• The device is like a stinger and injects ready-made bacterial proteins into mammalian cells to commandeer them for the benefit of the pathogen," said Jorge Galan , the Lucille P. Markey Professor of Microbial Pathogenesis and co-senior author of the paper. (yale.edu)
  • Articles published in Journal of Microbial Pathogenesis have been cited by esteemed scholars and scientists all around the world. (hilarispublisher.com)
  • Journal of Microbial Pathogenesis has got h-index 2, which means every article in Journal of Microbial Pathogenesis has got 2 average citations. (hilarispublisher.com)
  • Following are the list of articles that have cited the articles published in Journal of Microbial Pathogenesis . (hilarispublisher.com)
  • Tony has been an integral part of the Department's growth and activity in the area of microbial pathogenesis His research on Staphylococcus aureus is wide-ranging, spanning immunometabolism to pathogen evolution. (unc.edu)
  • My research is centered on bacterial pathogenesis of Yersinia enterocolitica and Y. pestis , etiologic agents of yersiniosis and bubonic plague respectively. (uidaho.edu)
  • Marshall et al (1967) has described an asymptomatic pharyngeal carrier state of Y pestis infection in patients with bubonic plague. (medscape.com)
  • Using these methods, we have repurposed cyanobacterial TCSs to function as optogenetic tools with wavelength specificities from the ultraviolet (380 nm) to the near infrared (770 nm), engineered gut bacteria that diagnose colon inflammation in mice, and discovered a novel pH-sensing TCS in the genome of Yersinia pestis, the causative agent of bubonic plague. (upenn.edu)
  • There is strong evidence that Yersinia pestis , the cause of bubonic plague, led to the positive selection of FMF-associated MEFV mutations. (msdmanuals.com)
  • Julian has played a major role in determining the reference genome sequences of many key bacterial pathogens, including Mycobacterium tuberculosis, Yersinia pestis and Salmonella typhi. (birmingham.ac.uk)
  • From the ASM Biodefense and Emerging Diseases Research meeting, Vincent Racaniello speaks with Rebekah and Wyndham about their work on Rift Valley Fever virus and other vector-borne pathogens, and the evolution and pathogenesis of Yersinia pestis, the agent of plague. (player.fm)
  • Finally, we are using our methods to develop new anti-virulence compounds that inhibit TCSs that regulate pathogenesis in major human pathogens. (upenn.edu)
  • Leo JC, Skurnik M. Adhesins of human pathogens from the genus Yersinia. (monz.pl)
  • Y. pestis is a non-motile coccobacillus, a facultative anaerobic bacterium with bipolar staining (giving it a safety pin appearance) that produces an antiphagocytic slime layer. (wikipedia.org)
  • The disease is caused by a coccobacillus-shaped, gram negative bacterium referred to as Yersinia pestis . (medscape.com)
  • The virulence of this bacterium results from the 32 Y pestis chromosomal genes and two Y pestis -specific plasmids, constituting the only new genetic material acquired since its evolution from its predecessor. (medscape.com)
  • Most likely, you were bitten by an infected flea, and the nasty bacterium which causes plague ( Yersinia pestis ) is now swimming around inside your body. (alexberezow.com)
  • This was because the plague bacterium ( Yersinia pestis ) was hundreds of times larger than the virus and would need to be carried in rather large droplets. (norwegianscitechnews.com)
  • Research is focused on studying the molecular mechanisms involved in the pathogenesis of Vibrio cholerae , the bacterium that causes cholera, and Francisella tularensis , the bacterium that causes tularemia. (utsa.edu)
  • citation needed] Several complete genome sequences are available for various strains and subspecies of Y. pestis: strain KIM (of biovar Y. p. medievalis), and strain CO92 (of biovar Y. p. orientalis, obtained from a clinical isolate in the United States). (wikipedia.org)
  • EAEC strains exhibit genetic heterogeneity, and identifying virulence factors important for pathogenesis has proven challenging. (microbiologynote.com)
  • Pathogenicity islands (PAIs), a subgroup of genomic islands that aid in and contribute to pathogenesis, have been found in clinical strains of both V. vulnificus and V. parahaemolyticus . (springeropen.com)
  • The family of Enterobacteriaceae comprises a multitude of pathogenic strains from the genera Salmonella , Yersinia , Klebsiella and Escherichia . (biomedcentral.com)
  • First I want to thank Mikael Skurnik, who kindly offered me clinical Yersinia strains and gave valuable information about Yersinia, and my colleagues and instructor from Orion Diagnostica, who helped me during this study. (9pdf.co)
  • Fredriksson-Ahomaa M, Hallanvuo S, Korte T, Siitonen A, Korkeala H. Correspondence of genotypes of sporadic Yersinia enterocolitica bioserotype 4/O:3 strains from human and porcine sources. (monz.pl)
  • In Finland Yersinia is one of the main causes of bacterial diarrhea in addition of Salmonella and Campylobacter. (9pdf.co)
  • He received his Ph.D. in microbiology in 1986, did a postdoctoral fellowship in the lab of Dr. Susan Straley focusing on plague pathogenesis, then took a position at Walter Reed Army Institute of Research, where he continued his research on pathogenesis, genotyping and plague vaccine development for the Army s biodefense program. (nih.gov)
  • Similar to other Yersinia species, it tests negative for urease, lactose fermentation, and indole. (wikipedia.org)
  • It also hosts two other plasmids, pPCP1 (also called pPla or pPst) and pMT1 (also called pFra) that are not carried by the other Yersinia species. (wikipedia.org)
  • The Yop-Ysc T3SS is a critical component of virulence for Yersinia species. (wikipedia.org)
  • The experiment and analysis of this study test the hypothesis that amoeboid species demonstrate reservoir potential for Y. pestis . (cdc.gov)
  • Pathogenesis of both species is complex, and while some virulence factor genes have been implicated, the mechanisms underlying V. vulnificus and V. parahaemolyticus virulence are not well understood (Broberg et al. (springeropen.com)
  • Yersinia enterocolitica is a common bacterial species which has been relatively recently recognized. (monz.pl)
  • However, there were no genomic data on the Yersinia species with more limited virulence potential, frequently found in soil and water environments. (biomedcentral.com)
  • In contrast to the current coronavirus, the plague pathogenesis rarely passed by droplet infection. (norwegianscitechnews.com)
  • This was reported as the sole presentation of Y pestis infection in 4 of 27 patients in a case series published in 1992. (medscape.com)
  • They will determine if anti-LcrV interferes with secretion of LcrV, whether LcrV can act alone to modulate a Y. pestis infection, when LcrV works during an infection, and whether it inhibits clearance or phagocytosis of yersiniae in vivo. (grantome.com)
  • Non-specific enteritis affects the total thickness of the gastrointestinal tract wall, whereas in Yersinia enterocolitica infection the lesions are located exclusively in the mucous membrane. (monz.pl)
  • My current interests are directed towards large-scale sequencing and phylogenomic studies investigating major public health threats, such as the causative agents of plague and cholera, Yersinia pestis and Vibrio cholerae , and the dominant cause of food-borne disease in North America, Escherichia coli O157:H7. (utsa.edu)
  • Benavides-Montaño JA , Vadyvaloo V . Yersinia pestis resists predation by Acanthamoeba castellanii and exhibits prolonged intracellular survival. (cdc.gov)
  • Hinnebusch BJ, Rudolph AE, Cherepanov P, Dixon JE, Schwan TG, Forsberg A. Role of Yersinia murine toxin in survival of Yersinia pestis in the midgut of the flea vector. (medscape.com)
  • Moreover, these infections the survival of Yersinia and other bacteria show a modest predilection for males, with in cold enrichment. (who.int)
  • The name for the genus Yersinia was derived from the French bacteriologist Alexander Yersin. (monz.pl)
  • Rapid high-quality draft sequencing was used successfully to compare pathogenic and non-pathogenic members of the Yersinia genus. (biomedcentral.com)
  • This work underscores the importance of the acquisition of horizontally transferred genes in the evolution of Y. pestis and points to virulence determinants that have been gained and lost on multiple occasions in the history of the genus. (biomedcentral.com)
  • Here we describe the deployment of new sequencing technology to extensively sample eight genomes from the Yersinia genus of the family Enterobacteriaceae. (biomedcentral.com)
  • Aerosolized Y pestis, causing primary pneumonic plague, has been recognized by bioterrorism experts as having one of the highest potentials as a bioterrorism agent due to its extremely high mortality, its high uptake into enzootic and epizootic animals as well as humans, and its ability to be spread over a large area. (medscape.com)
  • Together, these plasmids, and a pathogenicity island called HPI, encode several proteins that cause the pathogenesis for which Y. pestis is famous. (wikipedia.org)
  • Yersinia pestis has a set of virulence proteins encoded by plasmid pCD1. (grantome.com)
  • Like Y. pestis , the enteropathogenic Yersiniae can escape macrophages and multiply outside host cells, but unlike their more virulent cogener, they only usually cause self-limiting inflammatory diseases. (biomedcentral.com)
  • Ayyadurai S , Houhamdi L , Lepidi H , Nappez C , Raoult D , Drancourt M . Long-term persistence of virulent Yersinia pestis in soil. (cdc.gov)
  • Yersiniosis is a rare disease in Muslim of Yersinia from the stool samples only to countries due to the scarcity of pork con- determine the highest possible number of sumption. (who.int)
  • Dr. Maurelli has over 30 years of research experience in the field of molecular genetics of bacterial pathogenesis, specifically in the study of Shigella and Chlamydia. (ufl.edu)
  • A genomic island must contain at least one virulence gene, or gene that contributes to pathogenesis, to be considered a PAI. (springeropen.com)
  • Turning Yersinia pathogenesis outside in: subversion of macrophage function by intracellular yersiniae. (medscape.com)
  • Yersinia pestis is a parasite of its host, the rat flea, which is also a parasite of rats, hence Y. pestis is a hyperparasite. (wikipedia.org)
  • Transmission of Yersinia pestis from an infectious biofilm in the flea vector. (medscape.com)
  • Following introduction into a human through flea bite [ 16 ], Y. pestis is engulfed by macrophages and taken to the regional lymph nodes. (biomedcentral.com)
  • Yersinia are short, encapsulated, non motile gram negative rods. (howmed.net)
  • In a recent review published in the journal Pharmacological Research, researchers in Brazil investigated the role of gut microbiota in cognition, brain function, behavior, and neurodegenerative disease pathogenesis. (news-medical.net)
  • Despite extensive investigation, the etiology of nodding syndrome remains unclear, although much progress has been made in understanding the pathogenesis of the disease, as well as in treatment and prevention. (cdc.gov)
  • The generally accepted pathway for the evolution of these more severe disease-causing Yersiniae is memorably encapsulated by the recipe, 'add DNA, stir, reduce' [ 17 ]. (biomedcentral.com)
  • His research programme follows an integrated "viroscience" concept, bringing together world-leading scientists in molecular virology, immunology, epidemiology, pathogenesis, and intervention studies for human and animal virus infections. (eswiconference.org)
  • Rosner BM, Stark K, Werber D. Epidemiology of reported Yersinia enterocolitica infections in Germany 2001-2008. (monz.pl)
  • ABSTRACT All 250 children presenting with diarrhoea at 2 teaching hospitals in Mosul, Iraq over a 9-month period were studied for the presence of Yersinia spp. (who.int)
  • The group of intestinal pathogenic E. coli (IPEC) includes five pathotypes causing diarrheal diseases with distinct features in pathogenesis: Enterohaemorrhagic E. coli (EHEC) cause diarrhoea and haemolytic uremic syndrome. (biomedcentral.com)
  • Yersinia is named in honor of Alexander Yersin, who successfully isolated the bacteria in 1894 during the pandemic that began in China in the 1860s. (medscape.com)
  • [ 2 ] Three biovars (with minor genetic variations) have been identified within the Y pestis clone: Antiqua, Medievalis, and Orientalis. (medscape.com)
  • Yersinia outer protein called 'yops' is injected into humans via type 3 secretion system and inhibits phagocytosis and cytokine production by macrophages and neutrophils. (howmed.net)
  • Yersinia genomes had a similar global partition of protein functions, as measured by the distribution of Cluster of Orthologous Groups families. (biomedcentral.com)
  • We are focused on using microbial genetics to dissect the complex interaction between Yersinia pestis, the bacterial cause of plague, and its arthropod vectors. (utah.edu)
  • The aim of the study was to attract the attention of physicians, especially family practitioners, to the occurrence of Yersinia enterocolitica infections among the Polish population. (monz.pl)
  • Fredriksson-Ahomaa M, Stolle A, Siitonen A, Korkeala H. Sporadic human Yersinia enterocolitica infections caused by bioserotype 4/O:3 originate mainly from pigs. (monz.pl)
  • Differential plague-transmission dynamics determine Yersinia pestis population genetic structure on local, regional, and global scales. (cdc.gov)
  • Yersiniae are no exception to this rule, but their interaction with virions has not been studied thoroughly. (iimmun.ru)
  • Single-nucleotide polymorphisms reveal spatial diversity among clones of Yersinia pestis during plague outbreaks in Colorado and the western United States. (cdc.gov)
  • citation needed] A comprehensive and comparative proteomics analysis of Y. pestis strain KIM was performed in 2006. (wikipedia.org)
  • If Y. pestis is maintained within ameba reservoirs, we suspect that epizootic recrudescence may occur when infected soilborne amebae enter the bloodstream of naive rodent hosts (by entering wounds from antagonistic host-to-host interactions or burrowing activities). (cdc.gov)
  • Developed singleplex and duplex Yersinia assays were also shortly optimized by adjusting one parameter at the time. (9pdf.co)