography1