GondiiParasiteMetabolic pathwaysToxoplasmosisOxidativePlasmodiumInfectionSignalingInhibitorsMalariaMolecularProteinsRegulateSynthesisPhysiologyImmuneBehaviorDiseasesParasiticDamageStudySignalResearchResponsiblePotentialCommonBiologicalActivationDescribesPosterSimilarDisease featuresGroupFocusAdditionalPage
Gondii10
- We report here the identification of seven putative aspartic proteases, TgASP1 to TgASP7, in the apicomplexan parasite Toxoplasma gondii. (unige.ch)
- Toxoplasma gondii is an obligate intracellular protozoan parasite capable of infecting warm-blooded animals by ingestion. (life-science-alliance.org)
- Toxoplasma gondii ist ein obligater intrazellulärer Parasit, der bei Menschen und Nutztieren Toxoplasmose verursacht. (hu-berlin.de)
- Toxoplasma gondii is an obligate intracellular parasite that causes Toxoplasmosis in human and livestock. (hu-berlin.de)
- Protein O-fucosyltransferase 2-mediated O-glycosylation of the adhesin MIC2 is dispensable for Toxoplasma gondii tachyzoite infection. (edu.au)
- B y knocking out a key gene in the -parasite Toxoplasma gondii , DMS researchers hope to strike a blow for global health. (dartmouth.edu)
- The entire process is based on the Toxoplasma gondii parasite model. (linksium.fr)
- A new study demonstrates for the first time how the Toxoplasma gondii parasite enters the brain to influence its host's behavior. (medicalxpress.com)
- 1-Hydroxyquinolones were recently described as effective inhibitors of Toxoplasma gondii replication. (uni-goettingen.de)
- Associations between Toxoplasma gondii Infection and Multiple Sclerosis: A Case-Control Seroprevalence Study. (cdc.gov)
Parasite1
- We are using next generation sequencing technologies including chromatin conformation capture (Hi-C) together with mass spectrometry, metabolomics and systems biology approaches to identify key molecular components such as metabolic pathways, proteins and/or lncRNAs that control chromatin structure, parasite development and virulence factors of some of the most pathogenic Apicomplexan. (ucr.edu)
Metabolic pathways1
- 1-Hydroxyquinolones thus directly inhibit two important metabolic pathways: oxidative phosphorylation and pyrimidine de novo synthesis. (uni-goettingen.de)
Toxoplasmosis1
- Toxoplasmosis alters neural pathways specifically related to GABA, a new study reports. (neurosciencenews.com)
Oxidative1
- In clinical depression, however, a transition occurs to sensitization of immuno-inflammatory pathways, progressive damage by oxidative and nitrosative stress to lipids, proteins, and DNA, and autoimmune responses directed against self-epitopes. (biomedcentral.com)
Plasmodium1
- The prolonged duration of gametocyte maturation is a unique feature of only a few Plasmodium species infecting higher primates ( P. falciparum and P. reichenowi ) [ 1 , 2 ]. (biomedcentral.com)
Infection1
- At the same time, the weakened strain prompted an immune response that protected the mice against infection by virulent strains of Toxoplasma . (dartmouth.edu)
Signaling2
- The mTOR and p53 signaling pathways are connected by a number of different mechanisms. (hif-signal.com)
- Atorvastatin Improves Survival in Septic Rats: Effect on Tissue Inflammatory Pathway and on Insulin Signaling. (clipstonepress.com)
Inhibitors2
- We found that inhibitors of the mTOR pathway including rapamycin, wortmannin, and caffeine blunted the p53 response to nucleolar stress induced by actinomycin D. Synthetic inhibitors of mTOR (temsirolimus, LY294.002 and PP242) also impaired actinomycin D triggered p53 stabilization and induction of p21. (hif-signal.com)
- Our findings selleck may have implications for the design of combinatorial cancer treatments with mTOR pathway inhibitors. (hif-signal.com)
Malaria2
- David Bzik, Ph.D., a professor of microbiology and immunology, and Barbara Fox, a research associate in Bzik's lab, study Toxoplasma as a model organism that may help fight malaria and other diseases. (dartmouth.edu)
- He explains that the immune response prompted by Toxoplasma is just what's needed to combat a host of diseases, including malaria, tuberculosis, HIV, and cancer. (dartmouth.edu)
Molecular1
- Thus, our study identifies TSP-1:CD47 interaction as a molecular pathway that modulates IL-17-mediated VCAM-1 expression, contributing to its anti-inflammatory effect in chronic inflammatory conditions. (bvsalud.org)
Proteins1
- Upon activation, TLRs recruit adaptor proteins (proteins that mediate other protein-protein interactions) within the cytosol of the immune cell to propagate the antigen-induced signal transduction pathway. (wikipedia.org)
Regulate1
- Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)
Synthesis1
- Here, we dissected the physiological importance of two pathways accounting for the synthesis of PtdEtn and PtdIns. (hu-berlin.de)
Physiology1
- Thus, shared immuno-inflammatory pathways underpin the physiology of sickness behavior and the pathophysiology of clinical depression explaining their partially overlapping phenomenology. (biomedcentral.com)
Immune3
- As such, they are the master regulators of the immune response and serve this function by linking the microbial sensing features of the innate immune system to the exquisite specificity of the adaptive response. (aacrjournals.org)
- More than a billion people worldwide may be infected by Toxoplasma , which can cause damage to the central nervous system or death in infants and people with compromised immune systems. (dartmouth.edu)
- In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal–regulated kinase (MEK)/extracellular signal–regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)
Behavior1
- They thought it might be possible to identify-and knock out-a specific gene responsible for allowing Toxoplasma to exhibit this behavior. (dartmouth.edu)
Diseases2
- The anniversary event featured a keynote presentation from Progressor Giulio De Leo, Stanford University, who presented on the impact of climate change on NTDs, including how changing temperatures impacts the transmission of vector-borne diseases. (londonntd.org)
- With the NHEJ problem solved, creating new strains of Toxoplasma for use against these diseases will be much easier. (dartmouth.edu)
Parasitic2
- To address this problem, my laboratory has adapted several functional genomics approaches to probe the spatial organization of parasitic genomes as well as their epigenetics features to better understand their role in regulating biological processes including transcription. (ucr.edu)
- The Toxoplasma model enables to analyze both parasitic and human cells. (linksium.fr)
Damage1
- Damage to an eye or the visual pathway causes different types of vision loss depending on where the damage occurs. (msdmanuals.com)
Study1
- The study identified a mutant mouse lacking the Schnurri-2 protein (Shn-2 KO) that exhibits behavioral deficits and other brain features consistent with schizophrenia. (neurosciencenews.com)
Signal1
- The KEGG analysis and pathway-pathway network exhibited the potential signal pathways and their regulatory relationships. (biomedcentral.com)
Research3
- Feature papers represent the most advanced research with significant potential for high impact in the field. (mdpi.com)
- A Feature Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for future research directions and describes possible research applications. (mdpi.com)
- The December 2017 issue of Northwestern Medicine Magazine features an article devoted to skin research conducted at NU. (chicagobiomedicalconsortium.org)
Responsible1
- To distinguish whether the lack of TgDHODH-mediated electron transfer or the inhibition of de novo pyrimidine biosynthesis is responsible for growth inhibition, both pathways were uncoupled by expression of the ubiquinone independent Saccharomyces cerevisiae DHODH (ScDHODH). (uni-goettingen.de)
Potential1
- The images show the features of the druggable potential of these 2 mRNAs (Fig 3A). (clipstonepress.com)
Common1
- Some 2007 chemicals pathway common this of associated chills, development have nutrients in. (nattyscustomdesign.com)
Biological1
- The members of each group share predicted biological features that validate the phylogeny. (unige.ch)
Activation1
- Lastly, we demonstrate that exposure of T cells to EBOV resulted in autophagy through activation of ER-stress related pathways. (prolekarniky.cz)
Describes1
- For our February tale, we're continuing our focus on software developers with a story featuring Frank Delaglio , who describes how his interest in science was sparked at the age of seven. (sbgrid.org)
Poster1
- The conference featured seven speakers and 27 poster presentations. (cdc.gov)
Similar1
- formerly called microscopic polyarteritis) is an ANCA-associated systemic vasculitis that has some features similar to those of classic PAN, with the additional involvement of renal glomeruli and pulmonary capillaries. (medscape.com)
Disease features1
- 3) We are defining the properties of cancer stem cells that initiate and sustain the unique disease features of acute leukemias through the use of various adoptive animal models. (stanford.edu)
Group1
- The group identified a protein kinase MST4-dependant pathway that plays a tumor-promoting role in glioblastoma through increasing autophagic activity. (chicagobiomedicalconsortium.org)
Focus1
- There are a number of suggested treatment plans that focus on particular sites along the myocarditis-to-cardiomyopathy pathway. (ontariohomeopath.ca)
Additional1
- The iMosflm graphical interface for MOSFLM includes support for these new features and a long list of additional features and bugfixes. (sbgrid.org)
Page1
- More details on using these new features are available on the iMosflm home page . (sbgrid.org)