Filter...

AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science

Select a category...

ParaproteinsImmunoglobulin Fab FragmentsImmunoglobulin FragmentsParaproteinemiasPyroglobulinsImmunoglobulin GImmunoglobulin MImmunoglobulinsImmunoglobulin AImmunoglobulin Light ChainsImmunoglobulin Heavy ChainsImmunoglobulin kappa-ChainsBlood Protein ElectrophoresisWaldenstrom MacroglobulinemiaComplement Hemolytic Activity AssayImmunosorbentsMyeloma ProteinsImmunoglobulin lambda-ChainsImmunoglobulin Variable RegionImmunoelectrophoresisImmunoglobulins, IntravenousPeptide FragmentsGenes, ImmunoglobulinMultiple MyelomaHypergammaglobulinemiaImmunoglobulin IdiotypesElectrophoresis, Cellulose AcetateAntibody SpecificityImmunoglobulin ERheumatoid FactorCryoglobulinsElectrophoresis, CapillaryImmunoglobulin A, SecretoryImmunoglobulin Fc FragmentsImmunoglobulin mu-ChainsMolecular Sequence DataAntibodies, MonoclonalImmunoglobulin IsotypesCross ReactionsShockElectrophoresis, Agar GelBase SequenceImmunoglobulin DAutoantibodiesImmunoglobulin Constant RegionsElectrophoresisEpitopesB-LymphocytesAmino Acid SequencePolymorphism, Restriction Fragment Length

Multiple myelomaChainsHomogeneousMonoclonalMoleculeAntibodyDiseasesMeSHPatientsMonoclonal immunoglobulinProteinsMoleculesProteinConcentrationLight chainHumanBlood

Multiple myeloma2

• Multiple Myeloma Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin and invade and destroy adjacent bone tissue. (msdmanuals.com)
• Abnormal immunoglobulins characteristic of MULTIPLE MYELOMA. (lookformedical.com)

Chains8

• The proteins are immunoglobulin light chains (paraproteins) and are produced by neoplastic plasma cells. (wikipedia.org)
• The light chains can be immunoglobulin fragments or single homogeneous immunoglobulins. (wikipedia.org)
• Heavy chain diseases are neoplastic plasma cell disorders characterized by overproduction of monoclonal immunoglobulin heavy chains. (msdmanuals.com)
• The paired immunoglobulin fragments composed of the variable domains of the heavy and light chains. (nih.gov)
• It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. (lookformedical.com)
• Paraproteins containing only light chains lead to Bence Jones paraproteinemia, while the presence of only atypical heavy chains leads to heavy chain disease. (lookformedical.com)
• Two Ig light chains and two Ig heavy chains (IMMUNOGLOBULIN HEAVY CHAINS) make one immunoglobulin molecule. (lookformedical.com)
• It has been cross adsorbed against pooled mouse paraproteins with lambda light chains. (bio-rad-antibodies.com)

Homogeneous1

• These cells frequently secrete a structurally homogeneous immunoglobulin (M-component) and/or an abnormal immunoglobulin. (lookformedical.com)

Monoclonal5

• Bence Jones protein is a monoclonal globulin protein or immunoglobulin light chain found in the urine, with a molecular weight of 22-24 kDa. (wikipedia.org)
• In most plasma cell disorders, M-proteins (monoclonal immunoglobulin protein) are structurally similar to normal antibody molecules. (msdmanuals.com)
• In contrast, in heavy chain diseases, incomplete monoclonal immunoglobulins (true paraproteins) are produced. (msdmanuals.com)
• A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. (lookformedical.com)
• Most of the paraproteins show themselves as an M-component (monoclonal gammopathy) in electrophoresis. (lookformedical.com)

Molecule1

• That region of the immunoglobulin molecule that varies in its amino acid sequence and composition, and comprises the binding site for a specific antigen. (nih.gov)

Antibody1

• F(ab')2 fragments were prepared by gel filtration chromatography of pepsin-digested goat anti mouse kappa light chain antibody. (bio-rad-antibodies.com)

Diseases1

• A group of related diseases characterized by an unbalanced or disproportionate proliferation of immunoglobulin-producing cells, usually from a single clone. (lookformedical.com)

MeSH1

• Immunoglobulin Subunits" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)

Patients1

• PURPOSE: This study aimed to examine tubulointerstitial B-cell infiltration in patients with adult-onset immunoglobulin A vasculitis (IgAV) and nephritis (IgAV-N), and to evaluate whether B-cell infiltration correlated with clinicopathological variables at kidney biopsy and with short-term renal outcomes. (bvsalud.org)

Monoclonal immunoglobulin3

• Heavy chain diseases are neoplastic plasma cell disorders characterized by overproduction of monoclonal immunoglobulin heavy chains. (msdmanuals.com)
• In most plasma cell disorders, M-proteins (monoclonal immunoglobulin protein) are structurally similar to normal antibody molecules. (msdmanuals.com)
• Множинна мієлома Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin and invade and destroy adjacent bone tissue. (msdmanuals.com)

Proteins2

• The proteins are immunoglobulin light chains (paraproteins) and are produced by neoplastic plasma cells. (wikipedia.org)
• Light chains (kappa or lambda) are smaller fragments of immunoglobulin molecules that can be detected in serum (serum-free light chains) and are small enough to be filtered through the kidney (glomerulus) and can be detected in the urine (Bence Jones proteins). (medscape.com)

Molecules1

• Partial immunoglobulin molecules resulting from selective cleavage by proteolytic enzymes or generated through PROTEIN ENGINEERING techniques. (nih.gov)

Protein3

• Bence Jones protein is a monoclonal globulin protein or immunoglobulin light chain found in the urine, with a molecular weight of 22-24 kDa. (wikipedia.org)
• The presence of paraproteins causes the formation of a narrow and high peak in the area of ​​γ-globulins during serum protein electrophoresis. (wikilectures.eu)
• The modification of human immunoglobulin binding to staphylococcal protein A using diethylpyrocarbonate. (nih.gov)

Concentration1

• Increased concentration of monoclonal immunoglobulins or their fragments in serum . (wikilectures.eu)

Light chain1

• Proof the amyloid deposits are derived from light chain immunoglobulins. (coreimpodcast.com)

Human1

• Differential susceptibility of human IgA immunoglobulins to streptococcal IgA protease. (nih.gov)

Blood1

• The paraproteins can deposit within blood vessel walls, leading to vascular fragility. (coreimpodcast.com)