• A Cochrane Database review evaluated the results of 43 trials with 190,551 participants comparing rotavirus vaccines, both the monovalent and pentavalent types (RV1 and RV5), with placebo. (medscape.com)
  • This 14th module in the series focuses on Rotavirus and its related vaccines. (cdc.gov)
  • Both vaccines were found to be effective in preventing rotavirus diarrhea. (medscape.com)
  • Vaccines (eg, rotavirus) can help increase resistance to infection. (medscape.com)
  • Appropriate Technology in Health (PATH), have identified rotavirus vaccines are under development. (cdc.gov)
  • In both the ChAdOx1 nCoV-19 prime and BBV152 prime cohorts, 186 participants each received the study vaccines. (bvsalud.org)
  • Efficacy, safety and effectiveness of licensed rotavirus vaccines: A systematic review and meta-analysis for Latin America and the Caribbean. (ejournals.ca)
  • Soares-Weiser K, MacLehose H, Ben-Aharon I, Goldberg E, Pitan F, Cunliffe N. Vaccines for preventing rotavirus diarrhoea: vaccines in use. (ejournals.ca)
  • VBI Vaccines Inc. (Nasdaq: VBIV) (TSX: VBV) ("VBI") today announced that, following a review of safety data from the limited safety immunization period, the Data Safety Monitoring Board ("DSMB") has no objection to VBI continuing with the enrollment of participants across all sites and dose groups in the Phase I clinical study to evaluate its preventative cytomegalovirus ("CMV") vaccine candidate . (vbivaccines.com)
  • 116E based vaccine (now known as Rotavac) provided a level of protection (56% during the first year) comparable to other licensed rotavirus vaccines in developing countries [6] which did not drop significantly in the second year of life [7]. (her2signaling.com)
  • I reached out to Dr. Paul Offit, a paediatrician specialized in vaccines and immunology and the co-inventor of the rotavirus vaccine, to get his thoughts on whether antibiotic resistance and vaccine-associated immune escape are indeed comparable. (mcgill.ca)
  • Because of the high death rates in children, vaccination to prevent severe disease outcomes after rotavirus infection is an essential public health strategy ( 2 , 3 ). (cdc.gov)
  • Public health campaigns to combat rotavirus focus on providing oral rehydration therapy for infected children and vaccination to prevent the disease. (wikipedia.org)
  • Within seven days of vaccination, seven (58.3 percent) of the participants in the 10-µg group reported adverse reactions (pain) near the injection site and 24-or 100 percent-in the 30-µg and 100-µg groups and two (22.2 percent) in the placebo group reported reactions. (nvic.org)
  • Three weeks after the initial vaccination with the Pfizer-BioNTech experimental vaccine, all clinical trial participants were given a second dose of the vaccine at the same dosage. (nvic.org)
  • However, because of a lack of understanding and private payment for the rotavirus vaccine, the rotavirus vaccination rate is still low in some countries. (mendeley.com)
  • To assess the impact of shared decision-making (SDM) with the assistance of patient decision aids (PDAs) on the rotavirus vaccination rate, and the knowledge, confidence, and congruence of value among baby's parents when decision-making. (mendeley.com)
  • The influence of SDM on the acceptance of rotavirus vaccination was assessed when they were 2 months old. (mendeley.com)
  • Outcome measures were decisional conflict, decision-making difficulties, and rotavirus vaccine knowledge, and the overall rotavirus vaccination rate. (mendeley.com)
  • SDM, parents' education level, and rotavirus vaccination of a previous child were variables that influenced acceptance of rotavirus vaccination. (mendeley.com)
  • The rotavirus vaccination rate was 16.7% higher in the SDM group than the non-SDM group. (mendeley.com)
  • SDM assisted with PDAs gives more information and helps infants' families understand what they need, reduces their decision conflict, and increases their baby's vaccination against rotavirus, which promotes public health. (mendeley.com)
  • 11. Prior to study vaccination has received no doses of IPV or OPV or rotavirus vaccine, based upon documentation or parental history. (who.int)
  • There was significant association between vaccination status and the incidence of acute diarrhea due to rotavirus infection (p value=0.012). (ejournals.ca)
  • A systematic review of the effect of rotavirus vaccination on diarrhea outcomes among children younger than 5 years. (ejournals.ca)
  • Population Impact and Effectiveness of Monovalent Rotavirus Vaccination in Urban Malawian Children 3 Years after Vaccine Introduction: Ecological and Case-Control Analyses. (ejournals.ca)
  • A study of the Moderna vaccine in 34 participants showed "high levels of binding and neutralizing antibodies that declined slightly over time, as expected, but [that] remained elevated in all participants three months after the booster vaccination. (mcgill.ca)
  • an estimated 527,000 childhood deaths occur annually (who.int/immunization_monitoring/burden/rotavirus_estimates/en/index.htm). (cdc.gov)
  • Dr Kampu also informed the participants that Rotavirus is a new vaccine which will be launched in the State soon and it will be included in Routine Immunization as per WHO recommendation in India, an official release informed here today. (sentinelassam.com)
  • For Rotavirus, identify those for whom routine immunization is recommended. (cdc.gov)
  • Participants should have a basic educational background in science including general knowledge in the subject areas of biology, immunization and vaccine-preventable diseases. (cdc.gov)
  • The dataset can be used to generate aggregate measures of association stratified by age group, year of data collection, laboratory detection method, country rotavirus immunization status, clinical severity, strain of pathogen, and community or health facility setting. (uwstartcenter.org)
  • Immunization is an effort that can be done to prevent acute diarrhea due to rotavirus infection. (ejournals.ca)
  • This study aims to investigate the protective effect of immunization against rotavirus on the incidence of acute diarrhea in children due to rotavirus infection. (ejournals.ca)
  • Immunization against rotavirus infection has a statistically significant protective effect against acute diarrhea due to rotavirus infection. (ejournals.ca)
  • The most commonly detected pathogens in the included studies were Campylobacter, ETEC, rotavirus, and Shigella. (uwstartcenter.org)
  • ABSTRACT Data on the economic burden of rotavirus infection in Tunisia are needed to inform the decision to include rotavirus in routine childhood immunizations. (who.int)
  • Rotavirus is usually an easily managed disease of childhood, but worldwide nearly 500,000 children under five years of age still die from rotavirus infection each year and almost two million more become severely ill. (wikipedia.org)
  • Dehydration is more common in rotavirus infection than in most of those caused by bacterial pathogens, and is the most common cause of death related to rotavirus infection. (wikipedia.org)
  • Sanitary measures adequate for eliminating bacteria and parasites seem to be ineffective in control of rotavirus, as the incidence of rotavirus infection in countries with high and low health standards is similar. (wikipedia.org)
  • 3. Any self-reported known or suspected immunosuppressive or immunodeficiency condition (including human immunodeficiency virus [HIV] infection) in the participant or household member (living under the same roof/in the same building rather than in the same compound). (who.int)
  • Through extrapolation, we estimated that rotavirus infection causes approximately 260,910 emergency department visits per year among US children. (itg.be)
  • In Indonesia, the incidence of rotavirus infection was 67% of all cases of acute diarrhea. (ejournals.ca)
  • Rotarix ® vaccine is expected to have protective effect against acute diarrhea due to rotavirus infection. (ejournals.ca)
  • The incidence of rotavirus infection in vaccinated children was 6%, compared to 24% in the non-vaccinated children. (ejournals.ca)
  • The probability of acute diarrhea due to rotavirus infection in both groups were 15% and 52% for the vaccinated and non-vaccinated groups, respectively. (ejournals.ca)
  • John BM, Devgan A, Mitra B. Prevalence of rotavirus infection in children below two years presenting with diarrhea. (ejournals.ca)
  • During this period, 45% of Furthermore, rotavirus is responsible for 25% to 50% of all acute diarrheal hospitalizations among children 0-5 years hospitalizations of children for diarrhea in both industrial- were attributable to rotavirus, higher than previous esti- ized and developing countries (2). (cdc.gov)
  • We estimated that the mean annual incidence of emergency department visits attributable to rotavirus was 12 cases per 1000 children in Cincinnati and 15 cases per 1000 children in Oakland. (itg.be)
  • Background: ROTASIIL, an oral live attenuated bovine-human reassortant pentavalent rotavirus vaccine, was approved in 2017. (bvsalud.org)
  • Findings: 2036 infants were randomly assigned to receive pentavalent rotavirus vaccine (n=1018) or placebo (n=1018). (smu.ac.za)
  • 991 infants assigned to pentavalent rotavirus vaccine and 978 assigned to placebo were included in the per-protocol analysis. (smu.ac.za)
  • Rotaviruses are segmented, double-stranded (ds) RNA viruses that possess a triple-layered protein capsid. (cdc.gov)
  • There are actually five well-known viruses, and the most important one for risk--there is currently is already a vaccine available, even here in the U.S.--is rotavirus. (cdc.gov)
  • Rating the certainty in time-to-event outcomes-Study limitations due to censoring of participants with missing data in intervention studies. (ox.ac.uk)
  • To provide Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) guidance for the consideration of study limitations (risk of bias) due to missing participant outcome data for time-to-event outcomes in intervention studies. (ox.ac.uk)
  • The GRADE working group has published guidance on how to account for missing participant outcome data in binary and continuous outcomes. (ox.ac.uk)
  • When analyzing time-to-event outcomes (e.g., overall survival and time-to-treatment failure) data of participants for whom the outcome of interest (e.g., death and relapse) has not been observed are dealt with through censoring. (ox.ac.uk)
  • The study concluded that there was substantial heterogeneity in pathogen-specific burdens of diarrhea, with important determinants including age, geography, season, rotavirus vaccine usage, and symptoms. (medscape.com)
  • Rotavirus remains the most common cause of severe, Children's Vaccine Program at the Program for dehydrating diarrhea among children worldwide. (cdc.gov)
  • The Asian Rotavirus Surveillance Network, decision was made based on the high incidence of begun in 2000 to facilitate collection of these data, is a regional collaboration of 36 hospitals in nine countries or rotavirus, the most common cause of severe diarrhea in areas that conduct surveillance for rotavirus hospitalizations children worldwide. (cdc.gov)
  • Studies were selected for inclusion if they presented primary data, if their participants had diarrhea and an identified pathogen of interest, and if they either included information about the number of deaths or presented follow-up data for all participants, allowing the team to deduce that no participants died due to enteric pathogens during the study. (uwstartcenter.org)
  • Incidence of acute diarrhea in both groups were measured and subsequent statistical analyses were conducted to determine contributing factors for the protective effect of rotavirus vaccine against acute diarrhea. (ejournals.ca)
  • Burden of Severe Rotavirus Diarrhea in Indonesia. (ejournals.ca)
  • Dr. Bahl highlighted the excellent work done in India on Rotavirus Vaccine, Childhood Diarrhea and Kangaroo Mother Care which has significantly reduced neonatal mortality. (thsti.res.in)
  • It is said that probiotics are very effective in treating diarrhea that is caused by Rotavirus. (discountmill.com)
  • We obtained clinical and demographic information from participants and tested their stool specimens for rotavirus. (itg.be)
  • Stool specimens were requested from any participant who experienced any symptoms and from community members who prepared the food. (health.gov.au)
  • Vaccine response (serum immune response or shedding of RV3-BB in the stool) was assessed in 282 participants. (ebneo.org)
  • In addition to its impact on human health, rotavirus also infects animals, and is a pathogen of livestock. (wikipedia.org)
  • Itanagar: "Rotavirus accounts for 40 per cent of hospitalization due to diarrhoea amongst children and in India, about 78,000 children died annually due to diarrhoea," informed Papum Pare District Medical Officer (DMO) Dr Subu Tasso Kampu during a one-day district level ToT (Training of Trainers) workshop for Rotavirus vaccine introduction programme organized by Papum Pare District Health Society recently. (sentinelassam.com)
  • While stressing the need to vaccinate infants with Rotavirus Vaccine which will prevent 37 to 96 per cent of severe diarrhoea, she further directed all MO in-charges to conduct ToT at block level to the ASHA and anganwadi workers, PRI leaders create more awareness on introduction of the new Rotavirus vaccine. (sentinelassam.com)
  • Although rotavirus was discovered in 1973 and accounts for up to 50% of hospitalisations for severe diarrhoea in infants and children, its importance is still not widely known within the public health community, particularly in developing countries. (wikipedia.org)
  • Kadim M, Soenarto Y, Hegar B, Firmansyah A. Epidemiology of Rotavirus diarrhoea in children underfive: A hospital-based surveillance in Jakarta. (ejournals.ca)
  • Kazimbaya KM, Bosomprah S, Simuyandi M, Chisenga CC, Chilengi R, Munsaka S. Efficacy and Effectiveness of Rotavirus Vaccine on Incidence of Diarrhoea among Children: A Meta-analysis. (ejournals.ca)
  • An older rotavirus vaccine (RotaShield) was associated with an increased incidence of intussusception and is no longer on the market, but RotaTeq did not show an increased risk compared with placebo in clinical trials. (medscape.com)
  • The clinical trials for the rotavirus vaccine RotaTeq took four years and involved 70,000 participants - much more typical than the lightning speed of the COVID vaccine trajectory. (rickilewis.com)
  • However, following completion of clinical trials participants often either do not receive any feedback or materials provided are not appropriate for the context. (ox.ac.uk)
  • CONCLUSION: Active surveillance demonstrated that the burden of laboratory-confirmed rotavirus disease treated in emergency department settings among US children is substantial and greater than estimated previously. (itg.be)
  • PVP-I was tested against Klebsiella pneumoniae and Streptococcus pneumoniae according to bactericidal quantitative suspension test EN13727 and against severe acute respiratory syndrome and Middle East respiratory syndrome coronaviruses (SARS-CoV and MERS-CoV), rotavirus strain Wa and influenza virus A subtype H1N1 according to virucidal quantitative suspension test EN14476. (springer.com)
  • Participants filled an inclusion survey and reported weekly data on acute symptoms. (biomedcentral.com)
  • infants who received scheduled doses of vaccine or placebo without intervening laboratory-confirmed naturally occurring rotavirus disease earlier than 14 days after the third dose and had complete clinical and laboratory results were included in the analysis. (smu.ac.za)
  • 1649 infants underwent randomisation (intention-to-treat population) and 1513 participants who received all 4 doses of study drug were used to assess primary efficacy (per-protocol analysis). (ebneo.org)
  • On a global scale, rotavirus causes over 500,000 deaths in children per year, particularly in emerging countries. (georgeclinical.com)
  • In addition, the intensive monitoring and follow up of participants and provision of access to medical care these and referrals resulted in lower than expected numbers of deaths at all three sites, pointing to the attention paid to participant safety in the trial. (her2signaling.com)
  • During this webinar, participants will learn about common vaccine preventable illnesses (VPI) including human papillomavirus, viral hepatitis A, viral hepatitis B, Haemophilus influenzae type B, meningococcal disease, rotavirus, and varicella. (rxconsultant.com)
  • Participants will also learn about the vaccine to prevent each VPI including the patient population recommended to receive the vaccine, vaccine schedule, route of administration and common adverse effects. (rxconsultant.com)
  • Serotype G12 was identified in 30 (5%) of 546 rotavirus-positive fecal specimens. (cdc.gov)
  • Among rotavirus antigen-positive specimens, specimens that exhibited color intensity at least equal to the positive control provided with the Rotaclone kit were selected for further strain characterization. (cdc.gov)
  • Overall, rotavirus was detected in specimens from 27% of children (30% in Cincinnati and 24% in Oakland). (itg.be)
  • Rotavirus A infections can occur throughout life: the first usually produces symptoms, but subsequent infections are typically mild or asymptomatic, as the immune system provides some protection. (wikipedia.org)
  • The study of 195 participants reported that LGG can aid in the maintenance of a healthy microbiome, boost immunological function, can help prevent respiratory tract infections, and lessen symptoms of irritated skin and food allergies. (dairyreporter.com)
  • The SDM group scored significantly higher for understanding the information on the oral rotavirus vaccine than the non-SDM group, which helped them to decide whether to vaccinate the baby against rotavirus. (mendeley.com)
  • A fecal sample was collected from each case-patient and stored at -80°C until rotavirus detection and characterization were undertaken. (cdc.gov)
  • Rotavirus is transmitted by the faecal-oral route, via contact with contaminated hands, surfaces and objects, and possibly by the respiratory route. (wikipedia.org)
  • Oral human rotavirus vaccine (RV3-BB) was administered on a neonatal schedule (0-5 days, 8 weeks, and 14 weeks of age), or an infant schedule (8 weeks, 14 weeks, and 18 weeks of age), or as a placebo. (ebneo.org)
  • Results We fit a log-normal distribution to pooled data and found the median incubation period to be 4.5 days (95% CI 3.9-5.2 days) for astrovirus, 1.2 days (95% CI 1.1-1.2 days) for norovirus genogroups I and II, 1.7 days (95% CI 1.5-1.8 days) for sapovirus, and 2.0 days (95% CI 1.4-2.4 days) for rotavirus. (medscape.com)
  • The rotavirus outer capsid comprises 2 neutralization antigens, VP7 and VP4, which respectively define the G (for glycoprotein) and P (for protease-sensitive) serotypes. (cdc.gov)
  • The 5 globally most common rotavirus strain types comprise long electropherotype P[8] strains possessing G1, G3, G4, or G9 specificity and short electropherotype G2P[4] strains ( 4 ). (cdc.gov)
  • Our study assesses diversity of rotavirus strains in Lilongwe, Malawi, in anticipation of introduction of a rotavirus vaccine in this country. (cdc.gov)
  • Serotype G12 strains were further examined by polyacrylamide gel electrophoresis (PAGE) of rotavirus dsRNA followed by silver staining to determine the rotavirus electropherotype as previously described ( 10 ). (cdc.gov)
  • Within rotavirus A there are different strains, called serotypes. (wikipedia.org)
  • PVP-I gargle/mouthwash diluted 1:30 (equivalent to a concentration of 0.23% PVP-I) showed effective bactericidal activity against Klebsiella pneumoniae and Streptococcus pneumoniae and rapidly inactivated SARS-CoV, MERS-CoV, influenza virus A (H1N1) and rotavirus after 15 s of exposure. (springer.com)
  • The primary efficacy analysis was performed in 1513 participants (per-protocol population). (ebneo.org)
  • Participants will be randomly assigned to receive a single dose of RSV ΔNS2/Δ1313/I1314L vaccine, RSV 6120/ΔNS2/1030s vaccine, RSV 276 vaccine, or placebo intranasally at study entry. (ucsd.edu)
  • Human neonatal rotavirus vaccine (RV3-BB), administered on a neonatal schedule or infant schedule, compared with placebo. (ebneo.org)
  • This study aimed to describe the epidemiological profile of rotavirus disease in central-east Tunisia and to estimate its hospital cost. (who.int)
  • Study participants included outpatients and inpatients. (cdc.gov)
  • The study enrolled 180 participants. (mendeley.com)
  • 2. Participant or parent of the participant is willing and able to provide written informed consent prior to performance of any study-specific procedure. (who.int)
  • 3. Resides and plans to remain in study area and participants and parent, when applicable, understands and is able and willing to adhere to all study visits and procedures (as evidenced by a signed informed consent form [ICF] and assessment by the investigator). (who.int)
  • A retrospective cohort study of the visitor group of luncheon participants was performed. (health.gov.au)
  • An Oncology Nursing Society-funded study at Emory University is looking for healthy participants to compare the gut bacteria of healthy children to the gut bacteria of children with cancer. (pedsresearch.org)
  • Participants will be enrolled in the study outside of RSV season. (ucsd.edu)
  • All participants will remain on study until they complete the post-RSV season visit between April 1 and April 30 in the calendar year following enrollment. (ucsd.edu)
  • Participants' total study duration will be between 6 and 13 months, depending on when they enroll in the study. (ucsd.edu)
  • Participants will attend several study visits throughout the study, which may include physical examinations, blood collection, and nasal washes. (ucsd.edu)
  • Participants' parents or guardians will be contacted by study staff at various times during the study to monitor participants' health. (ucsd.edu)
  • Disseminating clinical study results to trial participants in Ethiopia: insights and lessons learned. (ox.ac.uk)
  • trial participants and medical staff were provided feedback on the study results. (ox.ac.uk)
  • Concern for risk of bias resulting from censoring of participants for whom follow-up data are missing in the underlying studies of a body of evidence can be expressed in the study limitations (risk of bias) domain of the GRADE approach. (ox.ac.uk)
  • They were 13,974 participants included in the study over the three seasons. (biomedcentral.com)
  • 8. Parent agrees for participant to receive all routine infant and childhood immunizations as per the protocol defined schedule (see Appendix I: Schedule of events table). (who.int)
  • A new and cheap rotavirus vaccine will bring life vaccine immunizations to the world's poorest areas. (medicaldaily.com)
  • RÉSUMÉ Des données sur le fardeau économique de l'infection à rotavirus en Tunisie sont nécessaires pour décider ou non d'inclure le rotavirus dans les vaccinations infantiles systématiques. (who.int)
  • For Rotavirus, describe this disease, including the causative agent. (cdc.gov)
  • For Rotavirus, describe characteristics of the vaccine used to prevent this disease. (cdc.gov)
  • There are five species of rotavirus, referred to as A, B, C, D and E. Humans are mostly infected by species A. All five species cause disease in other animals. (wikipedia.org)
  • Dr. Offit is best known for co-inventing a vaccine against rotavirus, a diarrheal disease that has claimed millions of lives. (rickilewis.com)
  • The good bacteria decrease the pH levels of these participants. (discountmill.com)
  • More than 50 percent of adult participants involved in the Phase 1/2 human trials of Pfizer and BioNTech's experimental messenger RNA (ribonucleic acid) COVID-19 vaccine reported adverse reactions. (nvic.org)
  • 5 years of age are due to rotavirus. (cdc.gov)
  • Design, Setting, and Participants: This phase 2-3 observer-blind randomized clinical trial was conducted in 2 cohorts, children (aged 2 to 11 years) and adolescents (aged 12 to 17 years) between August 2021 and August 2022. (bvsalud.org)
  • More recently, rotavirus serotype G12 has emerged in multiple countries ( 7 ). (cdc.gov)
  • Participants were from 17 countries on 6 continents and included representatives from academia, industry, government, and private charitable foundations. (cdc.gov)
  • Rotavirus was responsible for 65 (23.3%) of the 279 cases enrolled. (who.int)
  • In the second stage, cost data were collected retrospectively using an activity-based costing method from the medical records of the children who were positively diagnosed with rotavirus. (who.int)
  • Participants include one-hundred children aged 6 months was divided into two groups, i.e. vaccinated and non-vaccinated groups, each consisting of 50 children. (ejournals.ca)