• multiple pathways
  • However, the precise cellular events that occur following infection have not been quantitatively described, nor do we understand the interaction between multiple pathways that have been implicated in epithelium renewal. (beds.ac.uk)
  • genes
  • Transgenic zebrafish expressing either the wild type or a phosphorylation-resistant form of CagA exhibited significantly increased rates of intestinal epithelial cell proliferation and showed significant upregulation of the Wnt target genes cyclinD1 , axin2 and the zebrafish c-myc ortholog myca . (biologists.org)
  • CDK-dependent pRb hyperphosphorylation releases E2F transcription factors, thus contributing to the expression of several growth and cell cycle-regulatory genes with functional E2F-binding sites in their promoters. (ahajournals.org)
  • As one of the four genes involved in induced pluripotent stem (iPS) cells reprogramming, LIN28 expression is reciprocal to that of mature let-7. (wikipedia.org)
  • Let-7 has been demonstrated to be a direct regulator of RAS expression in human cells All the three RAS genes in human, K-, N-, and H-, have the predicted let-7 binding sequences in their 3'UTRs. (wikipedia.org)
  • A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. (wikipedia.org)
  • In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. (wikipedia.org)
  • Inflammation
  • RANKL derived from other cell types contributes to bone loss in conditions involving inflammation such as rheumatoid arthritis, and in lytic lesions caused by cancer, such as in multiple myeloma. (wikipedia.org)
  • EGFR
  • The EGFR pathway is activated by the EGF ligands, Spitz, Keren and Vein, the latter being induced in the surrounding visceral muscles in part under the control of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. (beds.ac.uk)
  • Additionally, the EGFR pathway synergizes with the JAK/STAT pathway in stem cells to promote their proliferation. (beds.ac.uk)
  • Finally, we show that the EGFR pathway contributes to gut morphogenesis through its activity in enterocytes and is required to properly coordinate the delamination and anoikis of damaged cells. (beds.ac.uk)
  • This function of the EGFR pathway in enterocytes is key to maintaining homeostasis, as flies lacking EGFR are highly susceptible to infection. (beds.ac.uk)
  • Western blot was used to analyse changes of the EGFR/AKT signal pathway in Hela cells after the overexpression of microRNA-93. (alliedacademies.org)
  • Western blot showed that heterologous overexpression of microRNA-03 inhibited the expression of the EGFR/AKT signal pathway. (alliedacademies.org)
  • cyclin
  • Previous studies have demonstrated a protective effect of the cyclin-dependent kinase (CDK) inhibitor p27 Kip1 against atherosclerosis and restenosis, two disorders characterized by abundant proliferation and migration of vascular smooth muscle cells and adventitial fibroblasts. (ahajournals.org)
  • Cell cycle progression is controlled by several cyclin-dependent kinases (CDKs) that associate with regulatory cyclins. (ahajournals.org)
  • One substrate of APCCdh1 is the transcription factor Ets2, which is activated by the Ras-Raf-MAPK signalling pathway and induces the expression of cyclin D1. (wikipedia.org)
  • tumor cell
  • The irreversible alkylation of DNA disrupts the nucleic acid architecture, which eventually leads to tumor cell death. (wikipedia.org)
  • Growing evidence suggests that DNA damaging agents, such as duocarmycins, are more efficacious in tumor cell killing than tubulin binders, particularly in case of solid tumors. (wikipedia.org)
  • inhibit cell
  • Intriguingly, TBP-1 overexpression can inhibit cell proliferation in a different celllular contexts suggesting that it may function as a negative regulator of cell proliferation. (unina.it)
  • In cellular migration, an integral aspect of inflammatory responses, the inhibition of GSK-3 has been reported to play conflicting roles, as local inhibition at growth cones has been shown to promote motility while global inhibition of cellular GSK-3 has been shown to inhibit cell spreading and migration. (wikipedia.org)
  • proteins
  • In addition, it provides a detailed description of the role of PI3K on the regulation of FOXO proteins, which are now becoming one of the most closely studied and important proteins in the regulation of cell death, cell proliferation and senescence. (eurolivre.fr)
  • Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. (wikipedia.org)
  • First discovered in 1980 as a regulatory kinase for its namesake, Glycogen synthase, GSK-3 has since been identified as a kinase for over forty different proteins in a variety of different pathways. (wikipedia.org)
  • Many of the mammalian Dbl family proteins are tissue-specific and their number in Metazoa varies in proportion of cell signaling complexity. (wikipedia.org)
  • mesangial cells
  • Moreover, Eviprostat suppressed PDGF-induced activation of ERK and Akt and inhibited cell proliferation and hillock formation in both mesangial cells and bladder smooth muscle cells. (mdpi.com)
  • 1)Ketamine inhibited [^3Hltymidine incorporation into the mesangial cells in a concentration-dependent manner (10 mM 1 mM). (nii.ac.jp)
  • induces
  • Previously, we demonstrated that ingestion of a nonlethal pathogen, Erwinia carotovora carotovora 15 , induces a massive increase in stem cell proliferation in the gut of Drosophila . (beds.ac.uk)
  • downstream
  • These results provide in vivo evidence of Wnt pathway activation by CagA downstream of or in parallel to the β-catenin destruction complex and upstream of Tcf4. (biologists.org)
  • cellular
  • We show here that p27 Kip1 inhibits cellular changes that normally occur during cell locomotion (eg, lamellipodia formation and reorganization of actin filaments and focal adhesions). (ahajournals.org)
  • Collectively, these results suggest that cellular proliferation and migration are regulated in a coordinated manner by the p27 Kip1 /CDK/pRb pathway. (ahajournals.org)
  • The duocarmycin analogues are able to exert their mode of action at any phase in the cellular cycle, whereas tubulin binders will only attack tumor cells when they are in a mitotic state. (wikipedia.org)
  • endothelial cells
  • Methods and Results- The role of TRAIL/TRAIL-Rs in vascular biology was investigated in primary human umbilical vein endothelial cells (HUVECs) and aortic endothelial cells, which showed comparable surface expression of death (TRAIL-R1 and -R2) and decoy (TRAIL-R3 and -R4) TRAIL-Rs. (ahajournals.org)
  • The aim of this study was to investigate the biological activity of TRAIL on vascular endothelial cells, which are among the principal physiological targets of the proinflammatory actions of TNF-α, the prototype of the TNF family of cytokines. (ahajournals.org)
  • Additionally, XBP1 protects endothelial cells from oxidative stress by interacting with HDAC3. (wikipedia.org)
  • inflammatory
  • Conversely, TRAIL did not activate NF-κB or affect the surface expression of the inflammatory markers E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1. (ahajournals.org)
  • Moreover
  • Moreover, the number of 5-bromo-2'deoxyuridine-5-monophosphate-labeled cells in the DES-treated testis was significantly reduced at E12.5 and E14.5, compared with controls, and that in the DES-treated ovary remained higher than that in the control ovary at E14.5. (diethylstilbestrol.co.uk)
  • transcription
  • It was specifically found that the circadian-driven transcription factor 'CLOCK' binds to the PFKFB3 promoter at a genuine 'E-box' site to increase transcription in cancer cells. (wikipedia.org)
  • tumors
  • Similar research that Boger utilized for comparison to his results involving elimination of cancerous tumors and antigens was centered around the use of similar immunoconjugates that were introduced to cancerous colon cells. (wikipedia.org)
  • Oncology
  • He is top ranked in the world by Google Scholar for his areas of research including: cell cycle (#1), prostate cancer (#1), Oncology (#3) and Breast cancer (#7) https://scholar.google.com/citations?user=RYlsfBQAAAAJ&hl=en&oi=ao. (wikipedia.org)
  • cycle
  • On one hand, hepatoma cell proliferation is facilitated by HCV infection through a positive feedback regulatory cycle. (sigmaaldrich.com)
  • Cell cycle was detected by flow cytometry. (europeanreview.org)
  • Depletion of RPS13 caused arrest of parasites in the G1 cell cycle phase, thereby stopping parasite proliferation. (blogspot.com)
  • The main function of Cdh1 is to suppress the re-accumulation of mitotic cyclins and other cell cycle determinants and therefore stabilising the G1-phase. (wikipedia.org)
  • The role of let-7 has been demonstrated in regulating the timing of neuromuscular junction formation in the abdomen and cell-cycle in the wing. (wikipedia.org)
  • upregulation
  • The Warburg effect, proposed by Otto Warbug in 1956, describes the upregulation of glycolysis in most cancer cells, even in the presence of oxygen. (wikipedia.org)
  • proliferate
  • Cdh1-deficient cells can proliferate but accumulate mitotic errors and have difficulties with cytokinesis. (wikipedia.org)
  • GSK-3 is therefore a part of the canonical Beta-catenin/Wnt pathway, which signals the cell to divide and proliferate. (wikipedia.org)
  • expression
  • Constructed microRNA-93 expression vectors were transfected into the HeLa cell line through lipofection, after which the expression of microRNA-93 in HeLa cells was detected through qRT-PCR. (alliedacademies.org)
  • It was shown that an increased expression of Ets2 can be associated with various cancer types, in the likes of cervical cancer or oesophageal squamous cell carcinoma. (wikipedia.org)
  • PFKFB3 expression exhibits circadian rhythmicity that is different between cancerous and non-cancerous cells. (wikipedia.org)
  • growth
  • However, the interplay between cell growth and locomotion remains obscure. (ahajournals.org)
  • BCAAs are broken down effectively by dehydrogenase and decarboxylase enzymes expressed by immune cells, and are required for lymphocyte growth and proliferation and cytotoxic T lymphocyte activity. (wikipedia.org)
  • The high rate of glycolysis is accompanied by increased lactic acid fermentation, providing additional nutrients for cancer cell growth and tumorigenesis. (wikipedia.org)
  • Reduced methylation of PFKFB3 is also found in some cancers, triggering the shift to the glycolytic pathway that supports cancerous growth. (wikipedia.org)
  • Cell Growth Differ. (wikipedia.org)
  • membrane
  • 7 It is also noteworthy that cleavage of membrane TRAIL from the cell surface requires the action of cysteine proteases, 2 which are abundantly present in the vessel wall. (ahajournals.org)