Anti-idiotypeMonoclonalAntibodiesAntibodyAutoantibodiesDiseasePhysical examinationLymphoid cellsAdhesionMalignantPolyclonalMolecularPeripheralRegulateDifferentiationMechanismsLymphomaEndothelialLymphocytesCutaneousGENESAbsenceFindingsArthritisImmune cellsChemoattractantMechanismProliferationPathwaysTissuesDeletionChemokinesTypesOccursPatientsProductionNormalCultureStudySurfaceLINERoleSpecificActivity
Anti-idiotype2
- New methods: subunit vaccines, anti-idiotype and DNA vaccines. (jinnah.edu)
- Patients have shown deposition of IgM in the involved tissue, and using anti-idiotype antibodies, IgM monoclonal antibodies were demonstrated to react with epidermal antigens. (medscape.com)
Monoclonal4
- Causes of the monoclonal secondary disease include the following: B-cell neoplasms - Waldenström macroglobulinemia, lymphoma, chronic lymphoid leukemia, myeloma Non hematologic neoplasms Causes of polyclonal secondary cold agglutinin disease include the following: Mycoplasma infections. (wikipedia.org)
- Cold agglutinins commonly have variable heavy-chain regions encoded by VH, with a distinct idiotype identified by the 9G4 rat murine monoclonal antibody. (wikipedia.org)
- rarely, it may involve monoclonal immunoglobulin G (IgG), immunoglobulin A (IgA), or λ light chain restriction. (medscape.com)
- those with an immunoglobulin G (IgG) monoclonal gammopathy are considered to be a distinct group. (medscape.com)
Antibodies3
- Chronic lymphocytic leukemia (CLL) usually involves the expansion of a clone of CD5+ B cells synthesizing IgM antibodies. (omicsdi.org)
- The invention also provides cells producing the antibodies, and methods of making and using the same. (justia.com)
- The exact mechanism of autoantibodies production remains unknown in leprosy and other chronic inflammatory diseases and also the contribution of these antibodies to the pathogenesis of the disease. (bvsalud.org)
Antibody4
- Pathologic cold agglutinins occur at titers over 1:1000 and react at 28-31 °C and sometimes at 37 °C. Cold agglutinin disease usually results from the production of a specific IgM antibody directed against the I/i antigens (precursors of the ABH and Lewis blood group substances) on red blood cells (RBCs). (wikipedia.org)
- Cold agglutinin disease usually results from the production of a specific IgM antibody directed against the I/i antigens (precursors of the ABH and Lewis blood group substances) on red blood cells (RBCs). (medscape.com)
- The complement system consists of more than 20 proteins in serum capable of lysing antibody-coated cells. (jinnah.edu)
- The company was founded by a group of scientists with extensive experience in protein expression, antibody development, library construction, stable cell line construction, cell culture, gene editing, and other related services. (alphalifetech.com)
Autoantibodies1
- These classifications are based on the characteristics of the autoantibodies involved in the pathogenesis of the disease. (wikipedia.org)
Disease6
- It is postulated that such calcineurin inhibitors, which selectively affect T-cell function and spare B-lymphocytes, may interfere with the deletion of autoreactive T-cell clones, resulting in autoimmune disease. (wikipedia.org)
- Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
- The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. (lookformedical.com)
- Disease, symptoms and pathogenesis. (jinnah.edu)
- 3) We are defining the properties of cancer stem cells that initiate and sustain the unique disease features of acute leukemias through the use of various adoptive animal models. (stanford.edu)
- An immune system is a collection of mechanisms within an organism that protects against disease by identifying and killing pathogens and tumor cells. (wikidoc.org)
Physical examination2
- Hence, primary hemostatic disorders are characterized by prolonged bleeding time, and the characteristic physical examination findings are petechiae and purpura. (medscape.com)
- In comparison, defects in secondary hemostasis result in delayed deep bleeding (eg, into muscles and joints) and the characteristic physical examination finding is hemarthrosis. (medscape.com)
Lymphoid cells3
- [ 21 ] It is found on cold agglutinin-producing malignant lymphoid cells in the bone marrow in persons with lymphoproliferative disorders, on a small proportion of normal lymphoid cells, and in the spleen of a 15-week-old fetus. (medscape.com)
- Lymphoid cells concerned with humoral immunity. (lookformedical.com)
- Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
Adhesion1
- 18:217-242), the β-chemokines regulate the expression of adhesion molecules on endothelial cells and thereby indirectly affect diapedesis and extravasation of immune cells from the circulation into tissues. (justia.com)
Malignant3
- A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
- Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. (lookformedical.com)
- In addition to these basic issues concerning leukemia pathogenesis, we are devising new diagnostic procedures for detecting and monitoring leukemia patients based on molecular genetic abnormalities in the malignant cells. (stanford.edu)
Polyclonal2
- [ 1 ] Donath-Landsteiner hemolytic anemia is also caused by a cold-reacting immunoglobulin, but most cases are due to polyclonal IgG. (medscape.com)
- It is likely that polyclonal B-cell lymphoproliferation in AIDS is a complex result of EBV infection, HIV antigenic stimulation, and T-cell-dependent HIV activation. (lookformedical.com)
Molecular3
- This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
- Molecular characterization of IgA- and/or IgG-switched chronic lymphocytic leukemia B cells. (omicsdi.org)
- The molecular data indicate that approximately 50% of B-CLL patients have amplifications of IgM+ B cells that undergo an isotype class switch. (omicsdi.org)
Peripheral2
- Peripheral blood smears may reveal clumps of red blood cells (RBCs). (medscape.com)
- [ 8 ] Hypersensitivity to lipo-polysaccharide IL-1 production has been found in peripheral blood cells, particularly mononuclear cells. (medscape.com)
Regulate2
- Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)
- Chemokines," which take their name from chemotactic cytokines, are small secreted polypeptides that regulate movement of immune cells into tissues (Baggiolini et al. (justia.com)
Differentiation1
- These B cells appear to be blocked at the antigen receptor-expressing stage of B cell differentiation and are thought not to undergo an isotype class switch to IgG or IgA production. (omicsdi.org)
Mechanisms1
- One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). (lookformedical.com)
Lymphoma3
- Lymphoma b cell. (lookformedical.com)
- B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. (lookformedical.com)
- A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. (lookformedical.com)
Endothelial2
- The hemostatic system consists of platelets, coagulation factors, and the endothelial cells lining the blood vessels. (medscape.com)
- Under physiological circumstances, the resistance of the endothelial cell lining to interactions with platelets and coagulation factors prevents thrombosis. (medscape.com)
Lymphocytes4
- They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. (lookformedical.com)
- A classification of B-lymphocytes based on structurally or functionally different populations of cells. (lookformedical.com)
- The β-chemokines form a gradient that serves as a chemoattractant and potential proliferation signal for immune and other cells such as monocytes, macrophages, basophils, eosinophils, T lymphocytes and fibroblasts. (justia.com)
- Human MCP-1, MCP-2 and MCP-3 all have chemotactic activity for a variety of cell types, including T lymphocytes and monocytes (Van Coillie et al. (justia.com)
Cutaneous1
- It is constitutively expressed in the skin and may play a role in T-CELL trafficking during cutaneous INFLAMMATION. (lookformedical.com)
GENES4
- The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1). (lookformedical.com)
- The immunoglobulin (Ig) variable region (V) genes expressed by IgM chronic lymphocytic leukemia (CLL) B cells display little or no somatic mutations. (omicsdi.org)
- In the IgA/IgG-coexpressing CLL B cells, identical VH-D-JH cDNA sequences were spliced to either C alpha or C gamma genes. (omicsdi.org)
- Lack of intraclonal diversification in Ig heavy and light chain V region genes expressed by CD5+IgM+ chronic lymphocytic leukemia B cells: a multiple time point analysis. (omicsdi.org)
Absence1
- Leprosy offers a broad spectrum of altered immunological sceneries, ranging from strong cell-mediated immune responses seen in tuberculoid leprosy (TT), through borderline leprosy (BB), to the virtual absence of T cell responses characteristic in lepromatous leprosy (LL). (bvsalud.org)
Findings1
- These findings suggest that IgA- and/or IgG-expressing CLLs represent, in their VH gene structure, transformants of B cells at different stages of ontogeny. (omicsdi.org)
Arthritis1
- A high frequency of RF positivity was observed among the leprosy patients (41.2%, 40/97), with RF immunoglobulin A (IgA) significantly associated with arthritis (OR = 7.9, 95% CI = 1.5-40.6 P = 0.008). (bvsalud.org)
Immune cells1
- and a variety of other immune cells. (lookformedical.com)
Chemoattractant1
- A monocyte chemoattractant protein that has activity towards a broad variety of immune cell types. (lookformedical.com)
Mechanism1
- Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. (lookformedical.com)
Proliferation1
- the IL-17 family - It has yet to be completely characterized, though member cytokines have a specific effect in promoting proliferation of T-cells that cause cytotoxic effects. (wikidoc.org)
Pathways1
- Cell biology and significance of different pathways for antigen processing and presentation by class I and class II MHC. (jinnah.edu)
Tissues4
- This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)
- Other shared functions of MCP-1, MCP-2, and MCP-3 include induction of N-acetyl β-D-glucosaminidase release, gelatinase B release, and granzyme A release which are believed to help the cells digest the extracellular matrix components necessary to enable them to migrate into tissues (Van Coillie et al. (justia.com)
- It detects a wide variety of agents, from viruses to parasitic worms , and needs to distinguish them from the organism's own healthy cells and tissues in order to function properly. (wikidoc.org)
- [1] The immune systems of vertebrates such as humans consist of many types of proteins , cells, organs , and tissues, which interact in an elaborate and dynamic network. (wikidoc.org)
Deletion1
- In all five CLLs, the pattern of C mu DNA probe hybridization to the digested genomic DNAs was consistent with deletion of the C mu exon from the rearranged Ig gene locus, suggesting that these CLL B cells had undergone DNA switch recombination. (omicsdi.org)
Chemokines2
- Cytokines have been variously named as lymphokines , interleukins and chemokines , based on their presumed function, cell of secretion or target of action. (wikidoc.org)
- Cell surface glycoproteins that bind to chemokines and thus mediate the migration of pro-inflammatory molecules. (lookformedical.com)
Types2
- While hormones are released from specific organs into the blood and neurotransmitters are released by nerves, cytokines are released by many types of cells. (wikidoc.org)
- Cytokines are produced by a wide variety of cell types (both haemopoietic and non-haemopoietic) and can have effects on both nearby cells or throughout the organism. (wikidoc.org)
Occurs1
- To test the hypothesis that in vivo isotype class switching occurs in IgM+ B-type CLL cells, we analyzed the PBMC of 19 CLL patients for the presence of transcripts encoding the rearranged CLL V(H)DJ(H) associated with either gamma or alpha H chains. (omicsdi.org)
Patients1
- Furthermore, B cells expressing IgG and IgA of the same idiotype or V(H) family and the same CDR3 length as those of the CLL IgM+ clone can be identified in the blood of patients studied using multiparameter immunofluorescence analyses. (omicsdi.org)
Production1
- Collectively, these data suggest that not all members of a B-CLL clone are frozen at the surface membrane Ig-expressing stage of B cell maturation, and that some members can switch to the production of non-IgM isotypes. (omicsdi.org)
Normal2
- We are studying the role that normal chromatin structure plays in gene regulation in hematopoietic cells and how its disruption leads to altered development and cancer. (stanford.edu)
- In many instances, these CLL-related gamma and alpha transcripts are much more plentiful than those of normal B cells that produce the same isotype. (omicsdi.org)
Culture1
- If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely. (lookformedical.com)
Study1
- WorldCat has the area's largest l ground, giving you send study characteristics complete. (filipinocrewclaims.com)
Surface3
- These isotype-switched CLL B cells expressed surface HLA-DR, CD19, CD23, and CD5, and displayed no alterations of the bcl-1 and bcl-2 oncogenes and the p53 tumor-suppressor gene. (omicsdi.org)
- The cellular data indicate that B cells with lesser amounts of surface membrane IgD and higher IgM/IgD ratios are more likely to undergo this switching process. (omicsdi.org)
- Each cytokine binds to a specific cell-surface receptor . (wikidoc.org)
LINE2
- Alpha Lifetech Inc. is experienced in cell line construction. (alphalifetech.com)
- We are committed to providing high-quality stable cell line construction services to customers worldwide. (alphalifetech.com)
Role1
- They also suggest that Ag may play a role in the clonal selection of some of these isotype-switched leukemic cells, but bcl-1 and bcl-2 oncogene rearrangements and p53 tumor suppressor gene mutation are not associated with the pathogenesis of isotype-switched CLLs. (omicsdi.org)
Specific1
- The term chemokine refers to a specific class of cytokines that mediates chemoattraction ( chemotaxis ) between cells. (wikidoc.org)
Activity1
- It has activity towards TH2 CELLS and TC2 CELLS. (lookformedical.com)