Pathway 1998 calmodulin dependent protein kinase cyclic amp dependent protein kinases. Medical search. Frequent questions

A serine threonine kinase that controls a wide range of growth-related cellular processes. (harvard.edu)
A protein serine-threonine kinase that catalyzes the PHOSPHORYLATION of I KAPPA B PROTEINS. (uchicago.edu)

Intracellular Signaling Peptides and Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
Proteins and peptides that are involved in SIGNAL TRANSDUCTION within the cell. (jefferson.edu)
Included here are peptides and proteins that regulate the activity of TRANSCRIPTION FACTORS and cellular processes in response to signals from CELL SURFACE RECEPTORS. (jefferson.edu)
Below are the most recent publications written about "Intracellular Signaling Peptides and Proteins" by people in Profiles. (jefferson.edu)

The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. (wikipedia.org)

In mammals, adenosine 3', 5'-cyclic monophosphate (cAMP) is known to play highly important roles in sperm motility and acrosomal exocytosis. (plos.org)
Cyclic AMP (adenosine 3', 5'-cyclic monophosphate) is an important player in sperm function. (plos.org)
As in somatic cells, sperm intracellular cAMP concentration is regulated by the opposite action of two enzymes: the adenylyl cyclases (AC), which synthesize cAMP from ATP, and the phosphodiesterases (PDE), which break the phosphodiester bond of cAMP to form 5'-adenosine monophosphate (AMP). (plos.org)
Thus, our discovery of the role of functional interaction between intracellular signaling pathways mediated by calcium ions (Ca 2+) and cyclic adenosine monophosphate (cAMP) (Ca 2+ /cAMP signaling interaction) in these cellular responses, opened a great avenue for the development of new antitumor therapeutic strategies. (researchgate.net)
The two well-established cyclic nucleotides are adenosine-3',5'-cyclic monophosphate (cyclic AMP) and guanine-3',5'-cyclic monophosphate (cyclic GMP). (pancreapedia.org)

It plays a key role during sperm capacitation [ 3 - 6 ] and the acrosomal exocytosis [ 7 - 10 ], where it affects different intracellular signalling pathways. (plos.org)

Sperm intracellular cAMP levels depend on the activity of adenylyl cyclases, mostly SACY, though transmembrane-containing adenylyl cyclases are also present, and on the activity of cyclic nucleotide phosphodiesterases (PDE) whose role is to degrade cAMP into 5'-AMP. (plos.org)
Considerably higher resistance against cyclic nucleotide phosphodiesterases compared to dibutyryl or 8-Br-cAMP, no metabolic side effects. (biolog.de)

It is known to act through protein phosphorylation via PRKA and through the activation of guanine nucleotide exchange factors like EPAC. (plos.org)
The reversible phosphorylation of proteins on serine, threonine, and tyrosine residues represents a fundamental strategy used by eukaryotic organisms to regulate a host of biological functions, including DNA replication, cell cycle progression, energy metabolism, and cell growth and differentiation. (rupress.org)
Levels of cellular protein phosphorylation are modulated both by protein kinases and phosphatases. (rupress.org)
Protein phosphorylation can regulate enzyme function, mediate protein-protein interactions, alter subcellular localization, and control protein stability. (rupress.org)
To fully understand this complex and essential regulatory process, the kinases and phosphatases mediating the changes in cellular phosphorylation must be identified and characterized. (rupress.org)
Repetto MV, Winters MJ, Bush A, Reiter W, Hollenstein DM, Ammerer G, Pryciak PM, Colman-Lerner A. CDK and MAPK Synergistically Regulate Signaling Dynamics via a Shared Multi-site Phosphorylation Region on the Scaffold Protein Ste5. (umassmed.edu)
Minimal model for signal-induced Ca2+ oscillations and for their frequency encoding through protein phosphorylation. (arasysperfector.com)

Protein expression of protein kinase B, calcium/calmodulin-dependent protein kinase II, and phospholamban was measured by Western immunoblotting. (silverchair.com)

This protein is a CREB transcription factor that is a member of the leucine zipper family of DNA-binding proteins. (wikipedia.org)
Antiapoptotic and trophic effects of dominant-negative forms of dual leucine zipper kinase in dopamine neurons of the substantia nigra in vivo. (rochester.edu)

Our results suggest that MEPY exerts its vasorelaxant effects via the activation of NO formation by means of l -Arg and NO-cGMP pathways and via the blockage of extracellular Ca 2+ channels. (biomedcentral.com)
One mechanism is the binding of an extracellular ligand to a transmembrane G-protein-coupled receptor (GPCR). (pancreapedia.org)
The receptor protein has seven transmembrane α-helices connected by alternating cytosolic and extracellular loops. (pancreapedia.org)
The ligand-binding site is in the extracellular domain and the cytosolic domain has a heterotrimeric G protein-binding site (127). (pancreapedia.org)

The non-canonical cyclic nucleotides include the purines inosine-3',5'-cyclic monophosphate (cyclic IMP), xanthosine-3',5'-cyclic monophosphate (cyclic XMP) and the pyrimidines cytidine-3',5'-cyclic monophosphate (cyclic cCMP), uridine-3',5'-cyclic monophosphate (cyclic UMP), and thymidine-3',5'-cyclic monophosphate (cTMP) (145). (pancreapedia.org)

Cyclic nucleotides, like other nucleotides, are composed of three functional groups: a ribose sugar, a nitrogenous base, and a single phosphate group. (pancreapedia.org)
A cyclic nucleotide, unlike other nucleotides, has a cyclic bond arrangement between the ribose sugar and the phosphate group. (pancreapedia.org)
There are two main groups of cyclic nucleotides: the canonical or well-established and the non-canonical or unknown-function cyclic nucleotides. (pancreapedia.org)
An overview of the non-canonical cyclic nucleotides is provided in Section V. (pancreapedia.org)
Cyclic nucleotides form when the phosphate group of the molecule of nucleotide triphosphate (ATP or GTP) is attacked by the 3' hydroxyl group of the ribose, forming a cyclic 3',5'-phosphate ester with release of pyrophosphate. (pancreapedia.org)
This cyclic conformation allows cyclic nucleotides to bind to proteins to which other nucleotides cannot. (pancreapedia.org)

A large family of regulatory proteins that function as accessory subunits to a variety of CYCLIN-DEPENDENT KINASES. (umassmed.edu)
This enzyme also activates the transcription factor NF-KAPPA B and is composed of alpha and beta catalytic subunits, which are protein kinases and gamma, a regulatory subunit. (uchicago.edu)

After a ligand binds to the GPCR, it activates a heterotrimeric G-protein, which is composed of three subunits: a guanine nucleotide binding α-subunit, and a βγ-heterodimer (98). (pancreapedia.org)

F-box protein specificity for g1 cyclins is dictated by subcellular localization. (umassmed.edu)

cAMP-mediated stimulation of tyrosine hydroxylase mRNA translation is mediated by polypyrimidine-rich sequences within its 3'-untranslated region and poly(C)-binding protein 2. (rochester.edu)

Pope PA, Bhaduri S, Pryciak PM. Regulation of cyclin-substrate docking by a G1 arrest signaling pathway and the Cdk inhibitor Far1. (umassmed.edu)

Adding further complexity to this picture is the fact that both kinases and phosphatases can function in signaling networks where multiple kinases and phosphatases contribute to the outcome of a pathway. (rupress.org)
Exploring the role of insulin-like growth factor binding protein-1 in identifying idiopathic multicentric Castleman's disease types: Implications for the mTOR signaling pathway. (harvard.edu)
PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer. (harvard.edu)
Cyclic nucleotide signaling can be initiated by two general mechanisms. (pancreapedia.org)
Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases. (umassmed.edu)
Intracellular signaling peptide and proteins may be part of an enzymatic signaling cascade or act through binding to and modifying the action of other signaling factors. (jefferson.edu)
signaling proteins , the PSD also contains scaffolding proteins . (arasysperfector.com)

Although the importance of kinases in this process has long been recognized, an appreciation for the complex and fundamental role of phosphatases is more recent. (rupress.org)
Through extensive biochemical and genetic analysis, we now know that pathways are not simply switched on with kinases and off with phosphatases. (rupress.org)
Furthermore, kinases and phosphatases may work together to modulate the strength of a signal. (rupress.org)
A variety of approaches, including biochemical purification, gene isolation by homology, and genetic screens, have been successfully used for the identification of putative protein kinases and phosphatases. (rupress.org)

Depending on which family the G protein is, it goes on to activate (G αs protein subunit) or inhibit (G αi protein subunit) the membrane-bound cyclase. (pancreapedia.org)
and Its Interaction with Kaposi Sarcoma-associated Herpes Virus Flice-interacting Protein and IKK Subunit ß by EPR Spectroscopy. (uchicago.edu)

Understanding the proteins that regulate the 5-HT1A promoter will lead to insights on receptor regulation and provide new therapeutic targets relevant to depression, anxiety, obsessive compulsive disorder and other mental illnesses. (vdocuments.net)

ICA69 regulates activity-dependent synaptic strengthening and learning and memory. (neurotree.org)

A cyclase enzyme (lyase) catalyzes the formation of the cyclic nucleotide from its nucleotide triphosphate precursor ( Figure 1 ). (pancreapedia.org)

This protein binds the cAMP response element, a DNA nucleotide sequence present in many viral and cellular promoters. (wikipedia.org)
This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. (wikipedia.org)

To understand the signal transduction required, we focused primarily on IL-6 induction by measuring mitogen-activated protein kinase activity and analyzing the effects of mutant or dominant negative forms of Vav, Rac1, and c-Jun N-terminal kinase-1 (JNK1). (aai.org)

Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins. (nature.com)
The miR-124-AMPAR pathway connects polygenic risks with behavioral changes shared between schizophrenia and bipolar disorder. (neurotree.org)

"It was expected answers would describe in detail the role of troponin, tropomyosin and calmodulin in mediating muscle contraction" , the examiners rejoined. (derangedphysiology.com)

The protein is referred to as the target of RAPAMYCIN due to the discovery that TACROLIMUS (commonly known as rapamycin) forms an inhibitory complex with TACROLIMUS BINDING PROTEIN 1A that blocks the action of its enzymatic activity. (harvard.edu)
Do most proteins show cross-species activity? (medchemexpress.com)
Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. (medchemexpress.com)
Other proteins may have a lower specific activity when used in the opposite species. (medchemexpress.com)

Vav overexpression resulted in the constitutive activation of JNK1 with little or no effect on p38 mitogen-activated protein kinase and ERK2. (aai.org)

In addition to its PRKA-dependent effects, different studies have clearly demonstrated that cAMP also activates EPAC ( E xchange P roteins directly A ctivated by c AMP) during capacitation and acrosome exocytosis [ 15 - 17 ]. (plos.org)

Most of the mechanisms of motion rely on the conformational change of some molecule (usually a protein), and so unsurprisingly there are a huge range of different mechanisms available, often developed independently of each other and therefore cardinally different from one another even where they look the same and do exactly the same thing. (derangedphysiology.com)

This graph shows the total number of publications written about "TOR Serine-Threonine Kinases" by people in Harvard Catalyst Profiles by year, and whether "TOR Serine-Threonine Kinases" was a major or minor topic of these publication. (harvard.edu)

At the most basic level we can separate muscle tissue into smooth and striated, where the striations originate from a repeating pattern of regularly arranged proteins, whereas "smoothness" is conferred by an irregular arrangement without a repeating pattern. (derangedphysiology.com)

Genistein sensitizes bladder cancer cells to HCPT treatment in vitro and in vivo via ATM/NF-?B/IKK pathway-induced apoptosis. (uchicago.edu)

Goupil S, Maréchal L, El Hajj H, Tremblay M-È, Richard FJ, Leclerc P (2016) Identification and Localization of the Cyclic Nucleotide Phosphodiesterase 10A in Bovine Testis and Mature Spermatozoa. (plos.org)

Although a high level of PDE10A gene expression is observed in the testis, information on the identity of the isoforms or on the cell type that express the PDE10 protein is lacking. (plos.org)

Impaired proteostatic mechanisms other than decreased protein synthesis limit old skeletal muscle recovery after disuse atrophy. (harvard.edu)

This was dependent on Vav-mediated activation of Rac1 as a Dbl domain-mutated Vav, inactive Rac N17, and inactive JNK1 down-regulated the Vav-induced JNK1 or IL-6 responses. (aai.org)

CAMP responsive element binding protein 1, also known as CREB-1, is a protein that in humans is encoded by the CREB1 gene. (wikipedia.org)

will be … Control of endocytosis by clathrin, adaptor proteins , dynamin, and hsc70 also uses ATP. (arasysperfector.com)

Anatomy16

Organisms10

Chemicals and Drugs126

Analytical, Diagnostic and Therapeutic Techniques and Equipment8

Phenomena and Processes34

Information Science3

Serine threon2

Peptides4

Induces1

Adenosine5

Intracellular signalli1

Nucleotide phosphodiesterases2

Phosphorylation7

Calcium1

Leucine zipper2

Extracellular4

Monophosphate1

Nucleotides6

Regulatory2

Subunits1

Specificity1

Tyrosine1

Inhibitor1

Signaling7

Phosphatases4

Subunit2

Regulate1

Synaptic1

Enzyme1

Binds2

Dominant-negative forms1

Schizophrenia2

Role1

Activity4

Constitutive1

Activates1

Molecule1

Minor1

Arrangement1

Vivo1

Identification1

Gene expression1

Mechanisms1

Activation1

CAMP1

Control1