Pathways gene comparative genomic hybridization. Medical search. Frequent questions

Neurodevelopmental Disorders and Array-Based Comparative Genomic Hybridization: Sensitivity and Specificity using a Criteria Checklist for Genetic Test Performance. (cdc.gov)

It uses NGS to gauge mutations in the coding regions of the genes of interest and confirms the findings by Sanger sequencing. (genomeweb.com)
Initiation and propagation of tumors reflect underlying genomic alterations such as mutations, polymorphisms, and copy number variations found in genes of multiple cellular pathways. (hindawi.com)
Inherited mutations in a small number of genes account for about five to ten percent of women's cancers.These inherited variations, identified in breast, ovarian, and endometrial cancer susceptibility, can be characterized in the general population by their frequency and the magnitude of their impact upon a patient (Table 1 ).Some inherited variants occur rarely in the general population, but confer large risks to the individual. (hindawi.com)
Although inherited mutations in a small number of genes account for only about five to ten percent of women's cancers, by far the BRCA1 and BRCA2 gene mutations are the most common examples of this observation (50-70% of familial breast cancers) [ 2 ]. (hindawi.com)
EXPERIMENTAL DESIGN: Using in silico genomic and transcriptomic tumor data, proteomics analysis, and genetically modified cell line models, we demonstrate mechanistic links between SPOP mutations, STING signaling alterations, and PARP inhibitor vulnerabilities. (bvsalud.org)
RESULTS: We demonstrate that SPOP mutations are associated with upregulation of a 29-gene noncanonical (NC) STING (NC-STING) signature in a subset of SPOPmut, treatment-refractory CRPC patients. (bvsalud.org)
Oncogenic point mutations in KIT or PDGFRA are recognized as the primary events responsible for the pathogenesis of most gastrointestinal stromal tumors (GIST), but additional genomic alterations are frequent and presumably required for tumor progression. (biomedcentral.com)
In addition to clinico-pathological high-risk groups, patients with KIT mutations, genomic complexity, genomic gains and deletions at either 1p or 22q showed a significantly shorter disease-free survival. (biomedcentral.com)
Furthermore, the relationship between the pattern of KIT and PDGFRA oncogenic mutations and that of cytogenetic changes has not been systematically studied, precluding a full understanding of the genetic pathways involved in GIST development. (biomedcentral.com)
These studies reveal that recurrent somatic mutations occur in only a handful of genes, with an overall mutational burden of roughly 1-2 per Mb. (springer.com)
Somatic mutations in phosphatase and tensin homolog (PTEN)/ phosphoinositide-3-kinase (PI3K) and RAS pathway members by Sequenom mutational profiling and targeted sequencing of candidate genes. (ucsf.edu)
The researchers discovered that people with the unique form of HIES had mutations in a gene called DOCK8 that led to deletions in parts of the gene. (nih.gov)
The study of inherited disorders and the genetic alterations that are responsible for their complex array of disease symptoms has often resulted in the discovery of causative genes that play a role in cancer initiation," said NCI Director John E. Niederhuber, M.D. "The disease mutations found in this study in the DOCK8 gene exemplify that kind of important finding. (nih.gov)
Somatic mutations in fibroblast growth receptor3 and tumor protein p53 in tumor cells appear to be important early molecular events in the noninvasive and invasive pathways, respectively. (healthybladderclub.com)
Epigenetic modifications may also play a role, as demonstrated by the occurrence of autism in genetic conditions caused by mutations in imprinted genes or regions. (biomedcentral.com)

Comparative genomic hybridization identified the following chromosomal abnormalities: deletions of 6q23 and 13q14, and gains of 3q13-q28, 6p and 18q. (wikipedia.org)
We identified 20 chromosomal imbalance regions harboring 459 genes for Caucasian and 17 regions containing 476 genes for Asian lung cancer patients. (biomedcentral.com)
Genomic DNA copy number variation is a hallmark of cancer and can lead to alteration in the expression and functions of genes residing within the affected chromosomal region [ 5 ]. (biomedcentral.com)
In addition to KIT/PDGFRA mutational status, our findings indicate that secondary chromosomal changes contribute significantly to tumor development and progression of GIST and that genomic complexity carries independent prognostic value that complements clinico-pathological and genotype information. (biomedcentral.com)
Senescent hepatocytes lose the telomeric repeats that protect chromosomal ends from inter- and intra-chromosomal fusion, deletion, rearrangement, and transposition events that contribute to genomic instability. (biomedcentral.com)
Patterns of genomic aberrations in primary colorectal tumors may reveal a chromosomal signature for organ specific metastases. (tudelft.nl)
Abstract BACKGROUND: Chromosomal abnormalities have been associated with most human malignancies, with gains and losses on some genomic regions associated with particular entities. (baudisgroup.org)
METHODS: Of the 15429 cases collected for the Progenetix molecular-cytogenetic database, 5918 malignant epithelial neoplasias analyzed by chromosomal Comparative Genomic Hybridization (CGH) were selected for further evaluation. (baudisgroup.org)
CONCLUSION: Although considerable case-by-case variation of genomic profiles can be found by CGH in epithelial malignancies, a limited set of variously combined chromosomal imbalances may be typical for carcinogenesis. (baudisgroup.org)

NEW YORK (GenomeWeb) - Pathway Genomics this week launched a next-generation sequencing test for gauging alterations in BRCA1 and BRCA2 genes, called BRCATrue, and a patient assistance program through which it is offering free testing to women in need. (genomeweb.com)
By offering free testing, Pathway is also hoping to extend this resource to underserved populations and improve knowledge about the prevalence and disease associations of BRCA1/2 alterations in the overall population. (genomeweb.com)
Based on the heterogeneity within a specific tumor type, a combination of genomic alterations defines the cancer subtype, biologic behavior, and in some cases, response to therapeutics. (hindawi.com)
[ 2 , 3 ] Conventional techniques of gene investigation in cancer rely on the identification of single genetic alterations associated with disease. (medscape.com)
Taken with each other, these final results sug gest that whilst the network framework had a predominant role over the metabolic flux distribution, gene expression adjustments contributed to flux regulation and had a major effect on metabolite concentration alterations. (pdpksignaling.com)
Copy number alterations (gains or losses) by array comparative genomic hybridization (aCGH). (ucsf.edu)
These abnormalities result in significant alterations in gene expression related to cell proliferation, apoptosis, migration and immune signaling pathways. (spandidos-publications.com)
Furthermore, we discuss recent findings on EBV associated gastric carcinogenesis by focusing on the roles of latent genes, epigenetic abnormalities, genomic alterations, and post-transcriptional regulation by cellular and viral microRNAs (miRNAs). (spandidos-publications.com)
A number of genetic studies led to the identification of genes and/or copy number variants whose alterations are associated with autism, but no specific factor has been found so far to be responsible for a substantial proportion of cases. (biomedcentral.com)
published this month in BMC Medicine , reports on genomic and epigenetic alterations of OXTR , the gene encoding the receptor for oxytocin. (biomedcentral.com)
The nature of this epigenetic dysregulation is unknown but, if proved to be true, might explain the failure to identify sequence alterations in a host of candidate genes. (biomedcentral.com)
Nonetheless, quantitative whole-genome analyses promise to identify one or a few autism-specific copy number variants (CNVs) harboring genes whose dosage alterations could be critical in causing ASD. (biomedcentral.com)

Identification of regions with copy number aberrations and the genes involved thus offers a basis for better understanding of cancer development [ 6 ]. (biomedcentral.com)
For a subset of 29 tumors, comparative genomic hybridization was additionally used to screen for chromosome copy number aberrations. (biomedcentral.com)
aCGH provides an understanding of genetic disorders, cancers and other genomic aberrations. (enzolifesciences.com)
The next most prevalent aberrations include a cohort of chromatin-modifying genes with diverse roles including PBRM1 , SETD2 , BAP1 , and KMD5C . (springer.com)
In addition, there are only a small number of recurrent copy number aberrations and rare gene fusions. (springer.com)
Genomic profiling also identifies genes associated with poor outcome in cases without molecular aberrations and specific genes that may be new therapeutic targets in adult ALL. (aacrjournals.org)

Using quantitative PCR assays, the test gauges large deletions and duplications with BRCA1/2 and confirms the results by array comparative genomic hybridization. (genomeweb.com)
utilizes a combination of high-resolution comparative genomic hybridization, short hairpin RNA inhibition of target genes at the locations of focal genomic deletions, and a primed cell mosaic mouse model to identify novel tumor suppressors in hepatocellular carcinoma. (biomedcentral.com)

Final results We now have performed many analyses which includes a taxo nomical evaluation based mostly to the gene expression profile of NB and PCC samples together with other tissues, and attempted to characterize quite possibly the most prominent distinctions in between neural crest derived tumors together with other tissues. (pdpksignaling.com)
Divergent, yet interconnected and overlapping, molecular pathways are likely responsible for the development of noninvasive and invasive bladder tumors. (healthybladderclub.com)

For all significantly differentially expressed microRNAs inside of the 2 groups, we now have produced gene sets from their expressed target genes. (pdpksignaling.com)
Both of these mechanisms prevent YAP and TAZ translocation to the nucleus and binding to TEAD transcription factors, thereby inhibiting transcription of downstream target genes implicated in proliferation, anti-apoptosis and EMT [ 9 ]. (oncotarget.com)

Genome wide association studies, fluorescence in situ hybridization, comparative genomic hybridization, and candidate gene studies have enumerated genetic contributors to cancers in women. (hindawi.com)
The intensity of fluorescence is analyzed and correlates with expression of the gene. (medscape.com)

Examples of these genes are BRCA1 and BRCA2 in breast and ovarian cancers. (hindawi.com)
Despite these advances made in identifying inherited breast cancer susceptibility genes, the vast majority of breast cancers are sporadic, that is, no identifiable mutation in one of the known breast cancer susceptibility genes. (hindawi.com)
[ 1 ] the Cancer Genome Anatomy Project index of tumor genes has classified more than 40,000 genes directly or indirectly involved in one or more cancers. (medscape.com)
For the study, we used histopathological H&E images (pre-treatment) of high-grade serous carcinoma from The Cancer Genome Atlas (TCGA) Genomic Data Commons portal to train the Inception V3 convolutional neural network system to predict whether cancers had independently been labeled as sensitive or resistant to subsequent platinum-based chemotherapy. (bvsalud.org)
The most common non-clear cell renal cancers have also undergone genomic profiling and are characterised by distinct genomic landscapes. (springer.com)
Background: Genomic gains and losses are a result of genomic instability in many types of cancers. (tudelft.nl)

Four candidate oncogenes were validated for DNA copy number and mRNA and protein expression by quantitative polymerase chain reaction (qPCR), chromogenic in situ hybridization (CISH), reverse transcriptase-qPCR (RT-qPCR), and immunohistochemistry (IHC) in more patients. (biomedcentral.com)
Using genomic sequence, RNA-Seq transcriptomic data, and in situ hybridization analysis of somite-stage embryos, we carried out comparative analyses of key genes and found that the anole segmentation clock displays features common to both amniote and anamniote vertebrates. (xenbase.org)
EBVaGC is defined by monoclonal proliferation of carcinoma cells with latent EBV infection, as demonstrated by EBV-encoded small RNA (EBER) in situ hybridization. (spandidos-publications.com)
Subsequent development of in situ hybridization (ISH) techniques to detect EBV-encoded small RNAs (EBERs) facilitated the detection of EBV in cancer tissues ( 4 , 5 ). (spandidos-publications.com)

Comparative genomic hybridization (aCGH) is a powerful diagnostic tool for detecting DNA copy number gains and losses associated with chromosome abnormalities. (enzolifesciences.com)

To characterize gene expression signatures in acute lymphocytic leukemia (ALL) cells associated with known genotypic abnormalities in adult patients. (aacrjournals.org)
We also identified a set of 83 genes that were highly expressed in leukemia blasts from patients without known molecular abnormalities who subsequently relapsed following therapy. (aacrjournals.org)

[ 6 ] Both technologies use hybridization of labeled nucleic acid transcripts to measure the gene expression. (medscape.com)

The NF2 gene is a tumour suppressor on chromosome 22. (bmj.com)
Comparative genomic hybridisation (CGH) was used to screen 76 vestibular schwannomas from 76 patients (66 sporadic and 10 NF2 related) to identify other chromosome regions that may harbour genes involved in the tumorigenesis. (bmj.com)
In 1986, the NF2 gene was mapped to chromosome 22, and in 1993, two groups independently isolated the gene and named its encoding protein merlin or schwannomin. (bmj.com)
The higher incidence of ccRCC in male patients may partially be accounted by mono-allelic inactivation of the chromatin remodelling gene, KDM5C on the X chromosome [ 6 ]. (springer.com)
Distribution and expression of the genes on chromosome 1. (nature.com)

Genomic instability is a hallmark of the cancer phenotype, and cancer is considered to be a disease of the cell's disordered genome. (biomedcentral.com)
RESULTS: With large variation in overall genomic instability, recurring genomic gains and losses were prominent. (baudisgroup.org)

Such a segment in the tumor genome may harbor either oncogenes or tumor suppressor genes depending on whether they are present in increased or decreased copy number, respectively. (biomedcentral.com)
The 'cancer platform' concept proposes that most oncogenic molecules also have the inherent ability to activate tumor suppressor genes or pathways through oncogene-induced apoptosis or senescence, thus limiting their oncogenic effects in a homeostatic fashion. (biomedcentral.com)
The specific effects that lead to inactivation of these pro-apoptotic or senescence pathways may impinge on major known tumor suppressors such as p53, but may also be due to effects on other genes and molecules within the p53 or other tumor suppressor pathways [ 5 ]. (biomedcentral.com)
Together, our results reveal that ITCH pro-tumorigenic functions in breast cancer are mediated, at least in part, through inactivation of the Hippo tumor suppressor pathway. (oncotarget.com)
In another research, repeated deletion of tumor suppressor genes BCL7A, SMAC/DIABLO, and RHOF in MF was noticed.4 Genomic patterns characteristic of MF differ markedly from SS.5 This may implicate discriminative molecular pathogenesis and various therapeutic requirements. (techblessing.com)
Global CpG island hypermethylation, which induces epigenetic silencing of tumor suppressor genes, is also a unique feature of EBVaGC and is considered to be crucial for its carcinogenesis. (spandidos-publications.com)

The genetic basis of this condition remains largely unknown, as no developmental genes other than paired box gene 6 ( PAX6 ) are known to be implicated in sporadic bilateral ONA. (molvis.org)
The Hippo kinase pathway is emerging as a conserved signaling pathway that controls cell proliferation, apoptosis, contact inhibition, cell migration, cell differentiation, stem cell self-renewal, genetic stability, and epithelial-to-mesenchymal transition (EMT). (oncotarget.com)
Regarding the etiology, it is generally accepted that genetic factors play a major role and it has become clear that, with the exception of a minority of instances (about 1%) in which the phenotype is caused by a single gene alteration, the genetic component leading to autism is complex, being based on interactions of multiple genetic changes and/or epigenetic regulation of gene expression. (biomedcentral.com)

A summary of the major findings to date for these genes is in Table 1 and is discussed in what follows. (hindawi.com)
Genotype and genomic findings were cross-tabulated and compared with available clinical and follow-up data. (biomedcentral.com)

MALT-lymphomas represent a wide range of extranodal lymphomas that often recognize environmental factors driving to specific genes deregulation. (biomedcentral.com)

Through the comparison of NB or PCC groups with all the investigated 54 usual tissues and tumor kinds, we've got recognized 36 genes appreciably differentially expressed in in excess of 80% of comparisons. (pdpksignaling.com)
The cyan rectangle indicates differentially expressed genes (DE genes), and the red rectangle indicates genes with a differentially methylated region (DMR gene). (biomedcentral.com)

Unlike Myriad, however, Pathway and most other BRCA testing providers are contributing de-identified test data to ClinGen , an-NIH funded effort to build a public, annotated database of genomic variants using standardized classification methods. (genomeweb.com)
The human genomic research program uses cutting-edge methods such as comparative genomic hybridization and whole exome sequencing to uncover the genes causing ID and autism. (ualberta.ca)
Three methods including MetaCore analysis for disease and pathway correlations, concordance analysis between array-CGH database and the expression array database, and literature search for copy number variation genes were performed to select novel lung cancer candidate genes. (biomedcentral.com)
The 37-Mb genome was predicted to contain a total of 12,074 genes encoding proteins with a length greater than 100 amino acid residues (see Methods). (nature.com)

The following signalling pathways have been implicated: CD154/CD40 Akt ubiquitination, p53 activation, cytochrome c release NF-κB WNT/beta-catenin mTOR ERK MAPK Bcl-2 The protein Src tyrosine kinase is overexpressed in Waldenström macroglobulinemia cells compared with control B cells. (wikipedia.org)
Supervised analysis of kinase genes revealed a high-level FLT3 expression in a subset of cases without molecular rearrangements. (aacrjournals.org)
The Hippo kinase pathway is emerging as a conserved signaling pathway that is essential for organ growth and tumorigenesis. (oncotarget.com)
The core of the Hippo pathway is composed of a kinase cascade that includes MST1/2 serine/threonine kinase (ortholog of Hpo in D. melanogaster ), WW45 scaffold protein (Sav), MOB (Mats) and LATS1/2 kinases (Wts). (oncotarget.com)
Three RAS (KRAS, NRAS, and HRAS), 3 RAF (ARAF, BRAF, and CRAF), 2 MEK (MEK1 and MEK2), and 2 ERK (ERK1 TCS ERK 11e (VX-11e) and ERK2) isoforms compose the canonical mitogen-activated proteins kinase pathway. (techblessing.com)

Genes in the 'Focal adhesion', 'Wnt signaling pathway' and 'MAPK signaling' pathway. (biomedcentral.com)

TRIM13 inhibited cell proliferation and induced cell apoptosis by regulating NF-κB pathway in non-small-cell lung carcinoma cells. (cancerindex.org)

Identification of an eight-gene signature for survival prediction for patients with hepatocellular carcinoma based on integrated bioinformatics analysis. (cdc.gov)

Identification of Prognostic Gene Signatures of Glioblastoma: A Study Based on Data Analysis. (mdanderson.org)
Within B-lineage ALL, distinct signatures were associated with ALL1/AF4 and E2A/PBX1 gene rearrangements. (aacrjournals.org)
Genomic signatures are associated with phenotypically and molecularly well defined subgroups of adult ALL. (aacrjournals.org)
Recent genome-wide association studies, gene expression profiling, DNA methylation and proteomic studies conducted in Japanese and Chinese ESCCs (reviewed in [ 6 ]) have identified multiple risk variants and gene signatures associated with ESCC. (biomedcentral.com)
Functional analysis of multiple genomic signatures demonstrates that classification algorithms choose phenotype-related genes. (clinbioinfosspa.es)

For the 22 clinico-pathological entities with more than 50 cases, summary profiles for genomic imbalances were generated from case specific data and analyzed. (baudisgroup.org)

The sequencing of the D.melanogaster genome revealed an unexpected small number of genes (~ 14,000) indicating that mechanisms acting on generation of transcript diversity must have played a major role in the evo. (biomedcentral.com)

MicroRNA-155 regulates the proliferation and growth of Waldenström macroglobulinemia cells in vitro and in vivo, by inhibiting MAPK/ERK, PI3/AKT, and NF-κB pathways. (wikipedia.org)
Gene validation for four genes including ARHGAP19 (10q24.1) functioning in Rho activity control, FRAT2 (10q24.1) involved in Wnt signaling, PAFAH1B1 (17p13.3) functioning in motility control, and ZNF322A (6p22.1) involved in MAPK signaling was performed using qPCR and RT-qPCR. (biomedcentral.com)

Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
Waldenström macroglobulinemia cells show only minimal changes in cytogenetic and gene expression studies. (wikipedia.org)
The introduction of complementary DNA (cDNA) microarray technology in 1995 has helped to facilitate the identification and classification of DNA sequence information and the assignment of functions to these new genes by allowing investigators to analyze expression of thousands of genes simultaneously in a single experiment. (medscape.com)
Microarrays may be used to assay gene expression within a single sample or to compare gene expression in 2 different cell types or tissue samples, such as in healthy versus diseased tissue. (medscape.com)
[ 5 ] Because a microarray can be used to examine the expression of hundreds or thousands of genes at once, it promises to revolutionize the way gene expression is examined. (medscape.com)
Because the locations of the probes are known, the intensity and pattern of the labeled mRNA can be used to measure the expression of the targeted gene. (medscape.com)
By this technique, NB and PCC have been clustered near to each other underlining their similarity in gene expression patterns. (pdpksignaling.com)
Effect of gene expression modifications on WOA tolerance We also utilised the constructed versions to investigate the role in the transcriptional response around the tolerance of S. cerevisiae to WOA treatment method. (pdpksignaling.com)
In principle, S. cerevisiae must change its gene expression amounts to far better cope with these anxiety conditions. (pdpksignaling.com)
To probe if model predictions were in line with this particular premise, we predicted the biomass level as being a function on the WOA uptake charge in treated cultures with and without having gene expression improvements. (pdpksignaling.com)
Also, hypothesizing the transcriptional response was graded based upon the tension intensity, we examined if, at increased inhibitor Telatinib WOA uptake charges, amplified gene expression improvements would result in higher biomass development compared to the measured gene expression adjustments. (pdpksignaling.com)
So, we also predicted the biomass amounts as suming gene expression changes extrapolated through the experimental information. (pdpksignaling.com)
Stress-induced changes of gene expression are crucial for survival of eukaryotic cells. (prolekarniky.cz)
Cells maintain their internal homeostasis by adequate reprogramming of metabolic activities at all levels of gene expression, including chromatin remodeling, mRNA expression and degradation, translation and protein degradation. (prolekarniky.cz)
Comparisons among vertebrate model systems have revealed fundamental shifts in the regulation of expression among critical genes in the notch pathway. (xenbase.org)
The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. (cancerindex.org)
These pipelines consist of a set of tools for GFF file processing of NimbleGen chromatin immunoprecipitation on microarray (ChIP-chip) datasets and more comprehensive workflows for Affymetrix gene expression microarray bioinformatics and basic primer design for PCR experiments, which are often used to validate microarray results. (biomedcentral.com)
There have been dimensional increases in 'omics datasets, including introduction of new types of data, increases in the size of individual datasets, increases in the varieties of experimental platforms within a given data type (e.g. more varieties of gene expression microarrays), and very large increases in the total number of datasets being generated. (biomedcentral.com)
Epigenetic regulators (histone acetyltransferases, methyltransferases, chromatin-remodelling enzymes, etc) play a fundamental role in the control of gene expression by modifying the local state of chromatin. (biomedcentral.com)
Gene expression profiles from 128 adult patients with newly diagnosed ALL were characterized using high-density oligonucleotide microarrays. (aacrjournals.org)
T-lineage ALL was characterized by a homogeneous gene expression pattern, whereas several subgroups of B-lineage ALL were evident. (aacrjournals.org)
BCR/ABL + gene expression pattern was more heterogeneous and was most similar to ALL without known molecular rearrangements. (aacrjournals.org)
How Reliable Are Gene Expression-Based and Immunohistochemical Biomarkers Assessed on a Core-Needle Biopsy? (lu.se)
Sääf AM, Halbleib JM, Chen X, Tsan Yuen S, Yi Leung S, Nelson WJ, Brown PO "Parallels between Global Transcriptional Programs of Polarizing Caco-2 Intestinal Epithelial Cells In Vitro and Gene Expression Programs in Normal and Colon Cancer. (openwetware.org)
Rubins KH, Hensley LE, Wahl-Jensen V, Daddario Dicaprio KM, Young H, Reed DS, Jahrling PB, Brown PO, Relman DA, Geisbert TW "The temporal program of peripheral blood gene expression in the response of non-human primates to Ebola hemorrhagic fever. (openwetware.org)
Buess M, Nuyten DS, Hastie T, Nielsen T, Pesich R, Brown PO "Characterization of heterotypic interaction effects in vitro to deconvolute global gene expression profiles in cancer. (openwetware.org)
Rinn JL, Bondre C, Gladstone HB, Brown PO, Chang HY "Anatomic demarcation by positional variation in fibroblast gene expression programs. (openwetware.org)
Palmer C, Diehn M, Alizadeh AA, Brown PO "Cell-type specific gene expression profiles of leukocytes in human peripheral blood. (openwetware.org)
Sood R, Zehnder JL, Druzin ML, Brown PO "Gene expression patterns in human placenta. (openwetware.org)
Our data have provided evidence for a comparable prediction of clinical outcome in CMF-treated breast cancer patients using conventional clinical variables and gene expression based markers. (lu.se)
To determine whether certain genes are uniquely altered in African-American ESCC we performed a meta-analysis of ESCC expression profiles in our African-American samples and those of several Asian samples. (biomedcentral.com)
A hierarchical Bayesian model for inference of copy number variants and their association to gene expression. (zbmath.org)
Here we focus on integrating gene expression levels with comparative genomic hybridization (CGH) array measurements collected on the same subjects. (zbmath.org)
We specify a measurement error model that relates the gene expression levels to latent copy number states which, in turn, are related to the observed surrogate CGH measurements via a hidden Markov model. (zbmath.org)
Furthermore, post-transcriptional gene expression regulation by cellular and/or EBV-derived microRNAs has attracted considerable attention. (spandidos-publications.com)
The subsequent analysis of a group of unrelated autistic subjects did not show an OXTR deletion, but rather hypermethylation of the gene promoter, with a reduced mRNA expression. (biomedcentral.com)
Parts of the gene expression analysis market continue to develop in a somewhat predictable manner, whereas other segments are becoming increasingly complex and volatile. (kaloramainformation.com)
Gene Expression Profiling Markets also details the business, regulatory, academic, and research trends in the market, providing comprehensive information on consortia, standardization efforts, and scores of recent deals in the sector. (kaloramainformation.com)
Gene Expression Integration into Pathway Modules Reveals a Pan-Cancer Metabolic Landscape. (clinbioinfosspa.es)

Genome-screening methodologies, such as conventional cytogenetics and comparative genomic hybridization (CGH), have been applied in order to identify these changes. (biomedcentral.com)

Gene sets established both by in silico examination of mRNA expres sion, GSEA of microRNA and comparative genomic hybridization gene sets have been subjected to IPA and considerable pathways were in contrast to each other. (pdpksignaling.com)

To better understand the molecular pathways and test potential treatments, we use various models including a well-established test for learning and memory in the fruit fly drosophila. (ualberta.ca)
Importantly, this analysis revealed a potential distinctive molecular underpinning of African-American ESCC, that is, a widespread and prominent involvement of the NRF2 pathway. (biomedcentral.com)

Opportunistic testing of BRCA1, BRCA2 and mismatch repair genes improves the yield of phenotype driven hereditary cancer gene panels. (cdc.gov)

RAF is definitely targeted by inhibitors in preclinical or medical development, including, for instance, RAF265 and PLX4720.12,13 However, targeting the RAF pathway is organic due to the settings of pathway activation and regulation. (techblessing.com)
Down-regulation of TP53 pathway components represented the most common feature in ESCC of all ethnic groups. (biomedcentral.com)

Consideration of tumor heterogeneity is therefore important in the critical analysis of gene associations in cancer. (hindawi.com)
Ways to abrogate heterogeneity will be required to optimise the genomic classification of tumours. (springer.com)

Gene set-based analysis of polymorphisms: finding pathways or biological processes associated to traits in genome-wide association studies. (clinbioinfosspa.es)

The RAS-RAF-MEK-ERK signaling pathway regulates cell reactions to environmental stimuli and takes on a crucial part in many malignancies.6 Thus, RAF and MEK are attractive therapeutic focuses on.7,8 RAS is a little guanine-nucleotide binding proteins that is mounted on the inner part from the plasma membrane. (techblessing.com)
Genomic subtyping and therapeutic targeting of acute erythroleukemia. (cdc.gov)

Alternatively spliced transcript variants have been identified for this gene. (cancerindex.org)

The non-invasive, saliva test, according to Pathway, has a sensitivity of greater than 99.99 percent. (genomeweb.com)
Not only has knowledge of the genomic landscape helped inform the development of new drugs, this understanding also promises to improve risk stratification of tumours and to determine their sensitivity to systemic therapies. (springer.com)

The phenotypes were comparable up to a deletion size of 7.1 Mb, and most features could be attributed to the terminally located gene DLL1 . (biomedcentral.com)
The involvement of this gene was suggested by its deletion in an autistic patient. (biomedcentral.com)
They identified a genomic deletion containing the gene encoding for the oxytocin receptor ( OXTR ) in an autistic male individual and in his mother, who probably experienced obsessive-compulsive disorder (OCD). (biomedcentral.com)

Genomic profiling in pancreatic ductal adenocarcinoma and a pathway towards therapy individualization: A scoping review. (cdc.gov)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

To explore the entire anatomy of the neoplastic genome in black ESCC, we performed comparative genomic hybridization (CGH) on a panel of 17 matched pairs of tumor and control esophageal tissues [ 13 ]. (biomedcentral.com)

Furthermore, genomic complexity was the best predictor of disease progression in multivariate analysis. (biomedcentral.com)
Genomic complexity (GC) and del(17p) status were assessed by array comparative genomic hybridization. (confex.com)

TRIM13-induced NSCLC cell apoptosis was attenuated by a caspase-3 inhibitor Ac-DEVD-CHO, suggesting that TRIM13 induced cell apoptosis partially through a caspase-3-dependent pathway. (cancerindex.org)

The scanner that records the intensity value is linked to digital image analysis software, which produces a color-coded image of the array, and a quantitative value is recorded for each target gene. (medscape.com)
In addition, CISH analysis of patients indicated that copy number amplification indeed occurred for ARHGAP19 and ZNF322A genes in lung cancer patients. (biomedcentral.com)
Folate synthesis and salvage pathways are relatively well known from classical biochemistry and genetics but they have not been subjected to comparative genomic analysis. (biomedcentral.com)
Large numbers of genomic changes have been detected using karyotyping and comparative genomic hybridization analysis in urothelial carcinoma. (healthybladderclub.com)

Oncogene activation is therefore generally only tumorigenic when it is coupled with inactivation or inhibition of oncogene-induced pro-apoptotic or senescence pathways [ 4 ]. (biomedcentral.com)

Some insights into clinical risk factors and their genomic correlates have been made. (springer.com)

5, 6 The NF2 gene is a tumour suppressor, as corroborated by studies showing complete inactivation of the gene in more than 60% of schwannomas, either by mutation in both alleles or by loss of one allele and mutation in the other. (bmj.com)

Clinical assessment and identification of immuno-oncology markers concerning the 19-gene based risk classifier in stage IV colorectal cancer. (cdc.gov)

Anatomy33

Organisms2

Diseases74

Chemicals and Drugs19

Analytical, Diagnostic and Therapeutic Techniques and Equipment47

Psychiatry and Psychology4

Phenomena and Processes115

Disciplines and Occupations4

Anthropology, Education, Sociology and Social Phenomena1

Information Science10

Named Groups1

Health Care7

Array-based comparative genomic hybri1

Mutations15

Chromosomal9

Alterations12

Aberrations6

Deletions2

Tumors2

Target genes2

Fluorescence2

Cancers6

Situ4

ACGH1

Abnormalities2

Nucleic1

Chromosome5

Instability2

Tumor suppressor6

Genetic3

Findings2

Specific genes1

Differentially expressed2

Methods4

Kinase5

Focal1

Cell Proliferation1

Hepatocellular carcinoma1

Signatures5

Imbalances1

Small number of genes1

MAPK2

Expression39

Cytogenetics1

MicroRNA1

Molecular2

BRCA21

Regulation2

Heterogeneity2

Polymorphisms1

Therapeutic2

Variants1

Sensitivity2

Deletion3

Pancreatic1

Cellular1

Tissues1

Complexity2

Apoptosis1

Analysis4

Senescence1

Correlates1

Inactivation1

Colorectal cancer1