Pathway expression rna. Medical search. Frequent questions

The RNA-loaded Ago then recruits other proteins such as RHA, also known as nuclear DNA helicase II, and CTR9 to form an RNA-induced transcriptional activation (RITA) complex. (wikipedia.org)
Salinity stress generates reactive oxygen species (ROS), namely, H 2 O 2 , O −2 , and OH − that damage the DNA, RNA, and proteins [ 12 , 13 ]. (hindawi.com)
The central dogma of molecular biology suggests that biological information is stored in DNA then flows via RNA into proteins, which execute the functions dictated by DNA. (videolectures.net)
The RNA world theory proposes that an RNA-based life predated today's DNA and proteins dominated cellular metabolism. (videolectures.net)
Interestingly, these studies show that AML patients are unique amongst other cancers in that they frequently harbor mutations in the "epigenome" and "RNA splicing," which are part of the cellular machinery that regulates which proteins are ultimately expressed in the cell. (lls.org)
Fast Fenton footprinting: a laboratory-based method for the time-resolved analysis of DNA, RNA and proteins. (nyu.edu)
ELAV/Hu proteins comprise a family of highly conserved neuronal RNA binding proteins important for the development of the nervous system and for neuronal functions. (findaphd.com)
ELAV/Hu proteins are gene-specific regulators of alternative splicing of mRNAs, but can also affect other aspects of the maturation of an mRNA and its cytoplasmic expression into a protein. (findaphd.com)
The Wnt signaling pathway creates a complex network of proteins that have different effects on cells, so they can be involved in many cancers, including gliomas. (researchsquare.com)
The Wnt signaling pathway creates a complex network of proteins that have different effects on cells. (researchsquare.com)
If this pathway is inactive, β-catenin levels will be kept lower by a set of proteins. (researchsquare.com)
And the LEF / TCF family transcription factor, along with other proteins, binds to DNA and inhibits gene expression. (researchsquare.com)
Several examples of the role of viral glycoproteins, their ligands, and cellular proteins of the signaling pathways have been described. (cdc.gov)
Binding of viral proteins to their ligands activates signaling pathways-focal adhesion kinase for human herpesvirus 8, JAK1, tyk2 and STAT1/2 for West Nile virus (WNV), I κ B-kinase, and nuclear transcription factor κ B (NF-κB) for influenza virus-resulting in virus entry, DNA delivery to nucleus, and modulation of protein expression that stimulate or inhibit virus replication. (cdc.gov)
To summarize, we were able to (i) link global protein expression profiles to survival, and they proved to be an independent prognostic indicator, as well as (ii) identify proteins that are potential predictors of a patient's response to immunotherapy and targeted therapy, suggesting new opportunities for precision medicine developments. (lu.se)
Programmable DNA binding proteins have emerged as an exciting platform for engineering synthetic transcription factors for modulating endogenous gene expression 5 - 11 . (cdc.gov)

Small Activating RNA Molecules and Methods of Use. (wikipedia.org)
Therefore, the understanding of the diverse signalling molecules, signal recognition mechanisms and signal transduction pathways is fundamental for the insight into physiological and pathophysiological processes. (mdpi.com)
I will present the current knowledge on the many functions RNA molecules have in controlling cellular metabolism. (videolectures.net)
A potent method, called SELEX, enables the isolation and selection of RNA molecules with desired functions and opens the potential for design of therapeutic molecules. (videolectures.net)
An analysis that integrates three large sets of genomic data available through The Cancer Genome Atlas has identified 37 RNA molecules that might predict survival in patients with the most common form of breast cancer. (sciencedaily.com)
Mechanisms of regulation of gene expression by structured RNA molecules and RNA-protein complexes. (nyu.edu)
Testing regulatory RNAs and small-molecules as novel therapeutic agents. (nyu.edu)
RNA molecules with conserved catalytic cores but variable peripheries fold along unique energetically optimized pathways. (nyu.edu)
Using Analytical Ultra Centrifugation to measure global structural changes during equilibrium folding of RNA molecules. (nyu.edu)
Circular RNAs (circRNAs) are a form of noncoding and closed loop RNA molecules and play vital roles in the progression of various types of cancer in humans. (hindawi.com)
Aim: To detect the expression of molecules associated with Notch signaling pathway in stem cells from human exfoliated deciduous teeth (SHED) cultured in specific differentiation medium, namely, keratinocyte growth medium (KGM). (bvsalud.org)
RNA was reverse-transcribed to obtain the cDNA and then proceeded with PCR using specific primers for the Notch signaling pathway molecules (Notch1, Jagged-1, Jagged-2 and, Hes1) as well as stem cell marker (Nanog). (bvsalud.org)

The Metabolic Pathway Engineering Handbook: Tools and Applications (1st ed. (taylorfrancis.com)
This second volume of the Metabolic Pathway Engineering Handbook delves into evolutionary tools and gene expression tools for metabolic pathway engineering. (taylorfrancis.com)
The latter will include measures of DNA methylation, RNA expression and read outs of metabolic pathways. (europa.eu)
Alterations in expression include metabolic genes (CYP11B1, MGMT), cell cycle control and DNA repair genes (GADD45, Cyclin G2, Cyclin D3, Cyclin A) and transcription factors (IF2, IF3). (cdc.gov)
Human biomonitoring samples have been analysed for identifying metabolomics and transcriptomics fingerprints, while they have also been mapped jointly into metabolic pathways, for identifying the perturbated pathways that are mostly associated with neurodegenerative diseases. (aiche.org)
Sucrose has been reported to enter into various metabolic pathways and initiate release of energy wherever required. (scialert.net)
We used histologic, immunofluorescence, RNA sequencing, and metabolic assays to characterize kidneys from these mice and controls during development and up to postnatal day 21. (lww.com)
Within immunotherapy and targeted therapy subgroups, the upregulation of the VEGFA-VEGFR2 pathway, RNA splicing, increased activity of immune cells, extracellular matrix, and metabolic pathways were positively associated with patient outcome. (lu.se)

Noncoding RNAs, including circRNAs, microRNAs, and lncRNAs, have become a significant focus of research attention due to their crucial role in regulating the progression of multiple malignancies [ 5 ], including bladder cancer, gastric cancer, nasopharyngeal carcinoma, and pancreatic cancer. (hindawi.com)

RNA activation (RNAa) is a small RNA-guided and Argonaute (Ago)-dependent gene regulation phenomenon in which promoter-targeted short double-stranded RNAs (dsRNAs) induce target gene expression at the transcriptional/epigenetic level. (wikipedia.org)
Whether alterations in the expression pattern of these genes, particularly transcriptional factors, is associated with carcinogenic potential of TCA needs to be elucidated. (cdc.gov)
The RNA MAPK-PI3K Pathways panel provides a curated gene set to measure transcriptional activity of those pathways. (genomeweb.com)
Characterizing post-transcriptional regulatory pathways implicated in oncogenesis. (nyu.edu)
Present work thus suggests that sucrose might be acting as an enhancer of transcriptional trigger to the genes of steviol glycoside biosynthesis pathway that could positively manipulate the production of steviol glycosides. (scialert.net)
We use these engineered Cas9 activation complexes to investigate sgRNA targeting rules for effective transcriptional activation, demonstrate multiplexed activation of 10 genes simultaneously, and upregulate long intergenic non-coding RNA (lincRNA) transcripts. (cdc.gov)
Although the current generation of dCas9-based transcription activators is able to achieve up-regulation of some endogenous loci, the magnitude of transcriptional up-regulation achieved by individual single-guide RNAs (sgRNAs) 12 typically ranges from low to ineffective 8 - 11 . (cdc.gov)

In C. elegans, Argonaute CSR-1 interacts with 22G small RNAs derived from RNA-dependent RNA polymerase and antisense to germline-expressed transcripts to protect these mRNAs from Piwi-piRNA mediated silencing via promoting epigenetic activation. (wikipedia.org)
A type of RNA polymerase, it sets the starting point for replication by adding small RNA primers. (aboutdarwin.com)

Whereas for endogenous RNAa, upregulation of gene expression is guided by naturally occurring endogenous small RNAs such as miRNA in mammalian cells and C. elegans, and 22G RNA in C. elegans. (wikipedia.org)
In most cases, circRNAs usually act as a competitive endogenous RNA (ceRNA) that can absorb miRNAs to regulate the expression of targeted genes [ 9 ]. (hindawi.com)
These dCas9-activator fusions targeted to the promoter region of endogenous genes can then modulate gene expression 7 - 11 . (cdc.gov)

To further understand electrotactic migration of tumor cells, we performed RNA-sequencing for pathway discovery to identify signaling that is differentially affected by the exposure of direct-current electrical fields. (nature.com)
687 genes differentiated tumor samples before and after treatment, among which 310 genes did not show the same differential expression in the placebo group or normal samples. (karger.com)
There has been an increase in the identification of disease-associated risk factors, such as histone deacetylases (HDACs) and vimentin, as well as the signaling pathways involved, including activation of the Wnt signaling pathway and inactivation of the cellular tumor antigen p53 signaling pathway ( 9 ). (spandidos-publications.com)
1999 ). Report showed that VEGF increased the permeability through caveolae-mediated transcellular pathway in the blood-tumor barrier (Zhao et al. (springer.com)
Principal investigator Dr. Carlo M. Croce, professor of molecular virology, immunology and medical genetics, and director of Human Cancer Genetics, notes that most of the genes involved in the RNA signature have not previously been linked to breast cancer and that unlike many other prognostic signatures, this one does not contain genes involved in the cell cycle or tumor grade. (sciencedaily.com)
circITGA7 serves as a tumor suppressor in CRC by inhibiting growth and metastasis by suppressing the Ras signaling pathway [ 8 ]. (hindawi.com)
Dissemination of medulloblastoma within cerebrospinal fluid (CSF) pathways is a defining pathobiologic characteristic of this tumor, and about 30% of patients will have CSF metastasis at presentation. (medscape.com)

Aberrantly elevated expression levels of histone deacetylase 1 (HDAC1) and vimentin are closely associated with disease progression in hepatocellular carcinoma (HCC). (spandidos-publications.com)
Knockdown of FRAT1 inhibits hypoxia-induced epithelial-to-mesenchymal transition via suppression of the Wnt/β-catenin pathway in hepatocellular carcinoma cells. (nih.gov)
High expression of Ptch1 messenger RNA indicates a risk of postresection recurrence of hepatocellular carcinoma [4] . (proteopedia.org)
High expression of patched homolog-1 messenger RNA and glioma-associated oncogene-1 messenger RNA of sonic hedgehog signaling pathway indicates a risk of postresection recurrence of hepatocellular carcinoma. (proteopedia.org)

With the discovery that ribonucleic acid (RNA) can store genetic information and execute catalytic and regulatory functions, the central dogma is now being challenged. (videolectures.net)
Briefly put, both DNA (Deoxyribonucleic Acid) and RNA (Ribonucleic Acid) carry genetic information of all life forms guiding their biological functions. (aboutdarwin.com)

Analysis of the WNK1-dependent transcriptome by RNA-Seq demonstrated that WNK1 regulates the expression of 1858 genes during decidualization. (bioone.org)
By characterizing the transcriptome patterns and pathways for these symptoms, our goal is to shed light on the biological mechanisms underlying this comorbidity, which can help prevent the exacerbation of physical symptoms by intervening at the level of etiological pathway. (cdc.gov)

We observed a downregulation in the expression of genes involved in host response, such as TNF signaling, IL-1β production, and phagosome formation in Mφ, and phosphatidylinositol signaling and TNF signaling in PMNs, being in line with the ability of the pathogen to survive within phagocytes. (frontiersin.org)
In present study, we analyzed the effect of varying sucrose (1, 3 and 5%) concentrations on the genes involved in steviol glycoside biosynthesis pathway and content of steviol glycosides. (scialert.net)

Just recently, a new class of RNAs have been discovered, the microRNAs, which regulate development through the modulation of gene expression. (videolectures.net)
The analysis identified 30 mRNAs and seven microRNAs -- short snippets of RNA -- that were consistently associated with patient outcome across 44 clinical and molecular subclasses, including early-stage tumors. (sciencedaily.com)

Total RNA was used for the preparation of double standard cDNA. (cdc.gov)
Total RNA from tumors the expression of thousands of genes (3) to address complex questions was isolated using two successive rounds of Trizol. (lu.se)

The study by researchers at the Ohio State University Comprehensive Cancer Center -- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC -- James) initially analyzed messenger RNA (mRNA) and microRNA expression, DNA methylation data and clinical findings for 466 patients with invasive ductal carcinoma, the most common type of breast cancer. (sciencedaily.com)

In epigenetics, he is studying gene expression regulation mechanisms through chromatin interaction, and RNA silencing pathways in the developmental stages of germ-line cells. (wpi.edu)
The CHD8 gene provides instructions for making a protein that regulates gene activity (expression) by a process known as chromatin remodeling. (medlineplus.gov)
Chromatin remodeling is one way gene expression is regulated during development. (medlineplus.gov)

who also coined the term "RNAa" as a contrast to RNA interference (RNAi) to describe such gene activation phenomenon. (wikipedia.org)
Knockdown of FRAT1 expression by RNA interference inhibits human glioblastoma cell growth, migration and invasion. (nih.gov)
To date, various genome-scale loss-of-function screening methods have been developed, including approaches employing RNA interference 1 , 2 and the RNA-guided endonuclease Cas9 from the microbial CRISPR (clustered regularly interspaced short palindromic repeat) adaptive immune system 3 , 4 . (cdc.gov)

The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. (nih.gov)
Long non-coding RNA LINC00926 regulates WNT10B signaling pathway thereby altering inflammatory gene expression in PTSD. (nih.gov)
Gene ontology and upstream regulator pathway analysis showed that WNK1 regulates cell migration, differentiation, and proliferation. (bioone.org)
Erect wing regulates synaptic growth in Drosophila by integration of multiple signaling pathways. (findaphd.com)

Increased antioxidant enzyme activities (SOD, APX, and CAT) and upregulation of ROS pathway genes (CAT, APX, GR, and DHAR) were observed in PGPR inoculated okra plants under salinity stress. (hindawi.com)

Diverse signal recognition receptors and signal transduction pathways were defined which regulate cellular functions, metabolism and development. (mdpi.com)
Furthermore, these pathways are essential for cellular dynamics and build a highly regulated cellular signalling network. (mdpi.com)
Geneset enrichment of these findings has identified pathways significant in metabolism, immune signaling, other psychiatric disorders, neurological signaling, and cellular structure. (cdc.gov)
RNA might be at the centre of life, at its origin, driving evolution and regulating cellular activities until today. (videolectures.net)

Altered gene expression patterns were observed in 133 RNA transcripts with at least a 2 fold change. (cdc.gov)
The nCounter Low RNA Input Kit employs multiplexed target enrichment to linearly amplify mRNA transcripts, enabling gene expression analysis with 1 nanogram to 10 nanograms of sample inputs. (genomeweb.com)

In contrast to RNAi, promoter-targeted saRNAs induce prolonged activation of gene expression associated with epigenetic changes. (wikipedia.org)
Aberrant expression of these two enzymes may result in epigenetic alteration and, consequently, dysregulated gene expression ( 10 , 11 ). (spandidos-publications.com)
Our understanding of how mutations in the epigenetic and RNA splicing machinery contribute to AML remains a mystery. (lls.org)
A team led by Omar Abdel-Wahab at Memorial Sloan Kettering Cancer Center (MSK) has now identified how alterations in the epigenetic and RNA splicing processes work together to drive AML development. (lls.org)
Exposome research tries to reverse the paradigm of â nature versus nurtureâ and adopt one defined by complex and dynamic interactions between DNA sequence, epigenetic DNA modifications, gene expression and environmental factors that all combine to influence disease phenotypes. (aiche.org)

The workflow starts from read alignment and continues on to data exploration, to differential expression and, finally, to pathway analysis. (bioconductor.org)
The differential gene expression data analysis was performed using GeneChip 4.0 software. (cdc.gov)
RNA sequencing analysis showed differential expression of genes in pathways related to proliferation and differentiation. (nih.gov)
The sequence reads were mapped to hg19 reference genome and hits that passed quality filters were analyzed for differential expression. (nih.gov)

The objective of this study is to explore the long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) expression profiles of monocyte-derived dendritic cells (DCs) obtained from peripheral blood mononuclear cells (PBMCs). (frontiersin.org)

This is the first prognostic signature in breast cancer or other type of cancer that combines both mRNA and microRNA," says first author and researcher Dr. Stefano Volinia, associate professor of molecular virology, immunology and medical genetics at the OSUCCC -- James, "and we believe this concise RNA signature could prove useful for the clinical management of breast-cancer patients. (sciencedaily.com)

PBMCs are divided into various functional subtypes with respect to the specific cytokine expression profiles, surface markers, and the transcription factors. (frontiersin.org)

Since then, a number of miRNAs have been shown to upregulate gene expression by targeting gene promoters or enhancers, thereby, exerting important biological roles. (wikipedia.org)
The project will identify key genes, pathways, and biological processes that are differentially regulated in response to hypoxia. (lu.se)

Primary human endometrial stromal cells (HESCs) were subjected to small interfering RNA knockdown of WNK1 followed by in vitro decidualization. (bioone.org)

The gene is involved in the hypoxia-induced RNA editing pathway in monocytes. (jax.org)

Our research studied the lncRNA and mRNA expression profiles of monocyte-derived DCs and demonstrated the functional networks that are involved in monocyte-derived DCs-mediated regulation in AR. (frontiersin.org)
Also, Quantitative RT-PCR was used to evaluate the mRNA expression level of genes related to the Wnt signal pathway in treated cancer cells and control groups. (researchsquare.com)

The first piece of information, which was a little surprising, was that there was no significant impact of any of the mutations on outcome, including the BRAF amplifications, mutations in the MAP kinase pathway, or MEK1/2 mutations. (medscape.com)
No. But what we do see is that in patients with low TMB and low interferon gamma, there were mutations in the Wnt signaling pathway and beta-catenin, which we know bodes a poor outcome. (medscape.com)
This gives more support to the idea that you can combine these different gene expression profiles and mutations. (medscape.com)
1%) are typically large deletions or inversions or point mutations that disrupt gene expression. (msdmanuals.com)

Is the Subject Area "Double stranded RNA" applicable to this article? (plos.org)

Mitra, S. ( 2014 ) Methods in Molecular Biology, Vol. 1086 (RNA Folding - Methods and Protocols), Chapter 16: 265-288. (nyu.edu)
Methods: RNA was extracted from SHED harvested on day 1, 3 and 7. (bvsalud.org)

RNA Isolation and cDNA Microarrays. (lu.se)
However, it is difficult to capture the complexity of transcript isoform variance using these libraries, and large cDNA sequences are often difficult to clone into size-limited viral expression vectors. (cdc.gov)

In this study, RNA-sequencing of pooled Uncaria capsules RNA samples taken at three developmental stages that accumulate different amount of RIN and IRN was performed. (biomedcentral.com)

The data in the present study demonstrated that HDAC1 is overexpressed in HCC and that HDAC1 may upregulate vimentin expression through the NF‑κB signaling pathway, thus demonstrating a causal link between HDAC1 and vimentin in HCC, and may provide valuable information in understanding the pathogenesis of HCC. (spandidos-publications.com)

The Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis found 16 significant regulated pathways in imDCs and 10 significant regulated pathways in mDCs, including the phagosome, cell adhesion signaling pathway, and inflammatory mediator regulation of TRP channels pathway. (frontiersin.org)
Aberrant regulation of their activity or expression results in a range of neurological phenotypes including learning deficits, epilepsy, synaptic growth defects and neurodegeneration in model organisms. (findaphd.com)
To obtain mechanistic insights into how phosphorylation impacts on alternative splicing regulation we will combine available structural information for molecular modelling of ELAV multimerization and RNA binding to instruct experimental validation. (findaphd.com)

As an example of application, a new drug, SC75741, which blocks the NF-κB pathway without affecting the interferon (IFN)-γ pathway, may suppress the cytokine storm observed during influenza A virus (H5N1) infection. (cdc.gov)
This is one of the first publications that describes a relatively rigorous assessment of biomarkers where, of the 870 patients randomized on this trial (roughly 430 per arm), about 250 per arm had NanoString RNA data where an interferon gamma expression signature was assessed, and about 180 patients per arm had genetic sequencing done. (medscape.com)

Previous studies have demonstrated that vimentin expression is associated with HCC progression and that the serum vimentin level may serve as an additional marker of HCC, suggesting a role of vimentin protein in HCC pathogenesis ( 20 - 22 ). (spandidos-publications.com)

The Hedgehog signaling pathway is a signaling pathway that transmits information to embryonic cells required for proper cell differentiation. (proteopedia.org)

Subsequently, truncation and mutation of a vimentin promoter demonstrated that HDAC1‑induced vimentin expression was dependent on a nuclear factor κ‑light‑chain‑enhancer of activated B cells (NF‑κB) binding site in the vimentin promoter sequence. (spandidos-publications.com)

I will further explain the catalytic potential of RNAs. (videolectures.net)
Cas9 nuclease can be converted into an RNA-guided DNA binding protein (dCas9) via inactivation of its two catalytic domains 12 , 13 and then fused to transcription activation domains. (cdc.gov)

The results show that the combination of TMZ and KC7F2 can be a promising anti-cancer agent for the treatment of glioblastoma through the Wnt / β-catenin signaling pathway. (researchsquare.com)

In this study, we examined the expressions of p33ING1, p14ARF, MDM2 and p21WAF1 mRNA in 25 advanced colorectal cancers by quantitative RT-PCR method, and compared the expression levels of p33ING1, p14ARF, p21WAF1 and MDM2 in relation to p53 status in the tumors. (nih.gov)
Heterogeneous antigen expression is a key barrier influencing the activity of chimeric antigen receptor (CAR) T cells in solid tumors. (nature.com)

Analysis of gene expression from these individuals can help in identifying biomarkers of PTSD. (cdc.gov)

Studies have been conducted in our laboratory to determine whether exposure to TCA causes alterations in expression of cancer related genes in cultured human cells. (cdc.gov)
Finally, these pathways have been associated with external exposure factors such as exposure to chemicals and air pollution, the role of diet and the presence of beneficial nutrients, as well as the overall health status. (aiche.org)
Since route of allergen exposure can influence mechanistic pathways, mice were sensitized by identical routes with a high molecular weight occupational allergen ovalbumin and a low molecular weight occupational allergen trimellitic anhydride (TMA). (cdc.gov)

We find that U87 mg electrotaxis is abolished under pharmacological inhibition of PI3Kγ, mTOR, AKT and ErbB2 signaling, whereas DAOY cell electrotaxis was not attenuated by these or other pathways evaluated. (nature.com)
LINC00926 is involved in hypoxia-induced vascular endothelial cell dysfunction via miR-3194-5p regulating JAK1/STAT3 signaling pathway. (nih.gov)
The Intracellular Compatible Universal Cell Capture Kit enables researchers to use the nCounter Vantage RNA:Protein Immune Cell Signaling Assay with as few as 20,000 cells. (genomeweb.com)
median, 1.5), signaling pathways are far from fully understood. (lu.se)
In addition, we demonstrate that combined targeting of IL-6 signaling and WNT5A expression, using an anti-IL-6 antibody and a WNT5A antagonist peptide (Box5), respectively, more effectively reduces melanoma cell dissemination, as compared to each factor alone. (lu.se)
Further analyses revealed that simultaneously targeting HuR, with MS-444, and WNT5A signaling, with Box5, reduces melanoma cell migration and invasion via two different and partially overlapping signaling pathways, which are PKC and PI3K-AKT. (lu.se)
Our results also show that acquired BRAF-inhibitor (BRAFi) resistance leads to increased expression of HuR and WNT5A in malignant melanoma cells, and simultaneous therapeutic inhibition of HuR function and WNT5A signaling could be an efficient treatment strategy to impair the invasive migration of BRAFi-resistant melanomas. (lu.se)

Using available RNA sequencing data from previously published studies on intestinal organoids, the project will compare the gene expression profiles with newly generated RNA sequencing data from our lab's organoid cultures at hypoxia. (lu.se)

The RNAi pathway is being used as a research tool and has great therapeutic potential. (videolectures.net)

Is the Subject Area "Viral gene expression" applicable to this article? (plos.org)
Viral proteases (HCV and SARS-CoV) and viral RNA-dependent RNA polymerases (Lassa virus, HCV, WNV) are major targets, but treatments targeting viral enzymes often induce the rapid emergence of drug-resistant viruses. (cdc.gov)

The researchers then validated the prognostic signature using genome-wide expression data from 2,399 breast-cancer patients in eight independent groups and found that it performed better than other RNA signatures currently used for breast-cancer risk stratification. (sciencedaily.com)
Further, this project will apply statistical analysis of data and we willl use molecular modelling of available structural information to make predictions how phosphorylations impacts on ELAV multimerization and RNA binding. (findaphd.com)
Statistical tools are required to analyze the large and hybridized as described previously (3, 10, 11) and according to standard amount of expression data generated by this methodology. (lu.se)
The signature of our top screening hits is significantly correlated with gene expression data from clinical melanoma samples. (cdc.gov)

Resveratrol also down-regulated the increased expressions of vascular endothelial growth factor (VEGF) and kinase insert domain receptor (KDR, or VEGF receptor-2) induced by high glucose. (springer.com)

In conclusion, our work reveals the impacts of circIFT80 as ceRNA in the progression of CRC, by which sponging miR-142, miR-568, and miR-634 enhanced the expression levels of β -catenin and activation Wnt/ β -catenin pathway. (hindawi.com)

these pro inflammatory cells also show increased TNFR2, type I, and type II IFN pathway gene expression. (nih.gov)

Therefore, we investigated the combined effect of Temozolomide (TMZ) and KC7F2 on cell survival and changes in gene expression in the Wnt signal pathway. (researchsquare.com)

This study aims to explore its mechanism by defining changes in gene expression between neoplastic and normal tissue samples before and after treatment. (karger.com)
The project aims to elucidate the impact of oxygen levels on the HIF-2α pathway and its target genes in the context of intestinal stemness and tissue renewal. (lu.se)

identified targets for miRNA miR-373 on the promoters of several human genes and found that introduction of miR-373 mimics into human cells induced the expression of its predicted target genes. (wikipedia.org)
Expression of Frat1 correlates with expression of β-catenin and is associated with a poor clinical outcome in human SCC and AC. (nih.gov)
RNA sequencing was performed in primary human macrophages (Mφ) and polymorphonuclear neutrophils (PMNs) infected with a clinical strain of Brucella spp. (frontiersin.org)
Villavicencio EH, Walterhouse DO, Iannaccone PM. The sonic hedgehog-patched-gli pathway in human development and disease. (proteopedia.org)
Moreover, we show that the RNA-binding protein human antigen R (HuR) drives melanoma cell motility, and targeting HuR with a specific HuR inhibitor, MS-444, significantly reduces melanoma cell migration. (lu.se)

Further transcriptomic analysis of isolated peripheral blood mononuclear cells (PBMCs) and PMNs from patients with acute brucellosis before treatment initiation and after successful treatment revealed a positive correlation of the molecular signature of active disease with pathways associated with response to interferons (IFN). (frontiersin.org)
In a single case of idiopathic bilateral HNA, clinicians discovered differing molecular expression in the patient's HNA versus a normal nipple areolar complex through RNA sequencing. (medscape.com)
Examples of high molecular environmental factors are known to influence the development weight occupational allergens include proteases used in the and expression of asthma, and a vast array of triggers of asthma detergent industry, laboratory animal allergens, and ovalbumin have been identified. (cdc.gov)

Anatomy16

Organisms27

Diseases1

Chemicals and Drugs120

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes76

Information Science4

Health Care1

Proteins16

Molecules12

Metabolic8

Noncoding RNAs1

Transcriptional7

Polymerase2

Endogenous3

Tumor7

Hepatocellular carcinoma4

Ribonucleic acid2

Transcriptome2

Genes involved2

MicroRNAs2

Total RNA2

Methylation1

Chromatin3

Interference3

Regulates4

Upregulation1

Cellular4

Transcripts2

Epigenetic5

Differential4

LncRNAs1

MicroRNA1

Transcription factors1

Biological2

Knockdown1

Monocytes1

MRNA expression2

Mutations4

Double-stranded1

Methods2

CDNA2

Developmental stages1

Upregulate1

Regulation3

Interferon2

Serum1

Embryonic cells1

Mutation1

Catalytic2

Glioblastoma1

Tumors2

Biomarkers1

Exposure3

Signaling7

Gene expression profiles1

RNAi1

Viral2

Data4

Kinase1

Progression1

Inflammatory1

Survival1

Tissue2

Human5

Molecular3