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Protein CPorphyrinsOncogene Proteins v-sisOncogene Protein tpr-metOncogene Protein v-mafProtein C DeficiencyOncogene Protein gp140(v-fms)Oncogene Proteins v-mosProtein C InhibitorOncogene Protein p55(v-myc)Genes, ablOncogene Protein p65(gag-jun)Oncogene Proteins v-rafOncogene Proteins v-ablOncogene Proteins v-fosActivated Protein C ResistanceOncogene Protein v-crkOncogene Protein v-cblOncogene Proteins v-mybOncogene Proteins v-erbBOncogenesOncogene Proteins v-relProtein SOncogene Proteins v-erbAThrombomodulinOncogene ProteinsOncogene Protein p21(ras)Proto-Oncogene Proteins c-ablBlood Coagulation FactorsPulmonary Surfactant-Associated Protein CFusion Proteins, bcr-ablFactor VOncogene Protein pp60(v-src)Factor VaOncogene Proteins, FusionThrombinCell Transformation, NeoplasticOncogene Proteins, ViralBlood CoagulationGenes, rasOncogene Protein v-aktProthrombinMolecular Sequence DataProtein S DeficiencyReceptors, Cell SurfaceMutationBase SequenceLeukemia, Myelogenous, Chronic, BCR-ABL PositiveAmino Acid SequenceReceptors, ThrombinCell LineThrombophiliaBlood Coagulation DisordersBenzamidesProto-Oncogene ProteinsProto-OncogenesPartial Thromboplastin TimePyrimidinesReceptor, PAR-1PiperazinesRecombinant ProteinsAnticoagulantsProtein-Tyrosine KinasesProtein BindingGlycoproteinsTransfectionCell FusionFactor Xa1-Carboxyglutamic AcidProto-Oncogene Proteins c-bcrBlood Coagulation TestsSignal TransductionTranslocation, GeneticGenes, mycDisseminated Intravascular CoagulationEnzyme ActivationCells, CulturedAntithrombin IIIMembrane FusionBinding SitesProto-Oncogene Proteins c-mycThrombosisGene Expression Regulation, NeoplasticThrombophlebitisFactor V DeficiencyCell Line, TransformedRNA, MessengerFactor XProto-Oncogene Proteins p21(ras)KineticsGene AmplificationAntithrombinsHemostasisCarrier ProteinsRetroviridae Proteins, OncogenicTumor Cells, CulturedSepsisCell Line, TumorFactor VIIIaPurpura Fulminans
Tumor supprGenesDifferentiationPI3K-AKTRegulateMutationsCellularEncodesAntibodiesApoptosisCell cycle arrestActivationProliferationSpecificityChromosomeReceptorKinaseTP53TranscriptionAntibodyAdultFunctionalRoleHumanDevelopmentRepairFusionComponent
Tumor suppr6
  • Usually multiple oncogenes, along with mutated apoptotic or tumor suppressor genes will all act in concert to cause cancer. (wikipedia.org)
  • In addition, these alterations affect 3 principal categories of genes, as follows: proto-oncogenes, tumor suppressor genes, and DNA repair genes. (medscape.com)
  • This article briefly discusses tumor suppressor genes and then focuses on the role of proto-oncogenes in childhood cancer. (medscape.com)
  • Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
  • Driver events in pediatric malignancies can occur through loss of function in tumor suppressor genes or gain of function in proto-oncogenes. (medscape.com)
  • Tumor suppressor genes encode proteins that normally provide negative control of cell proliferation. (medscape.com)
Genes3
  • Most oncogenes began as proto-oncogenes: normal genes involved in cell growth and proliferation or inhibition of apoptosis. (wikipedia.org)
  • Oncogenes are a physically and functionally diverse set of genes, and as a result, their protein products have pleiotropic effects on a variety of intricate regulatory cascades within the cell. (wikipedia.org)
  • Scaffoldattachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind toS/MAR. The encoded protein is thought to serve as a molecular base to assemble atranscriptosome complex in the vicinity of actively transcribed genes. (immune-source.com)
Differentiation2
  • Proto-oncogenes code for proteins that help to regulate the cell growth and differentiation. (wikipedia.org)
  • Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)
PI3K-AKT2
  • It specifically negatively regulates the PI3K-AKT signaling pathway to induce cell cycle arrest. (medscape.com)
  • The combination of growth factors and RTKs can activate the PI3K/AKT signaling pathway and negatively regulate TSC1/2, promoting Rheb to become GTP loaded, which can activate mTORC1. (biomedcentral.com)
Regulate1
  • 1) Characterize novel families of oncoproteins (Pbx and Meis) that dimerize with and regulate the DNA binding properties of Hox proteins. (stanford.edu)
Mutations1
  • A proto-oncogene is a normal gene that could become an oncogene due to mutations or increased expression. (wikipedia.org)
Cellular3
  • Bishop and Varmus were awarded the Nobel Prize in Physiology or Medicine in 1989 for their discovery of the cellular origin of retroviral oncogenes. (wikipedia.org)
  • Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)
  • Thus, lysosomes play important roles in cellular activity. (biomedcentral.com)
Encodes6
  • For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)
  • This locus, however, also encodes a protein from an alternative reading frame, designated p19ARF. (medscape.com)
  • RB1 encodes the protein pRB and was the first tumor suppressor gene to be molecularly defined. (medscape.com)
  • TP53 encodes the protein p53, which is known as the "guardian of the genome. (medscape.com)
  • PTEN encodes a protein kinase of the same name and functions as a tumor suppressor through regulation of cell proliferation. (medscape.com)
  • This gene encodes a DNA-binding protein which has high specificity for scaffold or matrixattachment region DNA elements (S/MAR DNA). (immune-source.com)
Antibodies1
  • Some cytotoxic drugs tend to be inactive or less active when conjugated to large antibodies or protein receptor ligands. (justia.com)
Apoptosis1
Cell cycle arrest1
  • The p19ARF protein, which is encoded by the same locus as p16, also leads to cell cycle arrest by inhibiting the ability of MDM2 to inactivate TP53. (medscape.com)
Activation1
  • Dr. Barbacid spent the following months extending his research, eventually discovering that the oncogene was a mutated allele of HRAS and characterizing its activation mechanism. (wikipedia.org)
Proliferation2
  • Bcr-Abl codes for a tyrosine kinase, which is constitutively active, leading to uncontrolled cell proliferation. (wikipedia.org)
  • Acute leukemias induced by MLL chimeric oncoproteins are among the subset of cancers distinguished by a paradoxical dependence on GSK-3 kinase activity for sustained proliferation. (stanford.edu)
Specificity1
  • We are investigating how Pbx and Meis proteins contribute to the specificity of Hox function in development and how disruption of their activities leads to neoplasia. (stanford.edu)
Chromosome3
  • Another example of an oncogene is the Bcr-Abl gene found on the Philadelphia chromosome, a piece of genetic material seen in Chronic Myelogenous Leukemia caused by the translocation of pieces from chromosomes 9 and 22. (wikipedia.org)
  • More information about the Philadelphia Chromosome below) The proto-oncogene can become an oncogene by a relatively small modification of its original function. (wikipedia.org)
  • The broken end of chromosome 22 contains the "BCR" gene, which fuses with a fragment of chromosome 9 that contains the "ABL1" gene. (wikipedia.org)
Receptor1
  • It is involved in theregulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressorand is a candidate for breast tumorigenesis. (immune-source.com)
Kinase1
  • The cyclin-dependent kinase (CDK) inhibitors p21 and p16 inhibit the activity of CDKs, such as CDK4. (medscape.com)
TP532
  • DNA damage increases TP53 levels through an ATM-dependent pathway. (medscape.com)
  • MDM2 binds to and inhibits TP53 activity. (medscape.com)
Transcription3
  • The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)
  • These are frequently activated by fusion to other transcriptional proteins resulting in chimeric transcription factors. (stanford.edu)
  • We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
Antibody1
  • Drug moieties used in antibody drug conjugates include bacterial protein toxins such as diphtheria toxin, plant protein toxins such as ricin, small molecules such as auristatins, geldanamycin (Mandler et al (2000) J. of the Nat. (justia.com)
Adult2
  • We will discuss three key proteins that function as tumor suppressors implicated in the development of pediatric (and some adult) cancers: pRB, p53, and PTEN. (medscape.com)
  • Next, we showed that the resulting hybrids can differentiate and acquire a proto-neural electrophysiology profile when the Wnt/beta-catenin pathway is activated in the adult stem cells prior fusion. (regenerativemedicine.net)
Functional2
  • [ 1 ] His prediction was subsequently supported by the cloning of the retinoblastoma tumor suppressor gene ( RB1 ) and by functional studies of the retinoblastoma protein, Rb. (medscape.com)
  • Then functional enrichment analyses, protein-protein interaction (PPI) network construction, and hub gene selection were conducted. (bvsalud.org)
Role2
  • Oncogenes play an important role in the regulation or synthesis of proteins linked to tumorigenic cell growth. (wikipedia.org)
  • The p16INK4A protein is a cell-cycle inhibitor that acts by inhibiting activated cyclin D:CDK4/6 complexes, which play a crucial role in the control of the cell cycle by phosphorylating Rb protein. (medscape.com)
Human2
  • Since the 1970s, dozens of oncogenes have been identified in human cancer. (wikipedia.org)
  • Dr. Robert Weinberg is credited with discovering the first identified human oncogene in a human bladder cancer cell line. (wikipedia.org)
Development1
  • The theory of oncogenes was foreshadowed by the German biologist Theodor Boveri in his 1914 book Zur Frage der Entstehung Maligner Tumoren (Concerning the Origin of Malignant Tumors) in which he predicted the existence of oncogenes (Teilungsfoerdernde Chromosomen) that become amplified (im permanenten Übergewicht) during tumor development. (wikipedia.org)
Repair1
  • 5) Lysosomes can also fuse with the plasma membrane to mediate membrane repair or discharge contents outside the cell, such as cathepsins or immune factors. (biomedcentral.com)
Fusion1
  • We are studying the effects and consequences of protein fusion on the transcriptional and transforming activities of these proteins using in vitro and animal models. (stanford.edu)
Component1
  • This protein is thought to be involved inattaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as towhether this protein is a component of chromatin or a nuclear matrix protein. (immune-source.com)