Pathological sudden death autopsy. Medical search. Frequent questions

SIDS is defined as the sudden, unexpected death of an infant less than 1 year of age that cannot be explained despite a thorough investigation, including a complete autopsy, examination of the death scene, and review of the clinical and social history. (medscape.com)

A large meta-analysis suggested that approximately one-third of death certificates are incorrect and that half of the autopsies performed produced findings that were not suspected before the person died. (wikipedia.org)
Also, it is thought that over one-fifth of unexpected findings can only be diagnosed histologically, i.e., by biopsy or autopsy, and that approximately one-quarter of unexpected findings, or 5% of all findings, are major and can similarly only be diagnosed from tissue. (wikipedia.org)
The family alleged that Dr. Gorengaut, the radiologist, chose not to report all of the significant findings, and they claimed if he had reported appendicitis that could not be ruled out, she would have been admitted to general surgery and operated on before her infection progressed to septic shock, which led to her untimely death. (robertkreisman.com)
This study aimed to\nreport the clinical and pathological findings in patients with SUDEP. (inventi.in)
Findings suggest that the serous fluid found in the alveoli was from the salivary glands, and thus, saliva aspiration may be associated with infant deaths due to SIDS. (journals.cz)
Pneumoconioses: pathological findings and differential diagnosis, in particular silicosis and asbestosis. (unibo.it)
There is very limited data on the clinical features, pathogenetic mechanisms, and pathological findings of patients who have had delayed complications related to the COVID-19 vaccine. (covid19criticalcare.com)
Here, he shares the most important findings and why sudden cardiac arrest is a common cause of death in patients with Lewy body disease. (lu.se)
The objectives of this repeated study were therefore, to reexamine the cases of AD coming to autopsy in an attempt to validate that impression, to identify any clinicopathological changes occurring during the course of this extended survey and to compare the overall findings of this new study with that of the previous one. (biomedcentral.com)
His findings included that Mr A had sudden onset of pain but did not have a fever, and that he had satisfactory vital signs, normal sensation in his legs, and an improvement over six hours of observation. (hdc.org.nz)

When the reason of death matched with the\ndefinition of SUDEP, the clinical and pathological data were analyzed. (inventi.in)
All cases of AD identified at autopsy, during the 20-year period since the conclusion of the last study, were collected and pertinent clinical and pathological data were analyzed and compared, both within the two decades of this study period and against the results of the last study. (biomedcentral.com)

A significant decrease of SIDS deaths occurred in the last decades in most countries after the beginning of national campaigns, mainly as a consequence of the implementation of risk reduction action mostly concentrating on the improvement of sleep conditions. (unipr.it)
Progress in SIDS research appears to be fundamental to the ultimate aim of eradicating SIDS deaths. (unipr.it)
A s udden infant death syndrome (SIDS) is diagnosed in the case of a sudden and unexpected death of an infant during sleep and where an autopsy shows no obvious pathological lesions or injuries. (journals.cz)
This paper describes a study of 191 infant deaths in which the State Forensic Medicine Service established 29 SIDS cases. (journals.cz)
Microscopical and histological results of samples taken from sections of the respiratory system reveal serous fluid in the alveoli and change specific to asphyxia in all autopsy cases of infants diagnosed with SIDS. (journals.cz)
SIDS and other sleep-related infant deaths: expansion of recommendations for a safe infant sleeping environment. (journals.cz)
1997). Combined effects of sleeping position and prenatal risk factors in sudden infant death syndrome: the Nordic Epidemiological SIDS Study. (journals.cz)
Sudden infant death syndrome (SIDS), the leading cause of SUID in the United States, is diagnosed only after a thorough investigation of the scene, interview of caregivers, and a complete forensic autopsy. (medscape.com)
Depiction of changes in sudden infant death syndrome (SIDS) incidence in United States before and after "Back to Sleep" campaign. (medscape.com)
about half of these deaths are due to SIDS, the leading cause of all infant deaths. (medscape.com)
SIDS is the leading cause of death among infants aged 1-12 months, and is the third leading cause overall of infant mortality in the United States. (medscape.com)
2] To confirm the diagnosis of SIDS, a complete forensic autopsy needs to be performed, using information gathered from the scene investigation, interview of caregivers and review of medical and social history. (medscape.com)
3] Another category, unclassified sudden infant deaths, was introduced for cases that do not meet the criteria for a diagnosis of SIDS and for which alternative diagnoses of natural or unnatural conditions were equivocal. (medscape.com)
When cases of SIDS are identified after a complete forensic investigation, it may be found that multiple modifiable environmental factors likely contributed to the infant's sudden death, such as prone sleep position, bed sharing with another adult/child, and maternal smoking. (medscape.com)
Medico-legal investigation of Sudden Infant Death Syndrome (SIDS): differential diagnosis between natural and unnatural death]. (unige.it)

The principal aims of an autopsy are to determine the cause of death, mode of death, manner of death, the state of health of the person before he or she died, and whether any medical diagnosis and treatment before death were appropriate. (wikipedia.org)
PMMRI can provide a valuable benefit to post-mortem investigations, helping to distinctly improve the success rate of histological sampling and investigations, which remains the gold standard in the diagnosis of sudden death. (univaq.it)
Following VATS biopsy a definite pathological diagnosis was made in 74.2% of cases. (biomedcentral.com)
death ensues at a median of 4.5 months following diagnosis. (vic.gov.au)
Definitive diagnosis is usually made at autopsy by detection of the PrP and demonstration of the typical pathological spongiform changes in the brain. (vic.gov.au)
A clinical diagnosis of AD was considered prior to surgery or autopsy in 25 (45%) cases overall, more during the second decade. (biomedcentral.com)

Handbook of pediatric autopsy pathology. (journals.cz)
Topics discussed during lectures represent an integral part of the program and are the subject of evaluation during exams, including knowledge of tissue fixation and of pathology reporting (biopsies, surgical specimens, autopsies). (unibo.it)
Knowledge of the underlying pathology associated with the death of a veterinary patient often provides emotional closure for the pet's owner as well as offering valuable retrospective information to the veterinarian who managed the case. (necropsyservices.com)
Dr. Taylor Spangler (Bill's son) was introduced at an early age to the practice of veterinary pathology and animal autopsies by his father. (necropsyservices.com)
It has been speculated whether they die from an unexplained sudden cardiac death or if the typical pathology seen in the brain in these individuals also appear in other organs, including the heart. (lu.se)
So, I wanted to investigate the cause of death in these individuals and explore if the typical pathology was also present in the heart. (lu.se)
In a retrospective analysis, all cases of AD that presented to the autopsy service, during the 20-year period 1989-2008, were identified from our pathology department's post-mortem records. (biomedcentral.com)

Autopsies are usually performed by a specialized medical doctor called a pathologist. (wikipedia.org)
Critics, including pathologist and former JAMA editor George D. Lundberg, have charged that the reduction in autopsies is negatively affecting the care delivered in hospitals, because when mistakes result in death, they are often not investigated and lessons, therefore, remain unlearned. (wikipedia.org)
Since the unruptured appendix had no pathological evidence of intrinsic appendicitis, the autopsy pathologist concluded bacteria had migrated through the wall of the appendix, which started the infection. (robertkreisman.com)

Sudden unexpected infant deaths (SUIDs) are specified as deaths in infants younger than 12 months of age that occur suddenly, unexpectedly, and without obvious cause in the ED. These cases require a complete investigation of the environmental circumstances at the time of death and a forensic autopsy. (medscape.com)
Guidelines for a complete forensic autopsy have been developed by the Centers for Disease Control (CDC). (medscape.com)
As a member of the Necropsy Service Group since its inception he has been focused on forensic necropsy examinations and cause of death determination. (necropsyservices.com)
Despite advances in public health, medicine, and technol- forensic pathologists and medical examiners, coupled with the ogy, infectious diseases remain a major source of illness and use of state-of-the-art technologies, has facilitated explanation death worldwide. (cdc.gov)
Laboratory evaluation and forensic measurements of drug(s) and substance(s) of interest on blood or tissue samples at/from autopsy is indicated in any unexplained death (PMID 24365689). (pneumotox.com)

In most cases, a medical examiner or coroner can determine the cause of death. (wikipedia.org)
Development of Emergency Department guidelines for the reporting and evaluation of SUID, in collaboration with the local medical examiner and child death review teams, will enable ED practitioners to collect important information in a compassionate manner that will be valuable to the investigating personnel. (medscape.com)
In the Office of the Chief Medical Examiner this class is accountable for performing autopsies and conducting investigations of sudden and medically unattended deaths. (jobapscloud.com)

2005). The changing concept of sudden infant death syndrome: diagnostic coding shifts, controversies regarding the sleeping environment, and new variables to consider in reducing risk (Vol. 116). (journals.cz)
Possible role of saliva in the sudden infant-death syndrome. (journals.cz)
Why the prone position is a risk factor for sudden infant death syndrome. (journals.cz)
Sudden infant death syndrome: an update. (journals.cz)
Side sleeping position and bed sharing in the sudden infant death syndrome. (journals.cz)
Bed-sharing is a known risk factor for suffocation and sudden infant death syndrome. (skepticalob.com)
Two of the deaths were attributed to sudden infant death syndrome, one to an epileptic fit and another cause of death was undetermined. (theage.com.au)

The autopsy\nshowed brain edema and pulmonary edema in all eleven patients. (inventi.in)
The main pathological changes in SUDEP include brain edema, pulmonary edema,\nloss of neurons and gliosis. (inventi.in)

Determination of the specific type(s) of asphyxia operative in a particular case, the cause of death, and the manner of death is dependent on information elicited during the medicolegal death investigation-namely, history (circumstances), scene investigation, and postmortem examination (including appropriate ancillary radiographic and laboratory studies). (medscape.com)
Brown-Séquard the clinical features of thyroid disease since demonstrated that in animals death from the dawn of the 20th century, the methods adrenalectomy could be delayed by infu- of investigation and treatment advanced sion of blood from healthy animals. (who.int)

This guidance is, therefore, based on our assessment of the likely pathogenic mechanisms underlying these delayed complications (spike protein-related disease) and the limited available autopsy data. (covid19criticalcare.com)
At the conference it was impressively demonstrated that these chronic diseases are based on similar pathological mechanisms. (csn-deutschland.de)
These mechanisms, in addition to increased cell death and turnover, are thought to lead to steatosis and carcinogenesis [Palmer and Phillips 2007]. (cdc.gov)
Prediction of prognosis of TBM is difficult because of the protracted course, diversity of underlying pathological mechanisms, variation of host immunity, and virulence of M tuberculosis . (medscape.com)

A 47-month-old girl was admitted to the pediatric intensive care unit following sudden cardiopulmonary arrest occurring at home. (biomedcentral.com)
We admitted a child of 3 years and 11 months to the pediatric intensive care unit (PICU) of Montpellier University Hospital following a sudden collapse at home. (biomedcentral.com)

prepare reports of medicolegal autopsies. (jobapscloud.com)

According to the Centers for Disease Control and Prevention (CDC) site's searchable database for Multiple Cause of Death 1999-2004, based on death certificates for United States residents, there are approximately 20,000 accidental and nonaccidental deaths within that period attributable to various types of mechanical asphyxia, such as drowning, hanging, strangulation, and suffocation. (medscape.com)

As Yerkovich was being prepped for surgery, she suffered a sudden cardiovascular collapse. (robertkreisman.com)
His areas of interest include toxicology, cardiovascular disease and sudden death syndromes. (necropsyservices.com)
In a nationwide autopsy study in the Netherlands, cardiovascular disease was the pathological substrate of SUDC in nearly 25% of the cases. (biomedcentral.com)
These results underscored the importance of cardiovascular examination and genetic testing of SUDC victims at autopsy, as well as their relatives. (biomedcentral.com)
Children and young adults with undiagnosed cardiovascular disorders at risk for sudden death may have warning symptoms or significant family history that is detectable through screening. (jabfm.org)
Sudden cardiac arrest (SCA) is the leading cause of nontraumatic sudden death in children and young adults and usually is the result of an undiagnosed cardiovascular disorder. (jabfm.org)
3 Sudden death is the first clinical manifestation of underlying cardiovascular disease in up to 50% to 80% of young athletes with SCD. (jabfm.org)

Autopsies can be further classified into cases where an external examination suffices, and those where the body is dissected and an internal examination is conducted. (wikipedia.org)
The most extreme example is the examination of murder victims, especially when medical examiners are looking for signs of death or the murder method, such as bullet wounds and exit points, signs of strangulation, or traces of poison. (wikipedia.org)

Sudden unexpected infant deaths (SUIDs) are deaths in infants younger than 12 months of age that occur suddenly, unexpectedly, and without obvious cause. (medscape.com)
Until recently, the accepted wisdom when dealing with infant deaths was probably best expressed by British child abuse expert Sir Roy Meadows: unless proven otherwise, one cot death is a tragedy, two is suspicious and three is murder. (theage.com.au)

A study that focused on myocardial infarction (heart attack) as a cause of death found significant errors of omission and commission, i.e. a sizable number of cases ascribed to myocardial infarctions (MIs) were not MIs and a significant number of non-MIs were MIs. (wikipedia.org)
Myocardial infarction means literally death of heart muscle (myocardium) due to interruption of its blood supply. (drdavidgrimes.com)

Autopsy studies have suggested that cardiac involvement with sarcoidosis occurs in up to 25% of cases, although more than half of these cases are sub-clinical. (myocarditisfoundation.org)
Cardiac involvement is common, and often presents with non-specific symptoms but can be potentially lethal due to increased risk of sudden cardiac death. (asnc.org)

Despite the eradication of smallpox in 1980, concerns about intentional or accidental release of variola virus and its potential for severe disease and high rates of death (average 30 percent) have fueled research into the development of new diagnostic tests, therapies, and vaccines. (cdc.gov)
Background: Sudden unexpected death of epilepsy (SUDEP) is a severe outcome of epilepsy. (inventi.in)
They had experienced severe sudden crushing chest pain, and they had usually been in good health previously. (drdavidgrimes.com)
LGE burden on CMR can also help identify CS patients without severe decline in ejection fraction where ICD placement is recommended for primary prevention of sudden cardiac death. (asnc.org)
However, a few weeks after the most recent surgery, he experienced sudden severe back pain. (hdc.org.nz)

Permission from next of kin may be required for internal autopsy in some cases. (wikipedia.org)
In the United States, the number of human deaths from rabies has declined to an average of 3 cases per year during the last several decades. (cdc.gov)
NSG uses ACVP board certified pathologists in those cases of sudden and unexplained death of a pet resulting from natural causes, aging, toxicity, trauma or death following routine surgical procedures that ordinarily result in successful long term outcomes. (necropsyservices.com)
Positive viral identification or lymphocytic myocarditis was found in 30 (68.2%) of 44 caseswith available early histology and 8 of 9 cases presenting with sudden death. (gotomydoctor.com)
In fatal cases, autopsies reveal permanent damage to nerve cells, with focal areas of fatty degeneration and necrosis [Stevens et al. (cdc.gov)

When the cardiorespiratory system becomes compromised due to noxious environmental conditions (hypoxia, hypercarbia) during sleep, such infants may not become aroused to defend against these conditions, resulting in sudden death. (medscape.com)

[19] The average survival from onset to death is two to four years, though this can vary, and about 10% of those affected survive longer than ten years. (wikipedia.org)

Prevalence of various types of asphyxial deaths by age groups. (medscape.com)
The objective of this study was to determine the prevalence of warning symptoms and family history in a cohort of children and young adults who suffered sudden cardiac arrest (SCA). (jabfm.org)
The prevalence of warning signs or symptoms in children and young adults who later suffer SCA is highly variable and poses a challenge to identifying through screening persons at elevated risk of sudden cardiac death (SCD). (jabfm.org)
An impression amongst our pathologists that, there might be an increase in the prevalence of AD in the autopsy service at our hospital, since that earlier report, led to this repeated study, in an attempt to validate that notion. (biomedcentral.com)

BrS is associated with an increased risk of syncope, palpitations, chest pain, convulsions, difficulty in breathing (nocturnal agonal breathing) and/or Sudden Cardiac Death (SCD) secondary to PVT/VF, unexplained cardiac arrest or documented PVT/VF or Paroxysmal atrial fibrillation (AF) in the absence of apparent macroscopic or structural heart disease, electrolyte disturbance, use of certain medications or coronary heart disease and fever. (bvsalud.org)

The word 'spikeopathy' was coined by French researcher Henrion-Caude [ 98 ] at a conference and given the varied and substantial pathological effects of the SARS-CoV-2 spike protein, we suggest the use of the term will have heuristic value» highlighted the study. (gospanews.net)
Does it matter that this pathological form of the protein is also inside the heart? (lu.se)

Freedom from death or transplantation was72% (95% CI, 65% to 78%) 1 year after presentation and 63% (95% CI, 55% to 70%) at 5 years. (gotomydoctor.com)
Primary outcome was transplantation or death.RESULTS: In total, 236 PPMv subjects and 213 matched controls were identified (22 centers, 9 countries). (stanfordchildrens.org)

The exams were performed on a 1.5 T scanner (Philips Intera Achieva, Best, the Netherlands) on hearts collected during autopsy and after a 30-day formalin fixation. (univaq.it)

[18] Death is usually caused by respiratory failure. (wikipedia.org)

In previous Posts I have presented much of the convincing evidence of the decline of deaths from (CHD) in the UK since the peak in 1967-1970. (drdavidgrimes.com)

For a select group of zoonotic infectious diseases with high death rates, the low incidence reflects infrequent spillover from an animal reservoir into humans. (cdc.gov)
In the United States alone, unexplained of many otherwise unexplained deaths, led to the discovery of deaths resulting from infectious disease agents have an esti- new pathogens, and enabled the monitoring of unexplained mated annual incidence of 0.5 per 100,000 persons aged 1-49 deaths and critical illnesses at the state and local levels. (cdc.gov)

Other infectious diseases, in contrast, may occur infrequently but are associated with high rates of death. (cdc.gov)
Geo- the effects of the aging of the population, increased each year graphic differentials also occur in death rates for Alzheimer's from 1979 to 1988. (cdc.gov)
death may occur as a result of missed diagnoses and delayed treatment. (medscape.com)

Only a small portion of deaths require an autopsy to be performed, under certain circumstances. (wikipedia.org)

We here present a case of SUDC in a girl of nearly 4 years old, whose postmortem analyses revealed the association of viral myoepicarditis at autopsy and a genetic variant in a cardiac gene at molecular autopsy. (biomedcentral.com)

A systematic review of studies of the autopsy calculated that in about 25% of autopsies, a major diagnostic error will be revealed. (wikipedia.org)
However, this rate has decreased over time and the study projects that in a contemporary US institution, 8.4% to 24.4% of autopsies will detect major diagnostic errors. (wikipedia.org)

Many children and young adults who suffered SCA are reported to have cardiac symptoms or a family history of premature cardiac death. (jabfm.org)

An autopsy study of aortic dissection (AD) at our institution was previously reported. (biomedcentral.com)

Organizations such as ZAKA in Israel and Misaskim in the United States generally guide families on how to ensure that an unnecessary autopsy is not made. (wikipedia.org)
as Europe's spike in excess deaths made news in Switzerland and Iceland. (substack.com)

nMethods: The record of patients with sudden death was screened. (inventi.in)
Not only would we see the patients presenting as emergencies, but we would see the pathological details in the autopsy room, most of the deceased having experienced sudden death before admission to hospital. (drdavidgrimes.com)
However, evolving data suggest that some patients who otherwise had no adverse events from the vaccine appear to have delayed acute cardiac events (often leading to sudden death). (covid19criticalcare.com)
And my examinations revealed that a majority of these patients displaying aggregated a-synuclein in their hearts died from what we think is sudden cardiac death. (lu.se)
Compared with the earlier review, a variety of changes in the profile of patients with AD in the autopsy service has been noted, including a reversal in the female predominance seen previously. (biomedcentral.com)

These changes vary from the merest transient exhilaration of the cerebral functions up to profound unconsciousness, ending in coma and perhaps in death. (newadvent.org)

It was the author's impression that, in the years since the conclusion of the previous study, there had been an increase in the frequency of AD in the autopsy service. (biomedcentral.com)

Initial autopsy results showed that Knut, the polar bear, suffered from a brain disease. (csn-deutschland.de)

Given now the Omicron variant is less virulent and is able to evade much of the protection offered by the vaccines, this creates a situation where the benefits of the vaccine have been dramatically reduced for hospitalization and death. (substack.com)

Autopsies are used in clinical medicine to identify a medical error or a previously unnoticed condition that may endanger the living, such as infectious diseases or exposure to hazardous materials. (wikipedia.org)

And when these a-synuclein aggregates in the brain, it causes neuronal cell death, so it is reasonable to assume that it is not healthy for other cell types. (lu.se)

Pathological features noted from the autopsy included information regarding classification of the sub-type of dissection. (biomedcentral.com)

The COVID-19 pandemic caused much illness, many deaths, and profound disruption to society. (gospanews.net)

Once an internal autopsy is complete, the body is reconstituted by sewing it back together. (wikipedia.org)

In 1991 a record 14,112 Alzheimer's deaths were reported statistically significant single-year increase. (cdc.gov)

Anatomy8

Organisms2

Diseases55

Chemicals and Drugs10

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Psychiatry and Psychology1

Phenomena and Processes11

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena6

Information Science6

Named Groups3

Health Care25

Geographicals5

Thorough investigation including a comple1

Findings10

Clinical and pathological2

SIDS15

Diagnosis6

Pathology7

Pathologist3

Forensic5

Medical examiner3

Syndrome7

Pulmonary edema2

Investigation2

Mechanisms4

Pediatric2

Medicolegal1

Asphyxia1

Cardiovascular7

Examination2

Infant deaths2

Myocardial infarction2

Cardiac involvement2

Severe5

Cases5

Infants1

Onset1

Prevalence4

Coronary1

Protein2

Transplantation2

Fixation1

Respiratory failure1

Evidence1

Incidence2

Occur3

Circumstances1

Postmortem1

Diagnostic2

Symptoms1

Institution1

Made2

Patients5

Coma1

Study1

Results1

Variant1

Infectious1

Brain1

Features1

Profound1

Complete1

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