• encephalitis
  • There are currently no effective treatments for arbovirus-induced encephalitis. (grantome.com)
  • We will perform microarray analysis on RNA extracted from the brains of mice infected with WNV or JEV in order to identify novel cellular genes and pathways that are differentially regulated in the brain following virus infection and which may provide therapeutic targets for viral encephalitis. (grantome.com)
  • Vector Infection Determinants of Venezuelan Equine Encephalitis Virus Reside Within the E2 Envelope Glycoprotein Journal of Virology. (jove.com)
  • Two MRIs, one at the time of admission and the second in the convalescent period, were performed for each patient in order to see if there is any sign of central nervous system (CNS) involvement, especially in terms of intracranial haemorrhage or viral encephalitis. (readbyqxmd.com)
  • vector
  • RRV infection occurs most frequently in tropical coastal regions with salt marsh habitats suitable for the principal mosquito vector species [ 19 ]. (uptodate.com)
  • Within this context, and together with our colleagues, we have undertaken a molecular and cellular examination of several elements of the olfactory signal transduction cascade in the principal African malaria vector mosquito Anopheles gambiae sensu stricto and the arbovirus vector Aedes aegypti. (vumc.org)
  • genetic
  • In the final part of this proposal we will evaluate these targets in in vivo and ex vivo models of viral pathogenesis using genetic, pharmacologic and siRNA directed approaches. (grantome.com)
  • Introduction of the PE2 gene from an enzootic subtype ID virus into an epizootic IAB or IC genetic backbone resulted in lower infection rates than those of the epizootic parent. (jove.com)
  • acute
  • Within the acute phase, two stages have been identified: a viral stage during the first five to seven days, during which viremia occurs, followed by a convalescent stage lasting approximately ten days, during which symptoms improve and the virus cannot be detected in the blood. (wikipedia.org)
  • Observations during recent epidemics have suggested chikungunya may cause long-term symptoms following acute infection. (wikipedia.org)
  • Infection of domestic pigs and wild boar results in an acute haemorrhagic fever with transmission by contact or ingestion, or by ticks of the genus Ornithodoros. (readbyqxmd.com)
  • Crimean-Congo haemorrhagic fever (CCHF) is an acute viral haemorrhagic disease. (readbyqxmd.com)
  • pivotal
  • Reactive oxygen species that are mainly generated by the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) enzyme family have a pivotal role in the pathophysiology of many diseases. (readbyqxmd.com)
  • susceptible
  • Other arthropods, like ticks, are also susceptible to WNV infection, and the virus has been repeatedly isolated from both soft and hard ticks [ 9 ], although their role as vectors of WNV transmission is still uncertain. (mdpi.com)
  • Pathogens
  • Chemosensory responses are critical components in the control of several essential behaviors of insects that are vectors for pathogens responsible for many important human diseases. (vumc.org)
  • membrane
  • The nucleocapsid, in turn, is enveloped within a host-derived membrane modified with two viral glycoproteins. (wikipedia.org)
  • precursor
  • Chimeras containing the IAB epizootic structural gene region and, more specifically, the IAB PE2 envelope glycoprotein E2 precursor gene demonstrated an efficient infection phenotype. (jove.com)
  • laboratory
  • Studies of laboratory infections in the natural host will help to understand variations in susceptibility and reservoir competence among bird species, as well as in the epidemiological patterns found in different affected areas. (mdpi.com)
  • occurs
  • To be most effective, they should be used before an infection occurs and are therefore recommended between the ages of nine and 13. (wikipedia.org)
  • people
  • Other epidemics of viral diseases that depend on large concentrations of people, such as mumps, rubella and polio, also first occurred at this time. (wikipedia.org)
  • In some people, an HPV infection persists and results in warts or precancerous lesions . (wikipedia.org)
  • clinical
  • This paper will review clinical aspects of pulmonary involvement in the systemic vasculitides and explores the impact which the discovery of auto-antibodies in these disorders has had on our understanding of their pathogenesis. (bmj.com)
  • nature
  • While cases of warts have been described since the time of ancient Greece , their viral nature was not discovered until 1907. (wikipedia.org)
  • Persons
  • TLC seeks to reduce "community viral load," reducing the risk to uninfected persons by reducing the infectiousness of HIV-infected individuals. (vumc.org)