• Uremic tumoral calcinosis (UTC) is a form of metastatic tissue calcification unique to dialysis patients, manifesting with amorphous and cystic masses containing calcium phosphate deposits in periarticular soft tissue. (springer.com)
  • Surgical removal of the destructive cervical spine lesion, showing typical tumoral calcinosis on histology, completely resolved the clinical symptoms. (springer.com)
  • Cofan F, Garcia S, Combalia A et al (1999) Uremic tumoral calcinosis in patients receiving longterm hemodialysis therapy. (springer.com)
  • Hamada J, Tamai K, Saotome K et al (2006) Uremic tumoral calcinosis in hemodialysis patients: clinicopathological findings and identification of calcific deposits. (springer.com)
  • Chu HY, Chu P, Lin SH et al (2011) Uremic tumoral calcinosis in patients on peritoneal dialysis: clinical, radiographic, and laboratory features. (springer.com)
  • Möckel G, Buttgereit F, Perka C et al (2005) Tumoral calcinosis revisited: pathophysiology and treatment. (springer.com)
  • Fernández E, Amoedo ML, Montoliu J et al (1993) Tumoral calcinosis in haemodialysis patients without severe hyperparathyroidism. (springer.com)
  • Matsukado K, Amano T, Nagata S et al (2001) Tumoral calcinosis in the upper cervical spine causing progressive radiculomyelopathy-case report. (springer.com)
  • Carlson AP, Yonas HM, Turner PT (2007) Disorder of tumoral calcinosis of the spine: illustrative case study and review of literature. (springer.com)
  • Remy-Leroux V, Reguiaï Z, Bernard P et al (2009) Tumoral calcinosis at an unusual site in a haemodialysis patient. (springer.com)
  • These include calcinosis cutis circumscripta, calcinosis cutis universalis, tumoral calcinosis, and transplant-associated calcinosis cutis. (medscape.com)
  • Tumoral calcinosis is a rare condition in which there is calcium deposition in the soft tissue in periarticular location, around joints, outside the joint capsule. (wikipedia.org)
  • A zebrafish animal model with reduced GALNT3 expression also showed HFTC-like phenotype, indicating an evolutionary conserved mechanism that is involved in developing tumoral calcinosis. (wikipedia.org)
  • Tumoral Calcinosis is a condition consisting of massive subcutaneous deposits of calcium salts often overlying large joints in otherwise healthy patients. (ajol.info)
  • To describe the characteristics of a series of patients with Tumoral Calcinosis in the Gurage Zone of Central Ethiopia. (ajol.info)
  • Hyperphosphatemic familial tumoral calcinosis (HFTC) is a condition characterized by an increase in the levels of phosphate in the blood (hyperphosphatemia) and abnormal deposits of phosphate and calcium (calcinosis) in the body's tissues. (medlineplus.gov)
  • Tumoral calcinosis is more common in blacks of South African heritage. (medscape.com)
  • Tumoral calcinosis usually arises in the first or second decade of life. (medscape.com)
  • Familial tumoral calcinosis (FTC) is a severe metabolic disorder characterised by the progressive deposition of calcified masses in cutaneous and subcutaneous tissues, which results in painful ulcerative lesions with severe skin and bone infections. (exeterlaboratory.com)
  • Scleroderma / CREST syndrome (calcinosis cutis, Raynaud phenomena, esophageal dysfunction, sclerodactyly, and telangiectasia) is the most common overlap syndrome resulting in sclerodermatomyositis. (medpagetoday.com)
  • A solitary report has described successful treatment with cyclophosphamide in a patient with both CREST (calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia) and Sjögren syndrome. (medscape.com)
  • CREST syndrome (calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasias) refers to a subset of patients with limited scleroderma. (logicalimages.com)
  • In generalized systemic sclerosis with diffuse skin involvement, patients have Raynaud syndrome and gastrointestinal (GI) complications. (msdmanuals.com)
  • Calcinosis cutis is classified into 4 major types according to etiology: dystrophic, metastatic, iatrogenic, and idiopathic. (medscape.com)
  • The early diagnosis of metastatic pulmonary calcification is beneficial, as some patients may develop restrictive changes in respiratory function or in some cases lethal acute respiratory distress. (nih.gov)
  • In the metastatic form, calcium salts are deposited in the dermis or subcutis in patients with elevated serum levels of phosphorus and calcium. (medicaljournals.se)
  • CHICAGO, June 5, 2023 - The Janssen Pharmaceutical Companies of Johnson & Johnson today announced results from an interim analysis of Cohort 1 of the Phase 3 THOR study, evaluating treatment with BALVERSA ® (erdafitinib) versus chemotherapy in patients with metastatic or unresectable urothelial carcinoma (UC) and selected fibroblast growth factor receptor (FGFR) gene alterations who had received prior treatment with an anti-programmed death ligand 1 (PD-[L]1) agent. (janssen.com)
  • The use of BALVERSA ® in this setting supports recommendations for FGFR testing in all patients with metastatic urothelial cancer. (janssen.com)
  • PRINCETON, N.J., Sept. 30, 2022 /PRNewswire/ -- Taiho Oncology, Inc. and Taiho Pharmaceutical Co., Ltd. announced today that the U.S. Food and Drug Administration (FDA) has approved LYTGOBI ® tablets for the treatment of adult patients with previously treated, unresectable, locally advanced or metastatic intrahepatic cholangiocarcinoma (iCCA) harboring fibroblast growth factor receptor 2 (FGFR2) gene fusions or other rearrangements. (biospace.com)
  • The approval of LYTGOBI is based on the results of the primary analysis of the FOENIX*-CCA2 trial, a global Phase 2 open-label trial evaluating 103 patients with unresectable, locally advanced or metastatic iCCA harboring FGFR2 gene rearrangements including fusions. (biospace.com)
  • LYTGOBI is indicated for the treatment of adult patients with previously treated, unresectable, locally advanced or metastatic intrahepatic cholangiocarcinoma harboring fibroblast growth factor receptor 2 (FGFR2) gene fusions or other rearrangements. (biospace.com)
  • The primary objective of the Part B is to compare progression-free survival (PFS) according to RECIST v1.1 of rogaratinib in combination with atezolizumab over placebo in combination with atezolizumab in untreated patients with FGFR-positive locally advanced or metastatic urothelial carcinoma. (bcan.org)
  • We also review other reported unusual cases of UTC involving the cervical spine and discuss the differential diagnosis of destructive spinal lesions in uremic patients, such as UTC, dialysis-related amyloidosis, and brown tumors. (springer.com)
  • These observations confirm previous findings that scintigraphy with ⁹⁹(m)Tc DPD may be efficious in early diagnosis of pulmonary calcification in hemodialised patients as well as the fact that spirometry is useful in patients with confirmed pulmonary calcifications. (nih.gov)
  • Data was collected from 59 patients who presented with clinical diagnosis of calcinosis cutis around hip region between January 2005 and January 2009. (ajol.info)
  • Therefore, the diagnosis and treatment of a patient with GM still remains a challenge for the clinician as well as for the patient who often has to suffer a protracted disease course with a significant impact on quality of life. (karger.com)
  • Dermatologists can assist in the management of these patients by facilitating early diagnosis, and treating cutaneous manifestations such as Raynaud's phenomenon, cutaneous calcinosis, and digital ulceration. (skintherapyletter.com)
  • The diagnosis and evaluation of patients with calcinosis cutis is discussed separately. (medilib.ir)
  • The contradictory results in these studies may be related to differences in the patient populations with respect to CTD diagnosis. (jrheum.org)
  • Our patient was referred to the rheumatology department, where she received, after clinical and paraclinical investigations, a diagnosis of scleroderma. (panafrican-med-journal.com)
  • Surgical excision of the lesions helps confirm the diagnosis of scrotal calcinosis and is the mainstay of treatment for cosmesis. (patientcareonline.com)
  • Although the patient refused liver biopsy, PBC diagnosis was established. (journalmc.org)
  • To compare survival of patients with connective tissue disease-associated interstitial lung disease (CTD-ILD) versus idiopathic pulmonary fibrosis (IPF) and patients with systemic sclerosis-associated ILD (SSc-ILD) versus other CTD-ILD followed at our center. (jrheum.org)
  • Solitary milialike idiopathic calcinosis cutis: a case unassociated with Down syndrome. (medscape.com)
  • Sais G, Jucglà A, Moreno A, Peyrí J. Milia-like idiopathic calcinosis cutis and multiple connective tissue nevi in a patient with Down syndrome. (medscape.com)
  • Idiopathic scrotal calcinosis is a rare, benign entity seen in the scrotum, comprised of calcified nodules, and some areas show foreign body-type granulomatous reaction. (utoronto.ca)
  • Some believe that calcinosis seen in this lesion is not idiopathic calcification, but rather dystrophic calcification, perhaps related to an epidermal cyst that preceded the lesion. (utoronto.ca)
  • Braun J (2005) Extraosseous calcification in patients with chronic renal failure-no escape? (springer.com)
  • In dermatomyositis, calcification occurs 3 times more commonly in juvenile dermatomyositis than the adult-onset form and may be seen in 30-40% of patients. (medscape.com)
  • In 1932, Scherrer (3) examined 800 apparently healthy patients and no evidence of calcification was documented. (medicaljournals.se)
  • Therefore, for many patients, the primary goal of treatment is to minimize symptoms and alleviate functional limitations rather than the complete resolution of cutaneous calcification [ 1 ]. (medilib.ir)
  • In secondary scrotal calcinosis, the causes are identified as calcification of epidermal cysts, calcific degeneration of the dartos muscle, and dystrophic calcification of subcutaneous soft tissue secondary to chronic inflammation or infection. (patientcareonline.com)
  • They examined 14 cases and concluded that scrotal calcinosis results from calcification of hair follicles and epidermal cysts. (patientcareonline.com)
  • Shah V, Shet T. Scrotal calcinosis results from calcification of cysts derived from hair follicles: a series of 20 cases evaluating the spectrum of changes resulting in scrotal calcinosis. (patientcareonline.com)
  • sclerodactyly, telangiectasias), patients develop skin tightening over the face and distal to the elbows and knees and may also have gastroesophageal reflux disease. (msdmanuals.com)
  • Anti-topo I and ACA were found primarily in patients with scleroderma, CREST syndrome, and Raynaud's phenomenon. (nih.gov)
  • DYSTROPHIC CALCINOSIS CUTIS - Dystrophic calcinosis cutis, the most common form of calcinosis cutis, results from local tissue injury. (medilib.ir)
  • Treatment principles - The treatment of dystrophic calcinosis cutis associated with autoimmune connective tissue disease is often difficult. (medilib.ir)
  • Although early reports documenting poor wound healing and sinus track formation led to the historical avoidance of surgical procedures for dystrophic calcinosis cutis, subsequent reports suggest that surgery can be effective for some patients. (medilib.ir)
  • Dystrophic calcinosis cutis is most common. (medscape.com)
  • Marzano AV, Kolesnikova LV, Gasparini G, Alessi E. Dystrophic calcinosis cutis in subacute lupus. (medscape.com)
  • The authors describe a case of a 76 year old male patient with Raynaud's phenomenon complaints in 1999. (journalmc.org)
  • In the prospective Autologous Stem Cell Transplantation International Scleroderma (ASTIS) trial, a phase 3 comparison of autologous HSCT with 12 successive monthly intravenous pulses of cyclophosphamide in 156 patients with early diffuse cutaneous systemic sclerosis, HCST was associated with higher treatment-related mortality than in the first year after treatment. (medscape.com)
  • In addition, patients with scleroderma may have an increased risk of cancer. (skintherapyletter.com)
  • In systemic sclerosis sine scleroderma, patients have systemic sclerosis-related antibodies and visceral manifestations of the disease but no skin tightening. (msdmanuals.com)
  • Though scleroderma manifests differently among patients, the most prominent symptom is hardening of the skin. (drwilderman.com)
  • In patients with systemic sclerosis-related interstitial lung disease, a clinically meaningful decline of 10% or more in lung function was seen in 24.5% of placebo recipients, compared with 8.6% of tocilizumab recipients. (medscape.com)
  • Does hand involvement in systemic sclerosis limit completion of patient-reported outcome measures? (harvard.edu)
  • Calcinosis is associated with ischemic manifestations and increased disability in patients with systemic sclerosis. (harvard.edu)
  • Baseline characteristics of patients with Systemic Sclerosis and controls groups. (reumatologiaclinica.org)
  • Association between NP and clinical variables among patients with Systemic Sclerosis in a multivariate logistic regression analysis. (reumatologiaclinica.org)
  • To investigate if patients with Systemic Sclerosis (SSc) show a higher prevalence of neuropathic pain (NP) in comparison with controls. (reumatologiaclinica.org)
  • Calcinosis cutis circumscripta tends to arise in the second half of life. (medscape.com)
  • Calcinosis circumscripta, a more localized form of calcium deposition in the skin, can occur on pressure points such as the paws and elbows, at suture sites, and on the tongue, but has different underlying causes than calcinosis cutis. (dermvetolympia.com)
  • ACA identified patients with less severe disease, whereas anti-topo I identified patients with skin and cardiac involvement and patients with malignancies. (nih.gov)
  • Fujisawa T, Shu E, Ikeda T, Seishima M. Primary localized cutaneous nodular amyloidosis that appeared in a patient with severe atopic dermatitis. (medscape.com)
  • These findings should raise the awareness of the clinician to recognize and address the presence of NP in these patients, especially in those with severe skin involvement. (reumatologiaclinica.org)
  • If the lesions have been present for a long time and are very severe, they may never resolve fully or the patient can be left with scarring. (dermvetolympia.com)
  • Juvenile myositis (JDM) diagnosed >5 years from screening or juvenile myositis with extensive calcinosis or severe calcinosis. (who.int)
  • They are frequently (0.5-3%) seen in patients undergoing renal dialysis. (wikipedia.org)
  • Forty-two patients with end-stage renal disease, who were treated by regular haemodialysis, were investigated. (nih.gov)
  • Dermatologic manifestations of renal disease are not uncommon findings in patients with end-stage renal disease (ESRD). (medscape.com)
  • Many cutaneous disorders experienced by patients undergoing dialysis have little to do with the uremic syndrome and are related to the same underlying pathologic process that caused the renal disease. (medscape.com)
  • Because dialysis and transplant centers are required to report specific information regarding each patient diagnosed with end-stage renal disease (ESRD) to the United States Renal Data System (USRDS), data regarding the causes of ESRD are readily available in the Annual Data Report published by the USRDS. (medscape.com)
  • Review of the 2019 report reveals that diabetes mellitus remains the most common cause of ESRD, responsible for approximately 42% of all patients on renal replacement therapy. (medscape.com)
  • Rocaltrol is indicated for the correction of the abnormalities of calcium and phosphate metabolism in patients with renal osteodystrophy. (medicines.org.uk)
  • Serum Phosphate and Calcium levels in selected patients were with in normal limit. (ajol.info)
  • Patients are usually asymptomatic, but some experience a degree of discomfort. (medicaljournals.se)
  • Most patients are asymptomatic or complain of external otalgia if the ear canal is involved (6). (medicaljournals.se)
  • Clinical follow-up without intervention to reduce calcium deposits is a reasonable option for calcinosis cutis that is asymptomatic, nonprogressive, unassociated with internal involvement, and of minimal concern to the patient. (medilib.ir)
  • Neutrophilic eccrine hidradenitis (NEH) is a neutrophilic dermatosis primarily affecting the eccrine glands and occurs most commonly in patients undergoing chemotherapy for a malignancy. (annals.edu.sg)
  • Calcinosis usually occurs in and just under skin tissue around the joints, most often the hips, shoulders, and elbows. (medlineplus.gov)
  • Rarely, calcinosis occurs in blood vessels or in the brain and can cause serious health problems. (medlineplus.gov)
  • Calcinosis cutis universalis occurs in the second decade of life. (medscape.com)
  • Calcinosis cutis occurs when calcium crystals are abnormally deposited in the skin. (dermvetolympia.com)
  • Treatment of calcinosis - Treatment of calcinosis cutis associated with autoimmune connective tissue diseases involves careful consideration of the need for treatment and the selection of an appropriate treatment regimen. (medilib.ir)
  • Transverse section of a female worm and surrounding tissue isolated from the patient (hematoxylin and eosin stained). (cdc.gov)
  • Calcinosis may also develop in the soft tissue of the feet, legs, and hands. (medlineplus.gov)
  • This can be a challenging task, especially in cases with larger defects that may be present after oncologic procedures both in young and old patients presenting with scleroatrophic skin and minimal tissue laxity. (rbcp.org.br)
  • Calcinosis cutis is definitively diagnosed using a biopsy (a sample of tissue taken and submitted to a pathologist for analysis). (dermvetolympia.com)
  • See "Calcinosis cutis: Etiology and patient evaluation" . (medilib.ir)
  • The pathogenesis of calcinosis cutis is not completely understood and a variety of factors allow for different clinical scenarios to occur. (medscape.com)
  • We identified the causative agent of a zoonotic Onchocerca infection with multiple nodules in a patient with systemic lupus erythematosus (SLE) who had been receiving hemodialysis. (cdc.gov)
  • Hands of a transfusion-dependent patient on long-term hemodialysis. (medscape.com)
  • In Western industrialized countries, most authors use a therapy regimen starting with antibiotics and corticosteroids, followed by continuous steroid therapy and surgery in patients with persisting symptoms. (karger.com)
  • Patients and their families should be advised that strict adherence to the prescribed diet is mandatory and they should be instructed on how to recognise the symptoms of hypercalcaemia. (medicines.org.uk)
  • Retinal Pigment Epithelial Detachment (RPED) , which may cause symptoms such as blurred vision, occurred in 9% of 318 patients who received LYTGOBI across clinical trials. (biospace.com)
  • Do the signs and symptoms of calcinosis cutis warrant treatment? (medilib.ir)
  • Decision to treat - Consideration of the severity of the signs and symptoms of calcinosis cutis is important because the response to treatment is variable and unpredictable, and there is risk for treatment-related adverse effects. (medilib.ir)
  • Clinical Factors Associated with Long-Term Damage and Calcinosis in an Adult-Age Referral Population of Juvenile Myositis Patients [abstract]. (acrabstracts.org)
  • We identified Onchocerca jakutensis as the causative agent of an unusual human filariasis in a patient with lupus erythematosus. (cdc.gov)
  • Miteva L, Pramatarov K, Vassileva S. Calcinosis cutis in childhood systemic lupus erythematosus. (medscape.com)
  • Extensive calcinosis cutis with systemic lupus erythematosus. (medscape.com)
  • Tristano AG, Villarroel JL, Rodriguez MA, Millan A. Calcinosis cutis universalis in a patient with systemic lupus erythematosus. (medscape.com)
  • Bullous systemic lupus erythematosus with milia and calcinosis. (medscape.com)
  • None of the patients gave history of evident trauma to the site of the lesions. (ajol.info)
  • Calcinosis cutis lesions commonly appear on the skin as bumps or flat raised areas (papules or plaques) with gritty yellow, white, or grey granules. (dermvetolympia.com)
  • The lesions are commonly surrounded by reddened skin, because calcinosis cutis often causes inflammation. (dermvetolympia.com)
  • This is one of the largest cohorts of patients with JIIM evaluated for long-term outcomes into adulthood. (acrabstracts.org)
  • Calcinosis typically develops in early childhood to early adulthood, although in some people the deposits first appear in infancy or in late adulthood. (medlineplus.gov)
  • Calcinosis cutis is a term used to describe a group of disorders in which calcium deposits form in the skin. (medscape.com)
  • They claim that this is because nanobacteria are the cause of calcium deposits-and conventional medicine isn't treating patients for nanobacteria. (alive.com)
  • There is a greater prevalence of anti-topoisomerase I antibodies, anti-RNP, and anti-Ro antibodies in these patients, although the frequency of anticentromere antibodies is less compared with White individuals. (logicalimages.com)
  • Surgery - Surgical removal of calcinosis may be useful for patients with discrete, symptomatic areas of calcinosis cutis as the primary treatment or as an adjunct to medical therapy. (medilib.ir)
  • The aim of the study was to assess the role of serum osteoprotegerin (OPG) as a biomarker in patients with aortic valve stenosis (AS) in relation to heart failure and symptomatic status. (kbco.hr)
  • Photographs were taken of this to demonstrate the calcinosis and the sarcoma (detailed in a separate image) for the patient's healthcare record and for referral at the Multidisciplinary Team (MDT) meeting. (bca.org)
  • It is possible that many people show some degree of involvement, and that the disease may be misdiagnosed or under-reported by clinicians because few patients come to the attention of dermatologists, or because it has rarely been the subject of wide dermatological studies. (medicaljournals.se)
  • Pulmonary - Some level of pulmonary involvement will be present in 15%-30% of patients. (medpagetoday.com)
  • Patients have acral sclerosis associated with vascular instability in addition to internal organ involvement. (skintherapyletter.com)
  • Peripheral nervous system involvement in SSc is not well studied and, as far as the authors are aware, this is the first study published evaluating NP in SSc patients and controls. (reumatologiaclinica.org)
  • Extended report: Erosive progression is minimal, but erosion healing rare, in patients with rheumatoid arthritis treated with adalimumab. (bmj.com)
  • Using data science and digital health to reimagine the discovery and development of medicines to advance our mission of bringing transformative therapies to patients. (janssen.com)
  • Duration of therapy - Patients who respond to systemic pharmacologic therapies for calcinosis cutis are often maintained on continuous or intermittent treatment for months to years in an attempt to reduce risk for recurrence of disease. (medilib.ir)
  • Objectives: We sought to evaluate the proportion of ossification of the posterior longitudinal ligament (OPLL) of the cervical spine and associated factors among Omani patients. (elsevierpure.com)
  • Methods: We reviewed the cervical spine computed tomography (CT) scans of all patients referred to the Radiology Department, Sultan Qaboos University Hospital, from 2011 to 2017. (elsevierpure.com)
  • A high prevalence of cutaneous disorders is expected, because most patients with ESRD have an underlying disease process with cutaneous manifestations. (medscape.com)
  • The patient denied any history of frostbite or trauma, but reported that the stiffening process had begun following a wasp bite 5 years previously. (medicaljournals.se)
  • The effect of cyclophosphamide therapy on longterm survival in patients with SSc-ILD is still unclear. (jrheum.org)
  • To date, the patient maintains uneventful postoperative course with tight control of serum phosphorus, calcium, and secondary hyperparathyroidism by medical treatment. (springer.com)
  • There is no pharmacological treatment that can prevent or reduce calcinosis. (skintherapyletter.com)
  • Object: The aim of this study was to examine the efficacy and the changes of amino acid sequences of the interferon sensitivity-determining region (ISDR) by prolonged interferon (IFN) treatment in patients who have serum hepatitis C virus (HCV)-genotype 1b and a high level of serum HCV-RNA. (go.jp)
  • These results represent the first data from a randomized, controlled trial evaluating BALVERSA ® for the treatment of patients with FGFR-altered urothelial carcinoma, who often experience poor disease outcomes," said Yohann Loriot*, M.D., Ph.D., Institut Gustave Roussy and University of Paris-Saclay, France, and principal study investigator. (janssen.com)
  • Patients were categorized to one of two cohorts based on the type of prior therapy they had received: prior treatment with an anti-PD-(L)1 agent (Cohort 1) or prior treatment not containing an anti-PD-(L)1 agent (Cohort 2). (janssen.com)
  • The treatment of calcinosis cutis is often challenging, and the subtype influences the approach to treatment. (medilib.ir)
  • With this case, we aim to discuss the options of management and rationalize the decisions, in which the course of treatment of this patient has proceeded. (jbstjournal.com)
  • The patient opted for conservative treatment with chemotherapy over hemipelvectomy. (jbstjournal.com)
  • Once the underlying cause is diagnosed, treatment is started to control and resolve the calcinosis cutis. (dermvetolympia.com)
  • If the patient has been diagnosed with Cushing's disease, then treatment for this disease will be started as soon as possible. (dermvetolympia.com)
  • Regular bloodwork monitoring is often recommended to make sure the liver and kidneys are unaffected by the underlying cause or the treatment for calcinosis cutis. (dermvetolympia.com)
  • For patient education information, see Diabetes Center , Cholesterol Center , and Chronic Kidney Disease . (medscape.com)
  • We report on a case of a patient with a calcifying lesion within the MCL and simultaneous calcifying tendinitis of the rotator cuff in both shoulders. (uni-wuerzburg.de)
  • Conclusion: This is the first case report of a patient suffering from both a calcifying lesion within the medial collateral ligament and calcifying tendinitis of the rotator cuff in both shoulders. (uni-wuerzburg.de)
  • The lesion, however, can present as an enlarging lesion, and can be quite alarming for the patient. (utoronto.ca)
  • A recent double-blind placebo-controlled study showed that patients with SSc-ILD treated with 1 year of oral cyclophosphamide experienced a statistically significant improvement in lung function, dyspnea, and health-related quality of life compared with those treated with placebo 15 , 16 . (jrheum.org)
  • Rarely, patients with nodular localized cutaneous amyloidosis develop systemic amyloidosis or multiple myeloma years later, suggesting the need for follow-up care. (medscape.com)
  • lipodystrophy and, as in the example here, calcinosis - hard calcium lumps under the skin or muscle. (bca.org)
  • This technique represents an alternative in cases of scleroatrophic skin in older patients, and for young people who do not have an upper eyelid skin redundancy, which prevents, for example, the use of upper eyelid grafts or flaps such as those of Fricke or Tripier. (rbcp.org.br)
  • Calcinosis: formation of white calcium lumps under the skin. (drwilderman.com)
  • In limited SSc, a significant proportion of patients develop life-threatening pulmonary hypertension. (skintherapyletter.com)
  • Therefore, guidelines have been published recommending that all patients with SSc undergo baseline and annual screening for ILD with pulmonary function testing and chest imaging 13 , 14 . (jrheum.org)
  • We describe the clinical presentation of the patient as well as the radiological findings, diagnostic tests, and management during the course of the disease. (jbstjournal.com)
  • Material and methods In this article we report the radiographic results of 30 patients with anteromedial osteoarthritis (OA) who were treated with a novel patient-specific fixed-bearing bi-compartmental knee resurfacing system using custom-made implants and instruments. (uni-wuerzburg.de)
  • The immediate and late results in terms of aesthetics and function were satisfactory and well accepted by patients and the surgical team, with adequate eyelid occlusion and preserved ocular lubrication. (rbcp.org.br)
  • Results: A total of 843 patients aged ≥ 20 years were included in the study. (elsevierpure.com)