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  • accumulation
  • Accumulation of acetaldehyde leads to the development of physical symptoms of hangover, which include fatigue, headache, increased sensitivity to light and sound, redness of the eyes, muscle aches, and thirst3. (redorbit.com)
  • While the causes of a hangover are still poorly understood, several factors are known to be involved including acetaldehyde accumulation, changes in the immune system and glucose metabolism, dehydration, metabolic acidosis, disturbed prostaglandin synthesis, increased cardiac output, vasodilation, sleep deprivation and malnutrition. (wikipedia.org)
  • reaction
  • The presence of Au in doped Ce-Zr-Co oxide catalyst decreases the temperature necessary to reduce the cobalt and the cerium loaded in the catalyst and favors a different reaction pathway, improving the acetaldehyde route by ethanol dehydrogenation, instead of the ethylene route by ethanol dehydration or methane re-adsorption, thus increasing the catalytic activity and selectivity into hydrogen. (mdpi.com)
  • In enzymology, a deoxyribose-phosphate aldolase (EC 4.1.2.4) is an enzyme that catalyzes the chemical reaction 2-deoxy-D-ribose 5-phosphate ⇌ {\displaystyle \rightleftharpoons } D-glyceraldehyde 3-phosphate + acetaldehyde Hence, this enzyme has one substrate, 2-deoxy-D-ribose 5-phosphate, and two products, D-glyceraldehyde 3-phosphate and acetaldehyde. (wikipedia.org)
  • reactive
  • Acetaldehyde is a highly reactive compound that causes various forms of damage to DNA, including DNA adducts, single- and/or double-strand breaks (DSBs), point mutations, sister chromatid exchanges (SCEs), and DNA-DNA cross-links. (mdpi.com)
  • alcoholic
  • Based on extensive epidemiological evidence, the International Agency for Research on Cancer defined acetaldehyde associated with the consumption of alcoholic beverages as a "group 1 carcinogen" (definite carcinogen) for the esophagus and/or head and neck. (mdpi.com)
  • however, signaling pathways that perpetuate inflammation in alcoholic liver disease are only partially understood. (umassmed.edu)
  • metabolites
  • The purpose of this FOA is to provide support for integrated, innovative research on the novel and unconventional contributions of ethanol metabolizing pathways, their metabolites, cofactors, and interactions with synergizing biological pathways in the development of alcohol- induced diseases and end organ injuries. (nih.gov)
  • redox
  • Instead, the whole pathway is more of an electron sink for redox balancing, instead of a respiratory chain. (asm.org)
  • concentrations
  • Experiments were performed in a fluoroplastic bag containing α-pinene or limonene as terpenes, ozone and acetaldehyde or formaldehyde as coexistent CCs adjusted to predetermined concentrations. (mdpi.com)
  • individuals
  • The metabolized acetaldehyde in the blood, which is six times higher than in individuals without the mutation, has shown to be a carcinogen in lab animals. (wikipedia.org)
  • The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. (wikipedia.org)
  • metabolize
  • Since ALDH2 assembles and functions as a tetramer and requires all four of its components to be active in order to metabolize acetaldehyde, heterozygotes have very little ALDH2 activity. (wikipedia.org)
  • contributions
  • named after Harland G. Wood and Lars G. Ljungdahl, who made major contributions to the elucidation of this pathway) ( 7 - 9 ). (asm.org)
  • enzyme
  • The systematic name of this enzyme class is 1-(4-hydroxyphenyl)-2-aminoethanol hydro-lyase [deaminating (4-hydroxyphenyl)acetaldehyde-forming]. (wikipedia.org)
  • 6-carboxytetrahydropterin synthase (EC 4.1.2.50, CPH4 synthase, queD (gene), ToyB , ykvK (gene)) is an enzyme with systematic name 7,8-dihydroneopterin 3'-triphosphate acetaldehyde-lyase (6-carboxy-5,6,7,8-tetrahydropterin and triphosphate-forming). (wikipedia.org)
  • compounds
  • A. Morata, F. Calderón, M.C. González, M.C. Gómez-Cordovés and J.A. Suárez, Food Chemistry, Volume 100, Issue 3, 2007, Pages 1144-1152, doi:10.1016/j.foodchem.2005.11.024 A novel synthetic pathway to vitisin B compounds. (wikipedia.org)
  • It occurs as a late step in the meta-cleavage pathways of a variety of compounds, including catechol, biphenyl, toluene, salicylate. (wikipedia.org)
  • glucose
  • Therefore, the flux of glucose through the GK pathway rises as the concentration of glucose in the blood increases from fasting (5 mM) to postprandial (≈10-15 mM) levels following a carbohydrate-containing meal [Printz, R. G., Magnuson, M. A., and Granner, D. K. in Ann. (patentsencyclopedia.com)
  • The lower-energy production, per glucose, of anaerobic respiration relative to aerobic respiration, results in greater flux through the pathway under hypoxic (low-oxygen) conditions, unless alternative sources of anaerobically oxidizable substrates, such as fatty acids, are found. (wikipedia.org)
  • While the causes of a hangover are still poorly understood, several factors are known to be involved including acetaldehyde accumulation, changes in the immune system and glucose metabolism, dehydration, metabolic acidosis, disturbed prostaglandin synthesis, increased cardiac output, vasodilation, sleep deprivation and malnutrition. (wikipedia.org)
  • immune
  • The Rochester team found that binge drinking-related levels of acetaldehyde make immune cells called monocyctes more likely to stick to blood vessel walls and cause inflammation that contributes to blood vessel blockage - atherosclerosis. (treatmentcenters.com)
  • aerobic
  • Further evolutionary events in the development of aerobic fermentation likely increased the efficiency of this lifestyle, including increased tolerance to ethanol and the repression of the respiratory pathway. (wikipedia.org)
  • formation
  • A) UV/vis spectra of the formation of acetaldehyde-semicarbazone complex at 223 nm. (nih.gov)
  • The formation of the acetaldehyde-semicarbazone complex was measured during time in hermetically closed cuvettes (Figure 4A). (nih.gov)
  • Robert E. Asenstorfer and Graham P. Jones, Tetrahedron, Volume 63, Issue 22, 28 May 2007, Pages 4788-4792, doi:10.1016/j.tet.2007.03.052 Effect of acetaldehyde and several acids on the formation of vitisin A in model wine anthocyanin and colour evolution. (wikipedia.org)
  • known
  • 23andMe blog carriers of the A allele are prone to esophageal cancer , which is also known as upper aerodigestive tract (UAT) cancer , due to acetaldehyde from smoking . (snpedia.com)
  • complex
  • Determination of acetaldehyde-semicarbazone complex as the final product of the ADHa. (nih.gov)
  • We previously motto that p53 can trigger apoptosis by inducing the mien of proteins complex in the natural pathway: it can also activate the outside pathway nigh upregulating the phrase of membrane receptors on apoptosis-inducing proteins such as Fas-L. What is screenland capable these life [url=http://www.craigak.com/plan/specification13/form2/]order 600 mg zyvox with amex[/url] virus incubation period. (rightconnectionstravel.com)
  • signal
  • The signal pathways that at propinquitous secure been targeted in clinical trials in endometrial cancer are the impediment of EGFR, VEGFR, and PI3K/PTEN/AKT/ mTOR signal pathways, of which multitarget VEGF inhibi- tors are presently considered most reassuring [7, (kobook.com.ua)