• Use of large-scale comparative genomic technologies to explore the molecular pathogenesis of chronic infectious diseases and the human genetics of susceptibility and resistance to infection. (drexel.edu)
  • The prevalence of HIV infection and malaria-HIV coinfection was too low to allow meaningful analysis of their association with anemia or hemoglobin concentration. (biomedcentral.com)
  • We combine analysis of clinical cohort samples to identify novel pathways of pathogenesis in humans, with in vitro models of TB, HIV and SARS-CoV-2 infection to determine the molecular mechanism underlying disease risk. (edu.au)
  • The pathogenesis of hairy leukoplakia is clearly complex, potentially requiring a convergence of factors including EBV co-infection, productive EBV replication, EBV genetic evolution, expression of specific EBV "latent" genes, and immune escape. (medscape.com)
  • My clinical investigation is focused on the pathogenesis and treatment of HIV infection and its complications, especially in resource-limited settings. (duke.edu)
  • Different symptoms developed by COVID-19 infection and its impacts on various organs of the human body have highlighted the importance of both coinfections and superinfections with other pathogens. (frontiersin.org)
  • The gastrointestinal (GI) tract is vulnerable to infection with COVID-19 and can be exploited as an alternative transmission route and target for virus entry and pathogenesis. (frontiersin.org)
  • The high prevalence of recurrent malaria, tuberculosis, chronic helminth infections, and water-borne pathogens in developing countries may play an important role in the pathogenesis of HIV-1 infection in persons living in such regions [ 1,2 ]. (lww.com)
  • Welcome to the Macrophage Infection of HIV Implications for Pathogenesis and Cure meeting, jointly organized by the National Institute of Mental Health and the Ragon Institute of MGH, MIT, and Harvard. (nih.gov)
  • HIV is a viral infection, and AIDS is the syndrome, which results - according to the Marshall Pathogenesis - in a dysregulated vitamin D metabolism. (mpkb.org)
  • Specifically, the mission of DAIDS is to help ensure an end to the HIV/AIDS epidemic by increasing basic knowledge of the pathogenesis and transmission of the human immunodeficiency virus (HIV), supporting the development of therapies for HIV infection and its complications and co-infections, and supporting the development of vaccines and other prevention strategies. (nonclinicaljobs.com)
  • April 24, 2023 - Notice of Change to PAR-23-024 -Catalyst Award for Early-Stage Investigators (ESIs) Pursuing Research on HIV Comorbidities, Coinfections, and Complications (DP1- Clinical Trial Optional). (nih.gov)
  • December 1, 2022 - Notice of Pre-Application Webinar for PAR-23-024, Catalyst Award for Early-Stage Investigators (ESIs) Pursuing Research on HIV Comorbidities, Coinfections, and Complications (DP1- Clinical Trial Optional). (nih.gov)
  • This funding opportunity announcement (FOA) supports research from creative early stage investigators who propose highly innovative, pioneering studies with potential to open new areas of HIV/AIDS research related to coinfections, comorbidities, and complications. (nih.gov)
  • Immune responses, pathogenesis and biomarker discovery in pulmonary and extrapulmonary TB, and the effect of co-infections and comorbidities (diabetes mellitus. (nih.gov)
  • New methods or technologies for research on HIV-associated comorbidities, coinfections and complications in heart, lung, blood or sleep. (nih.gov)
  • It will evaluate viral persistence and latent reservoirs, broadly neutralizing antibody approaches to treatment and prevention, and pathogenesis and treatment of inflammation and its impact on HIV comorbidities. (ucsd.edu)
  • In addition, investigators will study new antiretroviral drugs including long-acting drug formulations for HIV treatment and prevention, HIV-related coinfections and comorbidities, including metabolic and end organ complications and hepatitis B cure, as well as the treatment and prevention of tuberculosis (TB), including TB preventive vaccines, in persons with mono- and HIV-coinfection. (ucsd.edu)
  • Our group works on the immunology, pathogenesis, and epidemiology of helminth infections (particularly filariasis, strongyloidiasis, and hookworms), TB, and coexistent infectious diseases (helminths/ viruses and TB). (nih.gov)
  • 3rd IAS Conference on HIV Pathogenesis and Treatment From IAS-Rio 2005: Learn the latest about management of HIV and related conditions, and new data on pathogenesis, prevention strategies, global epidemiology, and care in resource-poor settings. (medscape.com)
  • The aim of this review is to provide scientific information for better understanding of the evolutionary biology, molecular epidemiology, pathogenesis, diagnosis, and prevention of Lassa fever in Nigeria and other endemic regions worldwide, which can lead to improved control efforts and reduce morbidity and mortality from recurrent epidemics. (bvsalud.org)
  • Our aim was to determine whether S. stercoralis coinfection influenced clinical presentation, cerebrospinal fluid (CSF) inflammation, and outcome from tuberculous meningitis (TBM). (ox.ac.uk)
  • En mayo de 2007 obtuve el Certificate of Training in Molecular Biological Techniques en el Department of Molecular Biology y desde Junio de 2008 a Junio de 2009 completé el Certificate in Clinical Research en el Center for Translational Science Activities en Mayo Clinic College of Medicine, Rochester Minnesota. (unav.edu)
  • Un 40% de esos trabajos han sido publicados en revistas del primer cuartil entre las que destacan New England Journal of Medicine, Lancet, Lancet Infectious Diseases, Clinical Infectious Diseases, Clinical Microbiology Reviews, Antimicrobial Agents and Chemotherapy, Journal Clinical Microbiology, Journal Antimicrobial Chemotherapy, Mayo Clinic Proceedings y Malaria Journal. (unav.edu)
  • AbbVie's new 8-week pangenotypic regimen combining glecaprevir and pibrentasvir cured almost all HIV-positive people with hepatitis C coinfection in the EXPEDITION-2 study, according to a presentation at the 9th International AIDS Society Conference on HIV Science (IAS 2017) last month in Paris. (hivandhepatitis.com)
  • Hepatitis B Virus Markers in Romanian Adolescents With HIV This article evaluates the frequency of hepatitis coinfection in Romanian adolescents who were diagnosed with HIV prior to 1995. (medscape.com)
  • People with HIV and hepatitis B virus (HBV) coinfection have more than double the risk of death if they have ongoing high-level HBV replication, indicating a need for prompt treatment, according to an analysis from the Temprano trial presented at an HIV and viral hepatitis coinfection session at the 21st International AIDS Conference (AIDS 2016) last month in Durban. (hivandhepatitis.com)
  • This review presents a comprehen- sive but concise overview of pathogenesis, management and prevention of IAH in SCD. (bvsalud.org)
  • So we at the NIMH Division of AIDS Research are very happy to be co-sponsoring this conference with the Ragon Institute, recognizing the importance of macrophages in HIV pathogenesis and cure efforts. (nih.gov)
  • As a result, en end-stage AIDS patients levels of 1,25-D approach zero. (mpkb.org)
  • Prevalence of malaria only, HIV only, and malaria- HIV coinfection in pregnant women was 31% (95% CI: 28.5 to 34.5%, n = 293), 1.3% (95% CI: 0.77 to 2.4%, n = 13) and 0.52% (95% CI: 0.02 to 1.3%, n = 5) respectively. (biomedcentral.com)
  • To determine the impact of Plasmodium falciparum malaria coinfection and its treatment on cellular reservoirs of viral replication in HIV-1-infected persons and to relate this to changes in systemic immune activation. (lww.com)
  • Compared with controls, the detectable proportion of HIV-1 particles derived from CD14 macrophages and CD26 lymphocytes was increased in persons with acute malaria coinfection and correlated with markedly increased plasma concentrations of both proinflammatory cytokines and soluble markers of macrophage and lymphocyte activation. (lww.com)
  • Acute P. falciparum malaria coinfection impacts virus-host dynamics in HIV-1-infected persons at the cellular level, notably showing a reversible induction of HIV-1 replication in CD14 macrophages that is associated with changes in immune activation. (lww.com)
  • The moderate risk of RESTV recurring among humans in the Philippines and its potential pathogenicity in humans reinforces the need for early detection, surveillance and continued studies of RESTV pathogenesis and its health consequences. (who.int)
  • We are attempting to catapult its pathogenesis analysis by developing various genetic and genomic approaches. (lsuhsc.edu)
  • Taken together, in addition to basic knowledge on HIV pathogenesis, we anticipate that our studies may contribute to optimized treatment and provide clues to how an effective HIV vaccine should work. (lu.se)
  • SFTSV infections are en- from 152 suspected scrub typhus patients in Myanmar revealed Orientia tsutsugamushi of genotypic heteroge- demic in eastern Asia, and retrospective studies have neity. (cdc.gov)
  • The New York Course 2007: HIV Pathogenesis -- Expert Interview HIV Management 2007: Dr. Douek speaks with Medscape about the crucial role of profound, early, and persistent depletion of CD4 cells in the gut and the gut's subsequent role in T-cell activation. (medscape.com)
  • Monocytes and IL-18, a signature cytokine of inflammasome activation, are implicated in TB-IRIS pathogenesis. (diva-portal.org)
  • De octubre de 2006 a mayo de 2009 (32 meses), realicé una estancia postdoctoral en la División de Enfermedades Infecciosas de la Mayo Clinic College of Medicine en Rochester, Minnesota (USA) donde completé un Research Fellowship en Enfermedades Infecciosas. (unav.edu)
  • Actualización sobre el virus la influenza aviar A (H5N1) en los seres humanos. (cdc.gov)
  • This coinfection may increase the potential transmissibility of both SARS-CoV-2 and C. difficile by fecal materials. (frontiersin.org)
  • Proposal for the CR Protocol and CR20 program, uno del National Health Institutes de USA y otro de una Fundación de Investigación Médica) y realicé 14 publicaciones, 10 de ellas (70%) en revistas del primer cuartil. (unav.edu)
  • As the symptoms of a virus infection are not always clear and obvious and can be also unspecific, this represents a high rate of documented or suspected viral coinfections. (medscape.com)
  • The proposed studies should include particular emphasis on the impact of viral subtype, sex, age, coinfections and comorbidities, and geography. (nih.gov)
  • To better understand viral-viral coinfections and predict potential mechanisms that result in distinct disease outcomes, we first systematically fit mathematical models to viral load data from ferrets infected with respiratory syncytial virus (RSV) followed by influenza A virus (IAV) after 3 days. (biorxiv.org)
  • We then explored the realm of possible dynamics for scenarios not examined experimentally, including different infection order, coinfection timing, interaction mechanisms, and viral pairings. (biorxiv.org)
  • IAV coinfection with rhinovirus (RV) or SARS-CoV-2 (CoV2) was examined by using human viral load data from single infections together with murine weight loss data from IAV-RV, RV-IAV, and IAV-CoV2 coinfections to guide the interpretation of the model results. (biorxiv.org)
  • Simulating viral-viral coinfections in this way provides new insights about how viral-viral interactions can regulate disease severity during coinfection and yields testable hypotheses ripe for experimental evaluation. (biorxiv.org)
  • Data on viral-viral coinfections is somewhat limited, but some studies have begun evaluating outcomes of coinfection with commonly observed viral pairs (e.g. (biorxiv.org)
  • Collectively, these studies observed diverse outcomes of viral-viral coinfections with some interactions resulting in enhanced spread of one or both viruses within the respiratory tract while other mechanisms seem to work in an inhibitory manner. (biorxiv.org)
  • People with HIV and hepatitis B virus (HBV) coinfection have more than double the risk of death if they have ongoing high-level HBV replication, indicating a need for prompt treatment, according to an analysis from the Temprano trial presented at an HIV and viral hepatitis coinfection session at the 21st International AIDS Conference (AIDS 2016) last month in Durban. (hivandhepatitis.com)
  • These results demonstrate the potential for mixed viral infections to modify arbovirus transmission and pathogenesis. (illinois.edu)
  • Plaques Formed by Mutagenized Viral Populations Have Elevated Coinfection Frequencies. (utsouthwestern.edu)
  • April 24, 2023 - Notice of Change to PAR-23-024 -Catalyst Award for Early-Stage Investigators (ESIs) Pursuing Research on HIV Comorbidities, Coinfections, and Complications (DP1- Clinical Trial Optional). (nih.gov)
  • December 1, 2022 - Notice of Pre-Application Webinar for PAR-23-024, Catalyst Award for Early-Stage Investigators (ESIs) Pursuing Research on HIV Comorbidities, Coinfections, and Complications (DP1- Clinical Trial Optional). (nih.gov)
  • This funding opportunity announcement (FOA) supports research from creative early stage investigators who propose highly innovative, pioneering studies with potential to open new areas of HIV/AIDS research related to coinfections, comorbidities, and complications. (nih.gov)
  • Hepatitis coinfection was present in 6% (34 of 563) of treatment-naïve patients (4% HBV only, 2% HCV only and 0.2% HBV+HCV) and 16% (114 of 699) of treatment-experienced patients (6% HBV only, 9% HCV only and 1% HBV+HCV). (nih.gov)
  • We carried out a genome-wide screening of a serotype 3 S. pneumoniae transposon insertion mutant library in a mouse model of coinfection with influenza A virus (IAV) to identify the bacterial factors required for this synergism. (biomedcentral.com)
  • The antimicrobial resistance of K. pneumoniae is a global concern and expresses several virulence factors contributing to the pathogenesis. (microbiologyjournal.org)
  • 9,10 The pathogenesis of K. pneumoniae is because of the production of different virulence factors such as capsular polysaccharide, siderophore production, biofilm formation, hypermucoviscosity, haemagglutination, haemolysis and production of extracellular enzymes. (microbiologyjournal.org)
  • These more cost-effective efforts could focus on investigating mechanisms of pathogenesis and testing prevention or clinical management interventions for multiple HIV-associated CCCs. (nih.gov)
  • However, the exact mechanisms and pathogenesis pertaining to how the onco-genetic antigens express in epithelial cells, weaken the immune response, and lead to the development of HPV-OPC in the context of HIV are unclear 7-9 . (nih.gov)
  • We aimed to investigate the mechanisms underlying the co-pathogenesis of influenza virus and serotype 3 pneumococci. (biomedcentral.com)
  • SFTSV infections are en- from 152 suspected scrub typhus patients in Myanmar revealed Orientia tsutsugamushi of genotypic heteroge- demic in eastern Asia, and retrospective studies have neity. (cdc.gov)
  • Coinfections and common acute infections may represent an under-recognized source of chronic pathology. (cdc.gov)
  • Heterogenous co-infections were indeed showed to complicate the pathogenesis during relevant diseases, such the emerging KSD (by M Adamek) or VHS on wild fish (by R Getchell), altering the immune response during sea lice infestation (by A Long and A Cabellero-Solares), or modulating the response to vaccination and genetic resistance (by D Jones). (thefishsite.com)
  • A review focuses on the current prevalence, risk factors, and pathogenesis of dual infections with HIV, HBV, and HCV. (hepcoalition.org)
  • HIV-positive people with hepatitis B virus (HBV) coinfection had impaired CD4 cell recovery after starting antiretroviral (ART) and a higher risk of death than those without hepatitis B, but use of ART regimens containing tenofovir significantly reduced mortality, according to a study presented at the recent Conference on Retroviruses and Opportunistic Infections (CROI 2016) in Boston. (hivandhepatitis.com)
  • These infections may be acquired simultaneously (coinfection) or result from two single infections at different time intervals (superinfection). (illinois.edu)
  • Here are some suggestions: novel strategies to combat infections, microbial pathogenesis and climate change, co-infections. (umich.edu)
  • Coinfections with pathogenic microbes continually confront cervical mucosa, yet their implications in pathogenesis remain unclear. (nih.gov)
  • Patients with chronic HBV and/or HCV coinfection were enrolled if baseline liver function tests were ≤5 times the upper limit of normal. (nih.gov)
  • These presentations emphasized the importance of considering coinfections in chronic disease pathology. (cdc.gov)
  • Data on chronic outcomes of malaria in infected persons and in unborn children and of other coinfections emphasized these points. (cdc.gov)
  • Treatment with tenofovir (Viread) led to hepatitis B surface antigen (HBsAg) clearance -- considered the closest outcome to a cure -- in 8% of HIV positive patients with chronic hepatitis B virus (HBV) coinfection, and in a subgroup clearance was associated with CD4 T-cell count, Dutch researchers reported in the September 15, 2012, Journal of Infectious Diseases . (hivandhepatitis.com)
  • The aim was to examine the long-term safety and efficacy of raltegravir in patients with HIV-1 and hepatitis B virus (HBV) and/or hepatitis C virus (HCV) coinfection in three double-blind, randomized, controlled Phase III studies. (nih.gov)
  • Patients with coinfection have shown diverse disease outcomes that ranged from mild to severe with severity increasing compared to patients who were infected with a single virus. (biorxiv.org)
  • Similar to the results with RSV-IAV coinfection, this analysis showed that the increased disease severity observed during murine IAV-RV or IAV-CoV2 coinfection was likely due to slower clearance of IAV infected cells by the other viruses. (biorxiv.org)
  • The cytokine profile predictive of fatal disease supports a key role of neutrophils in the pathogenesis of NTS sepsis. (ox.ac.uk)
  • We further investigated whether these responses are altered by HIV coinfection or severe malnutrition and whether cytokine responses predict inpatient mortality. (ox.ac.uk)
  • These cytokine responses were largely unaltered by either severe malnutrition or HIV coinfection. (ox.ac.uk)
  • Lack of in-vitro models recapitulating cervical epithelium has been a bottleneck to study coinfections. (nih.gov)
  • There is a significant body of research examining the role of human papillomavirus (HPV) in the pathogenesis of cervical cancer, with a particular emphasis on the oncogenic proteins E5, E6, and E7. (daharilab.com)
  • To date, studies examining the role of HSV in cervical cancer pathogenesis have yielded mixed results. (daharilab.com)
  • While several experiments have determined that HPV/HSV-2 coinfection results in a higher risk of developing cervical cancer, others have questioned the validity of this association. (daharilab.com)
  • These findings reveal a central role for AWL secretion in alveolar defense against inhaled SA and identify AWL inhibition as a critical mechanism of IAV lung pathogenesis. (flutrackers.com)
  • Role of HIV-1 Tat and CC chemokine MIP-1 a in the pathogenesis of HIV associated Central Nervous System disorders. (lsuhsc.edu)
  • It also briefly overviews the diagnosis and treatment of coinfections of these three blood-borne viruses. (hepcoalition.org)
  • Using patient-derived ectocervical organoids, we systematically modeled individual and coinfection dynamics of Human papillomavirus (HPV)16 E6E7 and Chlamydia, associated with carcinogenesis. (nih.gov)
  • Furthermore, influenza neuraminidases remove terminal sialic acid residues from host glycoconjugates to promote pneumococcal adherence and growth during coinfection [ 10 , 11 ]. (biomedcentral.com)