• genetic
  • In the final part of this proposal we will evaluate these targets in in vivo and ex vivo models of viral pathogenesis using genetic, pharmacologic and siRNA directed approaches. (grantome.com)
  • Introduction of the PE2 gene from an enzootic subtype ID virus into an epizootic IAB or IC genetic backbone resulted in lower infection rates than those of the epizootic parent. (jove.com)
  • cellular
  • Ross River virus: molecular and cellular aspects of disease pathogenesis. (ajtmh.org)
  • Herpes Simplex Virus 2 VP22 Phosphorylation Induced by Cellular and Viral Kinases Does Not Influence Intracellular Localization Virology. (jove.com)
  • Pubmed ID: 15527835 Phosphorylation of the herpes simplex virus (HSV) VP22 protein is regulated by cellular kinases and the UL13 viral kinase, but the sites at which these enzymes induce phosphorylation of HSV-2 VP22 are not known. (jove.com)
  • acute
  • Within the acute phase, two stages have been identified: a viral stage during the first five to seven days, during which viremia occurs, followed by a convalescent stage lasting approximately ten days, during which symptoms improve and the virus cannot be detected in the blood. (wikipedia.org)
  • Observations during recent epidemics have suggested chikungunya may cause long-term symptoms following acute infection. (wikipedia.org)
  • Infection of domestic pigs and wild boar results in an acute haemorrhagic fever with transmission by contact or ingestion, or by ticks of the genus Ornithodoros. (readbyqxmd.com)
  • Crimean-Congo haemorrhagic fever (CCHF) is an acute viral haemorrhagic disease. (readbyqxmd.com)
  • mosquito
  • We have identified viral genome-derived RNA segments that can be expressed in mosquito midguts and salivary glands to ablate homologous virus replication and transmission. (jove.com)
  • The finding that the E2 envelope glycoprotein, the site of epitopes that define the enzootic and epizootic subtypes, also encodes mosquito infection determinants suggests that selection for efficient infection of epizootic mosquito vectors may mediate VEE emergence. (jove.com)
  • vectors
  • Other arthropods, like ticks, are also susceptible to WNV infection, and the virus has been repeatedly isolated from both soft and hard ticks [ 9 ], although their role as vectors of WNV transmission is still uncertain. (mdpi.com)
  • Chemosensory responses are critical components in the control of several essential behaviors of insects that are vectors for pathogens responsible for many important human diseases. (vumc.org)
  • The distinction is of great practical importance because the two subfamilies tend to differ in their significance as vectors of different classes of diseases. (wikipedia.org)
  • clinical
  • The illnesses caused by the arbovirus have very similar/overlapping clinical presentation with prominent fever, headache, rash, myalgia and arthralgia. (biomedcentral.com)
  • This paper will review clinical aspects of pulmonary involvement in the systemic vasculitides and explores the impact which the discovery of auto-antibodies in these disorders has had on our understanding of their pathogenesis. (bmj.com)
  • pivotal
  • Reactive oxygen species that are mainly generated by the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) enzyme family have a pivotal role in the pathophysiology of many diseases. (readbyqxmd.com)
  • disease
  • There are numerous arboviruses throughout the world capable of causing human disease spanning different viral families and genera. (biomedcentral.com)
  • precursor
  • Chimeras containing the IAB epizootic structural gene region and, more specifically, the IAB PE2 envelope glycoprotein E2 precursor gene demonstrated an efficient infection phenotype. (jove.com)
  • pregnancy
  • The full range of birth defects caused by infection during pregnancy is not known, but they appear to be common, with large scale abnormalities seen in up to 42% of live births. (wikipedia.org)
  • Microbial etiology and susceptibility of community urinary tract infections during pregnancy in the south of Brazil]. (readbyqxmd.com)
  • Urinary tract infection (UTI) is one of the most common conditions during pregnancy. (readbyqxmd.com)
  • different
  • Studies of laboratory infections in the natural host will help to understand variations in susceptibility and reservoir competence among bird species, as well as in the epidemiological patterns found in different affected areas. (mdpi.com)
  • In reality, therefore "ANCA" now refer to an increasing number of autoantibodies directed against targets within neutrophils and are associated, in general with clinically different, although often overlapping, diseases. (bmj.com)
  • people
  • Other epidemics of viral diseases that depend on large concentrations of people, such as mumps, rubella and polio, also first occurred at this time. (wikipedia.org)
  • Persons
  • TLC seeks to reduce "community viral load," reducing the risk to uninfected persons by reducing the infectiousness of HIV-infected individuals. (vumc.org)