• Some lncRNAs affect the growth and development of breast cancer by regulating cell proliferation and apoptosis, and others are involved in invasion and metastasis and drug resistance of breast cancer [ 6 ]. (jcancer.org)
  • The SignalStain ® Proliferation/Apoptosis IHC Sampler Kit from Cell Signaling Technology allows the researcher to examine paraffin-embedded tissues or cells with antibodies that will detect cellular apoptosis or proliferation. (cellsignal.com)
  • Each antibody in the SignalStain ® Proliferation/Apoptosis IHC Sampler Kit detects endogenous levels of its target protein and does not cross-react with any related proteins. (cellsignal.com)
  • Survivin binds and inhibits caspase-3, controlling the checkpoint in the G2/M-phase of the cell cycle through inhibiting apoptosis and promoting cell division (4,5). (cellsignal.com)
  • In conjunctiva, the immunoreactivity, localized in cytoplasm of epithelial cells generally, may demonstrate VDR legislation of cell development most likely, differentiation, and apoptosis, while in pterygium VDR co-localization in the nucleus and cytoplasm of epithelial cells may suggest choice nuclear pathways where supplement D might exert its antiinflammatory and anti-proliferative results by the legislation of gene appearance. (bibf1120.com)
  • PFT-μ induces cell cycle arrest and apoptosis in leukemic cells To further evaluate the impact of PFT-μ on leukemic cells we performed cell cycle and apoptosis analyses with the cell lines NALM-6 and KG-1a. (tech-strategy.org)
  • The effect of PFT-μ on particular apoptosis was dependant on AnnexinV/7-AAD staining after incubation with different concentrations of KP372-1 IC50 PFT-μ for 48?h in NALM-6 KG-1a TOM-1 End up KP372-1 IC50 being-13 K562 and Jurkat cells. (tech-strategy.org)
  • In accordance with the results from cell cycle analyses induction of apoptosis by PFT-μ was more pronounced in NALM-6 cells as compared with KG-1a. (tech-strategy.org)
  • In NALM-6 incubation with PFT-μ at 4 5 and 6.5?μ resulted in 34 59 and 80% apoptotic cells above spontaneous apoptosis (11%) respectively. (tech-strategy.org)
  • KG-1a cells showed a rate of specific apoptosis of 17% (20?μ PFT-μ) 18 (30?μ PFT-μ) and 25% (40?μ PFT-μ) above control (11% Physique 2b). (tech-strategy.org)
  • This observation was further strengthened by the actual fact that pre-incubation with skillet caspase inhibitor Z-VAD-FMK (50?μ for 1?h) significantly reduced apoptosis after PFT-μ in NALM-6 whereas KG-1a cells weren't rescued by Z-VAD-FMK (data not shown). (tech-strategy.org)
  • Hence PFT-μ exerted different impacts in cell apoptosis and cycle in both leukemic cell lineages. (tech-strategy.org)
  • Overexpression and silencing of RASSF7 were performed to measure the impact on HCC cell proliferation, cell cycle and apoptosis. (cellmolbiol.org)
  • Overexpression of RASSF7 promoted HCC cell proliferation, drived G1-S phase cell cycle transition and inhibited apoptosis. (cellmolbiol.org)
  • Knockdown of RASSF7 suppressed cell growth, induced G1-S phase cell cycle arrest and cell apoptosis. (cellmolbiol.org)
  • The aim of this study was to elucidate the role of fucoxanthin on apoptosis via signaling pathway in ovarian cancer cells. (phcog.com)
  • We established the action potential of fucoxanthin on cell proliferation in addition to apoptosis in A2780 cells, which were measured using reactive oxygen species (ROS) generation and the mitochondrial membrane potential (MMP). (phcog.com)
  • Our results established that fucoxanthin stimulates apoptosis as confirmed through reduced cell viability, improved production of ROS, and altered MMP in A2780 cells. (phcog.com)
  • In addition, we uncovered upstream signaling cascade (Akt/mTOR) induced by incubation A2780 cell lines with fucoxanthin that mediated cell apoptosis, migration, and invasion process. (phcog.com)
  • In addition to promoting proliferation, SLC25A22 when expressed in vitro, progressed the cell cycle and inhibited apoptosis. (wikipedia.org)
  • The inhibitory effect of MicroRNA-16-5p on the proliferation, invasion, cell cycle and apoptosis of glioma cells was evaluated by the cell proliferation, invasion and flow cytometry. (ijpsonline.com)
  • The over expression of MicroRNA-16-5p can inhibit the growth and invasion of the glioma cell line, promote the apoptosis and delay the cell cycle. (ijpsonline.com)
  • Akt pathways have effects on apoptosis, protein synthesis, metabolism and cell cycle. (springer.com)
  • Silencing of Chl1 in INS-1 cells was done to assess its impact on the insulin secretion, content, cell viability, and apoptosis. (lu.se)
  • Cell viability, apoptosis, and proliferation rate were not affected. (lu.se)
  • Moreover, knocking down BDNF partially reversed esketamine-mediated activation of the mBDNF/TrkB/PI3K signaling pathway and inhibition of neuronal apoptosis in propofol-induced rats. (degruyter.com)
  • Sesquiterpene lactones containing a 3-methylenedihydrofuran-2(3H)-one (or α-methylene-γ-lactone) moiety, for example damsin (1), are Michael acceptors that affect biological processes such as cell proliferation, death/apoptosis, and cell migration, by interfering with cell signalling pathways. (lu.se)
  • PKC is an important signaling molecule in numerous cell pathways, including cell differentiation, proliferation and apoptosis. (medscape.com)
  • PKC isozymes are LR-dependent molecules that link psychosine-induced LR disruption to reduced PKC function and altered cell signaling activity, possibly driving demyelination and apoptosis in oligodendrocytes and Schwann cells. (medscape.com)
  • Recently, T β 4 has have been shown to promote the differentiation of progenitor cell lines to cardiomyocytes [ 8 ]. (oncotarget.com)
  • In recent years, interest in the possible molecular regulators of cell proliferation and differentiation in a wide range of regeneration models has grown significantly, but the cell kinetics of this process remain largely a mystery. (mdpi.com)
  • These pathways are important for the growth and division (proliferation) and maturation (differentiation) of cells. (medlineplus.gov)
  • In particular, Sonic Hedgehog appears to be essential for the proliferation and differentiation of cells that ultimately give rise to cartilage and bone. (medlineplus.gov)
  • Wang C, Yuan X, Yang S. IFT80 is essential for chondrocyte differentiation by regulating Hedgehog and Wnt signaling pathways. (medlineplus.gov)
  • We show that loss of Erk1/2 in intestinal epithelial cells results in defects in nutrient absorption, epithelial cell migration, and secretory cell differentiation," the authors wrote. (genengnews.com)
  • The differentiation of endometrial stromal cells into decidual cells, termed decidualization, is an integral step in the establishment of pregnancy. (bioone.org)
  • Gene ontology and upstream regulator pathway analysis showed that WNK1 regulates cell migration, differentiation, and proliferation. (bioone.org)
  • MAPK pathways refer to various cellular functions, including cell proliferation, differentiation and migration. (springer.com)
  • These growth factors promote cell migration, proliferation, and differentiation, which are essential for wound healing. (thieme-connect.de)
  • While substantial progress has been made to delineate the developmental pathway of T-cell lineage commitment, still little is known about the relationship between differentiation competence and the remarkable expansion of the earliest (DN1 stage) T-cell progenitors. (lu.se)
  • To satisfy differentiation kinetics and overall cell yield data, our models require that adult DN1 cells divide multiple times before becoming competent to progress into DN2 stage. (lu.se)
  • T cell differentiation. (cdc.gov)
  • Cancer stem cells are a selective clonal subset of tumour cells that have avoided various cell regulatory mechanisms, including terminal differentiation, and yet have retained the self-renewal properties and proliferative potential of adult stem cells. (who.int)
  • Signaling through CysLT1R results in increased proliferation, survival and migration of intestinal epithelial cells, whereas signaling through CysLT2R leads to differentiation of colorectal cancer cells. (lu.se)
  • Further studies showed that UASR1 activated AKT and AKT-mediated mTOR signaling pathway to stimulate cell proliferation and growth. (jcancer.org)
  • Taken together, our data suggest that UASR1 plays an oncogenic role in breast cancer cells through activation of the AKT/mTOR signaling pathway, being a novel RNA oncogene. (jcancer.org)
  • TIP30 regulates lipid metabolism in hepatocellular carcinoma by regulating SREBP1 through the Akt/mTOR signaling pathway. (cellmolbiol.org)
  • As an upstream signature component of FcεRI signaling, inhibition of spleen tyrosine kinase (Syk) abrogated the IgE-induced HASM proliferation. (harvard.edu)
  • Inhibition of ZL55 cell proliferation by ADP was completely reversed by inhibiting MEK1/2, or JNK1/2, or PKC-δ, and PKC-α. (unisalento.it)
  • Conclusions: Our findings indicate that the andrographolide constraints SW-480 cell growth through inhibition of the Notch signaling pathway. (notchgene.com)
  • Furthermore, pre-treatment of CA rescues the proliferation inhibition induced by a sub-IC 50 dose of paclitaxel (PTX), an anticancer drug. (tmu.edu.tw)
  • These results suggest that RSV prevents diabetes-induced renal inflammation and mesangial cell proliferation possibly through Akt/NF- κ B pathway inhibition. (hindawi.com)
  • demonstrated that RSV prevented high glucose-induced kidney mesangial cell proliferation and fibronectin expression through inhibition of high glucose-induced JNK and NF- B activation, NADPH oxidase activity elevation, and reactive oxygen species production [ 10 ]. (hindawi.com)
  • Given the high frequency of DDX5 amplification in breast cancer, our results highlight DDX5 as a promising candidate for targeted therapy of breast tumors with DDX5 amplification, and indeed we show that DDX5 inhibition sensitizes a subset of breast cancer cells to trastuzumab. (aacrjournals.org)
  • Mutations in K-Ras and B-Raf activate the phosphoinositide 3-kinase (PI3K)/AKT and mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) signaling pathways. (biomedcentral.com)
  • Activated PAK1 enhances cell survival and migration via the AKT pathway, and stimulates transformation through the Ras/Raf/ERK/MAPK pathway. (biomedcentral.com)
  • Collectively, RPL5 promoted colon cell proliferation and migration, at least in part, by activating the MAPK/ERK signaling pathway. (biomedcentral.com)
  • RPL5 promoted colon cell proliferation and migration, at least in part, by activating the MAPK/ERK signaling pathway, which may serve as a novel therapeutic target for cancers in which MAPK/ERK signaling is a dominant feature. (biomedcentral.com)
  • Here, we demonstrate that RPL5 promotes COAD cell proliferation and migration via the MAPK/ERK signaling pathway. (biomedcentral.com)
  • In this review, we studied on the effects and molecular mechanisms of Rhizoma coptidis on NF-κB/MAPK/PI3K-Akt/AMPK/ERS and oxidative stress pathways. (springer.com)
  • Evidence presented in this review implicated that Rhizoma coptidis exerted beneficial effects on various diseases by regulation of NF-κB/MAPK/PI3K-Akt/AMPK/ERS and oxidative stress pathways, which support the clinical application of Rhizoma coptidis and offer references for future researches. (springer.com)
  • In this review, we sorted out the relationship of Rhizoma coptidis among components, diseases and NF-κB/MAPK/PI3K/Akt/AMPK/ERS/oxidative stress pathways, systematically studying on how Rhizoma coptidis exerts beneficial effects to various diseases, which supported the clinical application of Rhizoma coptidis and provided references for the future researches. (springer.com)
  • However, intestinal epithelial cell proliferation is not impeded, implying compensatory mechanisms. (genengnews.com)
  • We find that the DDX5 locus is frequently amplified in breast cancer and that breast cancer-derived cells with amplification of DDX5 are much more sensitive to its depletion than breast cancer cells and a breast epithelial cell line that lacks DDX5 amplification. (aacrjournals.org)
  • We report here that IgE sensitization induces HASM cell proliferation, as measured by 3H-thymidine, EdU incorporation, and manual cell counting. (harvard.edu)
  • Our studies indicate that EOPK significantly reduced proliferation and migration of colorectal cancer cells. (biomedcentral.com)
  • Knockdown of RPL5 significantly inhibited the proliferation and migration of HCT16 and RKO cells, and arrested the cell cycle in G0/G1 phase. (biomedcentral.com)
  • Meanwhile, triptolide treatment combined with Cav-1 knockdown in PCa cells enhanced the effects of anti-migration and anti-invasion, and those effects were restored following Cav-1-rescued. (nih.gov)
  • Yu M, Yu S, Gong W, Chen D, Guan J, Liu Y. Knockdown of linc01023 restrains glioma proliferation, migration and invasion by regulating IGF-1R/AKT pathway. (jcancer.org)
  • Primary human endometrial stromal cells (HESCs) were subjected to small interfering RNA knockdown of WNK1 followed by in vitro decidualization. (bioone.org)
  • In conclusion, these findings indicate that FBXO17 is a novel inhibitor of endometrial tumor development and it likely exerts effects via regulation of the Wnt signaling pathway. (medsci.org)
  • Futhermore, the molecular mechanism of MEK1/2-ERK1/2 signaling pathway regulation by RASSF7 was explored. (cellmolbiol.org)
  • This study uncovered a new layer of regulation of pro-proliferative genes by menin via the Hedgehog signaling pathway," Hua says. (medindia.net)
  • AMPK pathways are energy regulation pathways. (springer.com)
  • The latter findings point to the participation of Nogo-A/NgR1 signaling in the regulation of other aspects of growth, such as tissue expansion or turnover by cell proliferation. (jneurosci.org)
  • Activated hepatic stellate cells (HSCs) have been shown to play a function in angiogenesis and vasculogenesis. (oncotarget.com)
  • Although its pathogenesis appears multi-factorial, chronic irritation, angiogenesis and uncontrolled proliferation possess a key function in the pathogenesis of pterygium. (bibf1120.com)
  • 29,31-34 Recently, supplement D position continues to be connected with risk for several malignancies inversely, since supplement D inhibits cell angiogenesis and proliferation, activates apoptotic pathways, and exerts pro-differentiative results.35,36 In 1980, Garland37 and Garland reported an inverse association between sunshine publicity and cancer of the colon mortality, hypothesizing for vitamin D a protective function against the chance of cancer of the colon. (bibf1120.com)
  • During the healing process, the transforming growth factor β1 (TGF-β1) is the primary growth factor for re-epithelialization, angiogenesis, and fibroblast proliferation. (thieme-connect.de)
  • This study examines the effect of RPL5 on the progression of colon adenocarcinoma (COAD), including cell proliferation, migration and determines its underlying molecular mechanism using CRC cell lines in vitro. (biomedcentral.com)
  • Taken together, this study provides a novel evidence for clinical significance of RASSF7 as a potential biomarker, and demonstrates that RASSF7- MEK1/2-ERK1/2 signaling pathway might be a novel pathway involved in HCC progression. (cellmolbiol.org)
  • Excessive proliferation of vascular smooth muscle cells contributes to the progression of pathological conditions, such as vascular inflammation, plaque formation, atherosclerosis, restenosis, and pulmonary hypertension. (wikipedia.org)
  • Accumulated data suggest that the predicted evolution of diabetic glomerulopathy is comprised of an early, transient mesangial cell proliferation and subsequent hypertrophy of these cells that herald the slow progression into glomerulosclerosis [ 2 ]. (hindawi.com)
  • Survivin is a 16 kDa anti-apoptotic protein highly expressed during fetal development and cancer cell malignancy (3). (cellsignal.com)
  • The ribosomal protein RPL5 is a component of the ribosome, a large ribonucleoprotein complex responsible for protein synthesis in cells. (biomedcentral.com)
  • Mechanistically, we found that U-73122 inhibited DES-induced activation of cAMP- response element binding protein (CREB) in gubernaculum testis cells . (bvsalud.org)
  • Further, the fucoxanthin upregulates the expression of caspase (3, 8, and 9) protein experimentally in A2780 cell. (phcog.com)
  • The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. (cancerindex.org)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • The IFT80 gene provides instructions for making a protein that is part of a group (complex) called IFT complex B. This complex is found in cell structures known as cilia. (medlineplus.gov)
  • The GAS1 protein promotes Hedgehog signaling, and thus by inhibiting Gas1 expression, menin and PRMT5 effectively dial down the pathway's tendency towards cell proliferation. (medindia.net)
  • This abrogated expression of the decidual marker genes, insulin like growth factor binding protein 1 ( IGFBP1 ) and prolactin ( PRL ), and prevented adoption of decidual cell morphology. (bioone.org)
  • We have demonstrated the MicroRNA-873-5p-p53/ Bcl-2 Associated X-protein regulatory pathway in the development of glioma, which provides a theoretical basis for the development of the alternative strategies for the clinical treatment of glioma. (ijpsonline.com)
  • AMPK pathways inhibit biosynthetic pathways with energy consumption, such as protein, fatty acid and glycogen synthesis. (springer.com)
  • Moreover, the Nogo-A-Δ20 domain promotes neuroblast migration toward the OB through activation of the Rho/ROCK (Rho-associated, coiled-coil containing protein kinase) pathway, without the participation of NgR1. (jneurosci.org)
  • A study by White et al found that psychosine's cytotoxic effects on oligodendroglia and Schwann cells was mediated through disruption of the architecture and composition of lipid rafts (cell membrane regions characterized by high cholesterol and sphingolipid concentration), followed by altered protein kinase C (PKC) function. (medscape.com)
  • Using SILAC and quantitative mass spectrometry, we examined the effects of activation of the miR-17-92 cluster on global protein expression in neuroblastoma (NB) cells. (lu.se)
  • Studies have shown that various signaling pathways serve crucial roles in the tumorigenesis of UCEC, amongst which the Wnt/β-catenin pathway is of great interest due to its crucial role in cell proliferation and the huge potential as a therapeutic target. (medsci.org)
  • These cell structures play central roles in many different chemical signaling pathways, including a series of reactions called the Sonic Hedgehog pathway. (medlineplus.gov)
  • PAKs are downstream effectors of the Rho family GTPases, which regulate cell motility and survival. (biomedcentral.com)
  • Extracellular nucleotides can regulate cell proliferation in both normal and tumorigenic tissues. (unisalento.it)
  • Here, we studied how extracellular nucleotides regulate the proliferation of ZL55 cells, a mesothelioma-derived cell line obtained from bioptic samples of asbestos-exposed patients. (unisalento.it)
  • Oxidative stress pathways regulate redox balance by Nrf2 and other ways. (springer.com)
  • After activation in the wound area, platelets will release growth factors to regulate cell migration, proliferation, and matrix deposition and reduce the risk of infection from the wound, increasing the quality of healing and tissue repair. (thieme-connect.de)
  • EOPK significantly decreased HCT116 cell proliferation and migration, and induced G1 arrest without affecting normal cells. (biomedcentral.com)
  • The expression of Tβ4 was significantly decreased in human HSC cell line LX-2 and CCl4-treated mouse liver. (oncotarget.com)
  • In this study, our data show that Tβ4 was significantly decreased in human HSC cell line LX-2 and CCl4-treated mouse liver, and Tβ4 significantly suppressed cell viability and migration of HSCs. (oncotarget.com)
  • However, its proliferation was significantly decreased by the treatment of steroid sulfatase or aromatase inhibitors. (scirp.org)
  • In the present study, it was shown that FBXO17, which is a member of the F-box family, is abnormally downregulated in UCEC tissues compared with non-tumor endometrial tissues, and this was significantly associated with the clinical histological grade, as well as the abnormal proliferation of the UCEC cell line, Ishikawa, both in vitro and in vivo . (medsci.org)
  • Further, a recent report on the effects of EOPK indicated that the oil has anti-obesity and hypolipidemic activity in vitro and in vivo , using 3 T3-L1 cells and high fat diet-fed rats [ 16 ]. (biomedcentral.com)
  • Moreover, loss-of-function studies reveal that restoration of linc01023 restrains glioma cell proliferation, migration and invasion by regulating IGF1R/AKT pathway in vitro and in vivo. (jcancer.org)
  • Moreover, linc01023 depletion inhibited glioma cell proliferation, migration and invasion by regulating IGF1R/AKT pathway in vitro and in vivo. (jcancer.org)
  • Using pharmacological approaches along with in vitro and in vivo experiments, we found that Nogo-A/NgR1 signaling regulates the pace of neuronal neogeneration by reducing NSC proliferation. (jneurosci.org)
  • The goal of this study was to investigate the anti-cancer mechanism of EOPK in HCT116 colorectal cancer cells. (biomedcentral.com)
  • Diethylstilbestrol (DES) is a nonsteroidal synthetic estrogen that disrupts the morphology and proliferation of gubernaculum testis cells , but the underlying mechanism is unclear. (bvsalud.org)
  • To explore the role of RASSF7 in hepatocellular carcinoma (HCC) cells proliferation and molecular mechanism. (cellmolbiol.org)
  • A low concentration arecoline can induce the proliferation and migration of HepG2 cells, with the potential mechanism of action linked to high levels of exosomal miR-21 and miR-1267, activation of the PI3K-AKT pathway, upregulation of CDK1 and CCND1, and downregulation of RAF1. (biomedcentral.com)
  • and reveals a potential mechanism of fucoxanthin-mediated Akt/mTOR suppression in human ovarian cancer cell line. (phcog.com)
  • Therapies aimed at targeting ERK1/2 likely fail because this mechanism is allowing proliferation through a different pathway," noted senior study author Eyal Raz, M.D., professor of medicine at UC San Diego School of Medicine. (genengnews.com)
  • In this paper, the mechanism of MicroRNA-16-5p in the occurrence and development of glioma was studied by the cell experiment in vitro. (ijpsonline.com)
  • This is an underappreciated escape pathway for tumor cells. (genengnews.com)
  • What's more, treating a mouse model of human MEN1 syndrome with a Hedgehog pathway inhibitor called Erivedge (FDA-approved in 2012 for metastatic or locally advanced basal cell carcinoma) reduced proliferation of tumor cells and blood insulin levels. (medindia.net)
  • PAK1 is an important effector of Rac and Cdc42 that regulates cell transformation and tumor proliferation [ 9 ]. (biomedcentral.com)
  • These DE-miRNAs, hub genes and pathway were proved in arecoline-treated HepG2 cells. (biomedcentral.com)
  • These genes are involved in the PI3K-AKT pathway. (biomedcentral.com)
  • We performed Kyoto Encyclopedia of Genes and Genomes (KEGG) and hub target genes analysis to illuminate potential biomarkers and related pathways in arecoline-induced cancer. (biomedcentral.com)
  • Oxidative stress pathways are caused by the imbalance of oxidation and antioxidation in body. (springer.com)
  • Collectively, our data provide mechanisms of a novel function of IgE which may contribute, at least in part, to airway remodeling observed in allergic asthma by directly inducing HASM cell proliferation. (harvard.edu)
  • Collectively, the study indicates that linc01023 plays an oncogenic role in glioma through activation of IGF1R/AKT signal pathway, and it could be a candidate therapeutic target. (jcancer.org)
  • The activation of P2Y1 receptor by ADP leads to activation of intracellular transduction pathways involving [Ca(2+) ]i , PKC-δ/PKC-α, and MAPKs, ERK1/2 and JNK1/2. (unisalento.it)
  • The results demonstrated that U-73122 impaired DES-evoked intracellular Ca2+ mobilization in gubernaculum testis cells and inhibited DES-induced proliferation of gubernaculum testis cells . (bvsalud.org)
  • Andrographolide plus intracellular ROS and induced G0 / G1 phase cell cycle arrest in SW480 colon cancer cells. (notchgene.com)
  • PFT-μ decreases intracellular concentrations of AKT and ERK1/2 in NALM-6 cells Following we performed intracellular staining and fluorescence-activated cell sorting analyses of AKT p-AKT ERK1/2 and p-ERK1/2 kinases in NALM-6 cells to judge whether PFT-μ impacts these two main signaling kinases or their phosphorylation position. (tech-strategy.org)
  • Besides, the results suggested that FBXO17 may inhibit the Wnt/β-catenin signaling pathway and influence the expression of adhesion molecules, such as E-cadherin and N-cadherin in Ishikawa cells. (medsci.org)
  • Herein, we investigated the potential role of Tβ4 in liver fibrosis by describing the effects of Tβ4, and we discuss the possible signaling pathway regulated by Tβ4. (oncotarget.com)
  • Recently, Notch signaling pathway has gained attention as a potential therapeutic target for chemotherapeutic intervention. (notchgene.com)
  • The purpose of this study was to determine the effect of andrographolide in aberrantly activated Notch signaling in SW-480 cells in vitro. (notchgene.com)
  • Our study suggested that the pro-survival effect of CA on PTX-treated lung cancer cells is mediated through a NF-κB signaling pathway. (tmu.edu.tw)
  • Previous studies have demonstrated that IGF-1R activates the phosphoinositide 3- kinase (PI3K)/AKT signaling pathways and promotes glioblastoma cell proliferation and survival by ligand binding [ 10 ]. (jcancer.org)
  • Researchers speculate that these changes in IFT alter certain signaling pathways, including the Sonic Hedgehog pathway, which may underlie the abnormalities of bone growth characteristic of asphyxiating thoracic dystrophy. (medlineplus.gov)
  • These signaling pathways are widely expressed and known to drive cancer growth in one-third of patients with colorectal cancer (CRC). (genengnews.com)
  • A research team led by Xianxin Hua, MD, PhD, associate professor of Cancer Biology at the Abramson Family Cancer Research Institute, report in Cancer Research that menin suppresses signaling in the much-studied Hedgehog pathway in endocrine organs. (medindia.net)
  • Menin mutations lead to increased Hedgehog signaling and cell proliferation. (medindia.net)
  • GSEA showed that the insulin-signaling pathway was influenced in Chl1 -silenced cells. (lu.se)
  • Silencing of Chl1 impairs β-cell function by disrupting the activity of key signaling pathways of importance for insulin biosynthesis and secretion. (lu.se)
  • Esketamine activated the mature brain-derived neurotrophic factor/tropomyosin receptor kinase B/phosphatidylinositide 3-kinase (mBDNF/TrkB/PI3K) signaling pathway in propofol-administrated rats. (degruyter.com)
  • An in vitro model of the US induced in vascular smooth muscle cells (VSMC) using oxidized (ox) -LDL. (notchgene.com)
  • Under NE binding alpha-1 receptors cause vasoconstriction (contraction of the vascular smooth muscle cells decreasing the diameter of the vessels). (wikipedia.org)
  • Agonism of beta-2 receptors causes vasodilation and low blood pressure (i.e. the effect is opposite of the one resulting from activation of alpha-1 and alpha-2 receptors in the vascular smooth muscle cells). (wikipedia.org)
  • The endothelial cells also exhibit cell turnover similar to normal vessels, supported by a paucity of mitoses or an uptake of tritiated thymidine. (medscape.com)
  • The findings from this study were published recently in Nature Communications in an article entitled "ERK5 Signalling Rescues Intestinal Epithelial Turnover and Tumour Cell Proliferation upon ERK1/2 Abrogation. (genengnews.com)
  • Vascular smooth muscle cell proliferation as a therapeutic target. (wikipedia.org)
  • Myeloid immune cells, specifically tumor-associated macrophages (TAMs), may represent potential novel therapeutic targets in HCC, complementing current ablative or immune therapies. (cancerindex.org)
  • An international research team lead by scientists at the University of California San Diego School of Medicine uncovered some surprising results while investigating a potential therapeutic target for the ERK1 and two pathways. (genengnews.com)
  • Our results show a novel role for DDX5 in cancer cell proliferation and suggest DDX5 as a therapeutic target in breast cancer treatment. (aacrjournals.org)
  • IgE was recently shown to induce HASM cell proliferation but the detailed mechanisms remain unknown. (harvard.edu)
  • Here we explore potential mechanisms how the proliferation and contractility of gubernaculum testis cells are regulated by diethylstilbestrol . (bvsalud.org)
  • Here, we investigated the effect of arecoline on the proliferation and migration of human HepG2 hepatoma cells and its potential oncogenic mechanisms. (biomedcentral.com)
  • For chemotherapy drugs, one of the best characterized resistance mechanisms is overexpression of MDR1 , a cell membrane transporter that causes efflux of certain drugs (eg, vinca alkaloids, taxanes, anthracyclines). (msdmanuals.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • However, the effect of triptolide on migration and invasion of human prostate cancer cells is still poorly understood. (nih.gov)
  • In this study, we demonstrated that triptolide significantly inhibited the proliferation, migration and invasion of prostate cancer cells in a time- and dose-dependent manner. (nih.gov)
  • Together, our research indicates that triptolide represses the migration and invasion through Cav-1/CD147/MMPs pathway in PCa cells, which gives a better understanding of triptolide in clinical aggressive prostate cancer therapy. (nih.gov)
  • Glioma, the vast majority of intracranial malignant tumors, is characterized by rapid proliferation and aggressive invasion [ 1 ]. (jcancer.org)
  • Ectopic expression of UASR1 promoted proliferation and clonogenic growth of breast cancer cells MCF7 and MDA-MB-231. (jcancer.org)
  • The expression level of RPL5 in colon cancer tissues and cell lines was significantly higher than that in adjacent tissues and NCM460 cells, respectively, and its expression level was higher in HCT116 cells and RKO cells. (biomedcentral.com)
  • Moreover, TBHQ could partially reverse the inhibitory effect of siRPL5 on the proliferation and migration of colon cancer cells. (biomedcentral.com)
  • Chen C, Song G, Xiang J, Zhang H, Zhao S, Zhan Y. AURKA promotes cancer metastasis by regulating epithelial-mesenchymal transition and cancer stem cell properties in hepatocellular carcinoma. (cellmolbiol.org)
  • First, fucoxanthin exhibited obvious cytotoxicity against A2780 human ovarian cancer cells. (phcog.com)
  • Here we used two human lung cancer cell lines, A549 and H1299, to clarify the role of CA in cancer cell proliferation. (tmu.edu.tw)
  • The growth assay showed that CA moderately promoted the proliferation of the lung cancer cells. (tmu.edu.tw)
  • We isolated stromal cells from endometrial cancer patients to examine local biosynthesis of estrogens and tumor-stromal interactions. (scirp.org)
  • Next we examined the effects of steroid sulfatase inhibitor and aromatase inhibitor in monoculture of endometrial cancer cell line (Ishikawa) and in a co-culture system involving an Ishikawa cells and stromal cells. (scirp.org)
  • Estrogen receptor and steroid sulfatase mRNA levels in cancer cells were significantly higher in the co-cultures compared with the monocultures of endometrial cancer cells. (scirp.org)
  • Proliferation of the cancer cells was significantly increased through the steroid sulfatase pathway, which metabolizes androgens, estrone sulfate, and estradiol sulfate as its substrates. (scirp.org)
  • We evaluated the effects of STS inhibitor and aromatase inhibitors on the proliferation of estrogen-dependent endometrial cancer cells. (scirp.org)
  • The ERK pathway plays a critical role in embryonic development and tissue repair because it instructs cells to multiply and start dividing, but when overactivated cancer growth often occurs. (genengnews.com)
  • If you block one pathway, cancer cells usually mutate and find another pathway that ultimately allows for a recurrence of cancer growth," remarked co-lead study author Koji Taniguchi, M.D., Ph.D., senior researcher at the Keio University School of Medicine in Tokyo. (genengnews.com)
  • Individuals with MEN1 are at a substantially increased risk of developing neuroendocrine tumors, including cancer of the pancreatic islet cells that secrete insulin. (medindia.net)
  • Researchers still did not exactly understand how menin mutations lead to MEN1 syndrome, and more importantly, what molecular pathways might be dysregulated by menin mutations and thus can be targeted to improve therapy against this type of cancer. (medindia.net)
  • Scientists have identified that pancreatic cancer cells growth and spread are fueled by an unusual metabolic pathway that someday might be blocked with targeted drugs to control the deadly cancer. (medindia.net)
  • ART3 regulates triple-negative breast cancer cell function via activation of Akt and ERK pathways. (nih.gov)
  • Defects in the control of cell proliferation are a hallmark of cancer, and DNA replication is a key process for cell proliferation. (aacrjournals.org)
  • Understanding how DNA replication is regulated in human cells can provide insight into cancer development and may reveal vulnerabilities that can be exploited therapeutically. (aacrjournals.org)
  • We make genetic and functional maps of cancer cell evolution in patients by analyzing multiple tumour samples from the same patient. (lu.se)
  • In this investigation, the cytotoxicity of 23 α-methylene-γ-lactones towards normal breast epithelial MCF-10A cells as well as breast cancer JIMT-1 cells is compared. (lu.se)
  • The ratio between the IC50 values for MCF-10A and JIMT-1 cells, as a measure for the selectivity of a compound to kill cancer cells, was calculated, and found to vary between just over 1 to more than 10. (lu.se)
  • This offers one of the most challenging paradoxes in cancer biology: what is required of a cell to not only survive massive genetic damage but also outcompete neighboring cells and present as a malignant tumor? (lu.se)
  • Загальні відомості про терапію злоякісних новоутворень Curing cancer requires eliminating all cells capable of causing cancer recurrence in a person's lifetime. (msdmanuals.com)
  • The ideal drug would target only cancer cells and have no adverse effects on normal cells. (msdmanuals.com)
  • Cytotoxic drugs damage DNA and kill many normal cells as well as cancer cells. (msdmanuals.com)
  • In contrast, other drugs (eg, DNA cross-linkers, also known as alkylating agents) have a linear dose-response relationship, killing more cancer cells at higher doses. (msdmanuals.com)
  • The miR-17-92 microRNA cluster is often activated in cancer cells, but the identity of its targets remains elusive. (lu.se)
  • Our results reveal cooperation between individual miR-17-92 miRNAs and implicate miR-17-92 in multiple hallmarks of cancer, including proliferation and cell adhesion. (lu.se)
  • The nucleotide potency profile and the blockade of the ADP-mediated inhibitory effect by the phospholipase C inhibitor U-73122 suggest that P2Y1 receptor controls ZL55 cell proliferation. (unisalento.it)
  • cell cycle phase distribution was evaluated Annexin V-FITC / PI staining. (notchgene.com)
  • RASSF7 Hepatocellular carcinoma Proliferation Cell cycle MEK1/2-ERK1/2 pathway. (cellmolbiol.org)
  • Amputation-induced proliferation occurred predominantly within the epidermal and intestinal epithelium, as well as wound-adjacent muscle fibers, where clusters of cells at the same stage of the cell cycle were found. (mdpi.com)
  • Antimetabolites such as fluorouracil and methotrexate are cell cycle-specific and have a nonlinear dose-response relationship. (msdmanuals.com)
  • Continuous infusion may increase cell kill with some cell cycle-specific drugs (eg, fluorouracil). (msdmanuals.com)
  • Genetic deletion of Erk1/2 or pharmacological targeting of MEK1/2 results in supraphysiological activity of the ERK5 pathway. (genengnews.com)
  • The migration of these cells also increased as demonstrated by wound healing and transwell assays. (jcancer.org)
  • HCT116 cell proliferation was assessed by conducting crystal violet and BrdU assays. (biomedcentral.com)
  • The two cell lines were treated with various concentrations of the compounds in dose response assays, and the 50 % inhibitory concentration (IC50) was determined from dose response curves. (lu.se)
  • To assess the effects of EOPK on cell migration, we performed a wound-healing assay. (biomedcentral.com)
  • The potential cytostatic andrografolida on SW-480 cells was evaluated by 3- (4,5-dimethylthiazol-2-yl) -2, 5-diphenyl tetrazolium bromide (MTT) assay, assessment of morphology and colony formation test. (notchgene.com)
  • MTT assay showed a dose and time dependent cytoxicity of andrographolide on SW-480 cells. (notchgene.com)
  • We applied an assay that measures the stability of maintenance of an episomal plasmid in human tissue culture cells to screen for new DNA replication factors. (aacrjournals.org)
  • For these short fibers, which can be fully engulfed by lung cells and do not dissolve in airway fluids in less than a few weeks, their clearance will be similar to other mineral and vitreous particles. (cdc.gov)
  • Our findings provide the first evidence that PLC-Ca2+ -CREB signalling pathway mediates the nongenomic effects of diethylstilbestrol on gubernaculum testis cells . (bvsalud.org)
  • These findings indicate that PPARγ plays a critical role in the control of B cell response and imply a role in diseases in which B cell hyperreactivity is involved, such as arthritis and autoimmunity. (jci.org)
  • The researchers were excited by their findings but urged caution at over interpretation of their initial findings and suggested that other classes of inhibitors be tested in combination with ERK5 inhibitors in human CRC cells in preclinical mouse models before any patient trial can begin. (genengnews.com)
  • and downregulation of Bcl-2 antiapoptotic in SW-480 treated cells. (notchgene.com)
  • To evaluate cytotoxicity of PFT-μ in non-malignant cells we analyzed BMSC samples of four AML patients as well as PB MNC (n=6) and CD34-positive cell samples (n=5) from healthy donors. (tech-strategy.org)
  • LncRNAs have been proved to be involved in the promotion of glioma cell malignant development. (jcancer.org)
  • Median IC50 values in PB MNC and CD34-positive cells were 17.6?μ (range 10.4-42.3) and 15.1?μ (range 8.0-20.0) respectively suggesting a higher resistance of normal hematopoietic and stromal cells to PFT-μ as compared with leukemic blasts. (tech-strategy.org)
  • RASSF7 was significantly up-regulated in HCC tissues and cell lines, and correlated with AFP, poor tumor histology and T stage. (cellmolbiol.org)
  • In this study, we confirm linc01023 is up-regulated in glioma tissues and cell lines. (jcancer.org)
  • Single drugs may cure selected cancers (eg, choriocarcinoma, hairy cell leukemia). (msdmanuals.com)