• Endocrine
  • Neuroendocrine tumors (NETs) are neoplasms that arise from cells of the endocrine (hormonal) and nervous systems. (wikipedia.org)
  • Although the cellular origin of NETs of the GI tract is uncertain, consistent expression of cytokeratins in NETs and the expression of the caudal-related homeodomain protein 2 (CdX2 protein), an intestinal transcription factor in endocrine tumors of the small intestine, suggests an origin from an epithelial precursor cell. (cancer.gov)
  • Most NETs of the small and large intestines occur sporadically, while others may occur within the background of an inherited neoplasia syndrome such as multiple endocrine neoplasia type 1 (MEN1) or neurofibromatosis type 1 (NF1) (e.g., gastrin-producing G-cell tumors and somatostatin-producing D-cell tumors of the duodenum, respectively). (cancer.gov)
  • Individual carcinoid tumors have specific histologic and immunohistochemical features based on their anatomic location and endocrine cell type. (cancer.gov)
  • Refer to the PDQ summary on Genetics of Endocrine and Neuroendocrine Neoplasias for more information. (cancer.gov)
  • Lesions
  • clonality studies suggest that most of these neoplasms are separate primary lesions. (cancer.gov)
  • Synchronous lesions of the right accessory parotid gland and left main parotid gland. (mayo.edu)
  • tuberin-hamartin complex functions as a tumor suppressor by suppression of the mTOR pathway.CNS lesions in TSC are the primary cause of mortality and morbidity and include cortical and cerebellar tubers, radial migration lines, subependymal nodules, and subependymal giant cell astrocytomas. (livermr.com)
  • PNETs
  • PanNETs are sometimes abbreviated as PETs or PNETs: such use should not to be confused with the primitive neuroectodermal tumor (PNET). (wikipedia.org)
  • treated with ipilimumab
  • I. To evaluate the Response Evaluation Criteria in Solid Tumors (RECIST) version (v)1.1 overall response rate (ORR) in subsets of patients with advanced rare cancers treated with ipilimumab plus nivolumab combination immunotherapy. (clinicaltrials.gov)
  • metastasis
  • Symptoms such as abdominal or back pain or pressure, diarrhea, indigestion, or yellowing of the skin and whites of the eyes can arise from the effects of a larger PanNET tumor, either locally or at a metastasis. (wikipedia.org)
  • Pancreatic neuroendocrine tumor staging (AJCC) Stage T1 Stage T2 Stage T3 Stage T4 Involvement of nearby lymph nodes - Stage N1 Metastasis - stage M1 In general, treatment for PanNET encompasses the same array of options as other neuroendocrine tumors, as discussed in that main article. (wikipedia.org)
  • Teratoma
  • Primary adrenal teratoma: An unusual tumor - Challenges in diagnosis and surgical management. (readbyqxmd.com)
  • Computed tomography scan revealed an adrenal mass for which a right open transperitoneal adrenalectomy was performed, and the lesion was diagnosed as mature teratoma on histopathological examination. (readbyqxmd.com)
  • Teratoma is an unusual neoplasm which arises from one or all the three germ layers. (readbyqxmd.com)
  • diagnosis
  • Patients must have a tissue diagnosis of any of the following metastatic, well or moderately differentiated, slow growing neuroendocrine tumor and must demonstrate progressive metastatic disease by prior serial computerized tomography (CT) or magnetic resonance imaging (MRI) scans, or have increased symptoms from their tumors while on sandostatin LAR or octreotide. (clinicaltrials.gov)
  • at five years from diagnosis, 65% of those diagnosed are living, though survival varies considerably depending on the type of tumor. (wikipedia.org)
  • occur
  • tumors occur at a younger age compared with the general population. (livermr.com)
  • Within the latter type, the hairs occur in structures called pilosebaceous units, each with hair follicle, sebaceous gland, and associated arrector pili muscle. (wikipedia.org)
  • Syndrome
  • Up to 60%[medical citation needed] of PanNETs are nonsecretory or nonfunctional, in which there is no secretion, or the quantity or type of products, such as pancreatic polypeptide (PPoma), chromogranin A, and neurotensin, do not cause a clinical syndrome although blood levels may be elevated. (wikipedia.org)
  • Blau syndrome Chronic infantile neurologic cutaneous and articular syndrome Familial cold urticaria (familial cold autoinflammatory syndrome) Familial Mediterranean fever Hyper-IgD syndrome Majeed syndrome Muckle-Wells syndrome TNF receptor associated periodic syndrome (familial Hibernian fever, TRAPS, tumor necrosis factor receptor associated periodic syndrome) Chronic blistering cutaneous conditions have a prolonged course and present with vesicles and bullae. (wikipedia.org)
  • lesion
  • The ssAVS technique was described, cases in which adrenal segmental lesion(s) were identified by ssAVS were presented, and the usefulness of ssAVS in future adrenal research was discussed. (jove.com)
  • symptoms
  • 3 ] However, it is possible that the association may be due in part to the serendipitous discovery of slow-growing carcinoid tumors, which are found while staging or investigating symptoms from other tumors. (cancer.gov)
  • patients
  • Ablative techniques including radiofrequency ablation and cryoablation may be used in patients with smaller tumors who are at high operative risk. (uni-bonn.de)
  • Thrombocytopenia is a frequent finding in patients with solid tumors. (readbyqxmd.com)
  • tissue
  • I. To evaluate the association of tumor mutational burden measured by tissue sequencing with durable response (complete response [CR] or partial response [PR] lasting 24 weeks or more). (clinicaltrials.gov)
  • Although there are many kinds of NETs, they are treated as a group of tissue because the cells of these neoplasms share common features, such as looking similar, having special secretory granules, and often producing biogenic amines and polypeptide hormones. (wikipedia.org)