• multiple pathways
  • However, the precise cellular events that occur following infection have not been quantitatively described, nor do we understand the interaction between multiple pathways that have been implicated in epithelium renewal. (beds.ac.uk)
  • epithelial
  • Transgenic zebrafish expressing either the wild type or a phosphorylation-resistant form of CagA exhibited significantly increased rates of intestinal epithelial cell proliferation and showed significant upregulation of the Wnt target genes cyclinD1 , axin2 and the zebrafish c-myc ortholog myca . (biologists.org)
  • Taken together, these data highlight mechanisms that promote epithelial fate acquisition in stem cell-derived RPE. (sigmaaldrich.com)
  • Inflammation
  • RANKL derived from other cell types contributes to bone loss in conditions involving inflammation such as rheumatoid arthritis, and in lytic lesions caused by cancer, such as in multiple myeloma. (wikipedia.org)
  • regulator
  • Let-7 has been demonstrated to be a direct regulator of RAS expression in human cells All the three RAS genes in human, K-, N-, and H-, have the predicted let-7 binding sequences in their 3'UTRs. (wikipedia.org)
  • phenotype
  • In vitro, -ATc, Δrps13 persists for months and the proliferation phenotype can be rescued with ATc. (blogspot.com)
  • The mutants of other let-7 family members have a radio-resistant phenotype in vulval cells, which may be related to their ability to repress RAS. (wikipedia.org)
  • EGFR
  • The EGFR pathway is activated by the EGF ligands, Spitz, Keren and Vein, the latter being induced in the surrounding visceral muscles in part under the control of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. (beds.ac.uk)
  • Additionally, the EGFR pathway synergizes with the JAK/STAT pathway in stem cells to promote their proliferation. (beds.ac.uk)
  • Finally, we show that the EGFR pathway contributes to gut morphogenesis through its activity in enterocytes and is required to properly coordinate the delamination and anoikis of damaged cells. (beds.ac.uk)
  • This function of the EGFR pathway in enterocytes is key to maintaining homeostasis, as flies lacking EGFR are highly susceptible to infection. (beds.ac.uk)
  • Western blot was used to analyse changes of the EGFR/AKT signal pathway in Hela cells after the overexpression of microRNA-93. (alliedacademies.org)
  • Western blot showed that heterologous overexpression of microRNA-03 inhibited the expression of the EGFR/AKT signal pathway. (alliedacademies.org)
  • Hence, microRNA-93 can regulate the proliferation of cervical cancer cells by suppressing the EGFR/AKT signal pathway. (alliedacademies.org)
  • gene
  • T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. (wikipedia.org)
  • When the Hippo pathway is not activated, YAP1/TAZ enter the nucleus and regulate gene expression. (wikipedia.org)
  • molecular
  • Molecular pathways regulating rapid proliferation and persistence are fundamental for pathogens but are not elucidated fully in Toxoplasma gondii. (blogspot.com)
  • 1,2 Thus, understanding the molecular mechanisms that control hyperplastic growth and the locomotion of vascular cells should aid in the development of novel therapeutic strategies to reduce neointimal thickening. (ahajournals.org)
  • Molecular Biology of the Cell. (wikipedia.org)
  • cyclin
  • Previous studies have demonstrated a protective effect of the cyclin-dependent kinase (CDK) inhibitor p27 Kip1 against atherosclerosis and restenosis, two disorders characterized by abundant proliferation and migration of vascular smooth muscle cells and adventitial fibroblasts. (ahajournals.org)
  • Cell cycle progression is controlled by several cyclin-dependent kinases (CDKs) that associate with regulatory cyclins. (ahajournals.org)
  • One substrate of APCCdh1 is the transcription factor Ets2, which is activated by the Ras-Raf-MAPK signalling pathway and induces the expression of cyclin D1. (wikipedia.org)
  • survival
  • Here, we show that rapamycin inhibited human soluble BAFF (hsBAFF)-induced cell proliferation and survival in normal and B-lymphoid (Raji and Daudi) cells by activation of PP2A and inactivation of Erk1/2. (njnu.edu.cn)
  • Conclusions- The ability of TRAIL to promote the survival/proliferation of endothelial cells without inducing NF-κB activation and inflammatory markers suggests that the TRAIL/TRAIL-R system plays an important role in endothelial cell physiology. (ahajournals.org)
  • mechanism
  • The aim of the present study was to examine the effect of intermedin (IMD) on hepatic carcinoma cell proliferation and its mechanism of action. (spandidos-publications.com)
  • On the other hand, hepatoma cell proliferation is attenuated by the bromodomain containing 7 (BRD7), a tumor suppressor, through a negative feedback regulatory mechanism. (sigmaaldrich.com)
  • Cdh1 plays a pivotal role in controlling cell division at the end of mitosis (telophase) and in the subsequent G1 phase of cell cycle: By recognizing and binding proteins (like mitotic cyclins) which contain a destruction box (D-box) and an additional degradation signal (KEN box), Cdh1 recruits them in a C-box-dependent mechanism to the APC for ubiquination and subsequent proteolysis. (wikipedia.org)
  • Because of their mechanism of action, phorbol esters can be used to study tumor proliferation and pain response. (wikipedia.org)
  • Adozelesin is an alkylating minor groove DNA binder that is capable of rapidly inhibiting DNA replication in treated cells through a trans-acting mechanism and preferentially arrests cells in S phase. (wikipedia.org)
  • tumor cell
  • The irreversible alkylation of DNA disrupts the nucleic acid architecture, which eventually leads to tumor cell death. (wikipedia.org)
  • Growing evidence suggests that DNA damaging agents, such as duocarmycins, are more efficacious in tumor cell killing than tubulin binders, particularly in case of solid tumors. (wikipedia.org)
  • mesangial cells
  • Moreover, Eviprostat suppressed PDGF-induced activation of ERK and Akt and inhibited cell proliferation and hillock formation in both mesangial cells and bladder smooth muscle cells. (mdpi.com)
  • 1)Ketamine inhibited [^3Hltymidine incorporation into the mesangial cells in a concentration-dependent manner (10 mM 1 mM). (nii.ac.jp)
  • induces
  • Previously, we demonstrated that ingestion of a nonlethal pathogen, Erwinia carotovora carotovora 15 , induces a massive increase in stem cell proliferation in the gut of Drosophila . (beds.ac.uk)
  • downstream
  • These results provide in vivo evidence of Wnt pathway activation by CagA downstream of or in parallel to the β-catenin destruction complex and upstream of Tcf4. (biologists.org)
  • proteins
  • Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. (wikipedia.org)
  • First discovered in 1980 as a regulatory kinase for its namesake, Glycogen synthase, GSK-3 has since been identified as a kinase for over forty different proteins in a variety of different pathways. (wikipedia.org)
  • A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. (wikipedia.org)
  • Many of the mammalian Dbl family proteins are tissue-specific and their number in Metazoa varies in proportion of cell signaling complexity. (wikipedia.org)
  • When the pathway is activated, YAP1 and TAZ are phosphorylated on a serine residue and sequestered in the cytoplasm by 14-3-3 proteins. (wikipedia.org)
  • upregulation
  • The Warburg effect, proposed by Otto Warbug in 1956, describes the upregulation of glycolysis in most cancer cells, even in the presence of oxygen. (wikipedia.org)
  • endothelial cells
  • Methods and Results- The role of TRAIL/TRAIL-Rs in vascular biology was investigated in primary human umbilical vein endothelial cells (HUVECs) and aortic endothelial cells, which showed comparable surface expression of death (TRAIL-R1 and -R2) and decoy (TRAIL-R3 and -R4) TRAIL-Rs. (ahajournals.org)
  • The aim of this study was to investigate the biological activity of TRAIL on vascular endothelial cells, which are among the principal physiological targets of the proinflammatory actions of TNF-α, the prototype of the TNF family of cytokines. (ahajournals.org)
  • Additionally, XBP1 protects endothelial cells from oxidative stress by interacting with HDAC3. (wikipedia.org)
  • inflammatory
  • Conversely, TRAIL did not activate NF-κB or affect the surface expression of the inflammatory markers E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1. (ahajournals.org)
  • vascular
  • Ectopic expression of miR-370-3p suppressed proliferation of vascular smooth muscle cells and blocked cell cycle. (europeanreview.org)
  • Importantly, a p27 Kip1 mutant lacking CDK inhibitory activity failed to inhibit vascular smooth muscle cell and fibroblast proliferation and migration. (ahajournals.org)
  • Excessive proliferation and migration of vascular smooth muscle cells (VSMCs) and adventitial fibroblasts play an important role in the pathobiology of vascular occlusive disease (eg, atherosclerosis, in-stent restenosis, transplant vasculopathy, and vessel bypass graft failure). (ahajournals.org)
  • Moreover
  • Moreover, the number of 5-bromo-2'deoxyuridine-5-monophosphate-labeled cells in the DES-treated testis was significantly reduced at E12.5 and E14.5, compared with controls, and that in the DES-treated ovary remained higher than that in the control ovary at E14.5. (diethylstilbestrol.co.uk)
  • tumors
  • Similar research that Boger utilized for comparison to his results involving elimination of cancerous tumors and antigens was centered around the use of similar immunoconjugates that were introduced to cancerous colon cells. (wikipedia.org)
  • Oncology
  • He is top ranked in the world by Google Scholar for his areas of research including: cell cycle (#1), prostate cancer (#1), Oncology (#3) and Breast cancer (#7) https://scholar.google.com/citations?user=RYlsfBQAAAAJ&hl=en&oi=ao. (wikipedia.org)
  • squamous cell carc
  • It was shown that an increased expression of Ets2 can be associated with various cancer types, in the likes of cervical cancer or oesophageal squamous cell carcinoma. (wikipedia.org)
  • cycle
  • On one hand, hepatoma cell proliferation is facilitated by HCV infection through a positive feedback regulatory cycle. (sigmaaldrich.com)
  • Cell cycle was detected by flow cytometry. (europeanreview.org)
  • Depletion of RPS13 caused arrest of parasites in the G1 cell cycle phase, thereby stopping parasite proliferation. (blogspot.com)
  • CDK-dependent pRb hyperphosphorylation releases E2F transcription factors, thus contributing to the expression of several growth and cell cycle-regulatory genes with functional E2F-binding sites in their promoters. (ahajournals.org)
  • The main function of Cdh1 is to suppress the re-accumulation of mitotic cyclins and other cell cycle determinants and therefore stabilising the G1-phase. (wikipedia.org)
  • APCCdh1 is thought to prevent premature S-phase entry by degrading mitotic cyclins in G1 and regulate processes unrelated to the cell cycle. (wikipedia.org)
  • The role of let-7 has been demonstrated in regulating the timing of neuromuscular junction formation in the abdomen and cell-cycle in the wing. (wikipedia.org)
  • proliferate
  • Cdh1-deficient cells can proliferate but accumulate mitotic errors and have difficulties with cytokinesis. (wikipedia.org)
  • GSK-3 is therefore a part of the canonical Beta-catenin/Wnt pathway, which signals the cell to divide and proliferate. (wikipedia.org)
  • expression
  • Constructed microRNA-93 expression vectors were transfected into the HeLa cell line through lipofection, after which the expression of microRNA-93 in HeLa cells was detected through qRT-PCR. (alliedacademies.org)
  • PFKFB3 expression exhibits circadian rhythmicity that is different between cancerous and non-cancerous cells. (wikipedia.org)
  • findings
  • In line with these findings, targeted manipulation of the TGF-β pathway with small molecules produces an increase in efficiency of RPE re-epithelialization. (sigmaaldrich.com)