• For example, T reg cells contribute to the complex pathogenesis of inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis during onset or development of that disease. (wjgnet.com)
  • This review briefly described the epidemiology and transmission of MPXV between animals and humans and summarizes past studies on the ecology of MPXV in wild animals and experimental studies in captive animal models, with a focus on how animal infections have informed knowledge concerning various aspects of this pathogen. (usgs.gov)
  • This application links with both current EC Concerted Actions in this area, studying the epidemiology and the neuropathology of human prion diseases to both provide a comprehensive range of tissues for study and to allow all the activities in this proposal to be placed within an epidemiological context within the EU. (europa.eu)
  • In contrast, certain immunodeficient mouse models infected with mouse-adapted DENV strains show signs of severe disease similar to the 'vascular-leak' syndrome seen in severe dengue in humans. (mdpi.com)
  • This zoonotic disease has been gradually re-emerging in humans with an increasing frequency of cases found in endemic areas, as well as an escalating frequency and size of epidemics outside of endemic areas in Africa. (usgs.gov)
  • The current unprecedented global outbreak of mpox has demonstrated higher numbers of human cases and greater human-to-human transmission than previously documented, necessitating an urgent need to better understand this disease in humans and animals. (usgs.gov)
  • Knowledge gaps were highlighted in areas where future research, both in captive and free-ranging animals, could inform efforts to understand and control this disease in both humans and animals. (usgs.gov)
  • There are over 2400 Salmonella serotypes each of which differs in their ability to cause disease in humans and animals, persist within the host, and survive in the environment. (usda.gov)
  • The new 4-year PhD programme in One Health Models of Disease: Science, Ethics and Society will provide unique training in state-of-the-art techniques in the design and application of new One Health models of neurodegenerative, cardiovascular, developmental, and infectious diseases of humans and animals. (ed.ac.uk)
  • Students will be supervised by world-leading life scientists addressing important diseases of humans and animals, and social scientists and bioethicists conducting cutting-edge research into the social and ethical dimensions of 21st century science. (ed.ac.uk)
  • 3) To estimate the efficacy of the species barriers limiting transmission of BSE and scrapie to humans to address the risk to public health within the EU posed by BSE and other animal prion diseases. (europa.eu)
  • Prion diseases are transmissible neurodegenerative diseases of humans and animals. (europa.eu)
  • We will develop and evaluate transgenic mouse, cell culture and in vitro models which, as well as allowing an experimental estimation of the risks of transmission of BSE to humans and a complete assessment of the transmission characteristics and phenotypic range of the human prion diseases, should provide the tools to study the mechanisms and pathways of prion neurodegeneration. (europa.eu)
  • Members of this species vary from very pathogenic agents causing different types of diseases including meningitis, gastroenteritis, and septicemia, just to cite a few, to harmless organisms living in the intestines of both humans and animals. (intechopen.com)
  • evaluated the role of abnormal bone in the pathogenesis of vascular calcification in animal models and humans, examined treatments to reduce fractures, and most recently examined the role of nutrition on CKD-Mineral Bone Disorder. (asn-online.org)
  • Vascular complications are responsible for the excess mortality associated with diabetes ( 1 ), and impaired endothelium-dependent vasodilation has been described in humans and in animal models of the disease ( 2 - 6 ). (diabetesjournals.org)
  • Animal models offer a unique opportunity to study the pathogenesis of neurologic diseases afflicting both humans and animals. (stanford.edu)
  • Inherited diseases in dogs reliably replicate many hereditary diseases in humans. (stanford.edu)
  • The Influenza Risk Assessment Tool (IRAT) is an evaluation tool developed by CDC and external influenza experts that assesses the potential pandemic risk posed by influenza A viruses that currently circulate in animals but not in humans. (cdc.gov)
  • Moreover, the results in humans and animals are controversial, pointing to a possible deleterious effect of steroidal anti-inflammatory drugs on periodontal structures. (bvsalud.org)
  • Melioidosis, a potentially fatal infectious disease of humans and animals, including nonhuman primates (NHPs), is caused by the high-consequence pathogen Burkholderia pseudomallei. (cdc.gov)
  • The global movement of humans and animals can introduce B. pseudomallei into nonendemic regions of the United States, where environmental conditions could allow establishment of the organism. (cdc.gov)
  • A neurodegenerative disease is caused by the progressive loss of structure or function of neurons, in the process known as neurodegeneration. (wikipedia.org)
  • Alzheimer's disease (AD) is a chronic neurodegenerative disease that results in the loss of neurons and synapses in the cerebral cortex and certain subcortical structures, resulting in gross atrophy of the temporal lobe, parietal lobe, and parts of the frontal cortex and cingulate gyrus. (wikipedia.org)
  • Experiments have revealed reduced transport rates of both wild-type and two familial Parkinson's disease-associated mutant alpha-synucleins through axons of cultured neurons. (wikipedia.org)
  • In this animal, the motor neurons of the brain and spinal cord deteriorate at 3-4 months of age and the mouse becomes paralyzed. (utoledo.edu)
  • Animal models and mechanisms of tobacco smoke-induced chronic obstructive pulmonary disease (COPD). (cdc.gov)
  • As animal models continue to aid in defining the pathobiological mechanisms of and possible novel therapeutic interventions for COPD, the advantages and disadvantages of each animal model are discussed. (cdc.gov)
  • Determining the mechanisms of HCMV-accelerated vascular disease through identification of the viral genes expressed during these diseases using a HCMV microarray chip developed by Dr. Streblow's laboratory in combination with the shared microarray core at VGTI. (ohsu.edu)
  • Determining the mechanisms of CMV-accelerated vascular disease in both mouse models of atherosclerosis and rat organ transplantation models using a DNA microarray approach. (ohsu.edu)
  • Determining the mechanisms of viral acceleration of chronic allograft rejection from latently infected donor, which is the most common cause of HCMV-associated disease in transplant patients associated with expression during the different stages of viremia associated with CMV including. (ohsu.edu)
  • Here, we propose to use a transgenic animal model system, Drosophila melanogaster (the fruit fly), to define the mechanisms by which mutations in various thin filament components lead to human cardiac disease. (hopkinsmedicine.org)
  • The recent identification of prion-like mechanisms in yeast suggests that the novel biology involved may not be restricted to this group of diseases but be of wider pathobiological importance. (europa.eu)
  • For this reason, its study provides a huge advantage and can help understand the mechanisms involved in different processes such as pathogenesis, environmental disinfection, nutrient utilization, antibiotic resistance, and diagnostic/detection methods, and these are indeed the topics discussed in this book. (intechopen.com)
  • In SSc, pulmonary disease can exist as a heterogeneous combination of pulmonary fibrosis and pulmonary arterial hypertension (PAH), but the pathogenic mechanisms that induce different pulmonary responses are poorly understood. (ersjournals.com)
  • 1.B. Define mechanisms of immune evasion that contribute to PRRSV disease pathogenicity, and which can be targeted through recombinant vaccines to improve vaccine efficacy. (usda.gov)
  • 3.A. Identify viral genes with mutations that are associated with SVA virulent and attenuated field strains and determine mechanisms of viral pathogenesis. (usda.gov)
  • These pathogens will be examined in the laboratory as well as in swine disease models to investigate mechanisms of pathogenesis, transmission, immunity, evolution and methods of intervention. (usda.gov)
  • Thus, we began with exploring the possible structural and functional alterations of the dCLN in a PD mouse model (A53T mice) and investigated the role of pathological α-syn in peripheral inflammation and its potential underlying molecular mechanisms. (lu.se)
  • Here we show OS involvement in brain damage in a diabetic animal model that is at least partially mediated through an AD-pathology-independent mechanism apart from amyloid-β accumulation. (nature.com)
  • For instance, amyloid peptides trigger a neuroinflammatory reaction in the Alzheimer's disease-afflicted brain. (utoledo.edu)
  • These animal models suggest that complement C3 is present after the amyloid pathogenesis of Alzheimer's disease is underway," Dr. Sullivan explained. (medicalnewstoday.com)
  • This study examines exciting new hallmarks for the strict involvement of autophagy and TGF-β signaling pathways in the pathogenesis of diabetes and the design of novel therapeutic strategies. (frontiersin.org)
  • This review article focuses on the role of T reg cells and outlines the pathogenesis and therapeutic strategies of IBD based on previous reports. (wjgnet.com)
  • 2) To study possible therapeutic strategies for the human prion diseases. (europa.eu)
  • These models will be used to evaluate therapeutic strategies and for testing of novel therapeutics. (europa.eu)
  • Parkinson's disease (PD) is the second most common neurodegenerative disorder. (wikipedia.org)
  • Membrane damage by alpha-synuclein could be another Parkinson's disease mechanism. (wikipedia.org)
  • Problems with the sense of smell is a widespread symptom of Parkinson's disease (PD), however, some neurologists question its efficacy. (wikipedia.org)
  • Neuroinflammation is a specific type of innate immune response that occurs in the brain during many, perhaps all, neurodegenerative diseases (including Alzheimer's disease, Parkinson's disease, Huntington's disease and various motor neuron diseases). (utoledo.edu)
  • Results show that JAK/STAT pathway inhibitors may be a new class of therapeutic treatments for patients with Parkinson's disease. (uab.edu)
  • Parkinson's Disease (PD) is characterized clinically by tremors at rest, bradykinesia (slowness of voluntary movement), muscle rigidity, decrease in postural reflex and facial expression and an altered gait (Kumar et al. (ukessays.com)
  • New research from the University of Alabama at Birmingham says the gut microbiome is involved in multiple pathways in the pathogenesis of Parkinson's disease. (microbiota-site.com)
  • The findings, published in Nature Communications, show a wide imbalance in microbiome composition in persons with Parkinson's disease. (microbiota-site.com)
  • The study reports Parkinson's disease metagenome is indicative of a disease-promoting microbiome. (microbiota-site.com)
  • Payami, who is the John T. and Juanelle D. Strain Endowed Chair in Neurology, and her team enrolled 490 persons with Parkinson's disease and 234 healthy controls. (microbiota-site.com)
  • The researchers studied 257 species of organisms in the microbiome, and of these, analysis indicated 84, more than 30 percent, were associated with Parkinson's disease. (microbiota-site.com)
  • We found that over 30 percent of the micro-organisms and bacterial genes and pathways tested have altered abundances in Parkinson's disease, which indicates a widespread imbalance. (microbiota-site.com)
  • Parkinson's disease is a progressively debilitating disorder that affected 4 million individuals in the year 2005 and is projected to double to 8.7 million individuals by the year 2030. (microbiota-site.com)
  • Background: Peripheral inflammation is an important feature of Parkinson's disease (PD). (lu.se)
  • Journal of Parkinson's Disease. (lu.se)
  • Petersén Å, Hansson O, Emgård M and Brundin P.Cell Transplantation 9: 577-584 (2000)AbstractTransplantation of embryonic ventral mesencephalon is a potential therapy for patients with Parkinson's disease. (lu.se)
  • Brundin P, Karlsson J, Emgård M, Kaminski Schierle GS, Hansson O, Petersén Å and Castilho RF.Cell Transplantation 9: 179-195 (2000)AbstractNeural transplantation is developing into a therapeutic alternative in Parkinson's disease. (lu.se)
  • Neutrophil extracellular traps in systemic autoimmune and autoinflammatory diseases. (news-medical.net)
  • In systemic autoimmune diseases, the immune system cannot distinguish between self and non-self and subsequently responds to and harms several tissues and organs, including joints, kidneys, and blood vessels. (news-medical.net)
  • SLE is a type I interferon response-heavy systemic autoimmune disease that displays high autoreactivity against nucleic acids and other nuclear and intracellular components. (news-medical.net)
  • Genetic heterogeneity, suggested by clusters of patients with the same human leukocyte antigen or autoimmune markers, may predispose to inflammatory bowel disease (IBD). (northwestern.edu)
  • MC is typically associated with autoimmune diseases and/or certain medications. (unboundmedicine.com)
  • Models of pathogenesis include autoimmune destruction, inflammatory response to luminal factors, and myofibroblast dysfunction (for CC). (unboundmedicine.com)
  • The Xinbo Yang lab is interested in studying the T cell receptor (TCR) specificity in Cancer and autoimmune disease. (mskcc.org)
  • Whereas mis-recognizing healthy tissue can cause collateral tissue damage that led to autoimmune disease. (mskcc.org)
  • Xinbo Yang's lab applies structural biology and protein engineering to decode T cell receptor specificity in Cancer and autoimmune disease. (mskcc.org)
  • scientists believe that an animal is the most likely source of the coronavirus. (nature.com)
  • Salmonella is a prevalent food-borne pathogen and a model system for the study of virulence and pathogenesis. (usda.gov)
  • These similarities suggest that therapeutic advances against one neurodegenerative disease might ameliorate other diseases as well. (wikipedia.org)
  • In addition, ER stress is a potential therapeutic target to ameliorate PD pathogenesis. (lu.se)
  • Standard infl uenza ly virulent infl uenza A viruses share the same pathogenesis, symptoms include fever, cough, headache, sore throat, and we compared 2 different infl uenza A virus subtypes, H1N1 dehydration, with some reports of diarrhea, vomiting, and and H5N1. (cdc.gov)
  • This research project will focus on swine diseases caused by viruses that are top concerns for United States pork producers: porcine reproductive and respiratory syndrome, porcine coronaviruses, and new and emerging diseases such as Seneca A virus. (usda.gov)
  • A key approach in the study of disease pathogenesis is to better understand the host response to viral infection to various viruses. (usda.gov)
  • In both human and animal disease models, these immune cells are frequently located at the areas of tissue inflammation where they support inflammatory response. (news-medical.net)
  • Interest in animal models of IBD is gaining increasing support, mostly to test inhibitors of inflammation. (northwestern.edu)
  • This expanding knowledge in the pathogenesis of intestinal inflammation is generating new therapies. (northwestern.edu)
  • Acting by reducing inflammation, they prevent neurodegeneration in animal models and may be an important new approach to slow progression of the disease. (uab.edu)
  • Once identified, the function of these viral genes will be examined using in vitro and in vivo models of CMV-accelerated vascular disease. (ohsu.edu)
  • Additionally, in vivo experiments demonstrate replication of the chimeric virus in mouse lung with notable pathogenesis. (nature.com)
  • Numerous in vivo models of prostate cancer have been developed. (helsinki.fi)
  • Imaging techniques, such as optical imaging, are being utilized in different in vivo models of prostate cancer. (helsinki.fi)
  • In this review we recorded several representative in vitro and in vivo studies performed in culture cell lines, in animal or clinical trials, indicating that the regular intake of EVOO is associated with enhanced neuroprotective, antioxidant, anti-inflammatory, anti-atherosclerotic, anti-cancer and anti-microbial properties. (researchgate.net)
  • We will produce several new models of actin and troponin-T-based cardiomyopathies to determine the molecular defects that drive diverse and complex tissue remodeling. (hopkinsmedicine.org)
  • Using a transgenic model system, the fruit fly Drosophila melanogaster, we will produce models of human myosin-based muscle disease (distal arthrogryposis) and heart disease (hypertrophic cardiomyopathy) to determine the molecular defects that cause abnormal skeletal and cardiac muscle function. (hopkinsmedicine.org)
  • 1.A. Characterize virus-host interactions and determine innate and adaptive immune pathways that contribute to PRRSV disease susceptibility or immunity to inform the development of highly effective vaccines against very virulent strains. (usda.gov)
  • The prion diseases are now the best understood neurodegenerative conditions and advances made in this area are already providing insights into processes of neurodegeneration which may well be of much wider application. (europa.eu)
  • New insights into the complex cellular contributions and interactions will be provided, comparing the role of cell subsets in the pathogenesis of IPF and systemic sclerosis. (ersjournals.com)
  • Their results suggest that stem cell studies may offer insights to disease pathogenesis that animal models cannot provide, the researchers say. (the-scientist.com)
  • Predict and characterize the ecology and evolution of emerging viral diseases of swine. (usda.gov)
  • The development of animal models of dengue virus (DENV) infection and disease has been challenging, as epidemic DENV does not naturally infect non-human species. (mdpi.com)
  • however, a new model using high doses of DENV has recently been shown to develop hemorrhagic signs after infection. (mdpi.com)
  • Animal Models of Chikungunya Virus Infection and Disease. (ohsu.edu)
  • His studies are directed at understanding why aged patients and mice developed more severe disease than younger individuals after infection with SARS-CoV or SARS-CoV-2 and also on why there is a male predominance in patients with more severe disease after infection with SARS-CoV, MERS-CoV or SARS-CoV-2. (hstalks.com)
  • He and his colleagues demonstrated that transduction of mice with an adenovirus expressing the human receptor for MERS-CoV, DPP4, rendered them sensitive to infection, providing the first rodent model useful for studying MERS. (hstalks.com)
  • They discussed two of Dr. Embers' published research projects where she demonstrates that Borrelia burgdorferi-the bacterium that causes Lyme disease-is able to survive a 28-day course of antibiotics when treatment is begun four months after infection. (lymedisease.org)
  • Her most recent research used animal models to study the natural course of infection in two groups of non-human primates. (lymedisease.org)
  • CoV-2 infection, achieve consensus on the time period at which to define the post-acute and long-term phases of COVID-19, and distinguish health effects exclusively related to infection with SARS-CoV-2 from consequences of procedures and treatments required for care of persons with severe disease of any etiology. (cdc.gov)
  • On the basis divided into aliquots for direct use in pathotyping studies, of these mostly retrospective studies, the pathogenesis of and their titers were determined by standard plaque (sub- infl uenza-associated ARDS is widely viewed as being the type H1N1) or median tissue culture infective dose assays same whatever the infecting strain. (cdc.gov)
  • Overall, each model has its advantages and disadvantages and is differentially suited for studies of dengue pathogenesis and immunopathogenesis and/or pre-clinical testing of antiviral drugs and vaccines. (mdpi.com)
  • Numerous studies have linked neutrophils to the pathogenesis of systemic autoimmunity. (news-medical.net)
  • Several studies have shown oxidative stress (OS) to be one of the major factors in the pathogenesis of diabetic complications. (nature.com)
  • Such mechanistic studies will facilitate animal model generation to further understand disease pathogenesis and ultimately benefit pMHC based therapeutic development. (mskcc.org)
  • Our studies have been focusing on the alterations of AMPs and filaggrin in the skin of atopic dogs to better understand the function that such proteins play in the pathogenesis of cAD. (illinois.edu)
  • Amiloride, an epithelial sodium channel (ENaC) inhibitor, was reported to reduce proteinuria in animal studies and case reports independent of ENaC inhibition. (karger.com)
  • More studies are needed to validate the model for example in proving the effects of the medical therapies. (helsinki.fi)
  • This article discusses the alloimmune-dependent and -independent risk factors for bronchiolitis obliterans, the current understanding of the pathogenesis of bronchiolitis obliterans based on results of animal and human studies, the clinical staging of the complication, strategies that may contribute to the prevention and/or early detection of bronchiolitis obliterans, and suggestions for future research. (ersjournals.com)
  • Animal experiments to be conducted involve one of three general designs: 1) disease pathogenesis and transmission studies, 2) vaccine efficacy studies, 3) sow/neonatal studies. (usda.gov)
  • establishment by the global donor community of a direct path for manufacturers from preclinical proof-of-concept studies to post-licensing procurement of MERS-CoV products, through initiation of a public health financial model for supporting research and product development on emerging pathogens prioritized in WHO's Blueprint process. (who.int)
  • A search in the main databases was performed and human and animal studies were selected. (bvsalud.org)
  • Few studies evaluated the effect of steroidal antiinflammatory drugs on the pathogenesis of periodontal diseases. (bvsalud.org)
  • The focus of the Streblow laboratory is on defining the role of human cytomegalovirus (HCMV) in the development of vascular disease and chronic rejection of organ allografts. (ohsu.edu)
  • Determining the function of CMV-encoded chemokine receptors in the context of viral pathogenesis and acceleration of vascular disease. (ohsu.edu)
  • Her background is in microbiology and immunology, with the focus of her research on Lyme disease pathogenesis, antibiotic efficiency and immunodiagnostics. (lymedisease.org)
  • http://toxsci.oxfordjournals.org/ respiratory disease in the industrial world. (cdc.gov)
  • 1999). Animal models are needed not only to understand how prior to intranasal challenge influences the respiratory response chemicals may induce asthma, but also to improve our ability to using toluene diisocyanate (TDI), a known respiratory sensitizer. (cdc.gov)
  • These in creating a mouse model for occupational asthma using HDI findings suggest that respiratory response to TDI depends on (hexamethylene diisocyanate), in which the sensitized mice prior frequency and concentration of dermal sensitization in mice. (cdc.gov)
  • Thus, the current study indicates a lack of overt changes in the electrical membrane properties of pyramidal cells in HD mice accurately modelling early stage HD pathology. (nih.gov)
  • By evaluating the pathology and physiologic function or behavior in animals, we can begin to design rational interventional strategies to prevent, treat, or to delay the onset of neurodegenerative diseases. (stanford.edu)
  • She stated that aberrant activation of several complements has been implicated in neurodegeneration, and has been identified as a key inflammatory protein activated in transgenic mice genetically programmed to develop Alzheimer's disease. (medicalnewstoday.com)
  • Our main tool for studying neuroinflammation is the SOD1 G93A transgenic mouse, which carries the human gene mutation responsible for hereditary amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease). (utoledo.edu)
  • In addition, one of the lymphatics draining components, CSF, contains abundant α-synuclein (α-syn), a protein critically involved in PD pathogenesis and neuroinflammation. (lu.se)
  • This model states that the microbiological challenge, including lipopolysaccharide liberations, cause injuries in the periodontal tissues, leading, an antigenantibody inflammatory response. (bvsalud.org)
  • Such models can transform our approach to understanding pathogenesis, facilitating the development of therapies or preventive measures. (ed.ac.uk)
  • Prostate cancer and new therapies to treat the disease are being investigated vigorously. (helsinki.fi)
  • Additionally, as three- and four-drug induction therapies are becoming increasingly available and effective, resulting in high minimal residual disease (MRD) negative rates, it is important to continue discussing and further personalizing upfront ASCT to avoid overtreatment and possible toxicities especially in the non-high-risk patient population (Tab. (bvsalud.org)
  • In these communities, a high prevalence of both poor diet and infectious disease exist in a vicious circle [ 1 ]. (who.int)
  • Here we examine the disease potential of a SARS-like virus, SHC014-CoV, which is currently circulating in Chinese horseshoe bat populations 1 . (nature.com)
  • Since then, several strains-including influenza A strains H5N1, H1N1 and H7N9 and MERS-CoV-have emerged from animal populations, causing considerable disease, mortality and economic hardship for the afflicted regions 5 . (nature.com)
  • The level of the polyglutamine-expanded protein is one of the factors that contributes to disease severity. (nih.gov)
  • We provide a new candidate mechanism for modulating the pathogenesis of neurodegenerative diseases sensitive to protein dosage. (nih.gov)
  • Biomedical research has revealed many similarities between these diseases at the subcellular level, including atypical protein assemblies (like proteinopathy) and induced cell death. (wikipedia.org)
  • It is thought that defects in protein transport machinery and regulation, such as RAB1, may play a role in this disease mechanism. (wikipedia.org)
  • Hensley K , Kursula P. Collapsin Response Mediator Protein-2 (CRMP2) is a Plausible Etiological Factor and Potential Therapeutic Target in Alzheimer's Disease: Comparison and Contrast with Microtubule-Associated Protein Tau. (utoledo.edu)
  • A new study recently discovered that women who died from Alzheimer's had a higher amount of a chemically-modified version of the protein complement C3 in their brains compared to men who died from the disease. (medicalnewstoday.com)
  • Researchers found a much higher level of a chemically-modified version of the C3 protein in the brains of women who died from Alzheimer's compared to men who also died from the disease. (medicalnewstoday.com)
  • We have discovered that complement C3 is aberrantly activated in Alzheimer's disease, namely by a chemical reaction that we first characterized some years ago called protein S-nitrosylation, which adds a nitrogen (N) and oxygen (O) to a sulfur (S) molecule, resulting in an 'SNO' tag on the protein, in this case, C3. (medicalnewstoday.com)
  • Recent Advances on Physiology, Pathogenesis and Biotechnological Applications' PRINT ISBN: 978-953-51-3329-2 Libraries are offered a 20% discount on retail book prices. (intechopen.com)
  • Transgenic mouse models are becoming more and more common in the research of prostate cancer. (helsinki.fi)
  • Transgenic models are able to model the initiation and progression of the disease more realistically. (helsinki.fi)
  • Animal models of the disease, created using neurotoxins such as rotenone or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), or transgenic mice that overexpress human SYN gene (for ï ¡-synuclein) mutations, do not faithfully replicate the structure and antigenicity of the Lewy bodies found in PD (Dickson 2001). (ukessays.com)
  • Methods: In this study, the transgenic mice (prnp-SNCA*A53T) which specifically overexpressed A53T mutant α-syn in CNS were employed as the PD animal model. (lu.se)
  • Even with billions of dollars being used to find a treatment for Alzheimer's disease, no effective treatments have been found. (wikipedia.org)
  • However, clinical trials have developed certain compounds that could potentially change the future of Alzheimer's disease treatments. (wikipedia.org)
  • Accumlating evidence have suggested that diabetes mellitus links dementia, notably of Alzheimer's disease (AD). (nature.com)
  • Previous research has shown that women are at a higher risk for developing Alzheimer's disease than men. (medicalnewstoday.com)
  • Although anyone can develop Alzheimer's disease (AD) , a type of dementia associated with cognitive decline and memory loss, previous research has shown that females are more likely to have the condition than men. (medicalnewstoday.com)
  • Researchers found S-nitrosylation-modified complement C3 proteins within the postmortem brains of people who had died from Alzheimer's disease. (medicalnewstoday.com)
  • The same is also true of the most common neurodegenerative disease, Alzheimer's Disease (AD). (ukessays.com)
  • It is the most common neurodegenerative disease. (wikipedia.org)
  • Targeting Microbiota 2023 will elaborate on the link between the gut microbiome and neurodegenerative disease. (microbiota-site.com)
  • 4) to establish the full phenotypic range and transmission characteristics of the human prion diseases. (europa.eu)
  • These findings suggested that CA is an effective treatment approach for preventing atherosclerotic lesion progression attributed to protection against oxidative stress and various enzymatic activities in the Ath model. (hindawi.com)
  • Proteinuria is a major determinant of progression of chronic kidney disease (CKD), which is associated with more rapid worsening of renal function and earlier initiation of renal replacement therapy independent of estimated glomerular filtration rate (eGFR) [ 1 ]. (karger.com)
  • PFS was defined by the time from ASCT to the disease progression. (bvsalud.org)
  • The OS was defined as the time from the the start of treatment to the death from disease progression. (bvsalud.org)
  • During the monitored period we recorded 4 deaths due to disease progression, all of them in the HCRA subgroup. (bvsalud.org)
  • The median OS in both subgroups was not reached, however the only deaths due to disease progression were recorded in the HRCA subgroup. (bvsalud.org)
  • We will use genetic suppression and drug treatment to better understand the bases of myosin malfunction and to develop our model system as a means of testing potential therapeutic approaches. (hopkinsmedicine.org)
  • 3.C. Develop SVA swine laboratory models to inform the development of vaccines. (usda.gov)
  • Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, and its global health burden is increasing. (cdc.gov)
  • A cluster of pathologies including chronic bronchitis, emphysema, asthma, and cardiovascular disease in the form of hypertension and atherosclerosis variably coexist in COPD patients. (cdc.gov)
  • Nonalcoholic steatohepatitis affects approximately 3% of the lean population and 19% of obese persons, making it the most prevalent cause of chronic liver disease in the country[ 6 ]. (wjgnet.com)
  • Canine atopic dermatitis (cAD) is a chronic inflammatory skin disease affecting up to 10% of the canine population, it is the second most common allergic disease in dogs. (illinois.edu)
  • Dementia is a chronic disease the prevalence of which is increasing worldwide. (benthamscience.com)
  • Dr. Moe's research is translational and involves the study of all aspects of chronic kidney disease mineral bone disorder. (asn-online.org)
  • The book has been divided into four main sections representing the different facets of E. coli applications, which include disease, biotechnology, environmental engineering and innovative approaches to detection, and lastly its physiology and cell biology. (intechopen.com)
  • Non-human primates (NHPs) can sustain viral replication in relevant cell types and develop a robust immune response, but they do not develop overt disease. (mdpi.com)
  • While no single animal model might mimic all features of human COPD, a wide variety of published models have collectively helped to improve our understanding of disease processes involved in the genesis and persistence of COPD. (cdc.gov)
  • This Wellcome programme combines training in experimental techniques, bioethics and social sciences for human and animal health. (ed.ac.uk)
  • Canine AD has many similarities to human AD and for this reason the dog has been suggested to be a good animal model to study AD in people. (illinois.edu)
  • Canine AMPs were more effective in killing bacteria more commonly involved in canine skin infections (Staphylococcus pseudintermedius and Malassezia pachydermatis) rather than pathogens involved in human skin diseases (Staphylococcus aureus and Candida albicans). (illinois.edu)
  • Secondly, the epidemic of an apparently new animal prion disease, BSE, in the UK has raised legitimate public concerns of a risk to human health from eating infected tissues. (europa.eu)
  • The work "highlights the value of [human embryonic stem cells] as a model system for early human embryo development," the study's coauthor, Rachel Eiges of the Hebrew University in Jerusalem, told The Scientist . (the-scientist.com)
  • U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, Center for Prevention Services, Division of TB Elimination. (cdc.gov)
  • Tumor models can be created by inoculating human cancer cells or solid parts of tumors into immune deficient mice. (helsinki.fi)
  • Comparative gene mapping among human, murine, and canine genomes have the potential to rapidly identify mutations that underlie various disease syndromes. (stanford.edu)
  • My research focused on the identification and characterization of animal models of human diseases. (stanford.edu)
  • These animal models may occur in non-human primates, dogs, cats, goats, mice in which mutations have been induced, or in other less common laboratory species such as bears. (stanford.edu)
  • Retroviruses of human A.I.D.S. and related animal diseases : 7e Colloque des "cent gardes", 26-27-28 octobre 1992, Marnes-la-Coquette, Paris, France / edited by Marc Girard, Louis Valette. (who.int)
  • Nonhuman primate models for human diseases / editor, W. Richard Dukelow. (who.int)
  • We designed and validated a culture-independent DNA capture and enrichment system for obtaining Leptospira genomic information from complex human and animal samples. (cdc.gov)
  • Implementation of this DNA capture and enrichment system will improve efforts to obtain genomic data from unculturable Leptospira-positive human and animal samples. (cdc.gov)
  • Previous research shows activation of complement C3 may be linked to various neurological diseases . (medicalnewstoday.com)
  • Research into the gene mutations discovered in such hereditary cases has also contributed to the understanding of the aetiology of the spontaneous, late onset form of the disease. (ukessays.com)
  • Dr Tamara Jamaspishvili is a research pathologist, translational research scientist focusing on developing, evaluating, validating, and applying tissue-based prognostic and predictive biomarkers and models for improved disease prognostication and management of cancer patients. (upstate.edu)
  • The epidemic of Ebola virus disease in West Africa in 2014-2016 and the current Zika virus outbreak have highlighted the importance of having a clear road map for research and development in place before such an event occurs in order rapidly to activate and coordinate research and development and disburse the necessary funds as soon as the need arises. (who.int)
  • 27 countries, and has attracted significant interest from the research and development community, with efforts to design diagnostic, preventive and therapeutic products for this pathogen and the disease it causes gaining momentum. (who.int)
  • The Armadillo as an experimental model in biomedical research : proceedings of a workshop held at the Pan American Center for Research and Training in Leprosy and Tropical Diseases, Caracas, Venezuela, 23-27 May 1977. (who.int)
  • Man and mouse : animals in medical research / William Paton. (who.int)
  • UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases. (who.int)
  • The prominent role of autophagy signaling pathway was supported by the alteration of autophagy markers in patients and animal models of T1DM, T2DM, and gestational diabetes. (frontiersin.org)
  • Diabetes mellitus (DM) is one of the most prevalent metabolic diseases worldwide. (frontiersin.org)
  • Non-alcoholic fatty liver disease is associated with obesity, non-insulin dependent diabetes, and hypertriglyceridemia and represents the hepatic manifestation of the metabolic syndrome[ 4 ]. (wjgnet.com)
  • At present, cardiovascular origin disorders such as atherosclerotic cardiovascular disease (ASCVD) are the chief reason of illness and death across the globe [ 1 ]. (hindawi.com)
  • MF is characterized by variable degrees of cytopenias, a leukoerythroblastic blood picture, and extramedullary hematopoiesis resulting in progressive splenomegaly and debilitating disease-related constitutional symptoms, compromising quality of life. (haematologica.org)
  • The interstitial lung diseases (ILDs) are a group of diffuse parenchymal lung disorders that are classified according to specific clinical, radiological and histopathological features. (ersjournals.com)
  • 3 Greek Association of Alzheimer's Disease and Related Disorders - GAADRD. (researchgate.net)
  • The MedDiet is suggested as the prevalent dietary regimen and is strongly correlated with prevention of degenerative diseases and longevity. (researchgate.net)
  • Mitochondrial biology, stress signaling and aging-related degenerative diseases. (upstate.edu)
  • The knock-in mice carrying a 72-80 CAG repeat mutation is an accurate genetic model of early stage HD, displaying a more subtle disease phenotype. (nih.gov)
  • Many animal models of IBD have been used to investigate factors such as pathogenic cytokines, pathogenic bacteria, and T-cell functions, including those of T reg cells. (wjgnet.com)
  • We investigate conserved myopathic (muscle disease) processes and perform hierarchical and integrative analysis of muscle function from the level of single molecules and macromolecular complexes through the level of the tissue itself. (hopkinsmedicine.org)
  • Broeckel R, Haese N,Messaoudi I, Streblow DN;Nonhuman Primate Models of Chikungunya VirusInfection and Disease (CHIKV NHP Model). (ohsu.edu)
  • Here we review the pathogenesis, biological consequences, and prognostic impact of bone marrow fibrosis. (haematologica.org)
  • Humanized mouse models can sustain DENV replication and show some signs of disease, but further development is needed to validate the immune response. (mdpi.com)
  • We can learn much by studying the temporal and spatial evolution of the lesions in the nervous system in spontaneously occurring or induced diseases in animals.The rapid development of the dog genome map brings an important benefit to the study of inherited canine diseases. (stanford.edu)
  • Interstitial lung disease (ILD) encompasses a large and diverse group of pathological conditions that share similar clinical, radiological and pathological manifestations, despite potentially having quite different aetiologies and comorbidities. (ersjournals.com)
  • Blueprint) for potentially epidemic diseases. (who.int)
  • 9) Likely, the persistent sequelae of COVID-19 represent multiple syndromes resulting from distinct pathophysiological processes along the spectrum of disease. (cdc.gov)
  • A growing body of literature implicates the peroxisome proliferators-activated receptors (PPARs) in the pathogenesis and treatment of NAFLD. (wjgnet.com)
  • Other proteins are implicated in other diseases, and different brain regions are affected, but the biochemical principles are very similar. (utoledo.edu)
  • Huntington's disease (HD) is a rare autosomal dominant neurodegenerative disorder caused by mutations in the huntingtin gene (HTT). (wikipedia.org)
  • It is unclear whether these aggregates contribute to the pathogenesis, are a simple by-product or even part of an attempted protective mechanism, described as the aggresome theory (McNaught et al. (ukessays.com)
  • Although SSc-associated ILD (SSc-ILD) is associated more frequently with a nonspecific interstitial pneumonia pattern, which is characterised by homogeneous lesions with predominant inflammatory infiltrates, some aspects of IPF and SSc-ILD suggest that these diseases could share some common features [ 7 ]. (ersjournals.com)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • Scientists at the U.S. Centers for Disease Control and Prevention (CDC), along with state and local public health partners, are tracking 3,487 cases of monkeypox in the United States as of July 25, 2022. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • To prevent the introduction of infectious agents to the United States, the Centers for Disease Control and Prevention (CDC) requires newly imported NHPs to be quarantined for at least 31 d, during which time their health is closely monitored. (cdc.gov)
  • The membranous neurocranium is derived from mesenchyme that invests the developing brain, a relationship that may help explain the etiology of diseases of premature suture fusion. (medscape.com)