Clinical and pathological data support the hypothesis that vasculature is the primary target in LS [ 6 , 7 , 9 ]. (hindawi.com)
Although FLC was historically considered to be a histologic variant of hepatocellular carcinoma (HCC), it is currently recognized as a distinct clinical entity with respect to its epidemiology, etiology, and prognosis. (medscape.com)
An integrated prognosis model of pharmacogenomic gene signature and clinical information for diffuse large B-cell lymphoma patients following CHOP-like chemotherapy. (cdc.gov)
Clinical Significance of BCL2 , C- MYC , and BCL6 Genetic Abnormalities, Epstein-Barr Virus Infection, CD5 Protein Expression, Germinal Center B Cell/Non-Germinal Center B-Cell Subtypes, Co-expression of MYC/BCL2 Proteins and Co-expression of MYC/BCL2/BCL6 Proteins in Diffuse Large B-Cell Lymphoma: A Clinical and Pathological Correlation Study of 120 Patients. (cdc.gov)
Breast cancer has been identified as a heterogeneous disease with marked differences in morphology, molecular biology, clinical findings and outcome [ 1 , 2 ]. (ecancer.org)
The molecular pathology of cancer has improved our understanding of carcinogenesis, and has enabled the discovery of diagnostic, prognostic, and predictive molecular markers of clinical utility. (org.sa)
EOCRC appears to have its own unique clinical and molecular features when compared with late-onset colorectal cancer. (wjgnet.com)
Future clinical trials will be needed to clarify the usefulness of indole-3-carbinol in this cancer and to understand the molecular mechanisms involved. (biomedcentral.com)
In this review, we focus on TDP-43 in aging and AD from clinical, pathological, and basic research perspectives. (biomedcentral.com)
The physiologic response and pathologic clinical syndromes are notated in the Figure. (biomedcentral.com)
Pathology11
Causal inference Epidemiology Molecular pathological epidemiology Molecular pathology Pathology Pathophysiology Salutogenesis Gellman, Marc D. (wikipedia.org)
As many of these neurodegenerative disorders are characterized by the presence of pathologic forms of tau and neurofibrillary tangles, studying the effects of tau pathology on the development of epilepsy might prove rewarding. (uantwerpen.be)
We reported increased seizure susceptibility in young Tau58/4 mice, which are still in an early pathologic stage, but not in old Tau58/4 mice with full-blown tau pathology. (uantwerpen.be)
By contrast, tau pathology might be more detrimental for the central regulation of sleep, regulated by sleep centers in the brainstem, because sleep disturbances are photoperiod-independent and arise around the time pathologic tau starts to accumulate in pontine regions. (uantwerpen.be)
Pathology and epidemiology of fatal toxoplasmosis in free-ranging marmosets (Callithrix spp. (growkudos.com)
In this review, an evaluation is carried out of the molecular pathology research of CRC emanating from Saudi Arabia. (org.sa)
This dearth of molecular pathology data is aptly reflected in the paucity of molecular markers recommended for testing by the Saudi National Cancer Centre guidelines for CRC management. (org.sa)
7 , 8 The aim of this review is to explore the molecular pathology research that has been carried out on CRC from Saudi patients, with a view to understanding the prevalence and clinicopathological correlates of clinically and biologically relevant genetic mutations in Saudi CRC patients. (org.sa)
9 - 13 However, most molecular pathology studies of CRC from Saudi Arabia have been hospital-based researches ( Tables 1 - 3 ). (org.sa)
As a result, the data emanating from the molecular pathology studies of Saudi CRC has been modest. (org.sa)
Molecular pathology of colorectal cancer syndromes from Saudi patients. (org.sa)
Biomarkers3
By reviewing biomarkers and breast cancer molecular subtypes, we propose that the divergent outcome observed from patients stratified by hormone status are driven by different cancer hallmarks. (jcancer.org)
In recent times, significant advancements have been made in elucidating the molecular alterations of the disease, and the results have been an improved understanding of CRC biology, as well as the discovery of biomarkers of diagnostic, prognostic, and therapeutic significance. (org.sa)
However, objective evaluation of the postoperative recurrence risk is difficult using conventional pathological prognostic factors because of their lack of reproducibility. (biomedcentral.com)
Lipids that were influenced by smoking status and reflected postoperative recurrence and pathological prognostic factors were screened. (biomedcentral.com)
Large scale multi-institutional and multiregional translational studies are required to generate molecular data that would inform diagnostic, prognostic, and risk-stratification guidelines for Saudi CRC patients. (org.sa)
Can better prognostic predictors be constructed based on these identified molecular processes? (escholarship.org)
Enrichment analysis of the enlarged signatures revealed 11 functional modules with prognostic ability. (escholarship.org)
The study revealed that the nine signatures perform similarly but exhibit a large degree of discordance in prognostic group assignment. (escholarship.org)
Tumors6
To our knowledge, this is the first study that has identified the viral signatures of OPSCC tumors. (oncotarget.com)
The World Health Organization 2021 Classification (WHO CNS5), based on an integrated taxonomy with a strong emphasis on molecular profiling, established two types of embryonal tumors: medulloblastomas and other CNS embryonal tumors. (medlink.com)
70 ). The term sPNET is now obsolete and was removed from the WHO 2016 Classification of CNS tumors, thanks to an increased understanding of the heterogeneity and biology of these tumors and the emergence of a classification based on molecular characteristics. (medlink.com)
In this article, the authors provide an overview of current concepts of clinicopathologic characteristics, specific molecular diagnosis, and general treatment strategies for these rare embryonal tumors of childhood. (medlink.com)
The patients' characteristics, the pathological characteristics of their tumors, the local and systemic treatments administered, their response evaluations and survival data were collected from the hospital files and analyzed. (cyprusjmedsci.com)
Elevated expression of this CTL signature was associated with longer survival in IC10/Basal-like tumors. (escholarship.org)
Biology1
It has been 17 years since the World Health Organization (WHO) classification was updated in 1981 1 , and since this time considerable progress has been made in understanding the epidemiological histogenetic and molecular biology of lung cancer. (ersjournals.com)
Mechanisms3
Many aspects regarding the molecular mechanisms of small heat shock proteins, both in health and disease, remain to be unraveled. (uantwerpen.be)
A number of pathological mechanisms are thought to contribute to the aetiopathogenesis of relative or absolute insulin deficiency, including immune-mediated destruction of pancreatic beta cells. (biomedcentral.com)
Physiological and pathological response mechanisms in sepsis. (biomedcentral.com)
Pathogenesis1
Molecular pathological epidemiology can help to assess pathogenesis and causality by means of linking a potential risk factor to molecular pathologic signatures of a disease. (wikipedia.org)
Assays2
Macroscopic lesions were recorded, and swabs and fragments of thoracic and abdominal organs were analyzed by bacteriological and pathological assays. (biomedcentral.com)
Molecular Diagnostic and Prognostication Assays for the Subtyping of Urinary Bladder Cancer Are on the Way to Illuminating Our Vision. (who.int)
Subtypes1
The tumor suppressor TP53 is mutated in approximately 30% of breast adenocarcinomas, with varying frequency across molecular subtypes. (escholarship.org)
Lesions2
Genetic and epigenetic changes have been identified between DCIS and IDC lesions through molecular profiling and qRT-PCR. (cancerbiomed.org)
Most DCIS lesions present without symptoms, and very few present with pathological nipple discharge. (cancerbiomed.org)
Epidemiological2
Often, a potential cause is identified by epidemiological observations before a pathological link can be drawn between the cause and the disease. (wikipedia.org)
The pathological perspective can be directly integrated into an epidemiological approach in the interdisciplinary field of molecular pathological epidemiology. (wikipedia.org)
Biologically1
It is a highly heterogeneous disease, encompassing a number of biologically distinct entities with specific pathologic features and biological behaviors [ 1 , 2 ]. (jcancer.org)
Genetics1
Address correspondence to: Jay D. Horton, Departments of Internal Medicine and Molecular Genetics, UT Southwestern Medical Center, 5323 Harry Hines Blvd. Dallas, Texas 75390-9046, USA. (jci.org)
20221
Epidemiology of Renal Cell Carcinoma: 2022 Update. (who.int)
Diagnosis2
The application of antigen receptor gene rearrangement of BIOMED-2 in the pathologic diagnosis of 348 cases with non-Hodgkin lymphoma in a single institution in Southwest of China. (cdc.gov)
Recent advances in the molecular diagnosis and treatment of pineoblastoma, a rare embryonal tumor of the pineal gland with particular penetrance in infants and young children, are also highlighted in this review. (medlink.com)
Predictive1
Several gene expression signatures have been proposed and demonstrated to be predictive of outcome in breast cancer. (escholarship.org)
Disturbances1
Here we use cellular and animal models as well as human biospecimens to show that AD-related stressors mediate global disturbances in dynamic intra- and inter-neuronal networks through pathologic rewiring of the chaperome system into epichaperomes. (nature.com)
Processes2
Are there (common) molecular processes reported by these signatures? (escholarship.org)
To better characterize the functional processes associated with these signatures, we enlarged each signature by including all probes with a significant correlation to at least one of the genes in the original signature. (escholarship.org)
Advances1
Although the known genotypes and serotypes have increased in number with advances in the knowledge of epidemiology and epizootiology of hantavirus infection (2) , some still-unidentified hantaviruses carried by specific rodent hosts may exist. (cdc.gov)
Journal2
European Journal of Nuclear Medicine and Molecular Imaging, 49(12):4064-4072. (uzh.ch)
The classification performance of the nine gene expression signatures is very similar in terms of assigning a sample to either a poor outcome group or a good outcome group. (escholarship.org)
Disease1
In scleroderma en coup de sabre (LScs) the atrophic lesion in frontoparietal area is the disease hallmark. (hindawi.com)
Patients2
The verdict is that the data on the molecular alterations in CRC from Saudi patients is at best modest. (org.sa)
Patients diagnosed with EOEC during 2004-2015 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. (preprints.org)
Immune2
In addition to protective "immune response", sepsis is characterized by destructive "endothelial response" of the host, leading to endotheliopathy and its molecular dysfunction. (biomedcentral.com)
One is physiologic defensive mechanism through immune system, and the other is pathologic destructive mechanism through endothelial system. (biomedcentral.com)
Review1
The expression-derived score agreed with the degree of lymphocytic infiltration assessed by pathologic review, and application of the Nanodissect algorithm was suggestive of this infiltration being primarily of cytotoxic T lymphocytes (CTL). (escholarship.org)
Breast cancer1
We performed a comprehensive analysis of the performance of nine gene expression signatures on seven different breast cancer datasets. (escholarship.org)
Present2
High hybridization signals were also detected for signatures of Baculoviridae, Reoviridae, Siphoviridae, Myoviridae, and Polydnaviridae in most of the cancer specimens, including the lymph nodes without cancer present. (oncotarget.com)
In the present article we address the following issues: Do these signatures perform similarly? (escholarship.org)
Data1
Based on the pathologic spread in the APP23 model and the spectral data of the EEG, we concluded that Aβ probably has toxic effects at the level of the cortex, resulting in disrupted patterns of cortical activation and sleep loss. (uantwerpen.be)
Specific1
To gain a better understanding of how certain dementia-specific pathologic proteins interact with sleep-regulating brain centers and influence cognition, two different transgenic mouse models were studied. (uantwerpen.be)
Survival1
Gene expression profiles analysis identifies a novel two-gene signature to predict overall survival in diffuse large B-cell lymphoma. (cdc.gov)
Primary1
Fibrolamellar carcinoma is a rare primary hepatic malignancy that was first described as a pathological variant of hepatocellular carcinoma by Edmondson in 1956. (medscape.com)