• Cellular senescence is a multifaceted process that arrests the proliferation of cells that are at risk of neoplastic transformation. (nature.com)
  • Furthermore, senescence activated by aberrant oncogenic activation, DNA damage or oxidative stress provides a failsafe mechanism that prevents proliferation of cells at risk of neoplastic transformation. (umassmed.edu)
  • Krüppel-like factors can bind to specific DNA motifs and regulate various cellular functions, such as metabolism, cell proliferation, and differentiation. (medsci.org)
  • KLFs regulate a wide range of cellular functions, including cell proliferation, apoptosis, differentiation, and neoplastic transformation, by binding to GC-rich promoter regions [ 1 , 2 ]. (medsci.org)
  • Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)
  • Symmetric cell division prompts multiplication and asymmetric cell division is an enlightening advance for differentiation. (researchsquare.com)
  • Myeloid-related precursor neoplasms derive from precursor cells that have at least one form of myeloid differentiation. (medscape.com)
  • The presence of the characteristic chromosomal translocation always involving the fibroblast growth factor receptor 1 ( FGFR1 ) gene at chromosome 8p11 in both the myeloid and lymphoid malignancies suggests bilineage differentiation from an affected pluripotent stem cell. (medscape.com)
  • Signal transduction plays an important role in activating cellular functions, cell differentiation , and cell proliferation . (lookformedical.com)
  • The common acquired melanocytic nevus is viewed as a focal proliferation of melanocytes, destined in most instances to follow a programmed pathway of differentiation that leads to disappearance of the nevus. (nih.gov)
  • If the pathway of differentiation is not followed, characteristic lesions result, and such lesions are regarded as the formal histogenetic precursors of melanoma. (nih.gov)
  • and cell differentiation ( SOX2 and TGFB3 ) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. (hindawi.com)
  • An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)
  • It is involved in p53 pathways and is implicated in cell death/survival signaling, the cell cycle, and differentiation, thereby playing a regulatory role in carcinogenesis [ 12 ]. (hindawi.com)
  • In this issue of Cancer Discovery , Dominguez and colleagues report that TET2 function is critical for germinal center exit and plasma cell differentiation, and its deficiency can lead to B-cell lymphoma phenotypes. (aacrjournals.org)
  • Its effect and effectiveness appear to be highly connected with the differentiation status of the cancerous cells, as Ang II appears to play a crucial role in the early and late stages of malignant transformation. (spandidos-publications.com)
  • Using computational predictions, we revealed that HPV-positive cervical cancers are regulated by transcription factors including, SOX2, E2F, NANOG, OCT4, and MYC, which control various processes such as the renewal of cancer stem cells, and the proliferation and differentiation of tumour cells. (fortuneonline.org)
  • Its prominent properties are A lack of cell differentiation Local invasion of adjoining tissue Metastasis, which is spread to distant sites through. (msdmanuals.com)
  • therefore, definitive differentiation of Hürthle cell carcinoma from Hürthle-cell adenoma is based on vascular invasion and/or capsular invasion, as well as on permanent histologic sections or extrathyroidal tumor spread and lymph node and systemic metastases. (medscape.com)
  • Some lncRNAs affect the growth and development of breast cancer by regulating cell proliferation and apoptosis, and others are involved in invasion and metastasis and drug resistance of breast cancer [ 6 ]. (jcancer.org)
  • Although KLF6 overexpression in human cancer cells inhibits cell proliferation, induces apoptosis, and attenuates cell migration, the effects of KLF6 on oral cancer remains poorly elucidated. (medsci.org)
  • however, forced KLF6 expression in lung cancer cell lines can trigger cells to undergo apoptosis and reduce colony formation ability [ 6 ]. (medsci.org)
  • More in detail, both conditions have been widely associated with the accumulation of genetic and epigenetic alterations responsible for the alteration of cell proliferation and apoptosis responsible for the neoplastic transformation of cells and the development of tumors (Candido et al. (researchgate.net)
  • We reported that silence of lncRNA GAS5 attenuated hypoxia-triggered cell death, as cell viability was increased and apoptosis rate was decreased. (molcells.org)
  • This study aimed to consider the oxidative damage induced by cadmium (Cd) and apoptosis and the role of N-acetylcysteine (NAC) in preserving hepatic cells against Cd toxicity. (springer.com)
  • Hepatic cells apoptosis was measured using TUNEL assay method. (springer.com)
  • Cd exposure is strongly associated with oxidative stress, inflammation, antioxidant depletion, and liver cells apoptosis. (springer.com)
  • Here, we investigated the effects of BPA on cell proliferation, apoptosis, and the wound healing process using prostate epithelial cells (RWPE-1) and stromal cells (WPMY-1). (bvsalud.org)
  • These results suggest that BPA exhibits prostate toxicity by inhibiting cell proliferation, inducing apoptosis, and interfering with the wound healing process. (bvsalud.org)
  • PGM1 knockdown stimulated both cell proliferation and colony formation, and inhibited cell cycle arrest and apoptosis, while overexpression of PGM1 produced the opposite effects in CRC cells both in vivo and in vitro. (biomedcentral.com)
  • Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. (lookformedical.com)
  • Many mechanisms have been proposed for the inhibition of carcinogenesis by tea, including the modulation of signal transduction pathways that leads to the inhibition of cell proliferation and transformation, induction of apoptosis of preneoplastic and neoplastic cells, as well as inhibition of tumor invasion and angiogenesis. (indexindex.com)
  • Crypt hyperplasia in GCC-/- mice was associated with compensatory increases in cell migration and apoptosis. (jefferson.edu)
  • Our study revealed that Ang II influences EC cells in terms of cancer-related processes, and is responsible for increased proliferation, reduction in apoptosis, increased mobility and modulation of adhesion potential. (spandidos-publications.com)
  • Zhang W, Kater AP, Widhopf GF, Chuang HY, Enzler T, James DF, Kipps TJ (2010) B-cell activating factor and v-Myc myelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemia. (springer.com)
  • Furthermore, recent findings showed the intriguing effects of microbiota in cancer susceptibility, neoplastic progression, co-infections with carcinogenic agents, and response to therapy. (biomedcentral.com)
  • We verified that PGM1 suppresses CRC progression via the PI3K/AKT pathway. (biomedcentral.com)
  • We identified a new mechanism by which PGM1 suppresses CRC progression by regulating glucose translocation via the PI3K/AKT pathway. (biomedcentral.com)
  • Molecular studies are usually needed, particularly in complex cases, including cases with transformation and/or progression. (fortuneonline.org)
  • The expression of p53 is directly linked to a blockage of cell cycle progression at G0/G1 phase and upregulates Bax, cytochrome studies have shown the ability of the bioactive compounds of flavokawain B and alpinetin to target UCK2 enzyme specifically, inducing cell cycle arrest and subsequently leading to cancer cell death, possibly through interfering the MDM2-p53 signalling pathway. (nanoker-society.org)
  • However, this approach requires prior in-depth understanding of the mechanisms by which lymphoid cells undergo neoplastic initiation and progression. (univ-mrs.fr)
  • Considering the important role of activator protein-1 (AP-1) in regulating multiple genes involved in the cell proliferation and inflammation and the induction of neoplastic transformation, we aimed to evaluate the potency of TiO2 NPs (≤ 20 nm) on the activation of AP-1 signaling pathway and the generation of reactive oxygen species (ROS) in a mouse epidermal cell line, JB6 cells. (cdc.gov)
  • Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. (novusbio.com)
  • This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
  • RESULTS: Expression of MnSOD and phase I genes that convert E2 into genotoxic metabolites 2-OH-E2 and 4-OH-E2 were significantly increased, whereas the expression of phase II gene COMT that detoxifies estrogen metabolites was significantly decreased in arsenic and estrogen coexposed cells. (bvsalud.org)
  • It is assumed though those endogenous molecular pathways could instigate mutations in respective genes with the support of reactive oxygen species, thus leading to DNA damage. (matjournals.co.in)
  • To date, researchers have already identified germline mutations in 22 specific genes associated with the FA pathway, each accounting for an individual FA complementation group ( 2 ). (frontiersin.org)
  • It is therefore conceivable that the inhibition of the function of these genes may specifically affect the proliferation and survival of brain tumor cells. (cancerindex.org)
  • We also showed that dose-dependent induction of proliferation was connected with changes in the expression of MKI67, CCND1 and CCNE1 genes in well- and poorly differentiated cancer cells. (spandidos-publications.com)
  • After Ang II treatment, poorly differentiated endometrial cancer cell line acquired a mesenchymal phenotype, which was characterized by induced expression of EMT-related genes (VIM, CD44, SNAI1, ZEB1 and ZEB2). (spandidos-publications.com)
  • Recently, a number of studies have shown that Ang II plays an important role in proliferation, invasiveness and migration of tumour cells, alteration of expression of cancer-related genes, as well as in physiological tissue remodelling. (spandidos-publications.com)
  • Moreover, we examined alterations in the expression of genes related to cancer cell behaviour after Ang II treatment. (spandidos-publications.com)
  • About 70% of breast cancers have mutations in genes that affect the PI3K signaling pathway. (bestpureessentialoils.com)
  • They have complementary mechanisms to hinder the carcinogenic process by searching free radicals, inhibiting survival and multiplication of malignant cells, as well as reducing invasiveness and angiogenesis of tumors. (researchsquare.com)
  • A single exposure or multiple exposures of these cells to MNU was effective in inducing tumorigenic cells that produced palpable tumors as early as 6 weeks after transplantation. (eurekamag.com)
  • Two treatments with MNU (100 micrograms/ml) were optimal for neoplastic transformation and produced tumors in 79% of the injected fat pads. (eurekamag.com)
  • Small tumors have a greater percentage of actively dividing cells than do large tumors. (msdmanuals.com)
  • Although Hürthle cell carcinoma was previously considered a variant of follicular cell neoplasms, which are generally less aggressive, the 2017 World Health Organization (WHO) classification of endocrine tumors reclassified it as a distinct entity. (medscape.com)
  • [ 5 ] The 2022 WHO classification of endocrine tumors has replaced the term Hürthle cell carcinoma with oncocytic carcinoma. (medscape.com)
  • Overall, only about 33% of Hürthle cell tumors demonstrate signs of that invasive growth that indicates malignancy and the possibility of metastasis. (medscape.com)
  • On balance, Hürthle cell tumors may be considered to be more likely to metastasize than follicular tumors. (medscape.com)
  • Permissive histologic interpretation may result in the designation of some non-neoplastic Hürthle cell lesions as malignant tumors. (medscape.com)
  • The clustering of cases and association of the tumors with the olfactory pathways suggested an infectious cause with a distinct route of transmission and tropism. (cdc.gov)
  • The mutations that comprise these pathways and the possible functional sequelae of these are explored. (ox.ac.uk)
  • References 2 and 3 describe the characteristics of cancer cells and the importance of mutations in cancer development. (nature.com)
  • Putative driver mutations affecting WNT (wingless-related integration site), JAK-STAT (Janus kinase/signal transducer and activator of transcription), or MAPK/PI3K (mitogen-activated kinase/phosphatidylinositol-3 kinase) pathways were found in all cases, aberrant activation of which converges on overexpression of MYC. (unige.ch)
  • Whole-exome sequencing (WES) verified RAD51C, BRIP1, PALB2 , and FANCG heterozygous germline mutations of the FA pathway, which were further confirmed in buccal swab samples by Sanger sequencing. (frontiersin.org)
  • Comprehensive genetic testing showed that many molecular variations (including FA gene germline mutations, RAS and epigenetic pathway somatic mutations, and NUP98-HOXC11 fusion) were highly linked to her serious and complex medical history ( Figures 1A, B ). (frontiersin.org)
  • She developed ovarian cancer, and then the altered FA pathway plus exposure to cytotoxic drugs promoted the emergence of acquired somatic mutations and the NUP98-HOXC11 fusion, all of which contributed to the development of secondary t-CMML. (frontiersin.org)
  • By limiting cell proliferation, senescence impedes the accumulation of multiple mutations that are necessary for tumorigenesis. (umassmed.edu)
  • Mutations have also been found in the blood of elderly patients without hematopoietic cancers, indicating that TET2 loss alone is not sufficient to trigger leukemic transformation (reviewed in ref. 5 ). (aacrjournals.org)
  • Genomic studies have uncovered silencing TET2 mutations in B-cell and T-cell lymphomas ( 6-8 ), indicating a tumor suppressor role for TET2 in lymphoid malignancies. (aacrjournals.org)
  • Disease and disorder research has been conducted in relation to the Histone Modification Pathway and Malignant Neoplasms, Neoplasms, Carcinogenesis, Cell Transformation, Neoplastic, Carcinoma. (novusbio.com)
  • Disease and disorder research has been conducted in relation to the Response To Uv Pathway and Neoplasms, Malignant Neoplasms, Skin Neoplasms, Malignant Neoplasm Of Skin, Carcinogenesis. (novusbio.com)
  • Lymphoid neoplasms are cancers of the immune system, which afflict both adults and children, and account for 6-10% of all neoplastic diseases. (univ-mrs.fr)
  • Overall, 60% of germ cell neoplasms have seminoma in their composition, but pure seminomas are genetically different from those that present as a component of a mixed tumor. (medscape.com)
  • therefore, few institutions have extensive experience with Hürthle cell neoplasms. (medscape.com)
  • Some investigators believe that this condition is distinct from other follicular cell neoplasms. (medscape.com)
  • The role of human parvovirus B19 (B19V) infection in malignant and benign lesions such as head and neck squamous cell carcinomas (HNSCCs) and oral mucocele lesions has not been established. (biomedcentral.com)
  • The Fanconi anemia (FA) pathway (also known as the FA-BRCA pathway) is involved in the repair of DNA lesions by homologous recombination, which plays a vital role in the maintenance of genomic stability ( 1 ). (frontiersin.org)
  • 2019). In the last decades, it was widely demonstrated how these two pivotal determinants of human pathologies are strongly associated with each other in a dual relationship where aging induces a pro-inflammatory state in the organism and inflammation, in turn, leads to the activation of cellular and molecular pathways involved in cell senescence and aging (Chung et al. (researchgate.net)
  • VEGF, produced in large amounts by cancer cells during tumor growth, interacts with its receptors VEGFR1 and VEGFR2 thereby causing endothelial cell survival, proliferation, and sprouting [7] . (plos.org)
  • Sensitization of cancer cells to conventional drugs using multi-target agents that block survival and oncogenic pathways, alone or in combination, is an emerging strategy to overcome drug resistance. (researchsquare.com)
  • All known oncogenic pathogens can promote cell survival and transformation because of their common abilities to cause chronic insults, genetic and epigenetic alterations, deregulated metabolic pathways, and immune escape. (biomedcentral.com)
  • The epidermal growth factor receptor (EGFR) signaling pathway plays a central role in the neoplastic transformation of NSCLC and promotes cancer cell survival, metastasis, and angiogenesis. (genglob.com)
  • Cell survival. (lookformedical.com)
  • It plays a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION . (lookformedical.com)
  • A critical requirement for developing such agents is to identify druggable targets required for the proliferation or survival of tumor cells, but not of other cell types. (cancerindex.org)
  • An evolving paradigm expanding the genetic basis of cancer suggests that developmental programs indelibly imprint restricted repertoires of homeostasis, forming the substrate for lineage-dependent tumor induction by deregulation of tissue-specific survival pathways. (jefferson.edu)
  • In addition to receptor-mediated pathways, DNA-reactive estrogen metabolites have also been shown to play a critical role in mutagenicity and carcinogenicity. (bvsalud.org)
  • Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. (lookformedical.com)
  • 2021). Similarly, cell senescence due to aging has been widely associated with the impairment of mitochondrial as well as proteosome and lysosome functions responsible for the accumulation of aberrant or misfolded proteins often observed in different neurodegenerative disorders (Sikora et al. (researchgate.net)
  • Two powerful tumour suppressor pathways, controlled by the p53 and retinoblastoma (pRB) proteins, are important for establishing and maintaining the senescence growth arrest. (nature.com)
  • These pathways respond to somewhat different stimuli but interact and cooperate to control the senescence response. (nature.com)
  • In mammalian organisms, cells that express markers of senescence have been shown to accumulate with age and at sites of certain age-related pathologies. (nature.com)
  • Proliferating cells can initiate an additional response by adopting a state of permanent cell-cycle arrest that is termed cellular senescence. (nature.com)
  • Understanding the causes and consequences of cellular senescence has provided novel insights into how cells react to stress, especially genotoxic stress, and how this cellular response can affect complex organismal processes such as the development of cancer and ageing. (nature.com)
  • Figure 4: Senescence controlled by the p53 and p16-pRB pathways. (nature.com)
  • However, dysregulation of the DDR pathway allows cells to proliferate beyond senescence limits. (oncotarget.com)
  • Senescence, a process by which cells enter an irreversible growth arrest state, is activated by many stimuli, including telomere attrition, aberrant oncogenic signaling, DNA damage or oxidative stress. (umassmed.edu)
  • By limiting cell proliferation and consequently depleting the renewal capacity of stem or progenitor cells, senescence is thought to contribute to the aging process. (umassmed.edu)
  • Using forward genetic screen as well as reverse genetics, we are interested in elucidating the genetic pathways that govern senescence. (umassmed.edu)
  • Using these 'senescence' mouse models, combined with different tumorigenesis models (for instance, p53 knockout, B cell lymphoma, skin cancer, colon cancer and liver cancer models), we hope to gain a better understanding of the regulation and contribution of senescence in tumor development. (umassmed.edu)
  • The mouse models we have generated to modulate senescence response in vivo are also used in our studies of senescence regulation in aging, with an emphasis on adult stem cells. (umassmed.edu)
  • These effects were due to massive cell senescence in mammary tissue, which was associated with upregulation of p21 and downregulation of survivin. (iucc.ac.il)
  • Therefore, Hsp72 has an essential role in Her2-induced tumorigenesis by regulating oncogene-induced senescence pathways. (iucc.ac.il)
  • ROS generation is involved in titanium dioxide nanoparticle -induced AP-1 activation through p38 MAPK and ERK pathways in JB6 cells. (cdc.gov)
  • Liang YJ, Yang WX (2019) Kinesins in MAPK cascade: how kinesin motors are involved in the MAPK pathway? (springer.com)
  • Bakuchiol also inhibited EGF-induced signaling pathways downstream of Hck, Blk and p38 MAPK, including the MEK/ERKs, p38 MAPK/MSK1 and AKT/ p70 S6K pathways. (umn.edu)
  • The potential for DNA damage and the activation of specific oncogenic pathways that cause inflammation are present in a wide range of physical, chemical, and biological variables that are constantly present in human beings. (matjournals.co.in)
  • An image depicting head and neck squamous cell carcinoma in vitro can be seen below. (medscape.com)
  • Head and neck squamous cell carcinoma in vitro (cell culture). (medscape.com)
  • Esophageal squamous cell carcinoma (ESCC) has a poor prognosis and is one of the deadliest gastrointestinal malignancies. (biomedcentral.com)
  • PGM1 inhibits hepatocellular carcinoma cell (HCC) proliferation and growth by utilizing sufficient extracellular glucose to convert glycogen, while deletion of the PGM1 gene inhibits glycogen synthesis and leads to glycolysis of additional glucose, thus promoting tumor cell proliferation and growth [ 15 ]. (biomedcentral.com)
  • Interleukin-6 (IL-6) is a cytokine that was initially recognized as a regulator of immune and inflammatory responses, but it also regulates the growth of many tumour cells, including prostrate carcinoma. (tmu.edu.tw)
  • Overexpression of the growth-factor receptors ErbB2/neu and ErbB3 has been implicated in the neoplastic transformation of prostate carcinoma. (tmu.edu.tw)
  • Renal cell carcinoma (RCC) incidence has increased over the past two decades. (hindawi.com)
  • Renal cell carcinoma (RCC) accounts for approximately 3% of human malignancies, and its incidence appears to be increasing globally [ 1 ]. (hindawi.com)
  • Bakuchiol also decreased viability and inhibited anchorage-independent growth of A431 human epithelial carcinoma cells. (umn.edu)
  • The present review scrutinize the existing documentation in the literature related to the oral squamous cell carcinoma. (ujds.in)
  • The present review spotlights on understanding the molecular mechanism and the genetic factors which is responsible for alteration in the cell which leads to oral squamous cell carcinoma. (ujds.in)
  • Hürthle cell carcinoma of the thyroid gland is an unusual and relatively rare type of differentiated thyroid cancer. (medscape.com)
  • Hürthle cell carcinoma. (medscape.com)
  • Obviously, this factor has a major impact in interpreting the natural history of this disease and adds to the controversy about the aggressiveness of Hürthle cell carcinoma. (medscape.com)
  • BACKGROUND: Previously we reported that arsenic and estrogen cause synergistic effects in the neoplastic transformation of human prostate epithelial cells. (bvsalud.org)
  • METHODS: Total RNA and protein were isolated from RWPE-1 human prostate epithelial cells that were coexposed to arsenic and estrogen for a chronic duration (6 months). (bvsalud.org)
  • Together, these genetic and epigenetic aberrations provide the molecular basis for the potentiation of carcinogenicity of arsenic and estrogen coexposure in prostate epithelial cells. (bvsalud.org)
  • Although estrogens have been shown to play a central role in breast cancer development, their carcinogenicity on human breast epithelial cells (HBECs) has not yet been clearly demonstrated. (eurekamag.com)
  • Recently, it was reported that miR-200a plays a crucial role in the development of cancer through its regulation of epithelial to mesenchymal transition (EMT), cell migration, proliferation and metastasis [ 11 , 12 , 13 ]. (oncotarget.com)
  • EMT is a process by which epithelial cells lose their cell-cell adhesion and gain invasive properties, which leads to the acquisition of mesenchymal stem cell characteristics [ 17 , 18 ]. (oncotarget.com)
  • Separately, deletion of GCC increased tumor growth by releasing a restriction on the cell cycle normally constraining epithelial cell proliferation. (jefferson.edu)
  • High-efficiency neoplastic transformation of mouse mammary epithelial cells in primary collagen gel culture was induced by N-methyl-N-nitrosourea (MNU). (eurekamag.com)
  • Mammary epithelial cells, isolated from virgin BALB/c mice, were embedded within collagen gels and grown in a serum-free medium containing prolactin, progesterone, and linoleic acid. (eurekamag.com)
  • Expression of Her2 in untransformed MCF10A mammary epithelial cells caused transformation, as judged by foci formation in culture and tumorigenesis in xenografts. (iucc.ac.il)
  • Likewise, cell cycle checkpoint regulation is ultimately controlled by phosphorylation activity of the ATM kinase, which is pathway dependent on both Nbs1 and MRE11. (wikipedia.org)
  • for example, protein kinase activation is part of the platelet activation signal pathway. (lookformedical.com)
  • Abstract Uridine-cytidine kinase 2 is an enzyme that is overexpressed in abnormal cell growth and its implication is considered a hallmark of malignancy. (nanoker-society.org)
  • Introduction Uridine-cytidine kinase 2 (UCK2) is an enzyme that catalyses the conversion of uridine and cytidine to their monophosphate form of uridine and cytidine in an alternative salvage pathway of pyrimidine biosynthesis [1]. (nanoker-society.org)
  • Thus ErbB2 is a critical component of IL-6 signalling through the MAP kinase pathway. (tmu.edu.tw)
  • These data show how a cytokine receptor can diversify its signalling pathways by engaging with a growth-factor receptor kinase. (tmu.edu.tw)
  • In close agreement, induction of GCC signaling in mucosal sheets ex vivo and intestinal cells in vitro inhibited proliferation by activating cGMP-dependent protein kinase and delaying the cell cycle at the G1/S transition. (jefferson.edu)
  • Cells from cancers show aberrant behaviour such as unrestrained growth, invasion into adjacent tissue and metastasis. (ox.ac.uk)
  • Our study is the first to provide demonstrate that KLF6 functions as a tumor suppressor gene and prevents the metastasis of oral cancer cells. (medsci.org)
  • MiR-200a suppressed metastasis of SP cells. (oncotarget.com)
  • Overexpression of miR-200a in SP cells decreased metastasis-related markers and expression of ZEB2. (oncotarget.com)
  • These findings reveal that miR-200a suppresses metastasis of SP cells by downregulating ZEB2. (oncotarget.com)
  • Although most circulating cancer cells die, an occasional cell may penetrate into tissues, generating a metastasis at a distant site. (msdmanuals.com)
  • The intracellular transfer of information (biological activation/inhibition) through a signal pathway. (lookformedical.com)
  • Two molecules exhibited significant inhibition percentages at 1 µM concentration without any apparent cytotoxicity on HepG2 cells. (thesciencein.org)
  • Due to the selective expression of UCK2 in malignancy cells, a selective inhibition of this important enzyme necessitates the discovery of its potential inhibitors for malignancy chemotherapy. (nanoker-society.org)
  • It is observed that aggregation of genetic alterations is the ground for advancement of a normal cell to cancer cells, which is known as a multi-step carcinogenesis. (ujds.in)
  • Biologic implications of genetic changes in head and neck squamous cell carcinogenesis. (ujds.in)
  • Genetic pathways in colorectal and other cancers. (ox.ac.uk)
  • This gives rise to preferred genetic pathways of tumorigenesis. (ox.ac.uk)
  • The factors which may influence the development and ultimate choice of genetic pathways are then examined. (ox.ac.uk)
  • Next, CRC is studied as a specific disease and the putative genetic pathways are described. (ox.ac.uk)
  • However, upregulation of MRN complex sub-units has been documented in certain cancer cell lines when compared to non-malignant somatic cells, suggesting some cancer cells have developed a reliance on MRN overexpression. (wikipedia.org)
  • KLF6 overexpression attenuated the migration and invasion of oral cancer SAS cells. (medsci.org)
  • We previously showed that VEGF signaling in primary endothelial cell cultures caused overexpression of VEGFR2 in a positive feed-forward loop, which is at least partly regulated by loss of miRNA-mediated control of VEGF receptor degradation. (plos.org)
  • Since tumor cells have increased mitotic rates compared to non-malignant cells this is not entirely unexpected, as it is plausible that an increased rate of DNA replication necessitates higher nuclear levels of the MRN complex. (wikipedia.org)
  • In addition to these basic issues concerning leukemia pathogenesis, we are devising new diagnostic procedures for detecting and monitoring leukemia patients based on molecular genetic abnormalities in the malignant cells. (stanford.edu)
  • PC-ALCL is one of the primary cutaneous CD30 + T-cell lymphoproliferative disorders, a wide spectrum of disease, with lymphomatoid papulosis (LyP) at the benign end of the spectrum and PC-ALCL at the malignant end. (medscape.com)
  • Eleven to 14 days after the final carcinogen treatment, the cells were removed from the collagen gels and injected into the cleared mammary fat pads of syngeneic hosts to assay for transformed cell populations. (eurekamag.com)
  • Control cells cultured for the same periods of time as MNU-treated cells produced only ductal outgrowths that were morphologically similar to those found in the mammary glands of adult virgin hosts. (eurekamag.com)
  • This system provides a distinct means to study the mechanism of mammary neoplastic transformation at cellular and molecular levels. (eurekamag.com)
  • This is the multihit theory of tumorigenesis, in which a series of multiple triggering events in the genetic and cellular makeup of a cell ultimately cause cancer. (medscape.com)
  • Guanylyl cyclase C (GCC), the intestinal receptor for the paracrine hormones guanylin and uroguanylin whose early loss characterizes transformation, has emerged as a component of developmental programs organizing spatiotemporal patterning along the crypt-surface axis whose loss promotes tumorigenesis through hyperproliferation and genetic instability. (jefferson.edu)
  • Here, we investigated the role of Hsp72 in Her2 oncogene-induced neoplastic transformation and tumorigenesis. (iucc.ac.il)
  • PyV-induced tumorigenesis in laboratory animals, by simian virus 40 (SV40) or by multiple human PyVs, such as JC virus (JCV), is used extensively as a cell transformation model. (cdc.gov)
  • Here, we report the chemopreventive properties of bakuchiol, which acts by inhibiting epidermal growth factor (EGF)-induced neoplastic cell transformation. (umn.edu)
  • KLF6 functions as a tumor suppressor gene and increases p21 expression via p53-independent pathway [ 3 ]. (medsci.org)
  • Tumour suppressor protein, p53, prevents cancer development by eliminating cells with mutagenic alterations or potential for neoplastic transformation or blocking their cell cycle permanently or by transient DNA repair [3C5]. (nanoker-society.org)
  • Splenic marginal zone lymphoma with circulating villous lymphoid cells (SMZL) is a distinct and very different pathological entity since the WHO 2008 classification: it is characterized by an expansion of the splenic white pulp with the infiltration of the red pulp. (fortuneonline.org)
  • Hairy cells are small to medium-sized lymphoid cells with an oval or indented nucleus with homogeneous and spongy chromatin. (fortuneonline.org)
  • We found that plasma telomeric cfDNA levels decreased with age in healthy individuals ( n = 42, R 2 = 0.094, P = 0.048), suggesting that cfDNA is likely derived from somatic cells in which telomere length shortens with increasing age. (oncotarget.com)
  • Chromosomal alterations in squamous cell carcinomas of the head and neck: window to the biology of disease. (ujds.in)
  • Their development is a complex multistep process of genetic alterations and cellular transformations, which can take decades to progress into invasive and metastatic tumor. (univ-mrs.fr)
  • Taken together, we uncover a landscape of the key regulatory pathways and proteins in HPV-positive cervical cancers, all of which may provide attractive drug targets for future therapeutics. (fortuneonline.org)
  • In vitro , the sprouting and migratory properties of primary endothelial cell cultures were reduced by inhibiting EZH2 through up-regulation of miR-101, siRNA-mediated knockdown of EZH2, or treatment with 3-Deazaneplanocin-A (DZNep), a small molecule inhibitor of EZH2 methyltransferase activity. (plos.org)
  • Hayflick, L. The limited in vitro lifetime of human diploid cell strains. (nature.com)
  • Cells propagated in vitro in special media conducive to their growth. (lookformedical.com)
  • Telomere lengthening in cancer cells by the alternative lengthening of telomeres (ALT) mechanism has also been shown to be dependent on MRN, especially on the Nbs1 subunit. (wikipedia.org)
  • Ectopic expression of UASR1 promoted proliferation and clonogenic growth of breast cancer cells MCF7 and MDA-MB-231. (jcancer.org)
  • Taken together, our data suggest that UASR1 plays an oncogenic role in breast cancer cells through activation of the AKT/mTOR signaling pathway, being a novel RNA oncogene. (jcancer.org)
  • All these features of cancer cell behaviour can be explained in terms of genetic changes and the functional impact of these changes. (ox.ac.uk)
  • In turn, as a result of research into the abnormal cancer cell, the basic understanding of the cell has greatly improved. (medscape.com)
  • Cancer is characterized by uncontrolled growth and division of a cell, with extension beyond the normally limiting basement membrane and through the boundaries of normal cells. (medscape.com)
  • [ 6 ] These events lead the cancer cell to escape normal cell growth and control mechanisms, to avoid system control mechanisms (ie, immunologic surveillance), and to establish a nutrient supply. (medscape.com)
  • We are studying the role that normal chromatin structure plays in gene regulation in hematopoietic cells and how its disruption leads to altered development and cancer. (stanford.edu)
  • 3) We are defining the properties of cancer stem cells that initiate and sustain the unique disease features of acute leukemias through the use of various adoptive animal models. (stanford.edu)
  • GLI1 interaction with p300 modulates SDF1 expression in cancer-associated fibroblasts to promote pancreatic cancer cells migration. (mayo.edu)
  • These phytochemicals frequently act by means of regulating molecular pathways which are embroiled in development and dissemination of cancer. (researchsquare.com)
  • Cancer is characterized as the uncontrolled multiplication and spread of the body's particular cells. (researchsquare.com)
  • There are numerous pathways that are associated with the cancer development in body. (researchsquare.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Because tumor-derived, cell-free DNA (cfDNA) is often released from cancer cells and circulates in the bloodstream, we hypothesized that breast cancer development is associated with changes in the amount of telomeric cfDNA that can be detected in the plasma. (oncotarget.com)
  • 2017). Since the importance of lncRNA GAS5 in cancer has been well-established, several researchers focused on investigating the role of lncRNA GAS5 in noncancerous cells. (molcells.org)
  • Six human viruses, including high-risk alpha human papillomaviruses (HPV), hepatitis B (HBV) and C (HCV) viruses, human T-cell lymphotropic virus 1 (HTLV-1), Epstein-Barr virus (EBV), and Kaposi sarcoma-associated herpesvirus (HHV-8), have been classified as class 1 carcinogens by the International Agency for Research on Cancer. (biomedcentral.com)
  • Treatment options in non-small-cell lung cancer (NSCLC) have expanded recently due to the demonstration of efficacy of targeted agents alone or in combination with existing cytotoxic chemotherapies. (genglob.com)
  • These carcinogens act as cancer cell growth initiators or promoters. (matjournals.co.in)
  • Cancer stem cells (CSCs) are characterized by their capacity for indefinite self-renew and by their relative quiescence [ 2 , 3 ]. (oncotarget.com)
  • In several types of cancer, side populations (SPs) have been shown to be enriched for cells with CSC-like activity and a CSC phenotype [ 4 ]. (oncotarget.com)
  • Recent studies have suggested that SP cells in human pancreatic cancer are characteristically chemoresistant [ 5 ]. (oncotarget.com)
  • Here we show that treatment of the prostate cancer cell line LNCaP with IL-6 induces tyrosine phosphorylation of ErbB2 and ErbB3, but not ErbB1/EGFR. (tmu.edu.tw)
  • Recently, signaling by GCC and its downstream effector, cyclic GMP (cGMP) has emerged as a principal regulator of proliferation in human colon cancer cells. (jefferson.edu)
  • In this issue of Cancer Discovery , Dominguez and colleagues report their findings on the mechanistic link between TET2 mutation and germinal center (GC) B-cell transformation (3). (aacrjournals.org)
  • Therefore, various biologically active peptides such as angiotensin, affecting cell proliferation, have become a new area of study in endometrial cancer research. (spandidos-publications.com)
  • Biological assays were performed on well-[Ishikawa (ISH)] moderately (MFE-296) and poorly (MFE-280) differentiated human adenocarcinoma cancer cell lines, representing the G1, G2 and G3 stage of EC. (spandidos-publications.com)
  • HPV-infection imparts specific changes in the regulatory network of infected cancer cells that are of diagnostic, prognostic and importance. (fortuneonline.org)
  • Researchers with the Department of Biomedicine of the University of Basel in Switzerland, found NAC restores the sensitivity of breast cancer cells to treatment. (bestpureessentialoils.com)
  • NAC, an antioxidant, affects energy metabolism similarly, so the researchers expected it would have similar effects in cancer cells as NF1 loss. (bestpureessentialoils.com)
  • NAC unexpectedly restored - and increased - alpelisib's effectiveness in previously resistant cancer cells. (bestpureessentialoils.com)
  • Many factors are involved in causing and permitting the unregulated proliferation of cells that occurs in cancer. (msdmanuals.com)
  • Загальні відомості про злоякісні новоутворення Cancer is an unregulated proliferation of cells. (msdmanuals.com)
  • Cancer cells, particularly those arising from the bone marrow or lymphatic system, may have a short generation time, and there usually are a smaller percentage of cells in G0 (resting phase). (msdmanuals.com)
  • A subpopulation of cells within a cancer has the properties of stem cells. (msdmanuals.com)
  • A cancer may release cells into the circulation at a very early stage of development. (msdmanuals.com)
  • Circulating cancer cells are present in many patients with advanced cancer and even in some with localized disease. (msdmanuals.com)
  • Silence of lncRNA GAS5 promoted the activation of PI3K/AKT and MEK/ERK signaling pathways in a miR-142-5p -dependent manner. (molcells.org)
  • Furthermore, the effects of PGM1 were related to the PI3K/ AKT pathway. (biomedcentral.com)
  • These findings indicate that ROS generation is involved in TiO2 NPs-induced AP-1 activation mediated by MAPKs signal pathway. (cdc.gov)
  • Further studies showed that UASR1 activated AKT and AKT-mediated mTOR signaling pathway to stimulate cell proliferation and growth. (jcancer.org)
  • Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasion. (mayo.edu)
  • The regulatory role of long noncoding RNA (lncRNA) growth arrest-specific transcript 5 ( GAS5 ) in both cancerous and noncancerous cells have been widely reported. (molcells.org)
  • Transcript levels of glutaminolytic factors were quantified in Huh7.5 cells or primary human hepatocytes infected with the JFH1 HCV strain as well as in biopsies of chronic HCV patients. (unibe.ch)
  • Because of this event, growth factor production increases as well as increase in total of receptors on cell surface and increased intracellular signal messengers. (ujds.in)
  • While HCV induces glutaminolysis to create an environment favorable for viral replication, it predisposes the cell to transformation. (unibe.ch)
  • Altogether, by identifying a pro-angiogenic VEGF/miR-101/EZH2 axis in endothelial cells we provide evidence for a functional link between growth factor-mediated signaling, post-transcriptional silencing, and histone-methylation in the angiogenesis process. (plos.org)
  • Observations revealed that BPA induced G2/M cell cycle arrest in both cell types through the ATM-CHK1/CHK2-CDC25c-CDC2 signaling pathway, and the IC50 values were estimated to be 150 µM. (bvsalud.org)
  • The predominance of EGFR signaling in NSCLC makes the pathway an attractive candidate for the development of targeted therapeutics. (genglob.com)
  • Acute tissue injury activates satellite cells and promotes sarcoma formation via the HGF/c-MET signaling pathway. (dukecancerinstitute.org)
  • 2018). Due to the strict relationship existing between inflammation and aging, the new term "inflammaging" has been coined to describe a condition characterized by chronic and systemic low-grade inflammation occurring during aging and potentially associated with the alteration of several cellular and molecular pathways and the development of different pathologies (Franceschi et al. (researchgate.net)
  • The migration of these cells also increased as demonstrated by wound healing and transwell assays. (jcancer.org)
  • In contrast, silencing of UASR1 suppressed cell proliferation and migration. (jcancer.org)
  • This protein promotes the reorganization of the actin cytoskeleton, thereby playing a role in cell migration and growth. (cancerindex.org)
  • However, GCTs, including seminomas, can occur in extragonadal sites along the midline of the body, following the embryologic migration route of its precursor cells -- the primordial germ cells. (medscape.com)
  • and myeloid cells are seen in stem cell leukemia/lymphoma (SCLL), which is also known as 8p11 myeloproliferative syndrome (EMS). (medscape.com)
  • Previous terms for this disorder have included CD4+CD56+ hematodermic tumor (HDT) and blastic natural killer (NK) cell lymphoma. (medscape.com)
  • Stem cell leukemia/lymphoma (SCLL), which is also known as the 8p11 myeloproliferative syndrome (EMS), is characterized in its typical form by the occurrence, either simultaneously or sequentially, of a bcr/abl-negative myeloproliferative disorder and a lymphoma, usually a precursor T-cell lymphoblastic lymphoma. (medscape.com)
  • The diagnosis of Hairy Cell Leukemia and HCL-like diosrders, including HCL variant (vHCL) and Splenic Diffuse Red Pulp Lymphoma (SDRPL), is based on the examination of the peripheral blood and bone marrow smears allowing the identification of hairy cells and the flow cytometric analysis. (fortuneonline.org)
  • This ulcerated nodule of localized primary cutaneous CD30+ anaplastic large cell lymphoma is relatively nonspecific in appearance. (medscape.com)
  • Because of its mutated aggressive genetics, this cell has a selective growth advantage over its neighbors. (medscape.com)
  • Biosynthesis occurring within the cell supplies the necessary components and imparts a selective advantage to neoplastic cells [ 8 ]. (biomedcentral.com)
  • For instance, H19 is the first lncRNA transcribed by RNA polymerase II and is expressed mainly in human embryonic cells. (jcancer.org)
  • This technologic and biologic revolution continued through the 1960s to today, and the explosion in technology has fueled the current expansion of knowledge into the working of the human cell. (medscape.com)
  • A classic paper that describes the limited replicative lifespan of normal human cells. (nature.com)
  • Our study provided new insights into the precise molecular mechanisms of BPA-induced toxicity in human prostate cells. (bvsalud.org)
  • The aim of the present study was to evaluate the influence of angiotensin II (Ang II) on human EC cells. (spandidos-publications.com)
  • Elevated serum human chorionic gonadotropin (hCG) levels can occur in seminomas and correlate with syncytiotrophoblastic giant cells seen histologically. (medscape.com)
  • This goal, however, cannot be accomplished until the specific agent(s) or mechanisms that initiate the neoplastic process are identified. (eurekamag.com)
  • Cells continually experience stress and damage from exogenous and endogenous sources, and their responses range from complete recovery to cell death. (nature.com)
  • We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
  • In aged mice, the self-renewal capacity of long-term hematopoietic stem cells (LT-HSC) diminishes. (umassmed.edu)
  • Other reports have indicated that SP cells may serve as an ideal model for stem cell for research [ 7 ]. (oncotarget.com)
  • Work in knockout mouse models has shown that TET2 loss enhances hematopoietic stem cell (HSC) self-renewal, expanding the HSC pool (reviewed in refs. (aacrjournals.org)
  • Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)
  • We applied functional pathway analysis to show that HPV-positive cancers are characterised by perturbations of numerous cellular processes, predominantly in those linked to the cell cycle, mitosis, cytokine and immune cell signalling. (fortuneonline.org)
  • Most recurring metastatic cancers are either drug resistant or will become resistant to therapy," researchers wrote in Cell Reports Medicine. (bestpureessentialoils.com)
  • The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability. (lookformedical.com)