• formation
  • Unlike thromboxane synthase inhibitors such as ozagrel, seratrodast does not affect thrombus formation, time to occlusion and bleeding time. (wikipedia.org)
  • cause
  • By the time accumulating epigenetic and mutational changes eventually cause hepatocellular carcinoma, epigenetic alterations appear to have an even larger role in carcinogenesis than mutations. (wikipedia.org)
  • risk
  • Despite the American Heart Association warning that people at high risk for heart disease should only use celecoxib if there are not other possible treatments and that celecoxib costs about five times more than acetaminophen, ibuprofen, or naproxen - which are equally effective for pain relief, 11 million prescriptions of celecoxib are filled each year. (wikipedia.org)