• A series of signal transduction events starting from the activation of cyclin-dependent kinase 2 (CDK2) to binding of E2F -target transcription to phosphorylation of Rb helps maintain cell-cycle progression. (bdbiosciences.com)
  • Cyclin-dependent kinase 2 (CDK2) continues to be reported to become needed for cell proliferation in a number of individual tumours and it's been suggested as a proper target to be looked at to be able to improve the efficacy of treatment regimens predicated on the usage of DNA damaging medications. (phytid.org)
  • Cyclacell Pharmaceuticals Inc, Berkeley Heights, NJ), a 2,6,9-tri-substituted purine analogue of olomoucine that competes with Rabbit Polyclonal to CBLN2 ATP because of its binding site on CDK2 and various other CDKs [4C6, 10, 23C25]. (phytid.org)
  • In today's research, we have evaluated the biologic relevance of CDK2 appearance in Operating-system cells with desire to to define whether this kinase could be considered as a fresh candidate focus on for healing interventions predicated on the usage of roscovitine. (phytid.org)
  • The activity of cyclin-dependent kinase 2 (cdk2) a serine/threonine kinase whose main function is the phosphorylation of substrates necessary for cell-cycle progression (reviewed in reference [18]) is usually inhibited by binding with p21. (biomasswars.com)
  • The dependence of the apoptotic pathway on cdk2 was exhibited by (knockout cells. (biomasswars.com)
  • Furthermore, genes near the chromosome-12q13 breakpoint exhibited increased expression of GG-62 including ERBB3, NR4A1 (nuclear receptor subfamily 4, group A, member 1), cyclin-dependent kinase 2 (CDK2), and alpha 5 integrin (ITGA5). (elsevierpure.com)
  • EEF2 phosphorylation by cyclin A-cyclin-dependent kinase 2 (CDK2) on a novel site, serine 595 (S595), directly regulates T56 phosphorylation by eEF2K. (cusabio.com)
  • Further, we found that SPD significantly reduced basal or hydrogen peroxide (H 2 O 2 )-induced up-regulated protein expression of the aging markers, cyclin dependent kinase inhibitor 2A (p16/CDKN2A) and tumor protein 53 (p53). (biomedcentral.com)
  • Cdk5 is a proline-directed serine/threonine kinase, which was first identified as a CDK family member due to its similar structure to CDC2/CDK1 in humans, a protein that plays a crucial role in the regulation of the cell cycle. (wikipedia.org)
  • Crucial regulators from the changeover along cell routine phases will be the cyclin-dependent kinases (CDKs), a family group of serine/threonine kinases that type heterodimeric complexes with cyclins and operate in specific phases from the cell routine playing an integral function also in tumour cells proliferation [4, 5, 10, 11]. (phytid.org)
  • [ 3-5 ] Over 800 human miRNAs have been identified so far, [ 2 ] and they have been shown to negatively regulate protein expression through the inhibition of translation and/or decrease in mRNA stability. (medscape.com)
  • Accordingly, peripheral SIRT2 inhibition with the blood brain barrier impermeable compound AGK-2, worsened the cognitive capacities and increased systemic inflammation. (unav.edu)
  • These genotoxic brokers create different DNA modifications, that are sensed by signaling pathways that eventually result in CDKs inhibition and cell routine arrest. (phytid.org)
  • Spleen tyrosine kinase (SYK) is amplified in some patients with MCL, and its inhibition leads to the arrest of cell proliferation and apoptosis. (cancernetwork.com)
  • According to what we observed, this study indicated that 18β-GA could treat PAH, which is related to the inhibition of PERK/eIF2α/NF-κB signaling pathway. (cjphysiology.org)
  • Western blot analysis demonstrated a significant reduction in the p-AKT/AKT ratio in the two-day group, with significantly lowered phosphorylated ribosomal protein S6 kinase beta-1 (p-p70S6K)/p70S6K ratios in the one-day and two-day groups, thus indicative of PI3K/AKT/p70S6K signalling inhibition by exposure to blue light. (worldmedicinefoundation.com)
  • Thus, hCEC proliferation inhibition by exposure to blue light is attributed to the PI3K/AKT pathway. (worldmedicinefoundation.com)
  • Exposure to blue light lowered hCEC viability and promoted apoptosis through time-dependent PI3K/AKT/p70S6K pathway inhibition. (worldmedicinefoundation.com)
  • eEF-2 is activated by both lithium and GSK-3, whereas, lithium treatment and inhibition of GSK-3 have opposing effects on eEF-2. (cusabio.com)
  • This effect was correlated with c-Jun activation because inhibition of c-Jun by its dominant negative mutant (TAM67) reversed B(a)P action on cell cycle with the down-regulation of expression of cyclin D1, pRb and E2F1. (cdc.gov)
  • However, the cellular signaling pathways controlling the proliferation and differentiation of myoblasts are not fully understood. (rupress.org)
  • We demonstrate that Janus kinase 1 (JAK1) is required for myoblast proliferation and that it also functions as a checkpoint to prevent myoblasts from premature differentiation. (rupress.org)
  • It was found that vitexicarpin may block the cell cycle in Growth 2 Phase (G2)/Mitosis (M) phase by inhibiting the expression of Cyclin-Dependent Kinase 1 (CDK1), Cellular Myelocytomatosis Oncogene (c-myc) and survivin, thereby inhibiting the proliferation and promoting the apoptosis of human non-small cell lung cancer cell line (H322) [ 3 ]. (ijpsonline.com)
  • MCL is characterized by overexpression of cyclin D1, a cell cycle regulator that promotes cellular proliferation. (cancernetwork.com)
  • These wild-types or 'redox-null' cells will undergo characterisation, including assessment of kinases' redox state and activity, substrate phosphorylation, proliferation and cell cycle progression assays in response to oxidants or growth factor stimulation. (kcl-mrcdtp.com)
  • 2012) Parkin pathway activation mitigates glioma cell proliferation and predicts patient survival. (nni.com.sg)
  • 2010) Parkin enhances the expression of cyclin-dependent kinase 6 and negatively regulates the proliferation of breast cancer cells. (nni.com.sg)
  • 2 Apoptosis is triggered by caspase-mediated signal transduction pathways. (bdbiosciences.com)
  • Vitexicarpin inhibits the growth of human prostate cancer cell line (PC-3) cells and promotes the apoptosis by blocking the cell cycle of prostate cancer PC-3 cells in G 2 /M phase [ 5 ]. (ijpsonline.com)
  • This review will focus on innovative drug development for the treatment of relapsed or refractory MCL, including therapies aimed at disrupting the B-cell receptor signaling pathway, regulators of apoptosis, and immunomodulators. (cancernetwork.com)
  • Secondary genetic events that enhance cell growth, activate cell survival pathways, inhibit apoptosis, and promote interactions with the tumor microenvironment also serve as potential targetable mechanisms of lymphomagenesis. (cancernetwork.com)
  • The broad cyclin-dependent kinase (CDK) inhibitor flavopiridol leads to downregulation of cyclin D1 and induces apoptosis of malignant lymphocytes in vitro and in murine lymphoma models. (cancernetwork.com)
  • Blue light exposure promotes reactive oxygen stress, apoptosis and suppresses viability, migration and wound healing of cornea via inhibiting PI3K/AKT signaling pathway in corneal epithelial cells. (worldmedicinefoundation.com)
  • This exhibited the involvement of a protein that previously was associated with cell-cycle progression with pathways of apoptosis. (biomasswars.com)
  • To induce apoptosis of cancer cells by targeting the specific signal-transduction pathway could be an effective anticancer therapy. (spandidos-publications.com)
  • Extracellular Gal-3 is secreted via a non-classical pathway (because of lack of signal peptides) and can bind to the cell surface through glycosylated proteins, thereby triggering or modulating cellular responses such as mediator release or apoptosis. (nature.com)
  • 16,17] In addition, BCR ligation activates the prosurvival phosphoinositide-3 kinase (PI3K) pathway via AKT, which itself has been implicated in MCL pathogenesis. (cancernetwork.com)
  • In a recent study under review at the journal Molecular Medicine and currently available on the Research Square * preprint server, researchers in China investigate the role of phosphatidylinositol 3 kinase (PI3K)/ protein kinase B (AKT) pathway in causing metabolic disruptions and tissue injury among human corneal epithelial cells (hCECs) and corneal tissues of mice. (worldmedicinefoundation.com)
  • However, whether the PI3K/AKT pathway is involved in the pathophysiology of damage is not clear. (worldmedicinefoundation.com)
  • In the present study, researchers explore the probable contribution of the PI3K/AKT pathway in mediating the effects of blue light exposure on the corneal tissues of humans and mice. (worldmedicinefoundation.com)
  • To investigate the role of the PI3K/AKT pathway, hCECs were treated with LY294002, an inhibitor of the AKT pathway. (worldmedicinefoundation.com)
  • Cyclin A2 and cyclin-dependent kinase 2 (CDK 2) levels, both of which are PI3K/AKT pathway substrates, were significantly reduced among the zero-hour LY294002, two-day DMSO, and two-day LY294002 treatment groups as compared to the zero-hour DMSO group. (worldmedicinefoundation.com)
  • SPD might induce autophagy in FGSCs via the PI3K/Akt pathway. (biomedcentral.com)
  • eEF2 may be activated in a positive feedback cycle through inactivation of eEF2K via the PI3K/Akt/mTOR pathway. (cusabio.com)
  • The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway is a central oncogenic pathway deregulated in cancer. (gabapathway.com)
  • PI3K kinases function as key signal transducers downstream of cell-surface receptors and key regulators of cell survival and metabolism (7). (gabapathway.com)
  • The PI3K kinase family comprises 8 enzymes organized into 3 classes (I-III) based on sequence homology. (gabapathway.com)
  • 12,18,19] The development of specific tyrosine kinase inhibitors that target elements in these pathways has allowed molecularly driven clinical investigation in MCL. (cancernetwork.com)
  • Pro-tumorigenic role may be described through IFN-γ signaling insensitivity, downregulation of major histocompatibility complexes, upregulation of indoleamine 2,3-dioxygenase, and checkpoint inhibitors such as programmed cell death ligand 1. (biomedcentral.com)
  • Conclusion: The relevance of this 2-thiohydantoin derivative was demonstrated by our experimental tests, docking studies, and bioinformatics analysis, and it may be investigated as a lead molecule for anticancer medicines, notably as AKT1 and CKD2 inhibitors. (eurekaselect.com)
  • Currently, in the absence of visceral crisis, the standard of care for these patients is an endocrine therapy (ET) and cyclin-dependent kinase 4 and 6 inhibitors (CDKi) combination (4). (gabapathway.com)
  • APOBEC Mutational Signatures in Hormone Receptor-Positive Human Epidermal Growth Factor Receptor 2-Negative Breast Cancers Are Associated With Poor Outcomes on CDK4/6 Inhibitors and Endocrine Therapy. (cdc.gov)
  • Identify specific genes involved in oxidant-induced cell cycle arrest by RNA-sequencing in the above cells, validate and characterise differentially expressed genes and pathways of interest identified by using qPCR, immunoblotting or confocal imaging. (kcl-mrcdtp.com)
  • Arginine-vasopressin (AVP) facilitates water reabsorption in renal collecting duct principal cells through regulation of the water channel aquaporin-2 (AQP2). (mdpi.com)
  • Ingenuity Pathway Analysis (IPA) was employed to understand the differential regulation of specific pathways. (nih.gov)
  • Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)
  • In addition, we demonstrate for the first time the interaction between LRP1 and PARP-1 and the LRP1-dependent regulation of PARP-1-signaling pathways. (nih.gov)
  • We identified a novel mechanism of CDK4-Cyclin D regulation through oxidation at a critical allosteric site that is essential for activity, causing cells stably expressing 'redox-null' CDK4 to proliferate at slower rates. (kcl-mrcdtp.com)
  • The model * relieson our earlier work on the regulation of cyclin-dependent * protein kinases during the cell division cycle of yeast. (nih.gov)
  • Alterations in the retinoblastoma pathway in germ cell tumors (GCTs) have been described. (nih.gov)
  • The authors conducted an open-label, phase 2 study to determine the efficacy and safety of palbociclib in patients with incurable, refractory, retinoblastoma protein (pRB)-expressing GCTs. (nih.gov)
  • 2. Retinoblastoma-cyclin-dependent kinase pathway deregulation in vestibular schwannomas. (nih.gov)
  • [ 2 ] They can influence the activity of about 50% or more of all protein-coding genes in mammals, [ 2 ] and their change in expression is associated with human diseases, including infectious diseases, cancer, and rheumatic diseases. (medscape.com)
  • triterpenoid abundantly found in Lagerstroemia speciosa L. is known to modulate various cellular process including cellular oxidative stress and signaling kinases in various diseases, including skin cancer. (nih.gov)
  • Several cancer related pathways were identified by Ingenuity Pathways Analysis (IPA) including p53, Erk, TGF beta signaling pathways. (nih.gov)
  • It is found that Traditional Chinese medicine (TCM) has certain curative effect and value in anticolorectal cancer, so it is of great significance to develop more new TCM for its treatment [ 1 , 2 ]. (ijpsonline.com)
  • Oral cancer is one of most common types of cancer and over 500,000 patients suffer from it every year ( 2 ). (spandidos-publications.com)
  • 1,2 In addition to advancing age, cancer development appears to be promoted by a number of lifestyle factors, including an unhealthy diet and low physical activity, which can be major challenges in the elderly. (dsm.com)
  • Huang F, Jiang J, Yao Y, Hu S, Wang H, Zhu M, Yu L, Liu Q, Jia H, Xu W. Circular RNA Hsa_circRNA_101996 promotes the development of Gastric Cancer via Upregulating Matrix Metalloproteinases-2/Matrix Metalloproteinases-9 through MicroRNA-143/Ten-eleven translocation-2 Pathway. (jcancer.org)
  • High serum eukaryotic elongation factor 2 level is associated with non-small cell lung cancer. (cusabio.com)
  • Breast cancer (BC) is the most common cancer in women worldwide and the leading cause of cancer- related death among women (1,2). (gabapathway.com)
  • In allusion to chemotherapy resistance related cell metabolism reprogramming, studies of targeting metabolic changes through the metabolic core pathways in tumor cells has been emerging [ 16 , 17 ], which may better solve the drug resistance of tumors and improve the prognosis of patients. (biomedcentral.com)
  • The documented survival of GC is greater than 90% for patients at the early stage, but the survival decreases to less than 20% when patients are diagnosed in the advanced stage, which is directly associated with tumor metastasis [ 2 ]. (jcancer.org)
  • 5-bromo-2'-deoxyuridine (BrdU), a thymidine analog, is widely used to measure de novo DNA synthesis. (bdbiosciences.com)
  • Thiopental inhibits global protein synthesis by repression of eukaryotic elongation factor 2 and protects from hypoxic neuronal cell death. (cusabio.com)
  • Investigating a link between redox-regulated cyclin-dependent kinases, cell cycle progression and cell metabolism and its role in hyper-proliferative vascular disease. (kcl-mrcdtp.com)
  • PYGL was identified as a metabolism-related oncogenic biomarker that promotes HNSCC progression, metastasis and chemotherapy resistance though GSH/ROS/p53 pathway. (biomedcentral.com)
  • Furthermore, Bcl-2 family such as mitochondrial pro‑apoptotic Bax, anti-apoptotic Bcl-xl and Bid were regulated by Manu A, triggering the mitochondrial apoptotic pathway. (spandidos-publications.com)
  • Cellular senescence has been for long time an underestimated biological process, even after its discovery in 1961 by Hayflick and Moorhead [ 2 ]. (hindawi.com)
  • Exposure to blue light can alleviate epithelial-mesenchymal conversion through impaired cellular autophagy, activation of the nuclear factor kappa B (NF-κB) pathway, and induce ocular dryness. (worldmedicinefoundation.com)
  • SPD induces cytoprotective autophagy in FGSCs in vitro and ameliorates cellular senescence of FGSCs induced by H 2 O 2 . (biomedcentral.com)
  • Although hyper-activation of autophagy is believed to cause autophagy-dependent cell death, autophagy primarily protects against cellular insults, nutrient starvation, or oxidative stress. (biomedcentral.com)
  • Moreover, SPD significantly changed the expression of autophagy-related genes and pathways in FGSCs, as shown by bioinformatics analysis of RNA sequencing data. (biomedcentral.com)
  • In the second quarter of 2022, we intend to initiate discussions with the U.S. Food and Drug Administration , or FDA, about the potential for an accelerated approval pathway with bavdegalutamide in molecularly defined mCRPC and finalize a partnership for a companion diagnostic. (metroresearch.org)
  • 11] Acting downstream of SYK, Bruton tyrosine kinase (BTK) is a promising target in a variety of B-cell malignancies, including MCL. (cancernetwork.com)
  • In addition, we analyzed the effect of attenuation of p53 function, via the p53 inhibitor pifithrin-α, and knockdown of p53 mRNA on the cytotoxicity of microcystin-LR using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. (nih.gov)
  • DNA affinity protein binding assay and chromatin immunoprecipitation assay showed the dissociation of HDAC1/2 and association of CBP, leading to the histone-H3 acetylation on the Sp1 sites of p21 promoter. (aacrjournals.org)
  • Cell activity was detected by 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide assay. (ijpsonline.com)
  • Further study found that overexpression of dominant negative mutants of, PI-3K or Akt, dramatically reduced B(a)P-induced the activation of c-Jun and extracellular signaling regulated kinase (ERK), but not c-Jun NH2 terminal kinase (JNK). (cdc.gov)
  • Phosphorylations are of vital importance during glycolysis, therefore, making kinases an essential part of the cell due to their role in the metabolism, cell signaling, and many other processes. (wikipedia.org)
  • Therefore, binding with the activator is sufficient to activate the kinase. (wikipedia.org)
  • Additionally, PPPm-1 could effectively activate the Wnt/ß-catenin signaling pathway, promote the expressions of Wnt/1, ß-catenin, CyclinD1, and TCF-4 mRNA and protein, and inhibit GSK-3ß mRNA and protein expression to improve the learning and memory abilities of offspring mice. (bvsalud.org)
  • Results are offered as means with 95% confidence intervals and were regarded as statistically significant at confidence interval, collagen antibody-induced arthritis, cyclin-dependent kinase inhibitor 1. (tech-strategy.org)
  • The cAMP activates protein kinase A (PKA), which initiates signaling that causes an accumulation of AQP2 in the plasma membrane of the cells facilitating water reabsorption from primary urine and fine-tuning of body water homeostasis. (mdpi.com)
  • Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. (cusabio.com)
  • The role of two members of the ETS (E26 avian leukemia oncogene) family of transcription factors, ETS-1 and ETS-2, has been investigated in many cancers but has not yet been studied in ocular tumors. (molvis.org)
  • This binding also affects the three-dimensional structure of DNA, allowing the interaction between the activators and enhancers, the transcription factors, as well as the core promoter region and the RNA polymerase [ 2 ]. (biomedcentral.com)
  • The expression of hsa_circRNA_101996, microRNA (miR)-143, and ten-eleven translocation (TET)-2 in GC tissues, the adjacent tissues, and cell lines were determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). (jcancer.org)
  • The human epithelial cell line Caco-2 cells were divided into control group, low, middle and high dose groups of vitexicarpin, plasmid cloning DNA-circ_0000419 group, plasmid cloning DNA group, anti-microRNA-224 group, anti-microRNA-224-negative control group, vitexicarpin+small interfering-circ_0000419 group and vitexicarpin+microRNA-224 group. (ijpsonline.com)
  • A single amino acid substitution in eukaryotic elongation factor 2 co-segregates with the disease phenotype of spinocerebellar ataxia 26. (cusabio.com)
  • In normal control adult mouse eyes, ETS-1 was mostly present in the nuclei of all neuroretinal layers whereas ETS-2 was mostly localized in the cytosol of the cell bodies of these layers with a smaller amount present in the nuclei. (molvis.org)
  • However, whether the therapeutic effects of WZ on aging-related testicular dysfunction are dependent on the restoration of Sertoli cell function remains unclear. (bvsalud.org)
  • The isoprenoids are lipid moieties that are added to various proteins, including Ras, Rho, and Rac of small G proteins during posttranslational modification (prenylation), and anchor these proteins to the cell membrane ( 2 ). (aacrjournals.org)
  • Deregulation of cell routine control systems and aberrant actions of cell cycle-related kinases have already been connected with neoplastic advancement and development of several individual cancers, including Operating-system [4C10]. (phytid.org)
  • 11-13] More specifically, evidence that MCL pathogenesis is antigen-dependent[14] and that these tumors exhibit constitutive B-cell receptor (BCR) activation[15] posits the BCR signaling pathway as a rational prospect for drug development. (cancernetwork.com)
  • It also was exhibited that this pathway of cisplatin-induced cell death can be interceded to prevent nephrotoxicity. (biomasswars.com)
  • However it is usually unclear whether cisplatin nephrotoxicity depends on any of these pathways or these apoptotic cascades merely amplify more proximal initiated cell death signals. (biomasswars.com)
  • We observed that Manu A reduced cell growth and Sp1 protein levels in OSCC cell lines (HN22 and HSC4) in a dose- and time-dependent manner. (spandidos-publications.com)
  • Take together, our results indicate that c-Jun activation by p53-dependent PI-3K/Akt/ERK pathway is responsible for B(a)P-induced cell cycle alternations in human embryo lung fibroblasts. (cdc.gov)
  • Accelerated approval from the FDA was supported by interim results from the phase 2/3 STARBEAM study, which concluded that elivaldogene autotemcel may be an effective alternative to allogeneic stem-cell transplantation in boys with early stage CALD. (medscape.com)
  • This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. (genetex.com)
  • Furthermore, we revealed that TET2 regulates MMP2/MMP9 expression through the DNA demethylation pathway. (jcancer.org)
  • CONCLUSION: Thus, PPPm-1 improved the learning and memory abilities in the offspring of aging pregnant mice by acting on the P19-P53-P21 and Wnt/ß-catenin signaling pathways. (bvsalud.org)
  • 10/15/2005) TOTAL DESCRIPTORS = 943 MH - 1-Acylglycerol-3-Phosphate O-Acyltransferase UI - D051103 MN - D8.811.913.50.173 MS - An enzyme that catalyzes the acyl group transfer of ACYL COA to 1-acyl-sn-glycerol 3-phosphate to generate 1,2-diacyl-sn-glycerol 3-phosphate. (nih.gov)
  • HN - 2006(1981) MH - 2-Aminoadipate Transaminase UI - D051307 MN - D8.811.913.477.700.120 MS - A PYRIDOXAL PHOSPHATE containing enzyme that catalyzes the transfer of amino group of L-2-aminoadipate onto 2-OXOGLUTARATE to generate 2-oxoadipate and L-GLUTAMATE. (nih.gov)
  • HN - 2006(1983) MH - 2-Oxoisovalerate Dehydrogenase (Acylating) UI - D050645 MN - D8.811.682.657.350.825 MS - An NAD+ dependent enzyme that catalyzes the oxidation 3-methyl-2-oxobutanoate to 2-methylpropanoyl-CoA. (nih.gov)
  • use AMINO ACIDS, BRANCHED-CHAIN 1979, & KETO ACIDS & VALERATES 1973-1979 MH - 3-Hydroxyanthranilate 3,4-Dioxygenase UI - D050561 MN - D8.811.682.690.416.328 MS - An enzyme that catalyzes the conversion of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde. (nih.gov)
  • use ANTHRANILIC ACID 1974-1979 MH - 3-Isopropylmalate Dehydrogenase UI - D050539 MN - D8.811.682.47.500 MS - An NAD+ dependent enzyme that catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate to 3-carboxy-4-methyl-2-oxopentanoate. (nih.gov)
  • use DICARBOXYLIC ACIDS 1970-1979 MH - 3-Phosphoshikimate 1-Carboxyvinyltransferase UI - D051229 MN - D8.811.913.225.735 MS - An enzyme of the shikimate pathway of AROMATIC AMINO ACID biosynthesis, it generates 5-enolpyruvylshikimate 3-phosphate and ORTHOPHOSPHATE from PHOSPHOENOLPYRUVATE and SHIKIMATE-3-PHOSPHATE. (nih.gov)
  • ETS-1 and ETS-2 mRNA and protein levels were much higher in the ocular tissues of Tyrp-1-TAg mice than in control ocular tissues from wild-type mice. (molvis.org)
  • A PIK3CA mutation is detected in 30-40% of all hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancers. (gabapathway.com)
  • About 70% of MBC are hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) (3). (gabapathway.com)
  • In the phase 1 trials of the selective cyclin-dependent kinase 4/6 inhibitor palbociclib, 3 patients with unresectable, growing, mature teratoma syndrome achieved prolonged disease stabilization. (nih.gov)
  • In the fourth quarter of 2020, we initiated ARDENT, the Phase 2 single agent expansion portion of the bavdegalutamide clinical trial. (metroresearch.org)
  • 5. Gene discovery using a human vestibular schwannoma cDNA library constructed from a patient with neurofibromatosis type 2 (NF2). (nih.gov)
  • Benzo(a)pyrene-caused increased G(1)-S transition requires the activation of c-Jun through p53-dependent PI-3K/Akt/ERK pathway in human embryo lung fibroblasts. (cdc.gov)
  • 10. Microarray analysis of gene expression in vestibular schwannomas reveals SPP1/MET signaling pathway and androgen receptor deregulation. (nih.gov)
  • 11. Schwannomas exhibit distinct size-dependent gene-expression patterns. (nih.gov)
  • 19. Serial analysis of gene expression in neurofibromatosis type 2-associated vestibular schwannoma. (nih.gov)
  • In addition, it enhanced the expression of the proteins linked to the AMPA signaling pathway as well as the immature form of BDNF (pro-BDNF). (unav.edu)
  • It also prevented cardiomyopathy caused by 6-OHDA-induced bilateral NTS lesions by inhibiting the FGF23-FGFR1 pathway and downregulating TNF-α expression. (cjphysiology.org)
  • Western blotting was used to analyze the expression of matrix metalloproteinases (MMP)2/MMP9. (jcancer.org)
  • 4. Mutations of the neurofibromatosis type 2 gene and lack of the gene product in vestibular schwannomas. (nih.gov)
  • 7. Clinical manifestations of mutations in the neurofibromatosis type 2 gene in vestibular schwannomas (acoustic neuromas). (nih.gov)
  • IFN-γ is a protein encoded by the IFNG gene, composed of two polypeptide chains associated in an antiparallel fashion [ 2 ]. (biomedcentral.com)
  • Endoplasmic reticulum stress (ERS)-induced inflammation participates in the occurrence of pulmonary arterial hypertension (PAH) by promoting pulmonary vascular remodeling, which involved in the activation of PERK/eIF2α/NF-κB signaling pathway. (cjphysiology.org)
  • Several distinct mechanisms have been proposed for cisplatin cytotoxicity in renal tubule cells including direct DNA damage (5) caspase activation (6) mitochondrial dysfunction (7) formation of reactive oxygen species (8) effects around the endoplasmic reticulum (9) and activation of TNF-α apoptotic pathways (10). (biomasswars.com)
  • Subsequent analysis targeted for phenotype differences between the METArisk subgroups identified PYGL as a key metabolism-related biomarker that enhances malignancy and chemotherapy resistance by GSH/ROS/p53 pathway, leading to poor prognosis of HNSCC. (biomedcentral.com)
  • Methods: We predicted the anticancer mechanism of N-(4-oxo-5-(2-oxo-2-(p-tolylamino)ethyl)-3- phenyl-2-thioxoimidazolidin-1-yl)benzamide as a derivative of 2-thiohydantoin by utilizing molecular docking and molecular dynamic simulation. (eurekaselect.com)
  • The molecule belongs to the cyclin-dependent kinase family. (wikipedia.org)
  • As a result, we tried to understand the underlying processes of the 2- thiohydantoin derivative's anti-LIHC activity. (eurekaselect.com)
  • Several key components of this pathway have been explored as potential targets in MCL therapy. (cancernetwork.com)
  • We anticipate that future studies will be planned to explore the potential to treat earlier-line patients with AR-dependent tumors who may benefit from bavdegalutamide therapy. (metroresearch.org)
  • Poor clinical outcomes are attributed to extensive inter-patient heterogeneity and chemotherapy resistance, highlighting the inadequacy of standard therapy for curing patients with HNSCC [ 2 ]. (biomedcentral.com)