• accumulation
  • Vascular calcification (VC), the accumulation of calcium phosphate products in the wall of arteries, is a common complication of diabetes and chronic kidney disease that contributes to their morbidity and mortality. (ahajournals.org)
  • uptake
  • For example, the protein 2A is encoded by the solute carrier family 34, member 1 (SLC34A1) gene and facilitates uptake of phosphate for normal cellular functions including cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. (wikipedia.org)
  • We have found that VSMCs exhibit both Na-dependent and Na-independent Pi transport components with similar kinetic behavior, but that only the Na-coupled saturable uptake can be explained by the expression of both type III NaPi (NaPi-III) transporters, Pit1 and Pit2. (ahajournals.org)
  • treatment
  • The main focus of this educational review article is to discuss the genetic and clinical features of phosphate regulation disorders and provide understanding and treatment options. (springer.com)
  • levels
  • Workup revealed a serum phosphorus of 1.8 mg/dl (4-5.4 mg/dl), elevated fractional excretion of phosphate (40%), 1,25 vitamin D levels of 129 pg/ml (15-75 pg/ml), 24-h urinary calcium of 7 mg/kg/day, and serum calcium 9.8 mg/dl (8.5-11 mg/dl). (springer.com)