Pathogen genome fungal. Medical search. Frequent questions

These studies strengthened U. maydis as a model organism, and began the functional investigation of NATs in U. maydis, which identified a new class of fungal pathogenesis genes. (trentu.ca)
Comparative analyses of its 38.5-megabase genome, which encodes 13,210 predicted genes, reveal the species's unique wood-degrading machinery. (nature.com)
Sequence data of the revised genome annotation including several hundreds of novel transcripts, improved gene models and candidate genes for alternative splicing have been made accessible in a comprehensive database. (biomedcentral.com)
Large-scale genomics and transcriptomics approaches have been proven to enable the identification of pathogenicity genes in fungi affecting humans or plants [ 8 ], which makes them valuable tools towards a better understanding of fungal infection mechanisms. (biomedcentral.com)
Her work has contributed to scientific understanding of the effects of agricultural practices on foodborne pathogens and antibiotic resistance genes in food-producing animals. (farmprogress.com)
With the availability of the genome sequence of Fusarium graminearum our focus is now on identification of new metabolites corresponding to the predicted secondary metabolite biosynthetic genes and the elucidation of the biochemical effects of such compounds. (boku.ac.at)
During the past decade he has led research on dissecting the wheat interactions with Septoria and identification of disease resistance genes in wheat, and more recently also on understanding the genetic basis of resistance to fungal pathogens such as Cercospora and mildew in legumes and development of new RNA-interference based and genome editing approaches for crop improvement. (niab.com)
Summary: This BBSRC/NSF-BIO funded project seeks to understand how the interactions between host immunity genes and pathogen virulence genes influence the evolution of pathogen populations to overcome host resistance. (niab.com)
The sources of genome expansion include group I introns and accessory genes encoding putative homing endonucleases, DNA and RNA polymerases (presumed to be of plasmid origin) and hypothetical proteins. (umd.edu)
The two smallest sequenced genomes (A. terreus and P. chrysogenum) do not contain introns in protein-coding genes, whereas the largest genome (T. stipitatus), contains a total of eleven introns. (umd.edu)
Despite the conservation of the core genes, the mitochondrial genomes of Aspergillus and Penicillium species examined here exhibit significant amount of interspecies variation. (umd.edu)
Published results of their research "provide a detailed overview of the functional portions of the barley genome, the order and structure of most of its 32,000 genes," according to a university statement. (parkbugle.org)
To put things in perspective, Muehlbauer says that, although the humble barley genome contains about the same number of genes as the human genome, it's twice as big as ours. (parkbugle.org)
Some of the induced genes participate in host defense against the pathogens, for example through ubiquitin-mediated inhibition. (bvsalud.org)

Direct interactions with other members of the community involved many fungal and bacterial ASVs (amplicon sequence variants). (biorxiv.org)
Genome sequence of Sclerotinia sclerotiorum hypovirulence-associated DNA virus-1 found in the fungus Penicillium olsonii isolated from Washington state, USA. (usda.gov)
Comparative analysis of RNA-Seq data and the genome sequence did not provide evidence for RNA editing in C. graminicola . (biomedcentral.com)
To facilitate analysis of copy number variations, single nucleotide polymorphisms and loss of heterozygosity events in these pathogens, we developed a pipeline for analyzing diverse genome-scale datasets from microarray, deep sequencing, and restriction site associated DNA sequence experiments for clinical and laboratory strains of Candida albicans, the most prevalent human fungal pathogen. (nih.gov)
Genome sequence and spore germination-associated transcriptome analysis will contribute to the understanding of the molecular mechanism of pathogenicity and spore germination of C. cassiicola . (biomedcentral.com)
Although conspecific, HGCC exhibited distinct genome sequence differences from a rubber tree-sampled isolate (CCP) and a human-sampled isolate (UM591). (biomedcentral.com)
Here we report the complete sequence and annotation of the mitochondrial genomes of six Aspergillus and three Penicillium species: A. fumigatus, A. clavatus, A. oryzae, A. flavus, Neosartorya fischeri (A. fischerianus), A. terreus, P. chrysogenum, P. marneffei, and Talaromyces stipitatus (P. stipitatum). (umd.edu)
In this study, the Illumina HiSeq 4000 and PacBio platforms were used to sequence and assemble the whole genome of Fusarium equiseti D25-1. (researchsquare.com)
The total repetitive sequence length was 1,713,918 bp, accounting for 4.2033% of the genome. (researchsquare.com)
For the TCAP," Muehlbauer says, "the barley genome sequence will be quite useful and a powerful tool to increase the efficiency of barley breeding. (parkbugle.org)
Its goal was to release an annotated assembly from 10X genome sequence coverage for Batrachochytrium dendrobatidis diploid strain JEL423, which was provided by Dr. Joyce Longcore at The University of Maine. (broadinstitute.org)
This basal position increases the value of a whole genome sequence for comparative genomics within the fungal clade and also with the sister animal clade. (broadinstitute.org)
Complete Genome Sequence of Mycoplasma pneumoniae Type 2 Reference Strain FH Using Single-Molecule Real-Time Sequencing Technology. (cdc.gov)

The research presented here improved U. maydis genome annotation through the analysis of cDNA library sequences and comparative genomics. (trentu.ca)
Broad Genomics Platform sequences a whole human genome every four minutes. (broadinstitute.org)
Binning of the metagenomic sequences allowed de novo assembly of mulitple high quality genomes of different endophytic bacterial genera. (apsnet.org)
First, we reported the draft genome sequences of the cucumber-sampled C. cassiicola isolate HGCC with high virulence. (biomedcentral.com)
Their mitochondrial genomic sequences may hold vital clues into the mechanisms of their evolution, population genetics, and biology, yet only a handful of these genomes have been fully sequenced and annotated. (umd.edu)
The genome can show multiple gene sequences providing some areas of resistance," Muehlbauer says. (parkbugle.org)
Phylogenetic studies based on rDNA and on whole mitochondrial genome sequences indicate that the chytrids are basal in the fungal clade (3,7). (broadinstitute.org)
Genome Sequences of Three Brucella canis Strains Isolated from Humans and a Dog. (cdc.gov)
This approach has been called " genomic epidemiology "-using pathogen genome sequences to detect emerging diseases, assess their potential virulence and resistance to antibiotics, and monitor their spread in populations. (cdc.gov)

involved in brown rot diseases, will serve as a valuable resource for studies on populations biology and plant-pathogen interactions. (uniba.it)
U. maydis is the model to study basidiomycete biotrophic plant-pathogen interactions. (trentu.ca)
This approach could be used to identify and promote micro-organisms with beneficial effects against residue-borne pathogens, and more broadly, to decipher the complex interactions between multi-species pathosystems and other microbial components in crop residues. (biorxiv.org)
Supercharging SIP in the Fungal Hyphosphere Applying high-throughput stable isotope probing to the study of a particular fungi, researchers identified novel interactions between bacteria and the fungi. (doe.gov)
Professor Rob Jackson is an expert in bacteria-plant interactions, making major contributions to the understanding of how pathogens cause disease and how pathogens evolve to evade host immunity. (birmingham.ac.uk)
This pre-packaging approach provides a simple, one step process to initiate microfluidics in any setting for fungal studies, bacteria-fungal interactions, and other biological inquiries. (springer.com)
More basic research concerned microbial ecology of BCAs including molecular interactions with their host fungal pathogen. (slu.se)
We are also building up expertise in genomics and transcriptomics for studying community structures and their function, and gene expression in fungal host interactions. (slu.se)
have been sequenced and annotated in the research group and analysis of several transcriptomes from biocontrol or plant pathogen interactions are studied. (slu.se)
Since the beginning of my research career, I have worked with Boolean gene regulatory network models, the HP model of protein folding, stem cell regulation, circadian clocks in plants, plant-pathogen interactions, evolutionary algorithms, degradation of soil organic matter by fungi and methods for processing spectroscopic imaging data. (lu.se)
Multi-kingdom microbiota analyses identify bacterial-fungal interactions and biomarkers of colorectal cancer across cohorts. (who.int)

In the human fungal pathogen Candida albicans, CNV and LOH confer increased virulence and antifungal drug resistance, yet the mechanisms driving these rearrangements are not completely understood. (technion.ac.il)
In addition to identifying pathogens faster and more precisely, high-throughput technologies and bioinformatics can provide new insights into disease transmission, virulence, and antimicrobial resistance. (cdc.gov)
Comparing the assembled genome with reference strains facilitates many different inferences, such as pathogen identification, high-resolution strain typing, and prediction of important phenotypic characteristics (e.g., virulence, antimicrobial resistance). (cdc.gov)
Well-curated and up-to-date reference databases are crucially important because microbial pathogens evolve rapidly and bacteria can exchange plasmids—often encoding virulence and antimicrobial resistance traits—across strains and species. (cdc.gov)

Advance the use of genomics and metagenomics for detecting fungal pathogens and antifungal drug resistance. (cdc.gov)
In November 2022, Broad's Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th. (broadinstitute.org)
Silver Age of GOLD Introduces New Features The Genomes OnLine Database makes curated microbiome metadata that follows community standards freely available and enables large-scale comparative genomics analysis initiatives. (doe.gov)
2006. Comparative genomics reveals what makes an enterobacterial plant pathogen . (hutton.ac.uk)
Through comparative and evolutionary genomics, five members of the Leptosphaeria maculans-Leptosphaeria biglobosa species complex (class Dothideomycetes, order Pleosporales), having different host ranges and pathogenic abilities towards cruciferous plants, were studied to infer the role of TEs on genome shaping, speciation, and on the rise of better adapted pathogens. (pasteur.fr)
These research directions required the establishment of firm interdisciplinary collaborations with chemists and plant breeders, which was achieved by obtaining funding for a larger consortium from the Austrian genome programme GEN-AU (coordinator: G. Adam) The establishment of Fusarium genomics resources (e.g. (boku.ac.at)
Integrating pathogen genomics with epidemiology is enhancing public health efforts to prevent transmission of communicable diseases, such as tuberculosis (TB). (cdc.gov)

however, thorough genome annotation is required to fully realize the value of this resource. (trentu.ca)

Fungal Genetics and Biology. (hutton.ac.uk)
In this we have gathered complementing methodological competences so we now have a platform for exploiting technologies with filamentous fungi such as: Fungal transformation & gene constructions, DNA reporter technology (GFP, DsRed etc.), advanced fluorescent microscopy, gene knock outs and complementation, arrays and quantitative PCR, fungal characterization and diagnostic molecular tools as well as methods in evolutionary genetics. (slu.se)
Prof. Gary Muehlbauer, 49, who holds the Endowed Chair in Molecular Genetics Research and Education at the University of Minnesota, was part of an international team that completed the sequencing of the barley genome. (parkbugle.org)

The decimation of susceptible "Gros Michel" bananas that were grown in large-scale monoculture plantations in Central America during the 1900s earned Fusarium wilt its reputation as a pathogen of global significance. (frontiersin.org)
2007): The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization. (boku.ac.at)
Güldener U, Mannhaupt G, Münsterkötter M, Haase D, Oesterheld M, Stümpflen V, Mewes H-W, Adam G (2006) FGDB: a comprehensive fungal genome resource on the plant pathogen Fusarium graminearum . (boku.ac.at)
Fusarium equiseti is a plant pathogen with a wide range of hosts and diverse effects, including probiotic activity. (researchsquare.com)
F. equiseti was most closely related to Fusarium pseudograminearum based on a phylogenetic analysis at the whole-genome level. (researchsquare.com)
Resistance to dry conditions has a special value for barley cultivation, because of a nasty, moisture-loving, fungal pathogen that causes a plant disease called fusarium head blight. (parkbugle.org)
The newly mapped genome may hold the key to eventually developing a strain of fusarium-resistant barley. (parkbugle.org)

In 2012, the same group of scientists decoded the genome of Macrophomina phaseolina, a Botryosphaeriaceae fungus, which is responsible for causing seedling blight, root rot, and charcoal rot of more than 500 crop and non-crop species throughout the world. (wikipedia.org)
However, the pathogen uses at least two different detoxification mechanisms that enable the fungus to successfully spread on plants defended in this way. (mpg.de)
Repeat-Induced Point mutation and gene conversion coinciding with heterochromatin shape the genome of a plant-pathogenic fungus. (mpg.de)
The team studied patients infected with the fungus Candida albicans ( C. albicans ), which causes common yeast infections and more serious bloodstream infections, who were being treated with fluconazole, one of the primary anti-fungal drugs now in use. (sciencedaily.com)
Nail fungus treatments may be failing because what we have identified as a fungal nail is actually a mixed bacterial and fungal infection (polymicrobial onychopathy). (nova.edu)
As part of earlier research, Drott, who works in the Keller Lab, had sequenced the genomes of 94 strains of Aspergillus flavus, a well-studied fungus known to cause corn rot and act as a human pathogen, sampled from across the eastern and central United States. (eurekalert.org)

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a comprehensive review of the biology and diseases of fungal pathogens. (cshlpress.com)
The Science: Researchers sequenced and analyzed the genome of Mixia osmundea, the smallest fungal plant pathogen (13.6 million bases) to date, to provide insight into its mode of pathogenicity and reproductive biology. (doe.gov)
Genome Biology. (hutton.ac.uk)
Measures to combat fungal infections require detailed knowledge of the fungal infection biology. (biomedcentral.com)
He serves on the Editorial Boards of Annual Review of Cell and Developmental Biology and Genome Biology. (elifesciences.org)

Genome rearrangements resulting in copy number variation (CNV) and loss of heterozygosity (LOH) are frequently observed during the somatic evolution of cancer and promote rapid adaptation of fungi to novel environments. (technion.ac.il)
Generate new information about fungal diseases and disease-causing fungi. (cdc.gov)
Use whole genome sequencing to study how and why certain fungi spread and make people sick. (cdc.gov)
Fungal community structure differed between the two lines at harvest, but not subsequently, suggesting that the presence/absence of the resistance gene influences the microbiome at the base of the stem whilst the plant is alive, but that this does not necessarily lead to differential colonisation of the residues by fungi. (biorxiv.org)
In this work we (1) determine the shelf-life of ready-to-use microfluidics, (2) demonstrate biofilm-like colonization on fungi, (3) describe bacterial motility on fungal hyphae (fungal highway), (4) report material-dependent bacterial-fungal colonization, (5) demonstrate germination of vacuum-sealed Arabidopsis seeds in microfluidics stored for up to 2 weeks, and (6) observe bidirectional cytoplasmic streaming in fungi. (springer.com)
In addition to its economical importance, C. graminicola is among the best characterized and most tractable fungi of the genus Colletotrichum , a genus comprising a broad range of hemibiotrophic plant pathogens that represent a constant threat to fruit and vegetable production worldwide ( http://www.broadinstitute.org ). (biomedcentral.com)
Many plant-pathogenic fungi have a tendency towards genome size expansion, mostly driven by increasing content of transposable elements (TEs). (pasteur.fr)
Before this study, most people just looked at one strain of a fungi species, one genome, and they determined that the metabolites present should be the same among all strains," said Tomás Rush, a postdoctoral researcher in ORNL's Biosciences Division who co-authored the research. (eurekalert.org)
The findings, published in the Proceedings of the National Academy of Sciences , represent a major shift from the conventional scientific understanding of fungal evolution, which is based on the idea that genetic diversity is relatively random within fungi species, with evolution occurring slowly and throughout an entire species. (eurekalert.org)
Likewise, for doctors treating fungal diseases, knowing which strain of fungi is afflicting a patient - and what that strain's metabolomic profile looks like - could be key to finding the correct cure. (eurekalert.org)
The accompanying comparative analysis of these and related publicly available mitochondrial genomes reveals wide variation in size (25-36 Kb) among these closely related fungi. (umd.edu)

2022) Genome-wide functional screens enable the prediction of high activity CRISPR-Cas9 and -Cas12a guides in Yarrowia lipolytica . (doe.gov)

Sclerotinia sclerotiorum is a devastating fungal pathogen that can infect more than 400 different plant species. (mpg.de)
In this study, we undertook extensive genome-wide comparative analyses of twelve species that conform the Pectobacterium genus. (mdpi.com)
2006. Assessing the potential of regions of the nuclear and mitochondrial genome to develop a 'molecular tool box' for the detection and characterization of Phytophthora species . (hutton.ac.uk)
Invasion of L. maculans 'brassicae' genome by TEs followed by bursts of TE activity allowed this species to evolve and to better adapt to its host, making this genome species a peculiarity within its own species complex as well as in the Pleosporales lineage. (pasteur.fr)
We focus on three related fungal rust species that infect different cereal crop hosts: stem rust infecting wheat, brown rust infecting barley, and crown rust infecting oats. (niab.com)
These present contrasting levels of sexuality versus clonality and provide an opportunity to compare and contrast between related pathogen species and their hosts and different levels of sexual versus clonal reproduction. (niab.com)
Focusing on the Aspergillus species complex, we will develop a systems-based approach that links the impact of fungicides on the ecology of fungal communities through to human exposure to these potentially deadly fungal bioaerosols. (niab.com)
This pathogen infects cucumber species and causes cucumber target spot, which has recently caused large cucumber yield losses in China. (biomedcentral.com)
The genera Aspergillus and Penicillium include some of the most beneficial as well as the most harmful fungal species such as the penicillin-producer Penicillium chrysogenum and the human pathogen Aspergillus fumigatus, respectively. (umd.edu)
All of the sequenced genomes have a group I intron in the large ribosomal subunit RNA gene, suggesting that this intron is fixed in these species. (umd.edu)
and 6 (3%) concerned genomes of other animal species (Figure). (cdc.gov)

The work started at UW-Madison, where Nancy Keller leads a research program on fungal pathogenesis in the UW School of Medicine and Public Health. (eurekalert.org)

Track the emergence and spread of fungal diseases by conducting molecular surveillance and genomic epidemiology. (cdc.gov)
Molecular (DNA) diagnostics, targeting the genome of microorganisms, have shown that there are often more and different pathogens causing nail disease than what we currently identify via cultivation in lab. (nova.edu)
Crouch is a molecular biologist whose work has been key to understanding the global diversity of fungal pathogens that cripple horticultural plants, turfgrass and cereal crops. (farmprogress.com)
She has developed molecular markers, diagnostic assays, genome tools and taxonomic resources that are used to combat downy mildews, boxwood blight, dollar spot and other plant diseases threatening crops across the United States and worldwide. (farmprogress.com)
With a background in virology, Dr Kanyuka's overall research interest is to understand how pathogens cause disease on plants and how plants resist pathogens at the mechanistic and molecular level with the aim of developing sustainable solutions for disease control in crops, extensively utilising existing and developing new plant virus-based expression tools for rapid gene function analysis in both plants and the associated pathogens. (niab.com)
Summary: This NERC funded project aims to use molecular-based surveys and ecological experimentation to map, measure and mechanistically dissect the eco-evolutionary processes including agricultural practices and green waste recycling that drive evolution of fungicide resistance in fungal pathogens. (niab.com)
Molecular epidemiological survey of bacterial and parasitic pathogens in hard ticks from eastern China. (cdc.gov)
The focus is on pathogen genomes, applying advances in molecular and bioinformatics methods first developed for human genome research. (cdc.gov)
The US public health system is integrating pathogen genome sequencing into infectious disease surveillance with support from the Advanced Molecular Detection (AMD) program established by Congress at the Centers for Disease Control and Prevention (CDC) in 2014. (cdc.gov)

CDC's lead group for preventing illness and death from fungal diseases in the United States and throughout the world. (cdc.gov)
The goal of CDC's Mycotic Diseases Branch (MDB) is to prevent illness and death from fungal diseases . (cdc.gov)
We are one of few public health groups in the world devoted to the prevention and control of fungal diseases. (cdc.gov)
We also investigate outbreaks and develop interventions to prevent fungal diseases. (cdc.gov)
Provide training and education about fungal diseases. (cdc.gov)
Calculate the number of people who get sick from fungal diseases. (cdc.gov)
Track trends and patterns in how fungal diseases affect people. (cdc.gov)
Promote education and awareness about fungal diseases. (cdc.gov)
Develop and evaluate ways to prevent fungal diseases. (cdc.gov)
Help prepare healthcare facilities and laboratories in other countries to better detect and treat fungal diseases. (cdc.gov)
Many people at risk for and suffering from fungal diseases live in limited-resource settings. (cdc.gov)
These areas of the world often lack the laboratory infrastructure needed to diagnose fungal diseases, and limited availability of antifungal medications means that some patients may not have access to lifesaving treatments. (cdc.gov)
Sign up for the Fungal Diseases Newsletter for updates from CDC's Mycotic Diseases Branch. (cdc.gov)
This novel genotyping approach is a new cost-effective tool to explore a previously unrecognized class of repeat variation in genome-wide association studies of complex diseases. (nanoporetech.com)
My research in Denmark was focussing on root pathology, seed borne pathogens and post harvest diseases - with the main effort on biological control. (slu.se)
Dr. Chiller is an Infectious Disease Physician, who has specialized in fungal diseases for the past 20 years. (cdc.gov)
He leads CDC's efforts to combat fungal diseases as the Chief of the Mycotic Diseases Branch in the Office of Emerging Infectious Diseases in the National Center for Emerging and Zoonotic Infectious Diseases at CDC. (cdc.gov)
Therefore, the pathogenic mechanism of C. cassiicola against plants should be well studied to effectively control diseases caused by this pathogen. (biomedcentral.com)

We work with partners to understand who gets fungal infections and why they get them by using epidemiology and microbiology research. (cdc.gov)
Oilseed rape residues are a crucial determinant of stem canker epidemiology, as they support the sexual reproduction of the fungal pathogen Leptosphaeria maculans . (biorxiv.org)
The ecology, evolution, and epidemiology of human fungal pathogens are also explored. (cshlpress.com)

Although microbial genomes are generally smaller and less complex than human genomes, long-read sequencing technologies (such as single-molecule real-time (SMRT) sequencing, Pacific Biosciences, Menlo Park, CA) are useful for constructing complete, highly accurate genomes and sorting out plasmids, repeats, and other complex regions. (cdc.gov)

The use of evolutionary analyses to predict functionally relevant traits in filamentous plant pathogens. (mpg.de)
Metagenomic analyses showed a significant enrichment of Chitinophagaceae, Flavobacteriaceae, Burkholderiaceae, Pseudomonadaceae and Xanthomonadaceae families in the endosphere of plants challenged with the fungal pathogen. (apsnet.org)
Subsequent trait-based analyses revealed numerous biosynthetic gene clusters (BGCs) overrepresented in the endophytic bacterial families of plants under pathogen attack, including BGCs involved in signal transduction, extracellular enzyme and secondary metabolite production. (apsnet.org)
Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives. (kegg.jp)

Serratia marcescensantibiotic resistance mechanisms of an opportunistic pathogen: a literature review. (mpg.de)

S. commune has been reported to be a pathogen of humans and trees, but it mainly adopts a saprobic lifestyle by causing white rot 6 . (nature.com)
Virtually all humans are colonized with Candida albicans , but in some individuals this benign organism becomes a serious, life-threatening pathogen," the team wrote. (sciencedaily.com)
Candida albicans is the most frequently isolated fungal pathogen of humans, affecting immuocompromised patients ranging from premature infants to AIDS sufferers. (sdsu.edu)

Candidemia, which is the bloodstream manifestation of fungal infections due to Candida , turns out in recent studies that we've looked at are the most common if not some of the most common healthcare associated bloodstream infections in our country, in the United States. (cdc.gov)
The risk factors for candid are sometimes we call in the fungal world the other C. diff , have somewhat similar characteristics in that broad spectrum antibacterial use is a very common association with those who develop infections due to Candida . (cdc.gov)

The aim of this study was to characterise the impact of a resistance gene against L. maculans infection on residue microbial communities and to identify micro-organisms interacting with this pathogen during residue degradation. (biorxiv.org)
Linkage QTL mapping and genome-wide association study on resistance in chickpea to Pythium ultimum. (usda.gov)
Here, we used genome sequencing of isolates sampled consecutively from patients that were clinically treated with fluconazole to systematically analyze the genetic dynamics that accompany the appearance of drug resistance during oral candidiasis [infection]. (sciencedaily.com)

This volume includes discussions about options for diagnosing and treating fungal infections, as well as challenges presented by emerging drug-resistant strains. (cshlpress.com)
Analyzing the entire genomes, Drott concluded that the strains comprised three genetically distinct populations. (eurekalert.org)
Examples of recent important projects are the 1001 Genomes project for Arabidopsis thaliana, and the systematic dissection of deleterious epistasis between Arabidopsis strains due to autoimmunity. (elifesciences.org)

Our comprehensive analysis of the whole genome of F. equiseti provides basic data for studies of gene expression, regulatory and functional mechanisms, evolutionary processes, as well as disease prevention and control. (researchsquare.com)

Genome Evolution and Innovation across the Four Major Lineages of Cryptococcus gattii. (broadinstitute.org)
Tracing the Evolution of Shiitake Mushrooms Understanding Lentinula genomes and their evolution could provide strategies for converting plant waste into sugars for biofuel production. (doe.gov)
The finding could open new avenues for drug discovery and provide a deeper understanding of fungal evolution. (eurekalert.org)

Fungal secondary metabolites have been widely studied because of their significance to human health. (eurekalert.org)
Her lab focuses on histones, which package the entirety of the human genome into chromatin. (elifesciences.org)
Genomes are found at all three corners of the epidemiologic triangle: human or animal hosts are engaged in genomic contests with pathogens of all kinds, played out in an environment teeming with the genomes of other people, animals, plants, and microbes. (cdc.gov)

We wanted to find out how successful plant pathogens overcome the plant defense and colonize these plants. (mpg.de)
The researchers were able to show experimentally that the defense based on glucosinolates is actually effective against fungal attacks. (mpg.de)

If a fungal infection spreads to the bloodstream (for example, via catheters or central intravenous lines), it can be deadly. (sciencedaily.com)
Here, we show that when the mosquito is infected with this parasite, it is also significantly more susceptible to infection by an opportunistic bacterial pathogen, Serratia marcescens. (bvsalud.org)
The model organism Caenorhabditis elegans is susceptible to infection by obligate intracellular pathogens, specifically microsporidia and viruses. (bvsalud.org)

Respond quickly to fungal disease outbreaks and other emerging issues. (cdc.gov)
The role of the microbiota in the plant's response to a disease or in the pathogenicity of a fungal pathogen is currently being studied in various pathosystems, but remains poorly understood. (biorxiv.org)
This study will test 25-50 individuals seeking treatment for suspected fungal nail disease (onychomycosis). (nova.edu)
It is certainly an honor and a pleasure to be here during our first inaugural Fungal Disease Awareness Week, and I look forward to talking to you a little bit about an emerging fungal pathogen that is really causing some consternation and challenges amongst the healthcare community. (cdc.gov)
So generally, as you all know who work in healthcare and see infections, you know that most of the time the public thinks of fungal disease as what is shown in the picture here. (cdc.gov)
Scientists like Muehlbauer are clearly in the frontlines of the global struggle against agricultural disease, but happily that's not the only use that they will find for the barley genome. (parkbugle.org)

Genome variation in Cryptococcus gattii, an emerging pathogen of immunocompetent hosts. (broadinstitute.org)

A thousand-genome panel retraces the global spread and adaptation of a major fungal crop pathogen. (mpg.de)
In fact, for plant science, you could say that completing the barley genome is something of a warm-up act for the real brass ring of crop sequencing. (parkbugle.org)

This genome sequencing of M. fructigena, as well as for other Monilinia spp. (uniba.it)
Advances in whole-genome sequencing technologies have enabled numerous key discoveries. (researchsquare.com)
The Batrachochytrium dendrobatidis sequencing project is part of the Broad Institute Fungal Genome Initiative. (broadinstitute.org)
Using whole genome sequencing to investigate transmission in a multi-host system: bovine tuberculosis in New Zealand. (cdc.gov)
Because of device portability, fast sample preparation, flexibility, and relatively low cost, nanopore sequencing is becoming a feasible first-line strategy for pathogen sequencing in clinical and public health settings. (cdc.gov)

It is therefore an essential reference for all fungal biologists and medical professionals who wish to understand and manage these difficult pathogens. (cshlpress.com)
The study expands the genomic resources available to fungal biologists by providing mitochondrial genomes with consistent annotations for future genetic, evolutionary and population studies. (umd.edu)

According to Shomron 7 (2010), this field of the clinical pharmacology studies the contribution of genomes, transcriptomes and proteomes in determining drug-response phenotypes (safety and efficacy). (bvsalud.org)

He presented work looking at genome organization and single-molecule transcript analysis of long cDNAs in C. elegans. (nanoporetech.com)

The barley genome is only one-third as big as the wheat genome," he notes. (parkbugle.org)

Assembled genomes can be compared with others to look for phylogenetic clustering as evidence of transmission. (cdc.gov)

The ability of Aedes aegypti mosquitoes to transmit vertebrate pathogens depends on multiple factors, including the mosquitoes' life history traits, immune response, and microbiota (i.e., the microbes associated with the mosquito throughout its life). (bvsalud.org)
aegypti mosquitoes and severely affects mosquito survival and other life history traits critical for pathogen transmission. (bvsalud.org)

Hybrid inferiority and genetic incompatibilities drive divergence of fungal pathogens infecting the same host. (mpg.de)

Detecting fungal outbreaks early is important so that the people affected can get the right treatment and so that health officials can prevent others from getting sick. (cdc.gov)

We therefore asked ourselves whether widespread fungal pathogens have strategies to adapt to the chemical defenses of plants of the cabbage family,' Jingyuan Chen, the first author of the study, explains. (mpg.de)

Anatomy14

Organisms48

Diseases12

Chemicals and Drugs32

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Phenomena and Processes120

Disciplines and Occupations4

Technology, Industry, Agriculture6

Information Science12

Health Care4

Genes14

Sequence13

Sequences9

Interactions11

Virulence4

Genomics7

Annotation1

Genetics3

Fusarium7

Fungus6

Biology5

Fungi11

20221

Species11

Pathogenesis1

Molecular9

Diseases18

Epidemiology3

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Analyses4

Opportunistic pathogen1

Humans3

Candida2

Resistance3

Strains3

Mechanisms1

Evolution3

Human3

Defense2

Infection3

Disease6

Cryptococcus1

Crop2

Sequencing5

Biologists2

Transcriptomes1

Single-molecule1

Wheat1

Phylogenetic1

Traits2

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Adapt1